ATE460415T1 - Therapeutische pyrazoloä3,4-büpyridine und - indazole - Google Patents

Therapeutische pyrazoloä3,4-büpyridine und - indazole

Info

Publication number: ATE460415T1
Authority: AT; Austria
Prior art keywords: pyrazoloa3; bupyridines; indazoles; therapeutic; therapeutic pyrazoloa3
Prior art date: 2004-11-29

Application number

AT05806091T

Other languages

English (en)

Inventor

Robert M Schelkun

Po-Wai Yuen

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-11-29

Filing date

2005-11-17

Publication date

2010-03-15

2005-11-17 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2010-03-15 Application granted granted Critical

2010-03-15 Publication of ATE460415T1 publication Critical patent/ATE460415T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT05806091T 2004-11-29 2005-11-17 Therapeutische pyrazoloä3,4-büpyridine und - indazole ATE460415T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US63138604P	2004-11-29	2004-11-29
PCT/IB2005/003549 WO2006056873A2 (en)	2004-11-29	2005-11-17	Therapeutic pyrazolo[3,4-b] pyridines and indazoles

Publications (1)

Publication Number	Publication Date
ATE460415T1 true ATE460415T1 (de)	2010-03-15

Family

ID=36218221

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05806091T ATE460415T1 (de)	2004-11-29	2005-11-17	Therapeutische pyrazoloä3,4-büpyridine und - indazole

Country Status (29)

Country	Link
US (3)	US7423054B2 (de)
EP (1)	EP1828182B1 (de)
JP (1)	JP4130219B2 (de)
KR (1)	KR20070094747A (de)
CN (1)	CN101111494A (de)
AP (1)	AP2007004024A0 (de)
AR (1)	AR051970A1 (de)
AT (1)	ATE460415T1 (de)
AU (1)	AU2005308523B2 (de)
BR (1)	BRPI0518693A2 (de)
CA (1)	CA2588812A1 (de)
CR (1)	CR9155A (de)
DE (1)	DE602005019913D1 (de)
DK (1)	DK1828182T3 (de)
EA (1)	EA012245B1 (de)
ES (1)	ES2339794T3 (de)
GT (1)	GT200500348A (de)
IL (1)	IL183485A0 (de)
MA (1)	MA29215B1 (de)
MX (1)	MX2007006408A (de)
NL (2)	NL1030540C2 (de)
NO (1)	NO20072972L (de)
PA (1)	PA8653901A1 (de)
PE (1)	PE20061062A1 (de)
TN (1)	TNSN07207A1 (de)
TW (1)	TWI304063B (de)
UY (1)	UY29228A1 (de)
WO (1)	WO2006056873A2 (de)
ZA (1)	ZA200704408B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU714980B2 (en)	1996-07-24	2000-01-13	Warner-Lambert Company Llc	Isobutylgaba and its derivatives for the treatment of pain
ATE460415T1 (de) *	2004-11-29	2010-03-15	Warner Lambert Co	Therapeutische pyrazoloä3,4-büpyridine und - indazole
SG176464A1 (en) *	2008-05-09	2011-12-29	Agency Science Tech & Res	Diagnosis and treatment of kawasaki disease
US9938269B2 (en)	2011-06-30	2018-04-10	Abbvie Inc.	Inhibitor compounds of phosphodiesterase type 10A
WO2014078568A1 (en)	2012-11-14	2014-05-22	The Johns Hopkins University	Methods and compositions for treating schizophrenia
EP2929883A1 (de) *	2014-04-08	2015-10-14	Institut Pasteur	Pyrazolderivate als Dihydroorotat-Dehydrogenase-(DHODH)-Hemmer
CN107082763A (zh) *	2016-02-15	2017-08-22	中山大学	一种合成吲唑酮类化合物的方法
US20240270726A1 (en) *	2021-06-04	2024-08-15	Pi Industries Ltd.	A novel process for the preparation of anthranilic diamides

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3428634A (en) *	1965-03-13	1969-02-18	Acraf	3-tertiary amino alkoxy-1-hydrocarbon indazoles
US3488353A (en) *	1967-05-29	1970-01-06	Sterling Drug Inc	New 1-((2-azaindolyl)-lower-alkyl) 4-substituted-piperazines
US3712903A (en) *	1968-04-17	1973-01-23	Cutter Lab	5(1-(phenyl or benzyl)-1h-indazol-3-yloxymethyl)-tetrazoles
IT1061791B (it)	1969-01-27	1983-04-30	Italfarmaco Spa	Derivati indazolici ad attivita antiinfiammatoria e anagesica
US3681382A (en) *	1969-02-07	1972-08-01	Ciba Geigy Corp	3-aminoindazoles
US3678059A (en) *	1969-10-07	1972-07-18	Ciba Geigy Corp	3-aminoalkylidene-indazoles
IT1044784B (it) *	1970-12-15	1980-04-21	Italfarmaco Spa	Farmaco adnattivita analgesica e antiinfiammatoria
DE3166987D1 (en) *	1980-09-18	1984-12-06	Asahi Chemical Ind	3-aminoindazole derivatives and process for preparation thereof
JPS58159469A (ja)	1982-03-17	1983-09-21	Asahi Chem Ind Co Ltd	新規な１，３位ジ置換３−アミノインダゾ−ル誘導体およびその製造法
US4933460A (en) *	1983-08-22	1990-06-12	Hoechst-Roussel Pharmaceuticals Inc.	Piperdine substituted phenyl hydrazones
US4758668A (en) *	1983-08-22	1988-07-19	Hoechst-Roussel Pharmaceuticals Inc.	3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles
US4853470A (en) *	1983-08-22	1989-08-01	Hoechst-Roussel Pharmaceuticals, Inc.	3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles
HU198036B (en)	1983-08-22	1989-07-28	Hoechst Roussel Pharma	Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them
US4806649A (en) *	1983-08-22	1989-02-21	Hoechst-Roussel Pharmaceuticals, Inc.	3-(piperidinyl)- and 3- (pyrrolidinyl)-1H-indazoles
US4775761A (en) *	1983-08-22	1988-10-04	Hoechst-Roussel Pharmaceuticals, Inc.	3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles
US4710573A (en) *	1983-08-22	1987-12-01	Hoechst Roussel Pharmaceuticals, Inc.	3-(piperidinyl)-and 3-(pyrrolidinyl)-1H-indazoles
US4670447A (en) *	1983-08-22	1987-06-02	Hoechst-Roussel Pharmaceuticals Inc.	Antipsychotic 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles
DE3338903A1 (de)	1983-10-27	1985-05-09	Basf Ag, 6700 Ludwigshafen	Neue 2-phenylindazole und deren verwendung
US4999356A (en) *	1987-08-07	1991-03-12	Hoechst-Roussel Pharmaceuticals, Inc.	1-phenyl-3-(1-piperazinyl)-1H-indazoles
US5134236A (en) *	1987-08-07	1992-07-28	Hoechst-Roussel Pharmaceuticals Incorporated	Phenylhydrazones as intermediates 1-phenyl-3-(1-piperazenyl)-1H-indazoles
US5015740A (en) *	1988-08-05	1991-05-14	Janssen Pharmaceutica N.V.	Antipsychotic 3-piperazinylbenzazole derivatives
US4957916A (en) *	1988-08-05	1990-09-18	Janssen Pharmaceutica N.V.	Antipsychotic 3-piperazinylbenzazole derivatives
US5077405A (en) *	1989-09-11	1991-12-31	Hoechst-Roussel Pharmaceuticals Incorporated	3-(1-Substituted-4-piperazinyl)-1H-indazoles
US4954503A (en) *	1989-09-11	1990-09-04	Hoechst-Roussel Pharmaceuticals, Inc.	3-(1-substituted-4-piperazinyl)-1H-indazoles
JPH03223265A (ja)	1990-01-26	1991-10-02	Dainippon Pharmaceut Co Ltd	環状ジアミン誘導体
US5346968A (en) *	1990-04-21	1994-09-13	Basf Aktiengesellschaft	Oligosiloxanes and reinforced thermoplastic and ceramic materials obtainable therewith
FR2663291A1 (fr) *	1990-06-15	1991-12-20	Oreal	Procede pour le conditionnement d'un produit dans un flacon, permettant d'assurer une meilleure conservation du produit au cours du stockage et ensemble de conditionnement correspondant.
US5750542A (en) *	1993-09-28	1998-05-12	Pfizer	Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
CA2092112A1 (en)	1992-03-23	1993-09-24	Nobuyoshi Iwata	Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use
DE4222705C2 (de)	1992-07-10	1996-04-04	Bartenbach Christian	Reflektorelement, Reflektorelementanordnung und Raumbeleuchtungsanordnung
EP0669920B1 (de) *	1992-11-23	2003-02-12	Aventis Pharmaceuticals Inc.	Substituierte 3-(aminoalkylamino)-1,2-benzisoxazole und verwandte verbindungen
US5494908A (en) *	1992-11-23	1996-02-27	Hoechst-Roussel Pharmaceutical Incorporated	Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
FR2701026B1 (fr) *	1993-02-02	1995-03-31	Adir	Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
GB9305623D0 (en) *	1993-03-18	1993-05-05	Merck Sharp & Dohme	Therapeutic agents
US5681954A (en) *	1993-05-14	1997-10-28	Daiichi Pharmaceutical Co., Ltd.	Piperazine derivatives
SE502602C2 (sv) *	1994-05-26	1995-11-20	Vattenfall Ab	Vägguttag
AU3162695A (en) *	1994-08-03	1996-03-04	Asta Medica Aktiengesellschaft	Indol, indazol, pyridopyrrol and pyridopyrazol derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effects
GB9423682D0 (en) *	1994-11-23	1995-01-11	Merck Sharp & Dohme	Therapeutic agents
WO1997016446A1 (en) *	1995-11-02	1997-05-09	Merck Sharp & Dohme Limited	Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation and their use as selective agonists of 5-ht1-like receptors
GB9523250D0 (en) *	1995-11-14	1996-01-17	Merck Sharp & Dohme	Therapeutic agents
GB9523583D0 (en) *	1995-11-17	1996-01-17	Merck Sharp & Dohme	Therapeutic agents
GB9524356D0 (en) *	1995-11-29	1996-01-31	Merck Sharp & Dohme	Therapeutic agents
FR2742148B1 (fr) *	1995-12-08	1999-10-22	Sanofi Sa	Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant
WO1998001428A1 (en)	1996-07-08	1998-01-15	Du Pont Pharmaceuticals Company	AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN
US6166027A (en) *	1996-10-14	2000-12-26	Bayer Aktiengesellschaft	Heterocyclylmethyl-substituted pyrazole derivatives and their use for treating cardiovascular diseases
US6015740A (en) *	1997-02-10	2000-01-18	Advanced Micro Devices, Inc.	Method of fabricating CMOS devices with ultra-shallow junctions and reduced drain area
US6329412B1 (en) *	1997-11-04	2001-12-11	Pfizer Inc	Bisamidine compounds as antiproliferative agents
BR9813926A (pt) *	1997-11-04	2000-09-19	Pfizer Prod Inc	Substituição de bioisóstero de catecol por indazol em compostos terapeuticamente ativos
US6451805B1 (en) *	1997-11-14	2002-09-17	Bayer Aktiengesellschaft	Substituted pyrazole derivatives for the treatment of cardiocirculatory diseases
JPH11279156A (ja)	1998-03-31	1999-10-12	Dai Ichi Seiyaku Co Ltd	インダゾール誘導体
DE19821002A1 (de) *	1998-05-11	1999-11-18	Dresden Arzneimittel	Neue 1,5- und 3-O-substituierte 1H-Indazole mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19834044A1 (de) *	1998-07-29	2000-02-03	Bayer Ag	Neue substituierte Pyrazolderivate
US6316440B1 (en)	1998-07-30	2001-11-13	Warner-Lambert Company	Reduced dipeptide analogues as calcium channel antagonists
GB9824310D0 (en)	1998-11-05	1998-12-30	Univ London	Activators of soluble guanylate cyclase
JP2000198734A (ja)	1998-12-30	2000-07-18	Pfizer Inc	胃運動性減弱および関連疾患の治療のための運動性増強薬
CZ27399A3 (cs) *	1999-01-26	2000-08-16	Ústav Experimentální Botaniky Av Čr	Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
US6465467B1 (en) *	1999-05-21	2002-10-15	Biovitrum Ab	Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
MXPA01011905A (es)	1999-05-21	2004-03-19	Biovitrum Ab	Compuestos novedosos, su uso y preparacion.
GB9929685D0 (en) *	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
US20030176421A1 (en) *	1999-12-30	2003-09-18	Watson John W.	Prokinetic agents for treating gastric hypomotility and related disorders
GB0002666D0 (en)	2000-02-04	2000-03-29	Univ London	Blockade of voltage dependent sodium channels
EP1268438A1 (de)	2000-03-17	2003-01-02	Alcon, Inc	6-hydroxy-indazolderivate zur behandlung von glaukoma
JP2003535821A (ja)	2000-03-17	2003-12-02	アルコン，インコーポレイティド	緑内障を治療するための５−ヒドロキシインダゾール誘導体
US20020052373A1 (en) *	2000-10-26	2002-05-02	Zorn Stevin H.	Combination treatment for dementia or cognitive deficits associated with alzheimer's disease and parkinson's disease
CA2432654A1 (en) *	2000-12-22	2002-07-04	Wyeth	Heterocyclindazole and azaindazole compounds as 5-hydroxytryptamine-6 ligands
US6777437B2 (en) *	2001-03-29	2004-08-17	Bristol-Myers Squibb Company	Cyclopropylindole derivatives as selective serotonin reuptake inhibitors
WO2003035005A2 (en) *	2001-10-26	2003-05-01	University Of Connecticut	Heteroindanes: a new class of potent cannabimimetic ligands
US20040034101A1 (en) *	2001-11-05	2004-02-19	Cypress Bioscience, Inc.	Treatment and prevention of depression secondary to pain (DSP)
JP2003146973A (ja)	2001-11-08	2003-05-21	Dai Ichi Seiyaku Co Ltd	うつ病、うつ状態又は不安障害の治療及び／又は予防薬
JP2003146879A (ja)	2001-11-08	2003-05-21	Dai Ichi Seiyaku Co Ltd	精神分裂病治療及び／又は予防薬
WO2003076408A2 (en) *	2002-03-08	2003-09-18	Abbott Laboratories	Indazole derivatives that are activators of soluble guanylate cyclase
US7057042B2 (en) *	2002-05-29	2006-06-06	Abbott Laboratories	Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction
WO2003101994A1 (en)	2002-05-29	2003-12-11	Abbott Laboratories	Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction
TW200505902A (en)	2003-03-20	2005-02-16	Schering Corp	Cannabinoid receptor ligands
US20060019967A1 (en) *	2004-07-21	2006-01-26	Su-Ying Wu	SARS CoV main protease inhibitors
ATE460415T1 (de) *	2004-11-29	2010-03-15	Warner Lambert Co	Therapeutische pyrazoloä3,4-büpyridine und - indazole

2005
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Also Published As

Publication number	Publication date
PE20061062A1 (es)	2006-10-26
WO2006056873A2 (en)	2006-06-01
EA200700963A1 (ru)	2008-02-28
GT200500348A (es)	2006-06-13
MA29215B1 (fr)	2008-02-01
PA8653901A1 (es)	2006-09-22
AU2005308523B2 (en)	2010-01-07
EA012245B1 (ru)	2009-08-28
WO2006056873A3 (en)	2006-12-28
EP1828182A2 (de)	2007-09-05
US7485636B2 (en)	2009-02-03
NL1033403A1 (nl)	2007-04-20
TW200631582A (en)	2006-09-16
US20060116376A1 (en)	2006-06-01
US7423054B2 (en)	2008-09-09
NL1030540A1 (nl)	2006-05-30
TNSN07207A1 (fr)	2008-11-21
AP2007004024A0 (en)	2007-06-30
NO20072972L (no)	2007-08-23
TWI304063B (en)	2008-12-11
NL1030540C2 (nl)	2007-02-26
EP1828182B1 (de)	2010-03-10
JP4130219B2 (ja)	2008-08-06
JP2008528444A (ja)	2008-07-31
US20080293715A1 (en)	2008-11-27
AR051970A1 (es)	2007-02-21
US20060217376A1 (en)	2006-09-28
IL183485A0 (en)	2007-10-31
ES2339794T3 (es)	2010-05-25
AU2005308523A1 (en)	2006-06-01
DE602005019913D1 (de)	2010-04-22
DK1828182T3 (da)	2010-05-10
CA2588812A1 (en)	2006-06-01
CR9155A (es)	2007-06-29
NL1033403C2 (nl)	2010-01-05
ZA200704408B (en)	2009-08-26
BRPI0518693A2 (pt)	2008-12-02
KR20070094747A (ko)	2007-09-21
MX2007006408A (es)	2007-06-22
UY29228A1 (es)	2006-06-30
CN101111494A (zh)	2008-01-23

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DE602005000574D1 (de)	2007-04-05	Verbinder
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DK1597171T3 (da)	2013-02-11	Terapeutisk mikroskum
DK1940840T3 (da)	2010-11-22	6-heteroarylpyridoindolon-derivater, fremstilling deraf og terapeutisk anvendelse deraf
EP2111484A4 (de)	2009-10-28	Polyamin-aufhellungsmittel
DK2119472T3 (da)	2014-10-13	Hud-/hårbehandlingssystem
DK1753725T3 (da)	2013-05-27	Tetra-hydro-iso-quinolinsulfonamidderivater, fremstilling og terapeutisk anvendelse heraf.
ATE460415T1 (de)	2010-03-15	Therapeutische pyrazoloä3,4-büpyridine und - indazole
DK1773829T3 (da)	2009-04-20	Aminotropanderivater, fremstilling og terapeutiske anvendelser heraf
DE602005020457D1 (de)	2010-05-20	Master-slave-flip-flop, trigger-flip-flop und zähler
DK1622892T3 (da)	2011-06-27	Indazoler med analgetisk aktivitet
ES1058102Y (es)	2005-02-16	Lentilla terapeutica.
NO20053189D0 (no)	2005-06-29	HVC-kombinasjonsterapi.
DE602005001739D1 (de)	2007-09-06	Verbinder
ATA13282004A (de)	2005-08-15	Massagegerät

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