ATE458727T1 - Zur modulation des 5-ht6-rezeptors, des 5-ht2a- rezeptors oder beider rezeptoren geeignete arylsulfonylbenzodioxane - Google Patents

Zur modulation des 5-ht6-rezeptors, des 5-ht2a- rezeptors oder beider rezeptoren geeignete arylsulfonylbenzodioxane

Info

Publication number: ATE458727T1
Authority: AT; Austria
Prior art keywords: receptor; arylsulfonylbenzodioxanes; receptors; modulation; ht2a
Prior art date: 2004-05-05

Application number

AT05734404T

Other languages

English (en)

Inventor

Jacob Berger

Shu-Hai Zhao

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-05

Filing date

2005-04-27

Publication date

2010-03-15

2005-04-27 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2010-03-15 Application granted granted Critical

2010-03-15 Publication of ATE458727T1 publication Critical patent/ATE458727T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

AT05734404T 2004-05-05 2005-04-27 Zur modulation des 5-ht6-rezeptors, des 5-ht2a- rezeptors oder beider rezeptoren geeignete arylsulfonylbenzodioxane ATE458727T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US56831404P	2004-05-05	2004-05-05
PCT/EP2005/004479 WO2005105776A1 (en)	2004-05-05	2005-04-27	Arylsulfonyl benzodioxanes useful for modulation the 5-ht6 receptor, the 5-ht2areceptor or both

Publications (1)

Publication Number	Publication Date
ATE458727T1 true ATE458727T1 (de)	2010-03-15

Family

ID=34965191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05734404T ATE458727T1 (de)	2004-05-05	2005-04-27	Zur modulation des 5-ht6-rezeptors, des 5-ht2a- rezeptors oder beider rezeptoren geeignete arylsulfonylbenzodioxane

Country Status (21)

Country	Link
US (1)	US7368567B2 (de)
EP (1)	EP1748995B1 (de)
JP (1)	JP2007536302A (de)
KR (1)	KR100823805B1 (de)
CN (1)	CN100540546C (de)
AR (1)	AR048936A1 (de)
AT (1)	ATE458727T1 (de)
AU (1)	AU2005238179B2 (de)
BR (1)	BRPI0510642A (de)
CA (1)	CA2566196A1 (de)
DE (1)	DE602005019562D1 (de)
ES (1)	ES2338668T3 (de)
HK (1)	HK1104533A1 (de)
IL (1)	IL178819A0 (de)
MX (1)	MXPA06012621A (de)
NO (1)	NO20065510L (de)
NZ (1)	NZ550441A (de)
RU (1)	RU2372344C2 (de)
TW (1)	TWI298636B (de)
WO (1)	WO2005105776A1 (de)
ZA (1)	ZA200608588B (de)

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CN101031338B (zh) *	2004-09-30	2013-01-02	弗·哈夫曼-拉罗切有限公司	治疗认知障碍的组合物和方法
CA2591810A1 (en) *	2004-12-21	2006-06-29	F.Hoffmann-La Roche Ag	Chroman derivatives and uses thereof in the treatment of cns disorders
EP1871759A1 (de) *	2005-04-22	2008-01-02	Wyeth a Corporation of the State of Delaware	Benzodioxan und benzodioxanderivate sowie ihre verwendung
ES2359735T3 (es)	2005-11-03	2011-05-26	F. Hoffmann-La Roche Ag	Arilsulfonilcromanos como inhibidores de 5-ht6.
WO2007120596A1 (en) *	2006-04-12	2007-10-25	Wyeth	DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS
AU2007263076A1 (en) *	2006-06-20	2007-12-27	F. Hoffmann-La Roche Ag	Arylsulfonyl naphthalene derivatives and uses thereof
FR2913886B1 (fr)	2007-03-22	2012-03-02	Guerbet Sa	Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer
EP2271635A1 (de) *	2008-04-29	2011-01-12	NSAB, Filial af NeuroSearch Sweden AB, Sverige	Modulatoren der dopamin-neurotransmission
MX2010011498A (es)	2008-04-29	2010-11-12	Nsab Af Neurosearch Sweden Ab	Moduladores de neurotransmision de dopamina.
BRPI0911772A2 (pt) *	2008-04-29	2017-06-27	Nsab Filial Af Neurosearch Sweden Ab Sverige	composto, composição farmacêutica, e, uso do composto.
CN114890978B (zh) *	2022-04-19	2023-07-25	宿迁医美科技有限公司	酚类化合物及其制备方法和应用

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WO1992002514A1 (en)	1990-07-27	1992-02-20	Chugai Seiyaku Kabushiki Kaisha	Novel benzopyran derivative
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JP2005505586A (ja) *	2001-10-04	2005-02-24	ワイス	５−ヒドロキシトリプタミン−６リガンドとしてのクロマン誘導体
RS51042B (sr) *	2002-05-13	2010-10-31	F. Hoffmann-La Roche Ag.	Derivati benzoksazina kao 5-ht6 modulatori i njihove primene
JP4754821B2 (ja)	2002-06-20	2011-08-24	プロキシマゲン・リミテッド	肥満症、ｉｉ型糖尿病およびｃｎｓ障害の治療に有用な新規化合物
WO2005037223A2 (en)	2003-10-15	2005-04-28	Brigham And Women's Hospital, Inc.	Methods and compositions for immunomodulation
JP2007527412A (ja)	2003-10-24	2007-09-27	エグゼリクシス，インコーポレイテッド	Ｔａｏキナーゼモジュレーターおよび使用方法

2005
- 2005-04-27 NZ NZ550441A patent/NZ550441A/en unknown
- 2005-04-27 AU AU2005238179A patent/AU2005238179B2/en not_active Ceased
- 2005-04-27 MX MXPA06012621A patent/MXPA06012621A/es active IP Right Grant
- 2005-04-27 BR BRPI0510642-7A patent/BRPI0510642A/pt not_active IP Right Cessation
- 2005-04-27 CA CA002566196A patent/CA2566196A1/en not_active Abandoned
- 2005-04-27 RU RU2006138180/04A patent/RU2372344C2/ru not_active IP Right Cessation
- 2005-04-27 EP EP05734404A patent/EP1748995B1/de active Active
- 2005-04-27 AT AT05734404T patent/ATE458727T1/de not_active IP Right Cessation
- 2005-04-27 JP JP2007511952A patent/JP2007536302A/ja not_active Ceased
- 2005-04-27 KR KR1020067023073A patent/KR100823805B1/ko not_active IP Right Cessation
- 2005-04-27 ES ES05734404T patent/ES2338668T3/es active Active
- 2005-04-27 WO PCT/EP2005/004479 patent/WO2005105776A1/en active Application Filing
- 2005-04-27 DE DE602005019562T patent/DE602005019562D1/de active Active
- 2005-04-27 CN CNB2005800143682A patent/CN100540546C/zh not_active Expired - Fee Related
- 2005-05-02 AR ARP050101740A patent/AR048936A1/es unknown
- 2005-05-03 TW TW094114308A patent/TWI298636B/zh not_active IP Right Cessation
- 2005-05-04 US US11/121,873 patent/US7368567B2/en not_active Expired - Fee Related
2006
- 2006-10-13 ZA ZA200608588A patent/ZA200608588B/en unknown
- 2006-10-23 IL IL178819A patent/IL178819A0/en unknown
- 2006-11-29 NO NO20065510A patent/NO20065510L/no not_active Application Discontinuation
2007
- 2007-09-05 HK HK07109656.9A patent/HK1104533A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU2005238179B2 (en)	2010-08-26
EP1748995A1 (de)	2007-02-07
CA2566196A1 (en)	2005-11-10
JP2007536302A (ja)	2007-12-13
TW200605894A (en)	2006-02-16
RU2006138180A (ru)	2008-06-10
CN1960983A (zh)	2007-05-09
EP1748995B1 (de)	2010-02-24
CN100540546C (zh)	2009-09-16
WO2005105776A1 (en)	2005-11-10
WO2005105776A8 (en)	2007-01-11
RU2372344C2 (ru)	2009-11-10
ES2338668T3 (es)	2010-05-11
DE602005019562D1 (de)	2010-04-08
BRPI0510642A (pt)	2007-11-20
AR048936A1 (es)	2006-06-14
US20050250943A1 (en)	2005-11-10
TWI298636B (en)	2008-07-11
AU2005238179A1 (en)	2005-11-10
NZ550441A (en)	2009-07-31
ZA200608588B (en)	2008-06-25
US7368567B2 (en)	2008-05-06
IL178819A0 (en)	2007-03-08
HK1104533A1 (en)	2008-01-18
NO20065510L (no)	2007-01-12
KR20070009664A (ko)	2007-01-18
MXPA06012621A (es)	2006-12-15
KR100823805B1 (ko)	2008-04-21

Publication	Publication Date	Title
ATE432056T1 (de)	2009-06-15	Zervikale zwischenwirbelprothese
IL177059A0 (en)	2006-12-10	Indazole-carboxamide compounds as 5-ht4 receptor agonists
DK1833799T3 (da)	2009-01-19	3-phenyl-pyrazol derivater, som modulatorer af 5-HT-2a-serotonin receptor nyttig til behandlingen af sygdomme relateret hertil
IL179462A0 (en)	2007-05-15	Use of the receptor gpr86
DK2041093T3 (da)	2010-08-02	Til behandling af GPR38-receptor medierede sygdomme anvendelige piperazinylderivativer
ATE509596T1 (de)	2011-06-15	Zervikale zwischenwirbelprothesen
HK1104533A1 (en)	2008-01-18	Arylsulfonyl benzodioxanes useful for modulating the 5-ht6 receptor, the 5- ht2a receptor or both
ATE382034T1 (de)	2008-01-15	Hydroisoindolin-tachykininrezeptorantagonisten
DK1896460T3 (da)	2009-11-16	Benzofuranylderivater som 5-HT6-receptorinhibitorer
EP1806147A4 (de)	2009-07-01	Verwendung eines immunsuppressiven rezeptors
SE0400953L (sv)	2005-10-09	Ortopedisk fotbeklädnad
IL185640A0 (en)	2008-01-06	Use of 2-anilino-3 ,4-dihydro-quinazolines as 5ht5a receptor antagonists
DE502005000496D1 (de)	2007-05-03	Verstellvorrichtung
FI20041538A0 (fi)	2004-11-29	Goniometri
SE0400530L (sv)	2005-09-05	Förfarande
SE0400321L (sv)	2005-07-26	Räddningsbåt
NO20043527L (no)	2006-02-27	Rorkutter
ES1056739Y (es)	2004-12-16	Columbario para urnas de cenizas mortuorias.
FI20041427L (fi)	2006-05-09	Pelastusvene
ES1058317Y (es)	2005-07-01	Kit para la fabricacion de balaustres.
FR2879145B1 (fr)	2008-06-27	Fixation amovible
DE112005002293A5 (de)	2007-07-12	Verstelleinrichtung
ES1058571Y (es)	2005-04-16	Disposicion para la fijacion de balaustradas.
ES1058540Y (es)	2005-04-01	Dispositivo para la fijacion de sombrillas.
ATE526016T1 (de)	2011-10-15	Calcium-rezeptor-aktivator

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2010-09-15	UEP	Publication of translation of european patent specification	Ref document number: 1748995 Country of ref document: EP
2012-01-15	REN	Ceased due to non-payment of the annual fee

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2010-09-15

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Publication of translation of european patent specification

Ref document number: 1748995

Country of ref document: EP

2012-01-15

REN

Ceased due to non-payment of the annual fee