ATE457725T1 - Kynurenine 3-hydroxylase inhibitoren zur behandlung von diabetes - Google Patents

Kynurenine 3-hydroxylase inhibitoren zur behandlung von diabetes

Info

Publication number: ATE457725T1
Authority: AT; Austria
Prior art keywords: kynurenine; diabetes; treatment; hydroxylase inhibitors; hydroxylase
Prior art date: 2003-01-07

Application number

AT03789341T

Other languages

German (de)

English (en)

Inventor

Valerie Autier

De Vacqueur Annick Arbellot

Gerard Moinet

Dominique Marais

Catherine Kargar

Micheline Kergoat

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-01-07

Filing date

2003-12-18

Publication date

2010-03-15

2003-01-07 Priority claimed from FR0300107A external-priority patent/FR2849599B1/fr

2003-12-18 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2010-03-15 Application granted granted Critical

2010-03-15 Publication of ATE457725T1 publication Critical patent/ATE457725T1/de

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/06—Phenols the aromatic ring being substituted by nitro groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Obesity (AREA)
Hematology (AREA)
Immunology (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT03789341T 2003-01-07 2003-12-18 Kynurenine 3-hydroxylase inhibitoren zur behandlung von diabetes ATE457725T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0300107A FR2849599B1 (fr)	2003-01-07	2003-01-07	Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete
FR0314263A FR2849598B1 (fr)	2003-01-07	2003-12-04	Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete, par augmentation du nombre de cellules des ilots de langerhans
PCT/EP2003/014539 WO2004060369A1 (en)	2003-01-07	2003-12-18	Kynurenine 3-hydroxylase inhibitors for the treatment of diabetes

Publications (1)

Publication Number	Publication Date
ATE457725T1 true ATE457725T1 (de)	2010-03-15

Family

ID=32598906

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03789341T ATE457725T1 (de)	2003-01-07	2003-12-18	Kynurenine 3-hydroxylase inhibitoren zur behandlung von diabetes

Country Status (17)

Country	Link
US (2)	US7727977B2 (xx)
EP (2)	EP1581215B1 (xx)
JP (2)	JP2006515594A (xx)
KR (2)	KR20050090443A (xx)
AR (2)	AR042712A1 (xx)
AT (1)	ATE457725T1 (xx)
AU (2)	AU2003296679A1 (xx)
BR (2)	BR0317950A (xx)
CA (2)	CA2512563C (xx)
DE (1)	DE60331359D1 (xx)
ES (1)	ES2339656T3 (xx)
FR (1)	FR2849598B1 (xx)
MX (2)	MXPA05007292A (xx)
PL (2)	PL378212A1 (xx)
RU (2)	RU2351329C2 (xx)
TW (2)	TW200418820A (xx)
WO (2)	WO2004060369A1 (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2849598B1 (fr) *	2003-01-07	2006-09-22	Merck Sante Sas	Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete, par augmentation du nombre de cellules des ilots de langerhans
US8071631B2 (en) *	2006-08-16	2011-12-06	The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone	Small molecule inhibitors of kynurenine-3-monooxygenase
WO2008022281A1 (en) *	2006-08-16	2008-02-21	The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone	Small molecule inhibitors of kynurenine-3-monooxygenase
WO2009071161A1 (en)	2007-12-03	2009-06-11	Merck Patent Gmbh	Use of 4-oxobutanoic acid derivatives in the treatment of pathologies associated with immunological disorders
JP5597555B2 (ja)	2008-03-12	2014-10-01	ユニバーシティー・オブ・マイアミ	低血糖症を治療するための医薬品の製造におけるグルカゴン放出を刺激する化合物の使用
PL228037B1 (pl) *	2009-03-23	2018-02-28	Marciniak Agnieszka Maria	Zastosowanie kwasu kynureninowego w zapobieganiu lub leczeniu chorób trzustki
EP2521558A4 (en) *	2009-12-30	2013-07-03	Avon Prod Inc	TOPICAL LIGHTING COMPOSITION AND USES THEREOF
RS62051B1 (sr)	2010-08-18	2021-07-30	Biosplice Therapeutics Inc	Diketoni i hidroksiketoni kao aktivatori katenin signalnog puta
US9533976B2 (en)	2013-02-22	2017-01-03	Samumed, Llc	γ-diketones as WNT/β-catenin signaling pathway activators
KR102165385B1 (ko)	2014-08-20	2020-10-15	사뮤메드, 엘엘씨	피부 노화 및 주름의 치료 및 예방을 위한 감마-디케톤
JP6898228B2 (ja) *	2014-09-26	2021-07-07	ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア	免疫調節における治療剤としてのキヌレニン及び抗原提示細胞（ａｐｃ）の組合せ及び免疫調節におけるその使用のための方法

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US4181474A (en) *	1978-03-02	1980-01-01	Dunham-Bush, Inc.	Vertical axis hermetic rotary helical screw compressor with improved rotary bearings and oil management
EP0570829B1 (de) *	1992-05-18	2001-04-25	CicloMulsion AG	Cyclosporin(e) enthaltende pharmazeutische Zubereitung zur intravenösen Applikation sowie Verfahren zu ihrer Herstellung
CA2155303C (en) *	1993-02-09	2010-04-20	Linda C. Burkly	Treatment for insulin dependent diabetes
DE69423343T2 (de) *	1993-12-22	2000-11-09	Entropy Systems, Inc.	Anlage und verfahren für wärmeübertragung mit luft als arbeitsmedium
GB9522615D0 (en) *	1995-11-03	1996-01-03	Pharmacia Spa	4-Phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity
KR19990082639A (ko) *	1996-02-19	1999-11-25	미즈노 마사루	당뇨병 치료제
JP3104966B2 (ja) *	1996-02-19	2000-10-30	日本たばこ産業株式会社	糖尿病治療薬
US5877193A (en) *	1996-07-19	1999-03-02	Hoffmann-La Roche Inc.	Use of N-(4-aryl-thiazol-2-yl)-sulfonamides
FR2752422B1 (fr) *	1996-08-16	1998-11-06	Lipha	Composition pharmaceutique contenant des acides 4-oxo-butanoiques
US6288063B1 (en) *	1998-05-27	2001-09-11	Bayer Corporation	Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
US6572542B1 (en) *	2000-03-03	2003-06-03	Medtronic, Inc.	System and method for monitoring and controlling the glycemic state of a patient
SE0001899D0 (sv) *	2000-05-22	2000-05-22	Pharmacia & Upjohn Ab	New compounds
JP2004509171A (ja) *	2000-09-29	2004-03-25	ゾーン、　ロバート　ズィー．	炎症及び免疫反応の治療方法及びその組成物
FR2849598B1 (fr) *	2003-01-07	2006-09-22	Merck Sante Sas	Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete, par augmentation du nombre de cellules des ilots de langerhans
TW200920357A (en) *	2007-09-10	2009-05-16	Curis Inc	HSP90 inhibitors containing a zinc binding moiety

2003
- 2003-12-04 FR FR0314263A patent/FR2849598B1/fr not_active Expired - Fee Related
- 2003-12-18 JP JP2004564203A patent/JP2006515594A/ja not_active Withdrawn
- 2003-12-18 EP EP03789341A patent/EP1581215B1/en not_active Expired - Lifetime
- 2003-12-18 CA CA2512563A patent/CA2512563C/en not_active Expired - Fee Related
- 2003-12-18 WO PCT/EP2003/014539 patent/WO2004060369A1/en active Application Filing
- 2003-12-18 PL PL378212A patent/PL378212A1/pl not_active Application Discontinuation
- 2003-12-18 MX MXPA05007292A patent/MXPA05007292A/es active IP Right Grant
- 2003-12-18 KR KR1020057012652A patent/KR20050090443A/ko not_active Application Discontinuation
- 2003-12-18 US US10/541,377 patent/US7727977B2/en not_active Expired - Fee Related
- 2003-12-18 BR BR0317950-8A patent/BR0317950A/pt not_active IP Right Cessation
- 2003-12-18 BR BR0317947-8A patent/BR0317947A/pt not_active IP Right Cessation
- 2003-12-18 JP JP2004564204A patent/JP4813800B2/ja not_active Expired - Fee Related
- 2003-12-18 EP EP03814462A patent/EP1581216A1/en not_active Withdrawn
- 2003-12-18 ES ES03789341T patent/ES2339656T3/es not_active Expired - Lifetime
- 2003-12-18 CA CA002512558A patent/CA2512558A1/en not_active Abandoned
- 2003-12-18 MX MXPA05007293A patent/MXPA05007293A/es unknown
- 2003-12-18 AU AU2003296679A patent/AU2003296679A1/en not_active Abandoned
- 2003-12-18 AT AT03789341T patent/ATE457725T1/de not_active IP Right Cessation
- 2003-12-18 WO PCT/EP2003/014538 patent/WO2004060368A1/en not_active Application Discontinuation
- 2003-12-18 US US10/541,493 patent/US20060052456A1/en not_active Abandoned
- 2003-12-18 KR KR1020057012707A patent/KR20050090447A/ko not_active Application Discontinuation
- 2003-12-18 RU RU2005125085/15A patent/RU2351329C2/ru not_active IP Right Cessation
- 2003-12-18 RU RU2005125086/04A patent/RU2005125086A/ru not_active Application Discontinuation
- 2003-12-18 DE DE60331359T patent/DE60331359D1/de not_active Expired - Lifetime
- 2003-12-18 PL PL03376017A patent/PL376017A1/xx not_active Application Discontinuation
- 2003-12-18 AU AU2003293937A patent/AU2003293937B2/en not_active Ceased
2004
- 2004-01-05 TW TW093100157A patent/TW200418820A/zh unknown
- 2004-01-05 TW TW093100159A patent/TW200503676A/zh unknown
- 2004-01-07 AR ARP040100025A patent/AR042712A1/es not_active Application Discontinuation
- 2004-01-07 AR ARP040100024A patent/AR043327A1/es unknown

Also Published As

Publication number	Publication date
DE60331359D1 (de)	2010-04-01
WO2004060369A1 (en)	2004-07-22
CA2512563A1 (en)	2004-07-22
FR2849598B1 (fr)	2006-09-22
EP1581216A1 (en)	2005-10-05
MXPA05007292A (es)	2005-09-08
RU2005125086A (ru)	2006-08-27
EP1581215A1 (en)	2005-10-05
AU2003296679A1 (en)	2004-07-29
RU2351329C2 (ru)	2009-04-10
AU2003293937A1 (en)	2004-07-29
BR0317947A (pt)	2005-11-29
KR20050090447A (ko)	2005-09-13
WO2004060368A1 (en)	2004-07-22
US20060052456A1 (en)	2006-03-09
MXPA05007293A (es)	2005-09-08
TW200418820A (en)	2004-10-01
PL376017A1 (en)	2005-12-12
AR043327A1 (es)	2005-07-27
KR20050090443A (ko)	2005-09-13
FR2849598A1 (fr)	2004-07-09
US20060142358A1 (en)	2006-06-29
AU2003293937B2 (en)	2009-03-26
TW200503676A (en)	2005-02-01
EP1581215B1 (en)	2010-02-17
PL378212A1 (pl)	2006-03-20
CA2512563C (en)	2012-06-19
AR042712A1 (es)	2005-06-29
JP2006516960A (ja)	2006-07-13
WO2004060369A8 (en)	2005-07-07
BR0317950A (pt)	2005-11-29
ES2339656T3 (es)	2010-05-24
JP2006515594A (ja)	2006-06-01
CA2512558A1 (en)	2004-07-22
US7727977B2 (en)	2010-06-01
JP4813800B2 (ja)	2011-11-09
RU2005125085A (ru)	2006-03-20

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DE602004022035D1 (de)	2009-08-27	Verwendung von pthalide derivativen zur behandlung
DE60331359D1 (de)	2010-04-01	Kynurenine 3-hydroxylase inhibitoren zur behandlung von diabetes
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Legal Events

Date	Code	Title	Description
2010-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties