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ATE45353T1 - Verfahren zur herstellung von forskolin aus 9deoxy-forskolinund zwischenprodukte dafuer. - Google Patents

Verfahren zur herstellung von forskolin aus 9deoxy-forskolinund zwischenprodukte dafuer.

Info

Publication number
ATE45353T1
ATE45353T1 AT87103939T AT87103939T ATE45353T1 AT E45353 T1 ATE45353 T1 AT E45353T1 AT 87103939 T AT87103939 T AT 87103939T AT 87103939 T AT87103939 T AT 87103939T AT E45353 T1 ATE45353 T1 AT E45353T1
Authority
AT
Austria
Prior art keywords
beta
alpha
epoxy
forskolin
tetrahydroxylabd
Prior art date
Application number
AT87103939T
Other languages
English (en)
Inventor
Nicholas J Hrib
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of ATE45353T1 publication Critical patent/ATE45353T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Toys (AREA)
  • Excavating Of Shafts Or Tunnels (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Shaping Of Tube Ends By Bending Or Straightening (AREA)
  • Steroid Compounds (AREA)
AT87103939T 1986-03-31 1987-03-18 Verfahren zur herstellung von forskolin aus 9deoxy-forskolinund zwischenprodukte dafuer. ATE45353T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/846,550 US4734513A (en) 1986-03-31 1986-03-31 Method of synthesizing forskolin from 9-deoxyforskolin
EP87103939A EP0243646B1 (de) 1986-03-31 1987-03-18 Verfahren zur Herstellung von Forskolin aus 9-Deoxy-Forskolin und Zwischenprodukte dafür

Publications (1)

Publication Number Publication Date
ATE45353T1 true ATE45353T1 (de) 1989-08-15

Family

ID=25298260

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87103939T ATE45353T1 (de) 1986-03-31 1987-03-18 Verfahren zur herstellung von forskolin aus 9deoxy-forskolinund zwischenprodukte dafuer.

Country Status (13)

Country Link
US (1) US4734513A (de)
EP (1) EP0243646B1 (de)
JP (1) JPS62249981A (de)
KR (1) KR900007626B1 (de)
AT (1) ATE45353T1 (de)
AU (1) AU585143B2 (de)
DE (1) DE3760422D1 (de)
DK (1) DK159987A (de)
ES (1) ES2010511B3 (de)
GR (1) GR3000203T3 (de)
IL (1) IL82047A (de)
PT (1) PT84584B (de)
ZA (1) ZA872266B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008407A (en) * 1986-03-31 1991-04-16 Hoechst-Roussel Pharmaceuticals Inc. Method of synthesizing forskolin from 9-deoxyforskolin
US4978678A (en) * 1986-11-20 1990-12-18 Hoechst-Roussel Pharmaceuticals Inc. 12-halogenated forskolin derivatives
US5023344A (en) * 1986-11-20 1991-06-11 Hoechst-Roussel Pharmaceuticals Incorporated 12-halogenated forskolin derivatives
US5070209A (en) * 1986-11-20 1991-12-03 Hoechst Roussel Pharmaceuticals Inc. 12-halogenated forskolin derivatives
US4999351A (en) * 1989-01-11 1991-03-12 Hoechst-Roussel Pharmaceuticals, Inc. 7-aryl and heteroaryl ethers of desacetylforskolin
JP3557095B2 (ja) * 1998-04-20 2004-08-25 高砂香料工業株式会社 メラニン産生抑制剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2654796A1 (de) * 1976-12-03 1978-06-08 Hoechst Ag Polyoxygenierte labdan-derivate
US4517200A (en) * 1982-12-27 1985-05-14 Schering-Plough Corporation Method for treating allergic reactions with forskolin
US4564626A (en) * 1983-04-01 1986-01-14 Schering Corporation Methods of inducing bronchodilation
DE3407514A1 (de) * 1984-03-01 1985-09-26 Hoechst Ag, 6230 Frankfurt Verwendung von polyoxygenierten labdanderivaten zur behandlung von konstriktionen der atemwege
DE3581725D1 (de) * 1984-12-14 1991-03-14 Hoechst Roussel Pharma Aminoacyllabdane, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.
US4639443A (en) * 1985-03-01 1987-01-27 Hoechst-Roussel Pharmaceuticals Inc. Labdane compounds, pharmaceutical compositions and use

Also Published As

Publication number Publication date
DE3760422D1 (en) 1989-09-14
KR900007626B1 (ko) 1990-10-17
ES2010511B3 (es) 1989-11-16
GR3000203T3 (en) 1990-12-31
EP0243646A1 (de) 1987-11-04
ZA872266B (en) 1987-11-25
PT84584A (en) 1987-04-01
IL82047A0 (en) 1987-10-20
DK159987D0 (da) 1987-03-30
DK159987A (da) 1987-10-01
US4734513A (en) 1988-03-29
AU585143B2 (en) 1989-06-08
KR870008908A (ko) 1987-10-21
AU7076587A (en) 1987-10-08
EP0243646B1 (de) 1989-08-09
JPS62249981A (ja) 1987-10-30
IL82047A (en) 1992-02-16
PT84584B (pt) 1989-11-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee