[go: up one dir, main page]

ATE44236T1 - Verfahren zur herstellung eines hochgereinigten antihaemophilfaktor-konzentrats. - Google Patents

Verfahren zur herstellung eines hochgereinigten antihaemophilfaktor-konzentrats.

Info

Publication number
ATE44236T1
ATE44236T1 AT85112070T AT85112070T ATE44236T1 AT E44236 T1 ATE44236 T1 AT E44236T1 AT 85112070 T AT85112070 T AT 85112070T AT 85112070 T AT85112070 T AT 85112070T AT E44236 T1 ATE44236 T1 AT E44236T1
Authority
AT
Austria
Prior art keywords
weight
solution
polyethylene glycol
combination
preparation
Prior art date
Application number
AT85112070T
Other languages
English (en)
Inventor
Gautam Mitra
Paul K Ng
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Inc filed Critical Miles Inc
Application granted granted Critical
Publication of ATE44236T1 publication Critical patent/ATE44236T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT85112070T 1984-10-04 1985-09-24 Verfahren zur herstellung eines hochgereinigten antihaemophilfaktor-konzentrats. ATE44236T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/658,081 US4543210A (en) 1984-10-04 1984-10-04 Process for producing a high purity antihemophilic factor concentrate
EP85112070A EP0176926B1 (de) 1984-10-04 1985-09-24 Verfahren zur Herstellung eines hochgereinigten Antihämophilfaktor-Konzentrats

Publications (1)

Publication Number Publication Date
ATE44236T1 true ATE44236T1 (de) 1989-07-15

Family

ID=24639818

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85112070T ATE44236T1 (de) 1984-10-04 1985-09-24 Verfahren zur herstellung eines hochgereinigten antihaemophilfaktor-konzentrats.

Country Status (7)

Country Link
US (1) US4543210A (de)
EP (1) EP0176926B1 (de)
JP (1) JPH0676337B2 (de)
AT (1) ATE44236T1 (de)
CA (1) CA1243950A (de)
DE (1) DE3571201D1 (de)
DK (1) DK163107B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3481109D1 (de) * 1983-05-09 1990-03-01 Novo Nordisk As Antihaemophilie-faktor-viii-konzentrat und dessen herstellungsverfahren.
SE8501050D0 (sv) * 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
AU6487286A (en) * 1985-11-08 1987-05-14 Baxter Travenol Laboratories Inc. Antihemophilic factor by cold precipitation
ATE73820T1 (de) * 1986-03-27 1992-04-15 Octapharma Ag Verfahren zur herstellung eines hochgereinigten antihaemophilie-faktors.
AT391808B (de) * 1986-11-03 1990-12-10 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion
US5177191A (en) * 1987-12-21 1993-01-05 Miles, Inc. Gel filtration of factor VIII
EP0321835B1 (de) * 1987-12-21 1994-09-28 Miles Inc. Faktor VIII- Gelfiltration
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
DE3904354A1 (de) * 1989-02-14 1990-08-16 Behringwerke Ag Pasteurisiertes, gereinigtes von willebrand-faktor-konzentrat und verfahren zu seiner herstellung
ES2042138T3 (es) * 1989-05-24 1993-12-01 Miles Inc. Filtracion en gel del factor viii tratado termicamente.
USH1509H (en) * 1989-06-09 1995-12-05 Eran; Harutyun Heparin enhanced process for separating antihemophilic factor (Factor VIII) and fibronectin from cryoprecipitate
FR2651437A1 (fr) * 1989-09-05 1991-03-08 Lille Transfusion Sanguine Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total.
DK162233C (da) * 1989-11-09 1992-03-16 Novo Nordisk As Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii
IT1248723B (it) * 1990-06-12 1995-01-26 Scalvo S P A Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo
FR2664165B1 (fr) * 1990-07-03 1992-10-16 Lille Transfusion Sanguine Composition pour stabiliser le plasma sanguin en cours de pasteurisation.
US5525519A (en) * 1992-01-07 1996-06-11 Middlesex Sciences, Inc. Method for isolating biomolecules from a biological sample with linear polymers
DE4202667C1 (de) * 1992-01-29 1993-05-13 Behringwerke Ag, 3550 Marburg, De
US5288853A (en) * 1992-04-30 1994-02-22 Alpha Therapeutic Corporation Factor viii purification process
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
CA2634674A1 (en) 1999-02-22 2000-08-24 Baxter International Inc. Novel albumin-free factor viii formulations
EP1250929A4 (de) * 1999-12-20 2004-12-29 Mitsubishi Pharma Corp MITTELS PORöSER MEMBRAN BEHANDELTE, VIREN-FREIE PLASMAPROTEIN-VERBINDUNG UND DEREN HERSTELLUNGSPROZESS
EP2385825B1 (de) 2008-11-07 2018-10-10 University of Connecticut Faktor-viii-formulierungen

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US29698A (en) * 1860-08-21 Improvement in harvesters
NL286954A (de) * 1962-01-03
US3652530A (en) * 1967-08-28 1972-03-28 American Nat Red Cross Antihemophilic factor prepared from blood plasma using polyethylene glycol
US3631018A (en) * 1970-05-01 1971-12-28 Baxter Laboratories Inc Production of stable high-potency human ahf using polyethylene glycol and glycine to fractionate a cryoprecipitate of ahf concentrate
US3682881A (en) * 1970-10-02 1972-08-08 Baxter Laboratories Inc Fractionation of plasma using glycine and polyethylene glycol
US3803115A (en) 1972-05-17 1974-04-09 Baxter Laboratories Inc Stabilization of ahf using heparin
US4188318A (en) * 1975-06-16 1980-02-12 Edward Shanbrom Simplified method for preparation of high yield, high purity Factor VIII concentrate
US4069216A (en) * 1975-06-16 1978-01-17 Edward Shanbrom, Inc. Simplified methods for preparation of very high purity Factor VIII concentrate
US4104266A (en) * 1977-04-14 1978-08-01 American National Red Cross Method for preparation of antihemophilic factor
CA1074698A (en) * 1977-12-19 1980-04-01 Gail A. Rock Method of collecting anti-hemophilic factor viii from blood and blood plasma
US4170639A (en) * 1978-07-10 1979-10-09 Warner-Lambert Company Antihemophilic factor concentrate and its production
US4210580A (en) * 1979-06-19 1980-07-01 David Amrani Process for separation and isolation of AHF and fibronectin from blood plasma
FR2460305A2 (fr) * 1979-06-29 1981-01-23 Merieux Inst Procede de preparation d'un concentre de facteur viii
SE448945B (sv) * 1979-12-20 1987-03-30 Blombaeck E G B Forfarande for rening och /eller koncentrering av faktor viii-komplexet
US4289691A (en) * 1980-01-18 1981-09-15 The Canadian Red Cross Society Method of obtaining intermediate purity factor VIII
US4386068A (en) * 1980-02-26 1983-05-31 Cutter Laboratories, Inc. Antihemophilic factor concentrate and method for preparation
US4294826A (en) * 1980-05-07 1981-10-13 Armour Pharmaceutical Company Process for the preparation of highly purified antihemophilic factor
AT369263B (de) * 1980-08-27 1982-12-27 Immuno Ag Verfahren zur herstellung eines faktor viii(ahf) -hochkonzentrates
US4359463A (en) * 1980-11-26 1982-11-16 Rock Gail A Stabilization of Factor VIII activity in whole blood or blood plasma
US4435318A (en) * 1981-05-22 1984-03-06 Ionics, Incorporated Electrodialysis preparation of purified AHF concentrate
CA1178887A (en) * 1981-10-01 1984-12-04 Gail A. Rock Factor viii concentrates prepared from heparinized plasma by the application of a cold precipitation technique
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4486410A (en) * 1984-02-09 1984-12-04 Armour Pharmaceutical Company Heat defibrinogenation of AHF preparation

Also Published As

Publication number Publication date
CA1243950A (en) 1988-11-01
DK450785D0 (da) 1985-10-03
JPH0676337B2 (ja) 1994-09-28
JPS6187626A (ja) 1986-05-06
EP0176926A2 (de) 1986-04-09
EP0176926B1 (de) 1989-06-28
US4543210A (en) 1985-09-24
EP0176926A3 (en) 1987-10-28
DK450785A (da) 1986-04-05
DE3571201D1 (en) 1989-08-03
DK163107B (da) 1992-01-20

Similar Documents

Publication Publication Date Title
ATE44236T1 (de) Verfahren zur herstellung eines hochgereinigten antihaemophilfaktor-konzentrats.
ES8702432A1 (es) Procedimiento para la purificacion de una proteina
HUP9900920A2 (hu) Eljárás emlőssejt-tenyészetekben termelt proteinek szializációjának szabályozására
ATE142255T1 (de) Verfahren zur herstellung eines aktivierten faktor vii-konzentrates mit einer hohen reinheit
US4266024A (en) Process for the production of human interferon
DE69333346D1 (de) Neuartiges p- selectin ligandenprotein
ES8505822A1 (es) Procedimiento para la obtencion de un preparado que contiene factor viii (ahf)
ATE97448T1 (de) Verfahren zur isolierung von ca 125-antigen.
ES8302017A1 (es) Procedimiento para la preparacion de un alto concentrado de factor viii (ahf).
ATE283864T1 (de) Ein verfahren zur herstellung therapeutisch wirksamer bruchstücke von von willebrand-faktor
EP0270516A3 (en) Process for the preparation of a fraction containing factor viii (ahf)
ATE44750T1 (de) Verfahren zur herstellung eines antihaemophiliefaktor-konzentrats.
EP0199568A3 (en) Method for purifying interferon and composition of matter produced thereby
ATE323760T1 (de) Verfahren zur herstellung eines eine hyaluronidase enthaltenden präparats
ATE73820T1 (de) Verfahren zur herstellung eines hochgereinigten antihaemophilie-faktors.
KR890001128B1 (ko) 조 임파구 인터페론의 정제방법
Myers et al. LARGE-SCALE PREPARATION OF A HIGHLY PURIFIED SOLVENT-DETERGENT TREATED FACTOR-VIII CONCENTRATE
ATE13633T1 (de) Verfahren zur herstellung von hochgereinigtem antihaemophiliefaktor.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time