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ATE430T1 - 16-ALPHA-ALKYLSTEROIDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM. - Google Patents

16-ALPHA-ALKYLSTEROIDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.

Info

Publication number
ATE430T1
ATE430T1 AT80102599T AT80102599T ATE430T1 AT E430 T1 ATE430 T1 AT E430T1 AT 80102599 T AT80102599 T AT 80102599T AT 80102599 T AT80102599 T AT 80102599T AT E430 T1 ATE430 T1 AT E430T1
Authority
AT
Austria
Prior art keywords
alpha
alkylsteroids
preparation
pharmaceutical preparations
preparations containing
Prior art date
Application number
AT80102599T
Other languages
German (de)
Inventor
Guenter Dr. Neef
Ulrich Dr. Eder
Gregor Dr. Haffer
Gerhard Dr. Sauer
Rudolf Prof. Dr. Wiechert
Hermann Dr. Steinbeck
Original Assignee
Schering Aktiengesellschaft Berlin Und Bergkamen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft Berlin Und Bergkamen filed Critical Schering Aktiengesellschaft Berlin Und Bergkamen
Application granted granted Critical
Publication of ATE430T1 publication Critical patent/ATE430T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

16 alpha -Alkyl steroids of the formula <IMAGE> wherein R1 is hydrogen or methyl, R2 is hydrogen, alkyl, acyl, or glycosyl R3 is hydrogen or a substituted or unsubstituted, saturated or unsaturated lower hydrocarbon residue, and R4 is methyl, ethyl or propyl, exhibit strong progestational activity and a very low androgenic activity.
AT80102599T 1979-05-17 1980-05-10 16-ALPHA-ALKYLSTEROIDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM. ATE430T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19792920184 DE2920184A1 (en) 1979-05-17 1979-05-17 16 ALPHA -ALKYLSTEROIDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
EP80102599A EP0019247B1 (en) 1979-05-17 1980-05-10 16-alpha-alkyl steroids, process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ATE430T1 true ATE430T1 (en) 1981-12-15

Family

ID=6071134

Family Applications (1)

Application Number Title Priority Date Filing Date
AT80102599T ATE430T1 (en) 1979-05-17 1980-05-10 16-ALPHA-ALKYLSTEROIDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.

Country Status (7)

Country Link
US (1) US4333928A (en)
EP (1) EP0019247B1 (en)
JP (1) JPS55154996A (en)
AT (1) ATE430T1 (en)
DE (2) DE2920184A1 (en)
DK (1) DK147684C (en)
IE (1) IE50019B1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3331288A1 (en) * 1983-08-26 1985-03-14 Schering AG, 1000 Berlin und 4709 Bergkamen NEW ESTRAN DERIVATIVES
DE3486450T2 (en) * 1984-01-05 1997-11-06 Pharmacia & Upjohn Co., Kalamazoo, Mich. 17-alpha-ethynyl steroids
JP2004520300A (en) * 2000-12-15 2004-07-08 アクゾ・ノベル・エヌ・ベー 14 (15) -unsaturated 15- and / or 16-substituted androgens with mixed androgen-progesterone activity profiles
FR2884501B1 (en) 2005-04-19 2007-06-08 Oreal DEVICE FOR PACKAGING AND APPLYING A PRODUCT, FOR EXAMPLE COSMETIC
FR2891708B1 (en) * 2005-10-10 2010-12-17 Oreal DEVICE FOR PACKAGING AND APPLYING A PRODUCT.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH488682A (en) * 1965-07-30 1970-04-15 Ciba Geigy Process for the preparation of 4,9,11-trienes of the 19-nor-androstane series
US3810885A (en) * 1967-12-12 1974-05-14 Roussel Uclaf Novel steroids and processes
FR2054525B1 (en) * 1969-07-28 1973-01-12 Roussel Uclaf
FR2129895B1 (en) * 1971-03-19 1975-04-18 Roussel Uclaf

Also Published As

Publication number Publication date
DE2920184A1 (en) 1980-11-27
DK208780A (en) 1980-11-18
EP0019247B1 (en) 1981-11-25
DK147684C (en) 1985-08-26
IE50019B1 (en) 1986-02-05
US4333928A (en) 1982-06-08
DE3060096D1 (en) 1982-01-28
JPS6321680B2 (en) 1988-05-09
EP0019247A1 (en) 1980-11-26
JPS55154996A (en) 1980-12-02
DK147684B (en) 1984-11-12

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee