ATE430734T1 - Isochinoline und deren herstellung - Google Patents

Isochinoline und deren herstellung

Info

Publication number: ATE430734T1
Authority: AT; Austria
Prior art keywords: isochinolines; production
Prior art date: 1997-03-25

Application number

AT03020565T

Other languages

English (en)

Inventor

John-Joseph Savarese

Roy-Archibald Swaringen

Vincente Samano

Original Assignee

Avera Pharmaceuticals Inc

Cornell Res Foundation Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-25

Filing date

1998-03-23

Publication date

2009-05-15

1997-03-25 Priority claimed from GBGB9706117.0A external-priority patent/GB9706117D0/en

1997-11-27 Priority claimed from GBGB9724987.4A external-priority patent/GB9724987D0/en

1998-03-23 Application filed by Avera Pharmaceuticals Inc, Cornell Res Foundation Inc filed Critical Avera Pharmaceuticals Inc

2009-05-15 Application granted granted Critical

2009-05-15 Publication of ATE430734T1 publication Critical patent/ATE430734T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Surgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT03020565T 1997-03-25 1998-03-23 Isochinoline und deren herstellung ATE430734T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9706117.0A GB9706117D0 (en)	1997-03-25	1997-03-25	Ultra-short acting neuromuscular blockers
GBGB9724987.4A GB9724987D0 (en)	1997-11-27	1997-11-27	Ultra-short acting neuromuscular blockers

Publications (1)

Publication Number	Publication Date
ATE430734T1 true ATE430734T1 (de)	2009-05-15

Family

ID=26311255

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT98922626T ATE254107T1 (de)	1997-03-25	1998-03-23	Substituierte isochinoline als ultra kurz wirkende neuromuskuläre blocker
AT03020565T ATE430734T1 (de)	1997-03-25	1998-03-23	Isochinoline und deren herstellung
AT98912494T ATE295351T1 (de)	1997-03-25	1998-03-23	Substituierte isochinoline als ultra kurz wirkende neuromuskuläre blocker

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT98922626T ATE254107T1 (de)	1997-03-25	1998-03-23	Substituierte isochinoline als ultra kurz wirkende neuromuskuläre blocker

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT98912494T ATE295351T1 (de)	1997-03-25	1998-03-23	Substituierte isochinoline als ultra kurz wirkende neuromuskuläre blocker

Country Status (37)

Country	Link
US (2)	US6187789B1 (de)
EP (4)	EP0971898B1 (de)
JP (3)	JP4112016B2 (de)
KR (2)	KR100554601B1 (de)
CN (1)	CN1203061C (de)
AP (1)	AP1797A (de)
AR (1)	AR012156A1 (de)
AT (3)	ATE254107T1 (de)
AU (2)	AU745382B2 (de)
BR (1)	BR9808422B1 (de)
CA (1)	CA2284802C (de)
CO (1)	CO4940499A1 (de)
CZ (1)	CZ293786B6 (de)
DE (3)	DE69840816D1 (de)
DK (2)	DK0971898T3 (de)
EA (1)	EA002224B1 (de)
EE (1)	EE04113B1 (de)
ES (2)	ES2242275T3 (de)
HK (1)	HK1023342A1 (de)
HR (1)	HRP980157B1 (de)
HU (1)	HU228230B1 (de)
ID (1)	ID22901A (de)
IL (1)	IL131918A (de)
IS (2)	IS2346B (de)
MA (1)	MA26476A1 (de)
MY (1)	MY121316A (de)
NO (1)	NO314726B1 (de)
NZ (1)	NZ337797A (de)
PE (1)	PE68399A1 (de)
PL (1)	PL190860B1 (de)
PT (2)	PT971898E (de)
RS (1)	RS49869B (de)
SI (1)	SI0975599T1 (de)
TR (1)	TR199902330T2 (de)
TW (1)	TW505635B (de)
UY (1)	UY24933A1 (de)
WO (2)	WO1998042674A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
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EP0971898B1 (de) *	1997-03-25	2005-05-11	Avera Pharmaceuticals, Inc.	Substituierte isochinoline als ultra kurz wirkende neuromuskuläre blocker
US6911455B2 (en)	1999-12-22	2005-06-28	Smithkline Beecham Corporation	Methods for preparing pharmaceutical formulations
US6844904B2 (en) *	2002-12-07	2005-01-18	Cubic Corporation	Fast PDLC device
US20050192243A1 (en) *	2003-10-28	2005-09-01	Savarese John J.	Neuromuscular blocking agents and antagonists thereof
JP5213137B2 (ja)	2006-12-06	2013-06-19	コーネルリサーチファウンデーション，インコーポレイテッド	中程度の持続時間の神経筋遮断剤およびそのアンタゴニスト
BRPI0808272A2 (pt) *	2007-03-08	2014-07-08	Chemagis Ltd	"método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio"
US20100087650A1 (en) *	2007-03-26	2010-04-08	Chemagis Ltd.	(1r,1'r)-atracurium salts separation process
WO2009007946A1 (en) *	2007-07-09	2009-01-15	Chemagis Ltd.	Process for producing cisatracurium and associated intermediates
AU2008243747B2 (en)	2007-05-01	2013-03-07	Chemagis Ltd.	Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
CA2685491A1 (en) *	2007-05-01	2008-11-06	Chemagis Ltd.	Process for producing cisatracurium compounds and associated intermediates
BRPI0811687A2 (pt)	2007-06-18	2015-02-18	Chemagis Ltd	MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO
AU2008320380A1 (en) *	2007-10-29	2009-05-07	Chemagis Ltd.	Novel R,R'-atracurium salts
AU2009241211A1 (en) *	2008-05-01	2009-11-05	Chemagis Ltd.	Cisatracurium derivatives, preparation and uses thereof
US8592451B2 (en)	2009-03-17	2013-11-26	Cornell University	Reversible nondepolarizing neuromuscular blockade agents and methods for their use
CN102573794B (zh)	2009-08-19	2017-03-15	康奈尔大学	供生理注射用的半胱氨酸
ES2625329T3 (es) *	2012-06-29	2017-07-19	Cornell University	Agentes bloqueantes neuromusculares asimétricos reversibles de duración ultra-corta, corta o intermedia
CN103373959A (zh) *	2013-06-14	2013-10-30	安徽省先锋制药有限公司	顺式苄基异喹啉类化合物的制备方法及其用途
WO2014210369A2 (en) *	2013-06-28	2014-12-31	Cornell University	Reversal of cysteine-inactivated neuromuscular blocking drugs with combinations of reversal agents
CN108375644B (zh) *	2016-12-07	2021-11-30	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂中间体的分析方法
CN108938573B (zh) *	2017-05-26	2021-08-10	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂组合物及其制备方法和用途
CN110776481B (zh) *	2018-07-24	2023-06-16	四川大学华西医院	一类双阳离子化合物及其制备方法和用途
CN109776486A (zh) *	2019-02-26	2019-05-21	武汉松石科技股份有限公司	一种硫酸亚丙酯的制备方法
CN111662230A (zh) *	2019-03-06	2020-09-15	四川道珍科技有限公司	一类苄基异喹啉化合物、制备方法和用途
CN110117297A (zh) *	2019-04-10	2019-08-13	珠海市赛纬电子材料股份有限公司	一种2-磷酸盐基硫酸丙烯酯的制备方法
WO2021115413A1 (zh) *	2019-12-11	2021-06-17	江苏恒瑞医药股份有限公司	神经肌肉阻滞剂及其制备方法
CN111471013B (zh) *	2020-05-26	2021-04-30	朗天药业(湖北)有限公司	一种米库氯铵及其注射液的制备方法
CN111909089B (zh) *	2020-08-14	2023-04-14	广东嘉博制药有限公司	一种米库氯铵对照品的制备方法
CN114057642B (zh) *	2021-12-10	2023-03-28	广东嘉博制药有限公司	一种米库氯铵中间体的合成方法
CN115073373A (zh) *	2022-07-08	2022-09-20	广东嘉博制药有限公司	一种不对称合成（r）-5’-甲氧基劳丹素的方法

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US3004031A (en)	1958-07-03	1961-10-10	Allen & Hauburys Ltd	Diquaternary salts of papaverino esters
AU506657B2 (en) *	1975-12-10	1980-01-17	Wellcome Foundation Limited, The	Isoquinoline derivatives
ES472229A1 (es) *	1977-08-01	1979-03-16	Massachusetts Gen Hospital	Un metodo de preparar un compuesto
US4701460A (en) *	1980-12-17	1987-10-20	Burroughs Wellcome Co.	Long duration neuromuscular blocking agents
JPS5899465A (ja) *	1981-11-23	1983-06-13	ザ・ウエルカム・フアウンデ−シヨン・リミテツド	イソキノリン誘導体
GB8418303D0 (en) *	1984-07-18	1984-08-22	Wellcome Found	Compounds
BG41897A1 (en)	1985-07-19	1987-09-15	Ivanov	Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation
GB9015473D0 (en) *	1990-07-13	1990-08-29	Wellcome Found	Neuromuscular blocking agents
JPH04112016A (ja) *	1990-09-03	1992-04-14	Fuji Electric Co Ltd	トランスファ成形金型用プランジャ及びトランスファ成形装置
US5240939A (en) *	1991-10-31	1993-08-31	Anaquest, Inc.	Nitrogen bridge tetrahydroisoquinolines
EP0971898B1 (de) *	1997-03-25	2005-05-11	Avera Pharmaceuticals, Inc.	Substituierte isochinoline als ultra kurz wirkende neuromuskuläre blocker

1998
- 1998-03-23 EP EP98912494A patent/EP0971898B1/de not_active Expired - Lifetime
- 1998-03-23 EP EP03020565A patent/EP1380573B1/de not_active Expired - Lifetime
- 1998-03-23 JP JP54323398A patent/JP4112016B2/ja not_active Expired - Fee Related
- 1998-03-23 DK DK98912494T patent/DK0971898T3/da active
- 1998-03-23 MA MA25006A patent/MA26476A1/fr unknown
- 1998-03-23 PT PT98912494T patent/PT971898E/pt unknown
- 1998-03-23 SI SI9830593T patent/SI0975599T1/xx unknown
- 1998-03-23 WO PCT/EP1998/001651 patent/WO1998042674A1/en not_active Application Discontinuation
- 1998-03-23 HU HU0001556A patent/HU228230B1/hu not_active IP Right Cessation
- 1998-03-23 AU AU75210/98A patent/AU745382B2/en not_active Ceased
- 1998-03-23 AT AT98922626T patent/ATE254107T1/de active
- 1998-03-23 RS YUP-483/99A patent/RS49869B/sr unknown
- 1998-03-23 CN CNB988053004A patent/CN1203061C/zh not_active Expired - Fee Related
- 1998-03-23 TR TR1999/02330T patent/TR199902330T2/xx unknown
- 1998-03-23 US US09/381,719 patent/US6187789B1/en not_active Expired - Lifetime
- 1998-03-23 AT AT03020565T patent/ATE430734T1/de not_active IP Right Cessation
- 1998-03-23 EE EEP199900424A patent/EE04113B1/xx not_active IP Right Cessation
- 1998-03-23 AU AU67305/98A patent/AU6730598A/en not_active Abandoned
- 1998-03-23 ES ES98912494T patent/ES2242275T3/es not_active Expired - Lifetime
- 1998-03-23 CZ CZ19993404A patent/CZ293786B6/cs not_active IP Right Cessation
- 1998-03-23 DE DE69840816T patent/DE69840816D1/de not_active Expired - Lifetime
- 1998-03-23 IL IL13191898A patent/IL131918A/xx not_active IP Right Cessation
- 1998-03-23 ID IDW991103A patent/ID22901A/id unknown
- 1998-03-23 PL PL335885A patent/PL190860B1/pl not_active IP Right Cessation
- 1998-03-23 AP APAP/P/1999/001658A patent/AP1797A/en active
- 1998-03-23 EA EA199900756A patent/EA002224B1/ru not_active IP Right Cessation
- 1998-03-23 ES ES98922626T patent/ES2210757T3/es not_active Expired - Lifetime
- 1998-03-23 PE PE1998000209A patent/PE68399A1/es not_active Application Discontinuation
- 1998-03-23 DE DE69830157T patent/DE69830157T2/de not_active Expired - Lifetime
- 1998-03-23 NZ NZ337797A patent/NZ337797A/xx not_active IP Right Cessation
- 1998-03-23 EP EP98922626A patent/EP0975599B1/de not_active Expired - Lifetime
- 1998-03-23 KR KR1019997008687A patent/KR100554601B1/ko not_active IP Right Cessation
- 1998-03-23 DK DK98922626T patent/DK0975599T3/da active
- 1998-03-23 EP EP05001475A patent/EP1526130A1/de not_active Withdrawn
- 1998-03-23 JP JP54323298A patent/JP4112015B2/ja not_active Expired - Fee Related
- 1998-03-23 CA CA002284802A patent/CA2284802C/en not_active Expired - Fee Related
- 1998-03-23 AT AT98912494T patent/ATE295351T1/de not_active IP Right Cessation
- 1998-03-23 WO PCT/EP1998/001652 patent/WO1998042675A1/en active IP Right Grant
- 1998-03-23 DE DE69819703T patent/DE69819703T2/de not_active Expired - Lifetime
- 1998-03-23 KR KR1020057019867A patent/KR100578443B1/ko not_active IP Right Cessation
- 1998-03-23 PT PT98922626T patent/PT975599E/pt unknown
- 1998-03-23 BR BRPI9808422-4A patent/BR9808422B1/pt not_active IP Right Cessation
- 1998-03-23 MY MYPI98001252A patent/MY121316A/en unknown
- 1998-03-23 US US09/381,721 patent/US6177445B1/en not_active Expired - Fee Related
- 1998-03-24 AR ARP980101340A patent/AR012156A1/es active IP Right Grant
- 1998-03-24 UY UY24933A patent/UY24933A1/es not_active IP Right Cessation
- 1998-03-24 HR HR980157A patent/HRP980157B1/xx not_active IP Right Cessation
- 1998-03-25 CO CO98016617A patent/CO4940499A1/es unknown
- 1998-04-29 TW TW087106631A patent/TW505635B/zh not_active IP Right Cessation
1999
- 1999-09-17 IS IS5185A patent/IS2346B/is unknown
- 1999-09-24 NO NO19994680A patent/NO314726B1/no not_active IP Right Cessation
2000
- 2000-04-25 HK HK00102447A patent/HK1023342A1/xx not_active IP Right Cessation
2007
- 2007-09-25 JP JP2007247928A patent/JP2008019272A/ja active Pending
2008
- 2008-03-03 IS IS8717A patent/IS8717A/is unknown

Also Published As

Publication number	Publication date
CN1257483A (zh)	2000-06-21
SI0975599T1 (en)	2004-04-30
NZ337797A (en)	2001-03-30
IS5185A (is)	1999-09-17
ES2242275T3 (es)	2005-11-01
CA2284802A1 (en)	1998-10-01
IL131918A0 (en)	2001-03-19
CO4940499A1 (es)	2000-07-24
IL131918A (en)	2005-09-25
EP0975599B1 (de)	2003-11-12
MY121316A (en)	2006-01-28
MA26476A1 (fr)	2004-12-20
CN1203061C (zh)	2005-05-25
JP4112016B2 (ja)	2008-07-02
TR199902330T2 (xx)	2000-02-21
EE04113B1 (et)	2003-08-15
HRP980157A2 (en)	1999-02-28
HUP0001556A2 (hu)	2001-04-28
EP0975599A1 (de)	2000-02-02
PL190860B1 (pl)	2006-02-28
DE69840816D1 (de)	2009-06-18
AU6730598A (en)	1998-10-20
EP1380573A3 (de)	2004-01-21
AU7521098A (en)	1998-10-20
RS49869B (sr)	2008-08-07
CA2284802C (en)	2009-06-16
EA199900756A1 (ru)	2000-08-28
DE69819703T2 (de)	2004-09-30
EP1526130A1 (de)	2005-04-27
PE68399A1 (es)	1999-07-23
DE69819703D1 (de)	2003-12-18
ES2210757T3 (es)	2004-07-01
AR012156A1 (es)	2000-09-27
US6177445B1 (en)	2001-01-23
HK1023342A1 (en)	2000-09-08
HU228230B1 (en)	2013-02-28
UY24933A1 (es)	2000-12-29
CZ293786B6 (cs)	2004-07-14
ATE295351T1 (de)	2005-05-15
PT971898E (pt)	2005-07-29
WO1998042674A1 (en)	1998-10-01
AP9901658A0 (en)	1999-09-30
BR9808422B1 (pt)	2010-08-24
CZ340499A3 (cs)	2000-04-12
JP2002503220A (ja)	2002-01-29
ATE254107T1 (de)	2003-11-15
NO994680L (no)	1999-11-24
DE69830157D1 (de)	2005-06-16
NO314726B1 (no)	2003-05-12
NO994680D0 (no)	1999-09-24
EE9900424A (et)	2000-04-17
EP1380573A2 (de)	2004-01-14
EP0971898A1 (de)	2000-01-19
US6187789B1 (en)	2001-02-13
JP4112015B2 (ja)	2008-07-02
PT975599E (pt)	2004-03-31
AP1797A (en)	2007-11-15
TW505635B (en)	2002-10-11
DE69830157T2 (de)	2006-05-11
WO1998042675A1 (en)	1998-10-01
PL335885A1 (en)	2000-05-22
DK0971898T3 (da)	2005-09-05
IS8717A (is)	2008-03-03
IS2346B (is)	2008-03-15
JP2008019272A (ja)	2008-01-31
KR20010005621A (ko)	2001-01-15
KR100578443B1 (ko)	2006-05-11
EP0971898B1 (de)	2005-05-11
ID22901A (id)	1999-12-16
BR9808422A (pt)	2000-05-23
EP1380573B1 (de)	2009-05-06
JP2002517168A (ja)	2002-06-11
EA002224B1 (ru)	2002-02-28
YU48399A (sh)	2002-06-19
HRP980157B1 (en)	2004-10-31
DK0975599T3 (da)	2004-03-15
KR20050103984A (ko)	2005-11-01
HUP0001556A3 (en)	2002-01-28
AU745382B2 (en)	2002-03-21
KR100554601B1 (ko)	2006-03-03

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