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ATE426599T1 - THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS - Google Patents

THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS

Info

Publication number
ATE426599T1
ATE426599T1 AT04735742T AT04735742T ATE426599T1 AT E426599 T1 ATE426599 T1 AT E426599T1 AT 04735742 T AT04735742 T AT 04735742T AT 04735742 T AT04735742 T AT 04735742T AT E426599 T1 ATE426599 T1 AT E426599T1
Authority
AT
Austria
Prior art keywords
mtp inhibitors
thiazolylpiperidine derivatives
thiazolylpiperidine
derivatives
mtp
Prior art date
Application number
AT04735742T
Other languages
German (de)
Inventor
Philippe Guedat
Francois Collonges
Herve Dumas
Jean-Yves Ortholand
Jacques Decerprit
Jacques Barbanton
Richard Foster
Peter Kane
Bernd Wendt
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE426599T1 publication Critical patent/ATE426599T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT04735742T 2003-06-25 2004-06-02 THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS ATE426599T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0307670A FR2856685B1 (en) 2003-06-25 2003-06-25 THIAZOLYLPIPERIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
ATE426599T1 true ATE426599T1 (en) 2009-04-15

Family

ID=33515396

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04735742T ATE426599T1 (en) 2003-06-25 2004-06-02 THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS

Country Status (18)

Country Link
US (1) US7674803B2 (en)
EP (1) EP1636218B1 (en)
JP (1) JP4629666B2 (en)
KR (1) KR20060024812A (en)
CN (1) CN1809560A (en)
AR (1) AR044909A1 (en)
AT (1) ATE426599T1 (en)
AU (1) AU2004253649B2 (en)
BR (1) BRPI0411721A (en)
CA (1) CA2531011C (en)
DE (1) DE602004020223D1 (en)
ES (1) ES2323463T3 (en)
FR (1) FR2856685B1 (en)
MX (1) MXPA05013521A (en)
RU (1) RU2006101890A (en)
TW (1) TW200518751A (en)
WO (1) WO2005003128A1 (en)
ZA (1) ZA200600690B (en)

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US20100267717A1 (en) * 2005-07-29 2010-10-21 4Sc Ag Novel Heterocyclic NF-kB Inhibitors
US7601745B2 (en) 2004-09-27 2009-10-13 4Sc Ag Heterocyclic NF-kB inhibitors
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TW200738701A (en) 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
JP2009502816A (en) * 2005-07-29 2009-01-29 ４エスツェー アクチェンゲゼルシャフト Novel heterocyclic NF-κB inhibitor
ATE430744T1 (en) 2005-08-18 2009-05-15 Hoffmann La Roche THIAZOLYLPIPERIDINE DERIVATIVES USEFUL AS H3 RECEPTOR MODULATORS
EP1832586A1 (en) * 2006-03-10 2007-09-12 Oridis Biomed Forschungs- und Entwicklungs GmbH Thiazole-piperidine derivatives in treatment of diseases of liver and the pancreas
EA200801838A1 (en) * 2006-03-15 2009-02-27 4ЭсЦэ АГ NEW HETEROCYCLIC INHIBITORS NF-kB
EP1834954A1 (en) * 2006-03-15 2007-09-19 4Sc Ag Thiazoles as NF-kB Inhibitors (proteasome inhibitors)
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US8163746B2 (en) 2006-04-19 2012-04-24 Astellas Pharma Inc. Azolecarboxamide derivative
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US9090604B2 (en) 2006-07-27 2015-07-28 E I Du Pont De Nemours And Company Fungicidal azocyclic amides
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PE20081559A1 (en) 2007-01-12 2008-11-20 Merck & Co Inc SPIROCHROMANONE DERIVATIVES SUBSTITUTED AS ACETYL COA CARBOXYLASE INHIBITORS
EP2121660B1 (en) 2007-01-25 2014-12-31 E. I. Du Pont de Nemours and Company Fungicidal amides
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CA2703978A1 (en) * 2007-10-29 2009-05-07 Schering Corporation Thiazole derivatives as protein kinase inhibitors
JP5529044B2 (en) 2008-01-25 2014-06-25 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー Bactericidal heterocyclic compounds
EA201001699A1 (en) 2008-04-30 2011-04-29 Байер Кропсайенс Аг COMPLEX ETHERS AND TIOESL TIAZOL-4-CARBONIC ACID AS PLANT PROTECTION MEANS
EP2334669B1 (en) * 2008-10-01 2015-12-23 Bayer Intellectual Property GmbH Heterocyclyl-substituted thiazoles as plant protection agents
AR074411A1 (en) 2008-12-02 2011-01-12 Du Pont FUNGICIDE HETEROCICLICAL COMPOUNDS
EP2404902A1 (en) * 2009-03-05 2012-01-11 Shionogi&Co., Ltd. Piperidine and pyrrolidine derivatives having npy y5 receptor antagonism
EP2272846A1 (en) * 2009-06-23 2011-01-12 Bayer CropScience AG Thiazolylpiperidine derivatives as fungicide
KR20120089644A (en) * 2009-08-12 2012-08-13 신젠타 파티서페이션즈 아게 Microbiocidal heterocycles
WO2011051243A1 (en) 2009-10-29 2011-05-05 Bayer Cropscience Ag Active compound combinations
EP2493886B1 (en) * 2009-10-30 2014-11-26 Bayer CropScience AG Heteroaryl piperidine and piperazine derivates
BR112012016923A2 (en) * 2009-12-22 2015-09-01 Syngenta Participations Ag Pyrazole Derivatives
ES2613066T3 (en) * 2010-04-28 2017-05-22 Bayer Intellectual Property Gmbh Ketoheteroarylpiperidine and -piperazine derivatives as fungicides
EP2595989B1 (en) 2010-05-06 2016-07-13 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
US8815775B2 (en) * 2010-05-18 2014-08-26 Bayer Cropscience Ag Bis(difluoromethyl)pyrazoles as fungicides
CN103492380A (en) * 2011-02-01 2014-01-01 拜耳知识产权有限责任公司 Heteroaryl piperidine and heteroaryl piperazine derivatives as fungicides
CN106008504A (en) 2011-02-02 2016-10-12 沃泰克斯药物股份有限公司 Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels
EP2673272A1 (en) * 2011-02-10 2013-12-18 Syngenta Participations AG Microbiocidal pyrazole derivatives
CN103443105A (en) * 2011-02-18 2013-12-11 沃泰克斯药物股份有限公司 Chroman-spirocyclic piperidine amides as modulators of ion channels
CN103517910B (en) 2011-03-14 2016-12-14 沃泰克斯药物股份有限公司 Morpholine-spirocyclic piperidine amide as ion channel modulators
MY169449A (en) 2011-04-01 2019-04-11 Astrazeneca Ab Therapeutic treatment
PL2785349T5 (en) 2011-11-30 2023-01-30 Astrazeneca Ab Combination treatment of cancer
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WO2015018027A1 (en) * 2013-08-08 2015-02-12 Merck Sharp & Dohme Corp. Thiazole orexin receptor antagonists
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JP2020506904A (en) * 2017-01-27 2020-03-05 シグナルアールエックス ファーマシューティカルズ，インコーポレイテッド Thienopyranones and furanopyranones as kinases, bromodomains and checkpoint inhibitors
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Also Published As

Publication number Publication date
FR2856685B1 (en) 2005-09-23
JP2007506651A (en) 2007-03-22
TW200518751A (en) 2005-06-16
RU2006101890A (en) 2007-07-27
AU2004253649A1 (en) 2005-01-13
AU2004253649B2 (en) 2009-09-24
BRPI0411721A (en) 2006-05-23
EP1636218A1 (en) 2006-03-22
CA2531011A1 (en) 2005-01-13
AR044909A1 (en) 2005-10-05
MXPA05013521A (en) 2006-03-09
FR2856685A1 (en) 2004-12-31
US7674803B2 (en) 2010-03-09
JP4629666B2 (en) 2011-02-09
ZA200600690B (en) 2007-05-30
US20070054939A1 (en) 2007-03-08
DE602004020223D1 (en) 2009-05-07
ES2323463T3 (en) 2009-07-16
CA2531011C (en) 2012-10-09
EP1636218B1 (en) 2009-03-25
WO2005003128A1 (en) 2005-01-13
CN1809560A (en) 2006-07-26
KR20060024812A (en) 2006-03-17

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