[go: up one dir, main page]

ATE423113T1 - SUBSTITUTED OXOAZAHETEROCYCLIC COMPOUNDS - Google Patents

SUBSTITUTED OXOAZAHETEROCYCLIC COMPOUNDS

Info

Publication number
ATE423113T1
ATE423113T1 AT00951781T AT00951781T ATE423113T1 AT E423113 T1 ATE423113 T1 AT E423113T1 AT 00951781 T AT00951781 T AT 00951781T AT 00951781 T AT00951781 T AT 00951781T AT E423113 T1 ATE423113 T1 AT E423113T1
Authority
AT
Austria
Prior art keywords
compounds
factor
substituted
inhibit
oxoazaheterocyclic compounds
Prior art date
Application number
AT00951781T
Other languages
German (de)
Inventor
William Ewing
Michael Becker
Yong CHOI-SLEDESKI
Heinz Pauls
Wei He
Stephen Condon
Roderick DAVIS
Barbara Hanney
Alfred Spada
Christopher J Burns
John JIANG
Aiwen Li
Michael Myers
Wan LAU
Gregory Poli
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of ATE423113T1 publication Critical patent/ATE423113T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Surgery (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Dental Preparations (AREA)
  • Steroid Compounds (AREA)

Abstract

This invention is directed to oxoazaheterocyclyl compounds which inhibit Factor Xa, to oxoazaheterocyclyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa.
AT00951781T 1999-07-28 2000-07-26 SUBSTITUTED OXOAZAHETEROCYCLIC COMPOUNDS ATE423113T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36319699A 1999-07-28 1999-07-28

Publications (1)

Publication Number Publication Date
ATE423113T1 true ATE423113T1 (en) 2009-03-15

Family

ID=23429232

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00951781T ATE423113T1 (en) 1999-07-28 2000-07-26 SUBSTITUTED OXOAZAHETEROCYCLIC COMPOUNDS

Country Status (25)

Country Link
EP (1) EP1208097B1 (en)
JP (1) JP4829449B2 (en)
KR (1) KR20020087041A (en)
CN (1) CN1420882A (en)
AT (1) ATE423113T1 (en)
AU (1) AU773227B2 (en)
BG (1) BG106340A (en)
BR (1) BR0013179A (en)
CA (1) CA2382755A1 (en)
CR (1) CR6563A (en)
CZ (1) CZ2002323A3 (en)
DE (1) DE60041584D1 (en)
EE (1) EE200200045A (en)
HK (1) HK1054227A1 (en)
HR (1) HRP20020076A2 (en)
HU (1) HUP0203375A3 (en)
IL (2) IL147495A0 (en)
MX (1) MXPA02000888A (en)
NO (1) NO20020214L (en)
PL (1) PL354998A1 (en)
RU (1) RU2002105011A (en)
SK (1) SK1182002A3 (en)
TR (1) TR200200225T2 (en)
WO (1) WO2001007436A2 (en)
ZA (1) ZA200200543B (en)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL150964A0 (en) 2000-03-21 2003-02-12 Smithkline Beecham Corp Protease inhibitors
JP2004509958A (en) * 2000-09-29 2004-04-02 ミレニアム・ファーマシューティカルズ・インコーポレイテッド Piperazin-2-oneamide as an inhibitor of factor Xa
KR20030079979A (en) * 2001-02-02 2003-10-10 브리스톨-마이어스스퀴브컴파니 Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0114005D0 (en) 2001-06-08 2001-08-01 Glaxo Group Ltd Chemical compounds
GB0114004D0 (en) 2001-06-08 2001-08-01 Glaxo Group Ltd Chemical compounds
MXPA03011722A (en) 2001-07-02 2004-03-19 Aztrazeneca Ab Piperidine derivatives useful as modulators of chemokine receptor activity.
GB0120461D0 (en) 2001-08-22 2001-10-17 Astrazeneca Ab Novel compounds
AU2007229363B2 (en) * 2001-08-24 2009-06-04 University Of South Florida Piperazinone Compounds as Anti-Tumor and Anti-Cancer Agents and the Methods of Treatment
ATE447955T1 (en) * 2001-08-24 2009-11-15 Univ Yale PIPERAZINONE COMPOUNDS AS ANTITUMORAL AND ANTI-CANCER AGENT
GB0122503D0 (en) 2001-09-18 2001-11-07 Astrazeneca Ab Chemical compounds
EP1314733A1 (en) 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
EP1483241A4 (en) 2002-03-08 2006-12-13 Bristol Myers Squibb Co Cyclic derivatives as modulators of chemokine receptor activity
SE0200844D0 (en) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
SE0200843D0 (en) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
AU2003231359B2 (en) 2002-04-16 2009-04-30 Teijin Limited Piperidine derivatives having CCR3 antagonism
KR20040104596A (en) 2002-04-25 2004-12-10 데이진 가부시키가이샤 4,4-disubstituted piperidine derivatives having ccr3 antagonism
AR040336A1 (en) 2002-06-26 2005-03-30 Glaxo Group Ltd PIPERIDINE COMPOUND, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND PROCEDURE TO PREPARE SUCH COMPOUND
WO2004032930A1 (en) * 2002-10-11 2004-04-22 Kowa Co., Ltd. Method of treatment for cancer
US7358268B2 (en) 2002-12-04 2008-04-15 Sanofi-Aventis Deutschland Gmbh Imidazole derivatives as factor Xa inhibitors
CA2508165C (en) * 2002-12-06 2014-05-06 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
US8729107B2 (en) 2002-12-06 2014-05-20 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
US7429581B2 (en) 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
AU2004218115A1 (en) 2003-03-07 2004-09-16 Astellas Pharma Inc. Nitrogenous heterocyclic derivative having 2,6-disubstituted styryl
SE0300957D0 (en) 2003-04-01 2003-04-01 Astrazeneca Ab Chemical compounds
US7317027B2 (en) 2003-05-19 2008-01-08 Sanofi-Aventis Deutschland Gmbh Azaindole-derivatives as factor Xa inhibitors
US7223780B2 (en) 2003-05-19 2007-05-29 Sanofi-Aventis Deutschland Gmbh Triazole-derivatives as blood clotting enzyme factor Xa inhibitors
EP1479675A1 (en) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Indazole-derivatives as factor Xa inhibitors
US7741341B2 (en) 2003-05-19 2010-06-22 Sanofi-Aventis Deutschland Gmbh Benzimidazole-derivatives as factor Xa inhibitors
GB0315111D0 (en) 2003-06-27 2003-07-30 Cancer Rec Tech Ltd Substituted 5-membered ring compounds and their use
ATE313532T1 (en) 2003-07-22 2006-01-15 Arena Pharm Inc DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONINE RECEPTOR, SUITABLE FOR THE PROPHYLAXIS AND TREATMENT OF RELATED DISEASES
SE0303180D0 (en) 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
TWI396686B (en) 2004-05-21 2013-05-21 Takeda Pharmaceutical Cyclic guanamine derivatives, as well as their products and usage
WO2006019497A2 (en) 2004-06-17 2006-02-23 Neurocrine Biosciences, Inc. Sleep-inducing compounds and methods related thereto
GB0420831D0 (en) 2004-09-17 2004-10-20 Glaxo Group Ltd Novel compounds
KR101063663B1 (en) 2005-02-17 2011-09-07 아스텔라스세이야쿠 가부시키가이샤 Pyridyl Non-aromatic Nitrogen-containing Heterocyclic-1-carboxylic Acid Ester Derivatives
WO2007008144A1 (en) * 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
WO2007008146A1 (en) * 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
US8314127B2 (en) 2005-07-21 2012-11-20 Astrazeneca Ab Piperidine derivatives
US8143285B2 (en) * 2005-09-06 2012-03-27 Shionogi & Co., Ltd. Indolecarboxylic acid derivative having PGD2 receptor antagonistic activity
EP1926735A1 (en) 2005-09-22 2008-06-04 Incyte Corporation Tetracyclic inhibitors of janus kinases
EP2407459A1 (en) 2005-09-27 2012-01-18 Shionogi & Co., Ltd. Synthetic intermediate in the production of a sulfonamide derivative having PGD2 receptor antagonistic activity
JP5473334B2 (en) 2005-12-23 2014-04-16 ジーランド ファーマ アクティーゼルスカブ Modified lysine mimetic compounds
US7935706B2 (en) 2006-02-23 2011-05-03 Shionogi & Co., Ltd. Nitrogen-containing heterocycle derivatives substituted with cyclic group
JP2009532504A (en) 2006-04-06 2009-09-10 グラクソ グループ リミテッド Antibacterial drugs
US8017612B2 (en) 2006-04-18 2011-09-13 Japan Tobacco Inc. Piperazine compound and use thereof as a HCV polymerase inhibitor
WO2007140263A2 (en) * 2006-05-26 2007-12-06 University Of Louisville Research Foundation, Inc. Macrophage migration inhibitory factor antagonists and methods of using same
EP1882688A1 (en) * 2006-07-25 2008-01-30 EPFL Ecole Polytechnique Fédérale de Lausanne Labelling of fusion proteins with synthetic probes
TWI415845B (en) 2006-10-03 2013-11-21 Arena Pharm Inc Pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
US20080188545A1 (en) 2006-12-21 2008-08-07 Alimardanov Asaf R Synthesis of pyrrolidine compounds
AU2008229216B2 (en) * 2007-03-20 2013-03-21 Curis, Inc. Fused amino pyridine as HSP90 inhibitors
WO2009023253A2 (en) 2007-08-15 2009-02-19 Arena Pharmaceuticals Inc. IMIDAZO[L,2-α]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
US20110021538A1 (en) 2008-04-02 2011-01-27 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
TW200944526A (en) 2008-04-22 2009-11-01 Vitae Pharmaceuticals Inc Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
HUE036506T2 (en) 2008-10-28 2018-07-30 Arena Pharm Inc Compositions comprising a 5-HT2A serotonin receptor modulator for the treatment of disorders associated with such receptor modulators
EP2480235A4 (en) 2009-09-24 2013-05-08 Univ Louisville Res Found Novel iodo pyrimidine derivatives useful for the treatment of macrophage migration inhibitory factor (mif)-implicated diseases and conditions
US9155790B2 (en) 2010-05-20 2015-10-13 University of Lousiville Research Foundation, Inc. Methods and compositions for modulating ocular damage
KR101251282B1 (en) 2010-10-18 2013-04-10 서울대학교산학협력단 Sulfonamide derivatives to inhibit Prostaglandin E2 production and the pharmaceutical composition comprising the derivatives
CN102532159B (en) * 2010-11-12 2015-02-11 姚雪彪 Small molecule inhibitors Syntelin for centromere-associated protein E (CENP-E)
WO2012071369A2 (en) 2010-11-24 2012-05-31 The Trustees Of Columbia University In The City Of New York A non-retinoid rbp4 antagonist for treatment of age-related macular degeneration and stargardt disease
PL395470A1 (en) 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Alicyclic amines sulfonamide derivatives for the treatment of diseases of the central nervous system
US9333202B2 (en) 2012-05-01 2016-05-10 The Trustees Of Columbia University In The City Of New York Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease
WO2014152013A1 (en) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York 4-phenylpiperidines, their preparation and use
WO2014151936A1 (en) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles, their preparation and use
US9637450B2 (en) 2013-03-14 2017-05-02 The Trustees Of Columbia University In The City Of New York Octahydrocyclopentapyrroles, their preparation and use
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
WO2014151959A1 (en) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York N-alkyl-2-phenoxyethanamines, their preparation and use
MX2016014197A (en) 2014-04-30 2017-05-03 Univ Columbia Substituted 4-phenylpiperidines, their preparaiton and use.
PT3174858T (en) 2014-07-31 2019-07-23 Basf Se Process for preparing pyrazoles
CN104650081B (en) * 2015-02-14 2016-06-01 佛山市赛维斯医药科技有限公司 Coagulation factor xa inhibitors, preparation method and its usage
CN104610260B (en) * 2015-02-14 2016-03-30 佛山市赛维斯医药科技有限公司 FXa inhibitor, the preparation method and its usage of one class amide containing and nitrogen heterocyclic structure
CN104592227B (en) * 2015-02-14 2016-06-01 佛山市赛维斯医药科技有限公司 The FXa inhibitor of one class amide containing and halogeno-benzene structure, preparation method and its usage
CN104610258B (en) * 2015-02-14 2016-03-30 佛山市赛维斯医药科技有限公司 FXa inhibitor, the preparation method and its usage of one class amide containing and methoxy benzene structure
CN104650082B (en) * 2015-02-14 2016-06-01 佛山市赛维斯医药科技有限公司 One class coagulation factor xa inhibitors, preparation method and its usage
CN104557929B (en) * 2015-02-14 2016-06-01 佛山市赛维斯医药科技有限公司 One class contains coagulation factor xa inhibitors and the purposes thereof of bicyclic amide structure
CN104557930B (en) * 2015-02-14 2016-06-01 佛山市赛维斯医药科技有限公司 A kind of containing bicyclic amide structure coagulation factor xa inhibitors and purposes thereof
CN104672235B (en) * 2015-02-14 2016-02-17 佛山市赛维斯医药科技有限公司 One class contains FXa inhibitor of bisamide base and alkoxyphenyl radical structure and uses thereof
CN104557927B (en) * 2015-02-14 2016-06-01 佛山市赛维斯医药科技有限公司 A kind of coagulation factor xa inhibitors containing bicyclic amide structure and purposes thereof
CN104610259B (en) * 2015-02-14 2016-06-01 佛山市赛维斯医药科技有限公司 The FXa inhibitor of amide containing and nitrogen heterocyclic structure, preparation method and its usage
CN104672236B (en) * 2015-02-14 2016-03-30 佛山市赛维斯医药科技有限公司 One class contains FXa inhibitor of bisamide base and halogeno-benzene structure and uses thereof
CN104557928B (en) * 2015-02-14 2016-08-24 佛山市赛维斯医药科技有限公司 A kind of containing bicyclic amide structure coagulation factor xa inhibitors, Its Preparation Method And Use
CN104610257B (en) * 2015-02-14 2016-06-01 佛山市赛维斯医药科技有限公司 The FXa inhibitor of one class amide containing structure, preparation method and its usage
US10584102B2 (en) 2015-05-11 2020-03-10 Basf Se Process for preparing 4-amino-pyridazines
CA2989343A1 (en) 2015-06-12 2016-12-15 Yandong Wen Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of rem sleep behavior disorder
US9878989B2 (en) 2015-06-26 2018-01-30 Takeda Pharmaceutical Company Limited Heterocyclic compound
JP2018520187A (en) 2015-07-15 2018-07-26 アクソヴァント サイエンシーズ ゲゼルシャフト ミット ベシュレンクテル ハフツングAxovant Sciences GmbH Diaryl and arylheteroaryl urea derivatives as modulators of 5-HT2A serotonin receptors useful for the prevention and treatment of hallucinations associated with neurodegenerative diseases
US10548899B2 (en) 2015-10-20 2020-02-04 Takeda Pharmaceutical Company Limited Quinazolinone and benzotriazinone compounds with cholinergic muscarinin M1 receptor positive allosteric modulator activity
WO2018082964A1 (en) 2016-11-04 2018-05-11 Basf Se Process for the production of pyridazinyl-amides in a one-pot synthesis
WO2018194181A1 (en) 2017-04-18 2018-10-25 Takeda Pharmaceutical Company Limited Heterocyclic compounds useful as modulators of acetylcholine receptors
ES2870106T3 (en) 2017-05-05 2021-10-26 Zealand Pharma As Modulators of gap junctional communication and their use for the treatment of diabetic eye disease
CN110054619A (en) * 2018-01-18 2019-07-26 西北农林科技大学 Novel diketopiperazine histone deacetylases inhibitor
EP3774748A1 (en) 2018-04-10 2021-02-17 Bayer Aktiengesellschaft Oxadiazoline derivatives
CN109991355B (en) * 2019-04-12 2021-05-11 中国烟草总公司郑州烟草研究院 Method for identifying NAB metabolite in animal body and method for evaluating exposure risk of NAB in animal body
WO2022228387A1 (en) * 2021-04-26 2022-11-03 Fochon Biosciences, Ltd. Compounds as parp inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ210895A3 (en) * 1993-02-22 1996-02-14 Merck & Co Inc Fibrinogen receptors antagonizing matters and pharmaceutical compositions containing thereof
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
US5612353A (en) * 1995-06-07 1997-03-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds
UA56197C2 (en) * 1996-11-08 2003-05-15 Зенека Лімітед Heterocyclic derivatives
WO1998046591A1 (en) * 1997-04-14 1998-10-22 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
AU1692399A (en) * 1997-12-26 1999-07-19 Mochida Pharmaceutical Co., Ltd. Aromatic compounds having cyclic amino or salts thereof
TR200002182T2 (en) * 1998-01-27 2000-12-21 Aventis Pharmaceuticals Products Inc. Substituted aksozaherosayklil factor xa inhibitors
JP2000204081A (en) * 1998-02-05 2000-07-25 Takeda Chem Ind Ltd Sulfonamide derivative, its production and use
US6403595B1 (en) * 1998-02-05 2002-06-11 Takeda Chemical Industries, Ltd. Sulfonamide derivatives, processes for producing the same and utilization thereof
WO2000032590A1 (en) * 1998-11-25 2000-06-08 Aventis Pharmaceuticals Products Inc. SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS

Also Published As

Publication number Publication date
ZA200200543B (en) 2003-08-27
TR200200225T2 (en) 2002-06-21
BG106340A (en) 2002-10-31
HUP0203375A3 (en) 2005-03-29
HUP0203375A2 (en) 2002-12-28
CR6563A (en) 2008-11-25
CA2382755A1 (en) 2001-02-01
AU773227B2 (en) 2004-05-20
EP1208097A2 (en) 2002-05-29
NO20020214L (en) 2002-04-02
RU2002105011A (en) 2004-01-20
SK1182002A3 (en) 2002-11-06
IL147495A (en) 2007-07-24
WO2001007436A2 (en) 2001-02-01
WO2001007436A3 (en) 2001-08-23
AU6462800A (en) 2001-02-13
KR20020087041A (en) 2002-11-21
HRP20020076A2 (en) 2003-12-31
IL147495A0 (en) 2002-08-14
HK1054227A1 (en) 2003-11-21
EE200200045A (en) 2003-06-16
CZ2002323A3 (en) 2002-05-15
MXPA02000888A (en) 2002-07-30
JP4829449B2 (en) 2011-12-07
DE60041584D1 (en) 2009-04-02
CN1420882A (en) 2003-05-28
NO20020214D0 (en) 2002-01-15
BR0013179A (en) 2002-04-02
EP1208097B1 (en) 2009-02-18
PL354998A1 (en) 2004-03-22
JP2003508353A (en) 2003-03-04

Similar Documents

Publication Publication Date Title
DE60041584D1 (en) SUBSTITUTED OXOAZAHETEROZYCLIC COMPOUNDS
AP2000001889A0 (en) Substituted ozoazaheterocyclyl factor Xa inhibitors.
ATE297203T1 (en) ANTITHRBOTIC AGENTS
DE69831868D1 (en) Antithrombosemittel
DE69919212D1 (en) AROMATIC AMIDES
DE60130771D1 (en) SUBSTITUTED HETEROCYCLIC AMIDS
DE69931393D1 (en) ANTITHROMBOTIC AMIDE
GB0129476D0 (en) Organic compounds
DE69919397D1 (en) Thrombin Inhibitors
DE60101000D1 (en) N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS
ATE394373T1 (en) SYNTHESIS OF INDOLTHIAZOLE COMPOUNDS AS LIGANDS OF THE AH RECEPTOR
TW200510317A (en) Caspase inhibitors and uses thereof
MXPA05009611A (en) SUBSTITUTED PIPERIDINES AS NOVEL MDM2-p53 INHIBITORS.
BR0206595A (en) Compound, pharmaceutical composition, and use of a compound
EA200300982A1 (en) HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF CANCER AND OTHER PROLIFERATIVE DISEASES
BR0313969A (en) Oxytocin Inhibitors
DE60221425D1 (en) SUBSTITUTED TETRAZYCLIC PYPROLOCHINOLON DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS
SE9901077D0 (en) Novel use
ATE453389T1 (en) CERTAIN PHARMACEUTICALLY VALUABLE SUBSTITUTED AMINOALKYL HETEROCYCLES
NO20045630L (en) Compounds for treating anthrax and lethal factor inhibition
DE60114640D1 (en) Antithrombosemittel
RS79703A (en) Phenyl heterocyclyl ether derivatives as serotonin re-uptake inhibitors
MXPA03002493A (en) Efficient process for the preparation of a factor xa inhibitor.
ATE382607T1 (en) ANTITROMBOTIC AETHERS
NO981089L (en) Epoxy-azetidinones, preparation and use thereof

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties