ATE423110T1 - Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen - Google Patents
Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungenInfo
- Publication number
- ATE423110T1 ATE423110T1 AT03764801T AT03764801T ATE423110T1 AT E423110 T1 ATE423110 T1 AT E423110T1 AT 03764801 T AT03764801 T AT 03764801T AT 03764801 T AT03764801 T AT 03764801T AT E423110 T1 ATE423110 T1 AT E423110T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- proliferative diseases
- compositions
- methods
- cellular proliferative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39669002P | 2002-07-17 | 2002-07-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE423110T1 true ATE423110T1 (de) | 2009-03-15 |
Family
ID=30116052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03764801T ATE423110T1 (de) | 2002-07-17 | 2003-07-17 | Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen |
Country Status (7)
Country | Link |
---|---|
US (2) | US6949538B2 (de) |
EP (1) | EP1539727B1 (de) |
JP (1) | JP2005533119A (de) |
AT (1) | ATE423110T1 (de) |
AU (1) | AU2003252025A1 (de) |
DE (1) | DE60326248D1 (de) |
WO (1) | WO2004006865A2 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04010240A (es) | 2002-04-17 | 2005-06-08 | Cytokinetics Inc | Compuestos, composiciones y metodos. |
US6949538B2 (en) | 2002-07-17 | 2005-09-27 | Cytokinetics, Inc. | Compounds, compositions, and methods |
EP1554265A4 (de) * | 2002-09-13 | 2008-05-07 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren |
WO2006018628A1 (en) * | 2003-03-07 | 2006-02-23 | Astrazeneca Ab | Enantiomers of selected fused pyrimidones and uses in the treatment and preventi on of cancer |
DK1601673T3 (da) * | 2003-03-07 | 2009-08-24 | Astrazeneca Ab | Kondenserede heterocykler og anvendelser af disse |
EP1670456A2 (de) * | 2003-10-06 | 2006-06-21 | Cytokinetics, Inc. | Verbindungen, zusammensetzungen und verfahren |
WO2005113507A1 (en) | 2004-05-21 | 2005-12-01 | Novartis Vaccines And Diagnostics Inc. | Substituted quinoline derivatives as mitotic kinesin inhibitors |
TW200612958A (en) | 2004-06-18 | 2006-05-01 | Chiron Corp | Substituted imidazole derivatives |
JP2008506759A (ja) * | 2004-07-22 | 2008-03-06 | アストラゼネカ アクチボラグ | 癌の処置および予防に有用な縮合ピリミドン類 |
BRPI0514390A (pt) * | 2004-08-18 | 2008-06-10 | Astrazeneca Ab | enanciÈmero de um composto ou um sal farmacêuticamente aceitável ou um éster hidrolisável in vivo do mesmo, uso do mesmo, métodos para o tratamento de cáncer, para produzir um efeito inibidor de eg5 em um animal de sangue quente e para tratar doenças, e, composição farmacêutica |
US20060041128A1 (en) * | 2004-08-18 | 2006-02-23 | Astrazeneca Ab | Selected fused heterocyclics and uses thereof |
EP1807399A2 (de) | 2004-10-19 | 2007-07-18 | Novartis Vaccines and Diagnostics, Inc. | Indol- und benzimidazolderivate |
CN101084194A (zh) * | 2004-12-21 | 2007-12-05 | 默克公司 | 有丝分裂驱动蛋白抑制剂 |
JP2009514866A (ja) * | 2005-11-02 | 2009-04-09 | サイトキネティクス・インコーポレーテッド | ある種の化学物質、組成物、および方法 |
US7902240B2 (en) | 2006-11-13 | 2011-03-08 | Novartis Ag | Substituted pyrazole and triazole compounds as KSP inhibitors |
CA2674318A1 (en) | 2007-01-05 | 2008-07-17 | Novartis Ag | Cyclized derivatives as eg-5 inhibitors |
Family Cites Families (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3177130D1 (de) * | 1980-08-30 | 1990-01-11 | Hoechst Ag | Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung. |
US4434296A (en) * | 1982-05-17 | 1984-02-28 | The Upjohn Company | Process for preparing intermediates for antiatherosclerotic compounds |
US4434295A (en) | 1982-05-17 | 1984-02-28 | The Upjohn Company | Anti-atherosclerotic 6,7-dihydro-7,7-disubstituted-khellin analogs |
US4482558A (en) * | 1982-06-18 | 1984-11-13 | Pfizer Inc. | Antifungal amide and urea derivatives of (3-amino-2-aryl-2-hydroxyprop-1-yl)-1H-1,2,4-triazoles |
JPS62201882A (ja) * | 1985-11-18 | 1987-09-05 | Yamanouchi Pharmaceut Co Ltd | イソフラボン誘導体 |
IN164232B (de) * | 1986-04-11 | 1989-02-04 | Hoechst India | |
IL85554A0 (en) * | 1987-03-02 | 1988-08-31 | Takeda Chemical Industries Ltd | Chromone derivatives |
JPH0753725B2 (ja) * | 1987-10-08 | 1995-06-07 | 富山化学工業株式会社 | 4h―1―ベンゾピラン―4―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
IL89840A (en) | 1988-04-06 | 1996-10-31 | Lipha | Substituted flavonoid compounds and salts thereof their preparation and pharmaceutical composition containing them |
USH1427H (en) | 1988-04-06 | 1995-04-04 | Briet; Phillipe | Substituted flavonoid compounds, their salts, their manufacture and their use in combination with interleukin-2 |
US5304548A (en) * | 1988-08-16 | 1994-04-19 | The Upjohn Company | Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol |
US5180717A (en) * | 1988-08-16 | 1993-01-19 | The Upjohn Company | Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol |
US5284856A (en) * | 1988-10-28 | 1994-02-08 | Hoechst Aktiengesellschaft | Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives |
DE3836676A1 (de) | 1988-10-28 | 1990-05-03 | Hoechst Ag | Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel |
US5703075A (en) * | 1988-12-21 | 1997-12-30 | Pharmacia & Upjohn Company | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
JPH04502322A (ja) | 1988-12-21 | 1992-04-23 | ジ・アップジョン・カンパニー | 抗アテローム性動脈硬化症性および抗血栓性1―ベンゾピラン―4―オン類および2―アミノ―1,3―ベンゾオキサジン―4―オン類 |
US4977162A (en) * | 1989-07-13 | 1990-12-11 | Rorer Pharmaceutical Corporation | Quinolinyl-chromone derivatives and use for treatment of hypersensitive ailments |
US5082849A (en) * | 1989-07-13 | 1992-01-21 | Huang Fu Chich | Quinolinyl-benzopyran derivatives as antagonists of leukotriene D4 |
US5215989A (en) * | 1989-12-08 | 1993-06-01 | Merck & Co., Inc. | Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents |
US5032598A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents |
ES2106783T3 (es) | 1990-06-20 | 1997-11-16 | Upjohn Co | 1-benzopiran-4-onas y 2-amino-1,3-benzoxacin-4-onas antiarterosclerosis y antitromboticas. |
ATE161837T1 (de) * | 1990-07-25 | 1998-01-15 | Teijin Ltd | Benzopyran derivat, seine darstellung und pharmazeutische zusammensetzung, welche dieses enthält |
AU8506791A (en) | 1990-10-01 | 1992-04-28 | Janssen Pharmaceutica N.V. | Novel 4-piperidinylcarbonyl derivatives |
US5605896A (en) * | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
FR2693196B1 (fr) | 1992-07-03 | 1994-12-23 | Lipha | Dérivés de benzopyranone ou de benzothiopyranone, procédé de préparation et composition pharmaceutique les contenant. |
WO1995022992A2 (en) * | 1994-02-23 | 1995-08-31 | Chiron Corp | Method and compositions for increasing the serum half-life of pharmacologically active agents |
JPH10501256A (ja) * | 1994-06-10 | 1998-02-03 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | C−4アミド置換化合物およびその治療剤としての使用 |
US5607928A (en) * | 1994-08-05 | 1997-03-04 | Zeneca Limited | Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives |
GB9417969D0 (en) | 1994-09-07 | 1994-10-26 | King S College London | Alkaloids and derivatives thereof |
US5602171A (en) * | 1995-06-07 | 1997-02-11 | Sugen Inc. | Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and derivatives thereof |
WO1997014419A1 (en) | 1995-10-20 | 1997-04-24 | Flora Inc. | Transdermal delivery of alpha adrenoceptor blocking agents |
US5908934A (en) | 1996-09-26 | 1999-06-01 | Bristol-Myers Squibb Company | Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs |
GB9807779D0 (en) | 1998-04-09 | 1998-06-10 | Ciba Geigy Ag | Organic compounds |
US6087385A (en) | 1998-10-30 | 2000-07-11 | University Of Mississippi | Flavonoid derivatives |
US6028088A (en) * | 1998-10-30 | 2000-02-22 | The University Of Mississippi | Flavonoid derivatives |
DE19850131A1 (de) | 1998-10-30 | 2000-05-04 | Merck Patent Gmbh | Chromenon- und Chromanonderivate |
DE19858341A1 (de) * | 1998-12-17 | 2000-06-21 | Merck Patent Gmbh | Chromanderivate |
GB9911071D0 (en) | 1999-05-12 | 1999-07-14 | Darwin Discovery Ltd | Hydroxamic and carboxylic acid derivatives |
ATE342257T1 (de) | 1999-08-27 | 2006-11-15 | Chemocentryx Inc | Heterozyclische verbindungen und verfahren zur modulierung von cxcr3 funktion |
GB9920910D0 (en) | 1999-09-03 | 1999-11-10 | Indena Spa | Novel chalcones |
GB9920912D0 (en) | 1999-09-03 | 1999-11-10 | Indena Spa | Novel derivatives of flavones,xanthones and coumarins |
ES2234662T3 (es) | 1999-09-16 | 2005-07-01 | Curis, Inc. | Mediadores de rutas de señalizacion hedgehog, composiciones y usos relacionados con los mismos. |
US6552016B1 (en) | 1999-10-14 | 2003-04-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
NZ518480A (en) * | 1999-10-27 | 2004-02-27 | Cytokinetics Inc | Methods and compositions utilizing quinazolinones |
US6545004B1 (en) * | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
US6683192B2 (en) | 2000-03-30 | 2004-01-27 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
US6559145B2 (en) | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
IL156304A0 (en) | 2000-12-11 | 2004-01-04 | Tularik Inc | Cxcr3 antagonists |
PL366799A1 (en) | 2001-07-27 | 2005-02-07 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
SE0103648D0 (sv) | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic quinolone compounds |
US7060705B2 (en) | 2001-11-07 | 2006-06-13 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
US20050107404A1 (en) | 2001-12-06 | 2005-05-19 | Fraley Mark E. | Mitotic kinesin inhibitors |
WO2003049527A2 (en) | 2001-12-06 | 2003-06-19 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
JP2005515208A (ja) | 2001-12-06 | 2005-05-26 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂性キネシン阻害剤 |
ATE372341T1 (de) | 2001-12-06 | 2007-09-15 | Merck & Co Inc | Inhibitoren von mitotischem kinesin |
EP1481077B1 (de) | 2001-12-06 | 2009-11-04 | Merck & Co., Inc. | Mitotische kinesin-hemmer |
ATE448207T1 (de) | 2002-03-08 | 2009-11-15 | Merck & Co Inc | Mitotische kinesin-hemmer |
MXPA04010240A (es) | 2002-04-17 | 2005-06-08 | Cytokinetics Inc | Compuestos, composiciones y metodos. |
CA2483627A1 (en) | 2002-05-23 | 2003-12-04 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
WO2003106417A1 (en) | 2002-06-14 | 2003-12-24 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
CN100421665C (zh) | 2002-06-14 | 2008-10-01 | 麦克公司 | 有丝分裂驱动蛋白抑制剂 |
JP2005537257A (ja) | 2002-07-08 | 2005-12-08 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン結合部位 |
US6949538B2 (en) * | 2002-07-17 | 2005-09-27 | Cytokinetics, Inc. | Compounds, compositions, and methods |
WO2004014388A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | 6,6-fused heteroaryl derivatives as matrix metalloproteinase inhibitors |
EP1670456A2 (de) * | 2003-10-06 | 2006-06-21 | Cytokinetics, Inc. | Verbindungen, zusammensetzungen und verfahren |
WO2005040163A1 (en) * | 2003-10-28 | 2005-05-06 | Dr. Reddy's Laboratories Ltd | Heterocyclic compounds that block the effects of advanced glycation end products (age) |
-
2003
- 2003-07-17 US US10/622,363 patent/US6949538B2/en not_active Expired - Fee Related
- 2003-07-17 AT AT03764801T patent/ATE423110T1/de not_active IP Right Cessation
- 2003-07-17 JP JP2004521967A patent/JP2005533119A/ja active Pending
- 2003-07-17 DE DE60326248T patent/DE60326248D1/de not_active Expired - Fee Related
- 2003-07-17 WO PCT/US2003/022466 patent/WO2004006865A2/en active Application Filing
- 2003-07-17 AU AU2003252025A patent/AU2003252025A1/en not_active Abandoned
- 2003-07-17 EP EP03764801A patent/EP1539727B1/de not_active Expired - Lifetime
-
2005
- 2005-06-29 US US11/172,400 patent/US20060004073A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2004006865A3 (en) | 2004-07-01 |
AU2003252025A8 (en) | 2004-02-02 |
JP2005533119A (ja) | 2005-11-04 |
US20040116400A1 (en) | 2004-06-17 |
EP1539727B1 (de) | 2009-02-18 |
US6949538B2 (en) | 2005-09-27 |
AU2003252025A1 (en) | 2004-02-02 |
EP1539727A4 (de) | 2007-04-04 |
DE60326248D1 (de) | 2009-04-02 |
WO2004006865A2 (en) | 2004-01-22 |
US20060004073A1 (en) | 2006-01-05 |
EP1539727A2 (de) | 2005-06-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2003103575A3 (en) | COMPOUNDS, COMPOSITIONS AND METHODS | |
MY140767A (en) | Compounds, methods and compositions | |
MY140169A (en) | Compounds, compositions, and methods | |
WO2004018058A3 (en) | Compounds, compositions, and methods | |
MXPA06012796A (es) | Ciertas entidades quimicas, composiciones y metodos. | |
DE60326248D1 (de) | Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen | |
WO2004009036A3 (en) | Compounds compositions and methods | |
WO2006113432A3 (en) | Compounds, compositions and methods | |
DE60118544D1 (de) | Methoden und zusammensetzungen zur modulation der aktivität der alpha-adrenergen rezeptoren | |
EA200900802A1 (ru) | Способы и композиции для лечения амилоидных заболеваний | |
DE602004017736D1 (de) | Verwendung von rapamycin und dessen derivaten zur behandlung von knochenverlust | |
EA200600078A1 (ru) | Способы и композиции для лечения амилоидных заболеваний | |
ATE448775T1 (de) | Rifalazil zur behandlung von infektionen mit clostridium difficile | |
DE60112766D1 (de) | Verwendung von derivaten der valproinsäureamide und 2-valproinsäureamid zur behandlung und prävention von schmerzen und/oder kopfschmerzen | |
ATE288747T1 (de) | Methoden und zusammensetzungen zur modulierung der aktivität von alpha-adrenergen rezeptoren | |
DE60103171D1 (de) | Verfahren und verbindungen zur behandlung proliferativer erkrankungen | |
NO20052267L (no) | Forbindelser, Preparater og Metoder | |
WO2004034972A3 (en) | Compounds, compositions, and methods | |
WO2005046588A3 (en) | Compounds, compositions, and methods | |
WO2004064741A3 (en) | Compounds, compositions, and methods | |
DE602004021363D1 (de) | Imidazotriazin verbindungen zur behandlung von krebserkrankungen | |
WO2004100873A3 (en) | Compounds, compositions, and methods | |
WO2005042697A3 (en) | Compounds, compositions and methods | |
WO2004024086A3 (en) | Compounds, compositions and methods | |
WO2004032879A3 (en) | Compounds, compositions, and methods |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |