ATE418543T1 - Substituierte 1,4-dipiperidin-4-yl- piperazinderivate und deren verwendung als neurokininantagonisten - Google Patents
Substituierte 1,4-dipiperidin-4-yl- piperazinderivate und deren verwendung als neurokininantagonistenInfo
- Publication number
- ATE418543T1 ATE418543T1 AT03773731T AT03773731T ATE418543T1 AT E418543 T1 ATE418543 T1 AT E418543T1 AT 03773731 T AT03773731 T AT 03773731T AT 03773731 T AT03773731 T AT 03773731T AT E418543 T1 ATE418543 T1 AT E418543T1
- Authority
- AT
- Austria
- Prior art keywords
- dipiperidine
- substituted
- piperazine derivatives
- neurokin antagonists
- neurokin
- Prior art date
Links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP0211328 | 2002-10-08 | ||
PCT/EP2002/014836 WO2004056772A1 (en) | 2002-12-23 | 2002-12-23 | Substituted 1,4-di-piperidin-4-yl-piperazine derivatives and their use as tachykinin antagonists |
Publications (1)
Publication Number | Publication Date |
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ATE418543T1 true ATE418543T1 (de) | 2009-01-15 |
Family
ID=32094938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03773731T ATE418543T1 (de) | 2002-10-08 | 2003-10-07 | Substituierte 1,4-dipiperidin-4-yl- piperazinderivate und deren verwendung als neurokininantagonisten |
Country Status (19)
Country | Link |
---|---|
US (1) | US7410970B2 (de) |
EP (1) | EP1551804B1 (de) |
JP (1) | JP4674086B2 (de) |
KR (1) | KR101049074B1 (de) |
AR (1) | AR041545A1 (de) |
AT (1) | ATE418543T1 (de) |
AU (1) | AU2003282115B2 (de) |
BR (1) | BR0315098A (de) |
CA (1) | CA2499903C (de) |
DE (1) | DE60325493D1 (de) |
EA (1) | EA009217B1 (de) |
ES (1) | ES2319642T3 (de) |
HK (1) | HK1084394A1 (de) |
HR (1) | HRP20050309A2 (de) |
IL (1) | IL167885A (de) |
MY (1) | MY141736A (de) |
PA (1) | PA8584901A1 (de) |
TW (1) | TWI324995B (de) |
WO (1) | WO2004033428A1 (de) |
Families Citing this family (26)
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GB9923748D0 (en) | 1999-10-07 | 1999-12-08 | Glaxo Group Ltd | Chemical compounds |
USRE39921E1 (en) | 1999-10-07 | 2007-11-13 | Smithkline Beecham Corporation | Chemical compounds |
GB0025354D0 (en) | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
EP1472222A1 (de) | 2002-02-08 | 2004-11-03 | Glaxo Group Limited | Piperidylcarbonsäure amidderivate und deren verwendung zur behandlung von durch tachykinin vermittelten erkrankungen |
GB0203022D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
JO2485B1 (en) * | 2002-12-23 | 2009-01-20 | شركة جانسين فارماسوتيكا ان. في | 1-Piperidine-3-Yl-4-Piperidine-4-Yl-Piperazine derivatives substituted and used as quinine antagonists |
JO2696B1 (en) | 2002-12-23 | 2013-03-03 | شركة جانسين فارماسوتيكا ان. في | Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists |
KR20060006098A (ko) | 2003-06-10 | 2006-01-18 | 얀센 파마슈티카 엔.브이. | 오피오이드 진통제와 배합된 치환된1,4-디-피페리딘-4-일-피페라진 유도체 및 오피오이드계치료와 관련된 통증 및 부작용 치료용으로 이들의 용도 |
RU2369604C2 (ru) | 2004-04-13 | 2009-10-10 | Инсайт Корпорейшн | Производные пиперазинилпиперидина в качестве антагонистов хемокинового рецептора |
WO2005123081A2 (en) * | 2004-06-22 | 2005-12-29 | Janssen Pharmaceutica N.V. | (2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)-pyrrolidin-3-yl]-piperazin-1-yl}-piperidin-1-yl)-(3,5-trifluoromethyl-phenyl))-methanone for the treatment of schizophrenia |
WO2006071958A1 (en) | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
US7880002B2 (en) * | 2004-12-29 | 2011-02-01 | Millennium Pharmaceuticals, Inc. | Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists |
CN101133064B (zh) * | 2005-03-03 | 2011-02-23 | 詹森药业有限公司 | 取代的氧杂-二氮杂-螺-[5.5]-十一烷酮衍生物及其作为神经激肽拮抗剂的应用 |
EP1858896B1 (de) | 2005-03-08 | 2010-08-18 | Janssen Pharmaceutica NV | Diazaspiro-[4,4]-nonanderivate als neurokinin-(nk1)-antagonisten |
US7592344B2 (en) * | 2005-11-30 | 2009-09-22 | Solvay Pharmaceuticals Gmbh | NK1 and NK2-antagonists and compositions and methods of using the same |
PE20071144A1 (es) * | 2006-03-21 | 2008-01-10 | Schering Corp | COMPUESTOS HETEROCICLICOS DE PIRIDINA SUSTITUIDA COMO ANTAGONISTAS DEL RECEPTOR 3 DE a-QUIMIOCINA (CXCR3) |
US20090209541A1 (en) * | 2006-06-16 | 2009-08-20 | Dr. Reddy's Laboratories Ltd. | Aprepitant compositions |
AR061975A1 (es) * | 2006-07-14 | 2008-08-10 | Schering Corp | Compuestos de piperazina 1,4-sustituida con actividad antagonista de cxcr3, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por el receptor de quimioquina cxcr3 |
RU2012112943A (ru) * | 2009-09-04 | 2013-10-10 | Юнайтед Парагон Эссоушиэйтс Инк. | Соединения для лечения расстройства или заболевания, связанного с активностью нейрокининового 2 рецептора |
CN105164245B (zh) | 2013-02-08 | 2018-05-22 | 通用磨坊公司 | 低钠食品 |
KR101472916B1 (ko) * | 2013-06-27 | 2014-12-16 | 한국과학기술연구원 | 모르폴린 또는 피페라진 화합물, 및 도네페질을 포함하는 인지 장애 관련 질병의 예방 또는 치료용 약학적 조성물 |
US10314835B2 (en) | 2014-06-25 | 2019-06-11 | Emory University | Methods of managing conditioned fear with neurokinin receptor antagonists |
RU2617694C1 (ru) * | 2015-12-24 | 2017-04-26 | Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) | Амиды акриловой и метакриловой кислот с олигопиперидинами и способ их получения |
US11458129B2 (en) | 2017-11-02 | 2022-10-04 | California Institute Of Technology | Neurokinin antagonists and uses thereof |
US20200206144A1 (en) * | 2019-01-02 | 2020-07-02 | Lauren Lukas VanderSpek | Targeted Nanoparticles for Glioblastoma Theranostics |
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FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
NZ321575A (en) * | 1995-10-30 | 1999-05-28 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives |
RU2135494C1 (ru) * | 1995-12-01 | 1999-08-27 | Санкио Компани Лимитед | Гетероциклические соединения и композиция на их основе, проявляющая антагонистическое действие в отношении рецепторов тахикинина |
JO2485B1 (en) * | 2002-12-23 | 2009-01-20 | شركة جانسين فارماسوتيكا ان. في | 1-Piperidine-3-Yl-4-Piperidine-4-Yl-Piperazine derivatives substituted and used as quinine antagonists |
CN100424830C (zh) * | 2004-04-23 | 2008-10-08 | Jsr株式会社 | 用于抛光半导体晶片的抛光垫、层叠体和方法 |
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Also Published As
Publication number | Publication date |
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CA2499903A1 (en) | 2004-04-22 |
HRP20050309A2 (en) | 2006-07-31 |
AU2003282115A1 (en) | 2004-05-04 |
WO2004033428A1 (en) | 2004-04-22 |
HK1084394A1 (en) | 2006-07-28 |
CA2499903C (en) | 2011-06-14 |
KR20050059164A (ko) | 2005-06-17 |
EP1551804B1 (de) | 2008-12-24 |
JP4674086B2 (ja) | 2011-04-20 |
JP2006510602A (ja) | 2006-03-30 |
US7410970B2 (en) | 2008-08-12 |
AU2003282115B2 (en) | 2009-10-01 |
PA8584901A1 (es) | 2005-10-28 |
DE60325493D1 (de) | 2009-02-05 |
EP1551804A1 (de) | 2005-07-13 |
BR0315098A (pt) | 2005-08-16 |
AR041545A1 (es) | 2005-05-18 |
ES2319642T3 (es) | 2009-05-11 |
TW200413319A (en) | 2004-08-01 |
MY141736A (en) | 2010-06-15 |
EA200500616A1 (ru) | 2005-10-27 |
KR101049074B1 (ko) | 2011-07-15 |
US20060167008A1 (en) | 2006-07-27 |
EA009217B1 (ru) | 2007-12-28 |
IL167885A (en) | 2010-04-29 |
TWI324995B (en) | 2010-05-21 |
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