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ATE408698T1 - Kommerzielle herstellung von aprotinin in pflanzen - Google Patents

Kommerzielle herstellung von aprotinin in pflanzen

Info

Publication number
ATE408698T1
ATE408698T1 AT96942722T AT96942722T ATE408698T1 AT E408698 T1 ATE408698 T1 AT E408698T1 AT 96942722 T AT96942722 T AT 96942722T AT 96942722 T AT96942722 T AT 96942722T AT E408698 T1 ATE408698 T1 AT E408698T1
Authority
AT
Austria
Prior art keywords
aprotinin
plants
protein
commercial production
plant
Prior art date
Application number
AT96942722T
Other languages
English (en)
Inventor
John Howard
Chris Baszcynski
Thomas Czapla
Elizabeth Hood
Terry Meyer
David Peterson
A Rao
James Register
Derrick Witcher
Original Assignee
Prodigene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24212272&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE408698(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Prodigene Inc filed Critical Prodigene Inc
Application granted granted Critical
Publication of ATE408698T1 publication Critical patent/ATE408698T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pest Control & Pesticides (AREA)
  • Insects & Arthropods (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT96942722T 1995-11-06 1996-10-31 Kommerzielle herstellung von aprotinin in pflanzen ATE408698T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/554,161 US5824870A (en) 1995-11-06 1995-11-06 Commercial production of aprotinin in plants

Publications (1)

Publication Number Publication Date
ATE408698T1 true ATE408698T1 (de) 2008-10-15

Family

ID=24212272

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96942722T ATE408698T1 (de) 1995-11-06 1996-10-31 Kommerzielle herstellung von aprotinin in pflanzen

Country Status (7)

Country Link
US (1) US5824870A (de)
EP (1) EP0859852B1 (de)
AT (1) ATE408698T1 (de)
AU (1) AU1156797A (de)
CA (1) CA2233538C (de)
DE (1) DE69637685D1 (de)
WO (1) WO1997017453A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039461A1 (en) * 1997-03-20 1998-09-11 Prodigene Inc. Methods of commercial production and extraction of protein from seed
EP0975777A1 (de) 1997-03-07 2000-02-02 Prodigene, Inc. Verfahren zur kommerziellen produktion und extraktion von proteinen aus pflanzlichen samen
US7071384B2 (en) 1997-03-07 2006-07-04 Genencor International, Inc. Methods for commercial production of heterologous laccase in plant tissue and extraction of the laccase from plant seed
AR020090A1 (es) * 1998-06-15 2002-04-10 John Innes Ct Celula vegetal monocotiledonea o semilla de ella,planta o parte de una planta, metodo para hacer una celula vegetal monocotiledonea, metodo para hacer unaplanta, uso de una construccion de expresion para producir una celula de planta o semilla monocotiledonea, y uso de una construccion de expresion
WO2000003012A2 (en) * 1998-07-10 2000-01-20 Calgene Llc Expression of eukaryotic peptides in plant plastids
US6512162B2 (en) 1998-07-10 2003-01-28 Calgene Llc Expression of eukaryotic peptides in plant plastids
US6232527B1 (en) * 1998-12-15 2001-05-15 Pioneer Hi-Bred International, Inc. Maize Rad2/FEN-1 orthologues and uses thereof
US7390936B1 (en) * 1999-08-23 2008-06-24 Sembiosys Genetics Inc. Commercial production of chymosin in plants
AU7709000A (en) * 1999-09-21 2001-04-24 Prodigene, Inc. Methods for producing recombinant proteins
NZ529597A (en) 2001-05-30 2005-12-23 Chromos Molecular Systems Inc Plant artificial chromosomes, uses thereof and methods of preparing plant artificial chromosomes
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
DK2298278T3 (en) 2002-06-07 2016-02-01 Dyax Corp Prevention and reduction of blood loss and inflammatory response
EP1517605A2 (de) 2002-06-28 2005-03-30 University of Guelph Gene aus luzerne (medicago sativa), die während der ernte induzierbar werden und methoden für deren verwendung
US7329798B2 (en) * 2002-06-28 2008-02-12 University Of Guelph Harvest-inducible regulatory elements and methods of using same
US20040106198A1 (en) * 2002-07-16 2004-06-03 Large Scale Biology Corporation Inhibition of peptide cleavage in plants
US7235530B2 (en) * 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2006042327A2 (en) * 2004-10-12 2006-04-20 Large Scale Biology Corporation Plant-produced recombinant aprotinin and aprotinin variants
US10150970B2 (en) 2011-07-27 2018-12-11 Applied Biotechnology Institute, Inc. Methods to increase antigenicity of membrane-bound polypeptides produced in plants
KR20230109785A (ko) 2014-03-27 2023-07-20 다케다 파머수티컬 컴패니 리미티드 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법
US11090380B2 (en) 2018-06-04 2021-08-17 Applied Biotechnology Institute, Inc. Methods and compositions to increase immune response to vaccines

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956282A (en) * 1985-07-29 1990-09-11 Calgene, Inc. Mammalian peptide expression in plant cells
US4914025A (en) * 1985-12-05 1990-04-03 Colin Manoil Export of intra-cellular substances
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
DE58909876D1 (de) * 1988-06-20 2000-09-14 Novartis Ag Verfahren zur Bekämpfung von Pflanzenschädlingen mit nicht-pflanzlichen Proteinase-Inhibitoren
EP0428572A1 (de) * 1988-07-29 1991-05-29 Washington University School Of Medicine Herstellung von kommerziell wertvollen polypeptiden durch genetisch transformierte endospermgewebe
NL8901932A (nl) * 1989-07-26 1991-02-18 Mogen Int Produktie van heterologe eiwitten in planten of plantecellen.
US5258302A (en) * 1990-07-03 1993-11-02 The Salk Institute Biotechnology/Industrial Associates, Inc. DNA for expression of aprotinin in methylotrophic yeast cells
WO1993021320A1 (en) * 1991-02-22 1993-10-28 University Technologies International, Inc. Oil-body proteins as carriers of high-value peptides in plants
US5618699A (en) * 1992-03-31 1997-04-08 Kanebo Limited Plant virus vector, plasmid, process for expression of foreign gene and process for obtaining foreign gene product
US5460952A (en) * 1992-11-04 1995-10-24 National Science Counsil Of R.O.C. Gene expression system comprising the promoter region of the α-amylase genes
AU6230194A (en) * 1993-01-25 1994-08-15 Pioneer Hi-Bred International, Inc. Aprotinin and synergistic combinations thereof with lectins as larvicides against insect pests of agronomic crops, harvested material thereof, and products obtained from the harvested material
US5693506A (en) * 1993-11-16 1997-12-02 The Regents Of The University Of California Process for protein production in plants

Also Published As

Publication number Publication date
AU1156797A (en) 1997-05-29
US5824870A (en) 1998-10-20
EP0859852A1 (de) 1998-08-26
EP0859852B1 (de) 2008-09-17
CA2233538A1 (en) 1997-05-15
WO1997017453A1 (en) 1997-05-15
DE69637685D1 (de) 2008-10-30
CA2233538C (en) 2010-05-25

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties
REN Ceased due to non-payment of the annual fee