ATE408695T1 - Menschliche cyclin-abhängige kinase (hpnqalre) - Google Patents
Menschliche cyclin-abhängige kinase (hpnqalre)Info
- Publication number
- ATE408695T1 ATE408695T1 AT99967389T AT99967389T ATE408695T1 AT E408695 T1 ATE408695 T1 AT E408695T1 AT 99967389 T AT99967389 T AT 99967389T AT 99967389 T AT99967389 T AT 99967389T AT E408695 T1 ATE408695 T1 AT E408695T1
- Authority
- AT
- Austria
- Prior art keywords
- hpnqalre
- dependent kinase
- cyclin dependent
- human cyclin
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11249798P | 1998-12-16 | 1998-12-16 | |
US46406599A | 1999-12-15 | 1999-12-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE408695T1 true ATE408695T1 (de) | 2008-10-15 |
Family
ID=26810024
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08006175T ATE519840T1 (de) | 1998-12-16 | 1999-12-16 | Menschliche cyclin-abhängige kinase (hpnqalre) |
AT99967389T ATE408695T1 (de) | 1998-12-16 | 1999-12-16 | Menschliche cyclin-abhängige kinase (hpnqalre) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08006175T ATE519840T1 (de) | 1998-12-16 | 1999-12-16 | Menschliche cyclin-abhängige kinase (hpnqalre) |
Country Status (11)
Country | Link |
---|---|
US (3) | US7250256B2 (de) |
EP (2) | EP1961813B1 (de) |
JP (3) | JP2003524389A (de) |
AT (2) | ATE519840T1 (de) |
AU (1) | AU2367600A (de) |
CY (1) | CY1108662T1 (de) |
DE (1) | DE69939599D1 (de) |
DK (1) | DK1141331T3 (de) |
ES (1) | ES2310055T3 (de) |
PT (1) | PT1141331E (de) |
WO (1) | WO2000036118A2 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE519840T1 (de) * | 1998-12-16 | 2011-08-15 | Novartis Vaccines & Diagnostic | Menschliche cyclin-abhängige kinase (hpnqalre) |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
WO2007087370A2 (en) * | 2006-01-25 | 2007-08-02 | Caprion Pharmaceuticals, Inc. | Tat-038 and methods of assessing and treating cancer |
WO2007147074A2 (en) | 2006-06-14 | 2007-12-21 | Living Microsystems, Inc. | Use of highly parallel snp genotyping for fetal diagnosis |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
EP2589668A1 (de) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten |
JP2010540534A (ja) | 2007-09-28 | 2010-12-24 | イントレキソン コーポレーション | 生体治療分子の発現のための治療遺伝子スイッチ構築物およびバイオリアクター、ならびにその使用 |
EP3378951B1 (de) | 2008-09-20 | 2020-05-13 | The Board of Trustees of the Leland Stanford Junior University | Nicht invasive diagnose von aneuploidie durch sequenzierung |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
US4551433A (en) | 1981-05-18 | 1985-11-05 | Genentech, Inc. | Microbial hybrid promoters |
US4405712A (en) | 1981-07-01 | 1983-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | LTR-Vectors |
US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
IE58011B1 (en) | 1983-05-27 | 1993-06-16 | Texas A & M Univ Sys | Method for producing a recombinant baculovirus expression vector |
US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
ZA848495B (en) | 1984-01-31 | 1985-09-25 | Idaho Res Found | Production of polypeptides in insect cells |
US4837148A (en) | 1984-10-30 | 1989-06-06 | Phillips Petroleum Company | Autonomous replication sequences for yeast strains of the genus pichia |
US4762915A (en) | 1985-01-18 | 1988-08-09 | Liposome Technology, Inc. | Protein-liposome conjugates |
GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
US4777127A (en) | 1985-09-30 | 1988-10-11 | Labsystems Oy | Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus |
IL77186A0 (en) | 1985-11-29 | 1986-04-29 | Touitou Elka | Pharmaceutical insulin composition |
US5091309A (en) | 1986-01-16 | 1992-02-25 | Washington University | Sindbis virus vectors |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
GB2189699A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
GB8702816D0 (en) | 1987-02-07 | 1987-03-11 | Al Sumidaie A M K | Obtaining retrovirus-containing fraction |
US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
US4980289A (en) | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
WO1989001973A2 (en) | 1987-09-02 | 1989-03-09 | Applied Biotechnology, Inc. | Recombinant pox virus for immunization against tumor-associated antigens |
WO1989002468A1 (en) | 1987-09-11 | 1989-03-23 | Whitehead Institute For Biomedical Research | Transduced fibroblasts and uses therefor |
US4929555A (en) | 1987-10-19 | 1990-05-29 | Phillips Petroleum Company | Pichia transformation |
WO1989005349A1 (en) | 1987-12-09 | 1989-06-15 | The Australian National University | Method of combating viral infections |
RO114469B1 (ro) | 1987-12-15 | 1999-04-30 | Gene Shears Pty Ltd | Compus oligoribonucleotidic, procedeu de preparare si metoda de inactivare |
US5662896A (en) | 1988-03-21 | 1997-09-02 | Chiron Viagene, Inc. | Compositions and methods for cancer immunotherapy |
US5422120A (en) | 1988-05-30 | 1995-06-06 | Depotech Corporation | Heterovesicular liposomes |
AP129A (en) | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
JP3082204B2 (ja) | 1988-09-01 | 2000-08-28 | ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ | 両栄養性および環境栄養性宿主域を持つ組換え体レトロウイルス |
WO1990003430A1 (en) | 1988-09-23 | 1990-04-05 | Cetus Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
US5217879A (en) | 1989-01-12 | 1993-06-08 | Washington University | Infectious Sindbis virus vectors |
JP2752788B2 (ja) | 1989-01-23 | 1998-05-18 | カイロン コーポレイション | 感染および過剰増殖障害の為の組換え療法 |
JP3140757B2 (ja) | 1989-02-06 | 2001-03-05 | デイナ・フアーバー・キヤンサー・インステイテユート | パッケージング欠陥hivプロウイルス、細胞系及びその使用 |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
CA2357538A1 (en) | 1989-03-21 | 1990-10-04 | Wisconsin Alumni Research Foundation | Expression of exogenous polynucleotide sequences in a vertebrate |
FR2649120B1 (fr) | 1989-06-30 | 1994-01-28 | Cayla | Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede |
EP1645635A3 (de) | 1989-08-18 | 2010-07-07 | Oxford Biomedica (UK) Limited | Replikationdefiziente Rekombinante Retroviren, die eine palliative Wirkung exprimieren |
GB8919607D0 (en) | 1989-08-30 | 1989-10-11 | Wellcome Found | Novel entities for cancer therapy |
AU7007491A (en) | 1990-02-02 | 1991-08-08 | Schweiz. Serum- & Impfinstitut Bern | Cdna corresponding to the genome of negative-strand rna viruses, and process for the production of infectious negative-strand rna viruses |
ZA911974B (en) | 1990-03-21 | 1994-08-22 | Res Dev Foundation | Heterovesicular liposomes |
EP0854193A1 (de) | 1990-09-21 | 1998-07-22 | Chiron Corporation | Humanische Retroviren- Packaging Zellinie |
SE9003978D0 (sv) | 1990-12-13 | 1990-12-13 | Henrik Garoff | Dna expressionssystem baserade paa ett virus replikon |
NZ314630A (en) | 1991-01-17 | 2000-11-24 | Harvard College | Use of trans-splicing ribozymes for genetic modification and cell ablation in a host cell |
ATE175997T1 (de) | 1991-08-10 | 1999-02-15 | Medical Res Council | Behandlung von zellpopulationen |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
FR2681786A1 (fr) | 1991-09-27 | 1993-04-02 | Centre Nat Rech Scient | Vecteurs recombinants d'origine virale, leur procede d'obtention et leur utilisation pour l'expression de polypeptides dans des cellules musculaires. |
IL103059A0 (en) | 1991-09-30 | 1993-02-21 | Boehringer Ingelheim Int | Conjugates for introducing nucleic acid into higher eucaryotic cells |
NZ244306A (en) | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
WO1993010218A1 (en) | 1991-11-14 | 1993-05-27 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Vectors including foreign genes and negative selective markers |
GB9125623D0 (en) | 1991-12-02 | 1992-01-29 | Dynal As | Cell modification |
EP0650370A4 (de) | 1992-06-08 | 1995-11-22 | Univ California | Auf spezifische gewebe abzielende verfahren und zusammensetzungen. |
JPH09507741A (ja) | 1992-06-10 | 1997-08-12 | アメリカ合衆国 | ヒト血清による不活性化に耐性のあるベクター粒子 |
GB2269175A (en) | 1992-07-31 | 1994-02-02 | Imperial College | Retroviral vectors |
ATE199392T1 (de) | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
DK0814154T3 (da) | 1993-09-15 | 2009-08-31 | Novartis Vaccines & Diagnostic | Rekombinante alfavirusvektorer |
JP3002702B2 (ja) | 1993-11-16 | 2000-01-24 | スカイファーム インコーポレーテッド | 活性物質の制御放出を有する小胞 |
US6105575A (en) | 1994-06-03 | 2000-08-22 | Respironics, Inc. | Method and apparatus for providing positive airway pressure to a patient |
US5674748A (en) * | 1995-03-14 | 1997-10-07 | Thomas Jefferson University | Human cyclin-dependent kinase-like proteins and methods of using the same |
CA2241849A1 (en) * | 1996-01-05 | 1997-07-17 | Eli Lilly And Company | Fusion proteins comprising cell cycle regulatory proteins |
CA2280206A1 (en) * | 1997-02-07 | 1998-08-13 | Merck & Co., Inc. | Cyclin-dependent protein kinase |
US5968800A (en) * | 1997-02-07 | 1999-10-19 | Merck & Co., Inc. | Cyclin-dependent protein kinase |
EP0973892A2 (de) * | 1997-03-14 | 2000-01-26 | Human Genome Sciences, Inc. | 28 menschliche sekretierte proteine |
FR2774994B1 (fr) | 1998-02-13 | 2000-05-05 | Rhodia Chimie Sa | Particules composites comprenant un coeur a base d'un polymere organique contenant une matiere active et un revetement externe a base d'au moins un oxyde et/ou un hydroxyde, leur procede de preparation et leurs utilisations |
ATE519840T1 (de) | 1998-12-16 | 2011-08-15 | Novartis Vaccines & Diagnostic | Menschliche cyclin-abhängige kinase (hpnqalre) |
US20070011783A1 (en) * | 1999-05-06 | 2007-01-11 | Jingdong Liu | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
-
1999
- 1999-12-16 AT AT08006175T patent/ATE519840T1/de not_active IP Right Cessation
- 1999-12-16 JP JP2000588367A patent/JP2003524389A/ja not_active Withdrawn
- 1999-12-16 WO PCT/US1999/030113 patent/WO2000036118A2/en active Application Filing
- 1999-12-16 AU AU23676/00A patent/AU2367600A/en not_active Abandoned
- 1999-12-16 AT AT99967389T patent/ATE408695T1/de active
- 1999-12-16 ES ES99967389T patent/ES2310055T3/es not_active Expired - Lifetime
- 1999-12-16 DE DE69939599T patent/DE69939599D1/de not_active Expired - Lifetime
- 1999-12-16 PT PT99967389T patent/PT1141331E/pt unknown
- 1999-12-16 EP EP08006175A patent/EP1961813B1/de not_active Expired - Lifetime
- 1999-12-16 EP EP99967389A patent/EP1141331B1/de not_active Expired - Lifetime
- 1999-12-16 DK DK99967389T patent/DK1141331T3/da active
-
2003
- 2003-09-16 US US10/663,896 patent/US7250256B2/en not_active Expired - Fee Related
-
2007
- 2007-06-07 US US11/759,726 patent/US7855058B2/en not_active Expired - Fee Related
- 2007-07-06 US US11/774,306 patent/US7566559B2/en not_active Expired - Fee Related
-
2008
- 2008-12-16 CY CY20081101453T patent/CY1108662T1/el unknown
-
2010
- 2010-03-04 JP JP2010048410A patent/JP2010162036A/ja not_active Withdrawn
-
2013
- 2013-05-07 JP JP2013097306A patent/JP2013162795A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2000036118A3 (en) | 2000-11-16 |
EP1961813A2 (de) | 2008-08-27 |
JP2013162795A (ja) | 2013-08-22 |
CY1108662T1 (el) | 2014-04-09 |
DE69939599D1 (de) | 2008-10-30 |
EP1961813B1 (de) | 2011-08-10 |
EP1141331A2 (de) | 2001-10-10 |
EP1961813A3 (de) | 2009-01-21 |
US7566559B2 (en) | 2009-07-28 |
DK1141331T3 (da) | 2009-01-05 |
EP1141331B1 (de) | 2008-09-17 |
ES2310055T3 (es) | 2008-12-16 |
AU2367600A (en) | 2000-07-03 |
ATE519840T1 (de) | 2011-08-15 |
JP2010162036A (ja) | 2010-07-29 |
US20080176279A1 (en) | 2008-07-24 |
US20040077009A1 (en) | 2004-04-22 |
US7250256B2 (en) | 2007-07-31 |
PT1141331E (pt) | 2008-12-22 |
US20080050797A1 (en) | 2008-02-28 |
JP2003524389A (ja) | 2003-08-19 |
WO2000036118A2 (en) | 2000-06-22 |
US7855058B2 (en) | 2010-12-21 |
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