ATE401325T1 - C10-carbamoyloxysubstituierte taxane als antitumormittel - Google Patents
C10-carbamoyloxysubstituierte taxane als antitumormittelInfo
- Publication number
- ATE401325T1 ATE401325T1 AT01905434T AT01905434T ATE401325T1 AT E401325 T1 ATE401325 T1 AT E401325T1 AT 01905434 T AT01905434 T AT 01905434T AT 01905434 T AT01905434 T AT 01905434T AT E401325 T1 ATE401325 T1 AT E401325T1
- Authority
- AT
- Austria
- Prior art keywords
- tumor agents
- substituted taxanes
- carbamoyloxy substituted
- carbamoyloxy
- taxanes
- Prior art date
Links
- 229940123237 Taxane Drugs 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- -1 carbamoyloxy substituent Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17979300P | 2000-02-02 | 2000-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE401325T1 true ATE401325T1 (de) | 2008-08-15 |
Family
ID=22658023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01905434T ATE401325T1 (de) | 2000-02-02 | 2001-02-02 | C10-carbamoyloxysubstituierte taxane als antitumormittel |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6596737B2 (de) |
| EP (1) | EP1165551B1 (de) |
| JP (1) | JP2003522173A (de) |
| KR (1) | KR20020000159A (de) |
| CN (1) | CN1362959A (de) |
| AT (1) | ATE401325T1 (de) |
| AU (1) | AU783422B2 (de) |
| BR (1) | BR0104352A (de) |
| CA (1) | CA2368541A1 (de) |
| CZ (1) | CZ20013520A3 (de) |
| DE (1) | DE60134814D1 (de) |
| HK (1) | HK1047936A1 (de) |
| HU (1) | HUP0200721A3 (de) |
| IL (1) | IL145640A (de) |
| MX (1) | MXPA01009921A (de) |
| NO (1) | NO20014760L (de) |
| NZ (1) | NZ514407A (de) |
| PL (1) | PL350331A1 (de) |
| WO (1) | WO2001057033A1 (de) |
| ZA (1) | ZA200108053B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA01009900A (es) * | 2000-02-02 | 2003-08-20 | Univ Florida State Res Found | Formulaciones de taxano que tienen solubilidad mejorada. |
| EP1165551B1 (de) * | 2000-02-02 | 2008-07-16 | Florida State University Research Foundation, Inc. | C10-carbamoyloxysubstituierte taxane als antitumormittel |
| CN1712399B (zh) * | 2004-06-24 | 2010-08-11 | 中国医学科学院药物研究所 | 紫杉醇和免疫增强剂胞壁酰二肽共轭物的制备及用途 |
| WO2007112570A1 (en) * | 2006-04-03 | 2007-10-11 | Pharmatherm Chemicals Inc. | Thermal extraction method and product |
| CN103183724B (zh) | 2010-05-27 | 2015-01-14 | 深圳信立泰药业股份有限公司 | 多西紫杉醇共缀物的制备方法 |
| JP6959096B2 (ja) * | 2017-10-13 | 2021-11-02 | エイブリック株式会社 | 充放電制御回路及びこれを備えたバッテリ装置 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| FR2679230B1 (fr) * | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
| SG46582A1 (en) | 1991-09-23 | 1998-02-20 | Univ Florida State | 10-Desacetoxytaxol derivatives |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| CA2087359A1 (en) | 1992-01-15 | 1993-07-16 | Ramesh N. Patel | Enzymatic processes for resolution of enantiomeric mixtures of compoundsuseful as intermediates in the preparation of taxanes |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| FR2691460B1 (fr) | 1992-05-21 | 1994-07-22 | Rhone Poulenc Rorer Sa | Nouveaux derives du taxane, leur preparation et les compositions qui les contiennent. |
| CA2109861C (en) | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
| EP0982302B1 (de) | 1993-06-11 | 2004-04-14 | PHARMACIA & UPJOHN COMPANY | Delta 6,7-Taxol Derivate antineoplastische Verwendung und diese enthaltende pharmazeutische Zusammenstellungen |
| IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| US6100411A (en) * | 1994-10-28 | 2000-08-08 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| WO1996013495A1 (en) * | 1994-10-28 | 1996-05-09 | The Research Foundation Of State University Of New York | Taxoid derivatives, their preparation and their use as antitumor agents |
| FR2732342B1 (fr) | 1995-04-03 | 1997-04-30 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2732968B1 (fr) | 1995-04-14 | 1997-05-16 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| CA2231837A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| JP2000510470A (ja) | 1996-05-06 | 2000-08-15 | フロリダ・ステイト・ユニバーシティ | １―デオキシバッカチンｉｉｉ、１―デオキシタキソールおよび１―デオキシタキソール類似体、ならびにこれらの製造方法 |
| CN1097044C (zh) * | 1996-07-15 | 2002-12-25 | 亚库尔特株式会社总社 | 紫杉烷衍生物以及含有该衍生物的药物 |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| JPH1192468A (ja) | 1997-09-17 | 1999-04-06 | Yakult Honsha Co Ltd | 新規なタキサン誘導体 |
| BR9813779A (pt) * | 1997-12-19 | 2000-10-03 | Yakult Honsha Kk | Novos derivados do taxano |
| JP2003026673A (ja) | 1999-03-05 | 2003-01-29 | Asahi Kasei Corp | 骨形成促進剤 |
| MXPA01009900A (es) * | 2000-02-02 | 2003-08-20 | Univ Florida State Res Found | Formulaciones de taxano que tienen solubilidad mejorada. |
| IL145635A0 (en) | 2000-02-02 | 2002-06-30 | Univ Florida State Res Found | Taxane formulations having improved solubility |
| EP1165551B1 (de) * | 2000-02-02 | 2008-07-16 | Florida State University Research Foundation, Inc. | C10-carbamoyloxysubstituierte taxane als antitumormittel |
| GB2370649B (en) * | 2000-11-09 | 2003-06-25 | Toppan Printing Co Ltd | Measurement of rate of transmission of a vapour through a sample |
-
2001
- 2001-02-02 EP EP01905434A patent/EP1165551B1/de not_active Expired - Lifetime
- 2001-02-02 IL IL145640A patent/IL145640A/en not_active IP Right Cessation
- 2001-02-02 DE DE60134814T patent/DE60134814D1/de not_active Expired - Fee Related
- 2001-02-02 CZ CZ20013520A patent/CZ20013520A3/cs unknown
- 2001-02-02 PL PL01350331A patent/PL350331A1/xx not_active Application Discontinuation
- 2001-02-02 WO PCT/US2001/003633 patent/WO2001057033A1/en active Application Filing
- 2001-02-02 JP JP2001557865A patent/JP2003522173A/ja not_active Withdrawn
- 2001-02-02 CN CN01800317A patent/CN1362959A/zh active Pending
- 2001-02-02 AU AU33313/01A patent/AU783422B2/en not_active Ceased
- 2001-02-02 AT AT01905434T patent/ATE401325T1/de not_active IP Right Cessation
- 2001-02-02 NZ NZ51440701A patent/NZ514407A/xx unknown
- 2001-02-02 KR KR1020017012573A patent/KR20020000159A/ko active IP Right Grant
- 2001-02-02 MX MXPA01009921A patent/MXPA01009921A/es active IP Right Grant
- 2001-02-02 CA CA002368541A patent/CA2368541A1/en not_active Withdrawn
- 2001-02-02 BR BR0104352-8A patent/BR0104352A/pt not_active IP Right Cessation
- 2001-02-02 HU HU0200721A patent/HUP0200721A3/hu unknown
- 2001-02-02 US US09/775,852 patent/US6596737B2/en not_active Expired - Fee Related
- 2001-10-01 ZA ZA200108053A patent/ZA200108053B/en unknown
- 2001-10-01 NO NO20014760A patent/NO20014760L/no not_active Application Discontinuation
-
2003
- 2003-01-07 HK HK03100170.9A patent/HK1047936A1/zh unknown
- 2003-07-11 US US10/618,063 patent/US6906088B2/en not_active Expired - Fee Related
-
2005
- 2005-02-28 US US11/067,882 patent/US7230013B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL145640A0 (en) | 2002-06-30 |
| AU3331301A (en) | 2001-08-14 |
| US20040034230A1 (en) | 2004-02-19 |
| JP2003522173A (ja) | 2003-07-22 |
| CA2368541A1 (en) | 2001-08-09 |
| KR20020000159A (ko) | 2002-01-04 |
| AU783422B2 (en) | 2005-10-27 |
| BR0104352A (pt) | 2002-01-02 |
| US20020077341A1 (en) | 2002-06-20 |
| NO20014760L (no) | 2001-11-30 |
| US7230013B2 (en) | 2007-06-12 |
| ZA200108053B (en) | 2003-12-01 |
| HK1047936A1 (zh) | 2003-03-14 |
| EP1165551A1 (de) | 2002-01-02 |
| US6596737B2 (en) | 2003-07-22 |
| MXPA01009921A (es) | 2003-08-01 |
| NO20014760D0 (no) | 2001-10-01 |
| WO2001057033A1 (en) | 2001-08-09 |
| DE60134814D1 (de) | 2008-08-28 |
| PL350331A1 (en) | 2002-12-02 |
| CN1362959A (zh) | 2002-08-07 |
| EP1165551B1 (de) | 2008-07-16 |
| US20050182098A1 (en) | 2005-08-18 |
| US6906088B2 (en) | 2005-06-14 |
| NZ514407A (en) | 2004-12-24 |
| IL145640A (en) | 2007-02-11 |
| HUP0200721A3 (en) | 2005-02-28 |
| CZ20013520A3 (cs) | 2002-03-13 |
| HUP0200721A2 (hu) | 2002-07-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE381328T1 (de) | Heterosubstituierte taxan-c10-acetate als antitumormittel | |
| BG105967A (en) | C(7) ester substituted taxanes and their use as antitumor agents | |
| DK1643984T3 (da) | Anvendelse af parthenolidderivater som antileukæmiske og cytotoksske midler | |
| ATE401325T1 (de) | C10-carbamoyloxysubstituierte taxane als antitumormittel | |
| NO20014758L (no) | C(7)-heterosubstituerte acetattaxaner som antitumormidler | |
| ATE392422T1 (de) | C7-carbamoyloxysubstituierte taxane als antitumormittel | |
| BG105964A (en) | C(10) carbonate substituted taxanes and their use as antitumor agents | |
| DE60138853D1 (de) | C10-taxanester als antitumormittel | |
| BG105966A (en) | C7 carbonate substituted taxanes and their application as antitumor agents | |
| BR0113202A (pt) | Compostos de trioxepano | |
| MXPA01007972A (es) | Esteres de taxanos c10 sustituidos. | |
| DE69915688D1 (de) | Benzonaphtyridin-1,8 derivate | |
| SG125888A1 (en) | C10 carbonate substituted taxanes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |