ATE400554T1 - 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives als muskarin-rezeptor antagonisten - Google Patents

2-arylethyl-(piperidin-4-ylmethyl)amine derivatives als muskarin-rezeptor antagonisten

Info

Publication number: ATE400554T1
Authority: AT; Austria
Prior art keywords: muscariine; arylethyl; ylmethyl; piperidine; receptor antagonists
Prior art date: 1998-02-27

Application number

AT99908933T

Other languages

English (en)

Inventor

Joan Caroon

Robin Clark

Michael Dillon

Ralph Harris

Sharathchandra Hegde

Clara Lin

Hans Maag

David Repke

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-27

Filing date

1999-02-19

Publication date

2008-07-15

1999-02-19 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE400554T1 publication Critical patent/ATE400554T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/08—Mydriatics or cycloplegics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Psychology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT99908933T 1998-02-27 1999-02-19 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives als muskarin-rezeptor antagonisten ATE400554T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7611398P	1998-02-27	1998-02-27
US10909798P	1998-11-19	1998-11-19

Publications (1)

Publication Number	Publication Date
ATE400554T1 true ATE400554T1 (de)	2008-07-15

Family

ID=26757679

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99908933T ATE400554T1 (de)	1998-02-27	1999-02-19	2-arylethyl-(piperidin-4-ylmethyl)amine derivatives als muskarin-rezeptor antagonisten

Country Status (26)

Country	Link
US (1)	US6319920B1 (de)
EP (1)	EP1058680B1 (de)
JP (1)	JP3523198B2 (de)
KR (1)	KR100384906B1 (de)
CN (1)	CN1143848C (de)
AR (1)	AR015523A1 (de)
AT (1)	ATE400554T1 (de)
AU (1)	AU753255B2 (de)
BR (1)	BR9909253A (de)
CA (1)	CA2321198C (de)
CO (1)	CO4990939A1 (de)
DE (1)	DE69939053D1 (de)
ES (1)	ES2310032T3 (de)
HR (1)	HRP20000544A2 (de)
HU (1)	HUP0100760A3 (de)
IL (1)	IL137936A0 (de)
MA (1)	MA26610A1 (de)
MY (1)	MY133445A (de)
NO (1)	NO317106B1 (de)
NZ (1)	NZ506317A (de)
PE (1)	PE20000325A1 (de)
PL (1)	PL194037B1 (de)
RU (1)	RU2220138C2 (de)
TR (1)	TR200002481T2 (de)
WO (1)	WO1999043657A1 (de)
YU (1)	YU53100A (de)

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WO1998052944A1 (en) *	1997-05-19	1998-11-26	Sugen, Inc.	Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders
HUP0302010A2 (hu) *	2000-05-25	2003-09-29	F.Hoffmann-La Roche Ag.	Helyettesített 1-aminoalkil-laktámok, és felhasználásuk mint muszkarin receptor antagonisták, a vegyületek elżállítása és az ezeket tartalmazó gyógyszerkészítmények
WO2001090082A1 (en)	2000-05-25	2001-11-29	F. Hoffmann-La Roche Ag	Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists
CA2468691C (en) *	2001-12-03	2011-03-08	F. Hoffmann-La Roche Ag	4-piperidinyl alkylamine derivatives as muscarinic receptor antagonists
AU2002352124A1 (en)	2001-12-03	2003-06-17	F. Hoffmann-La Roche Ag	Aminotetralin derivatives as muscarinic receptor antagonists
IL165370A0 (en) *	2002-06-07	2006-01-15	Astellas Pharma Inc	Therapeutic agent for overactive bladder
JP2006502985A (ja)	2002-07-08	2006-01-26	ランバクシーラボラトリーズリミテッド	ムスカリン性受容体拮抗剤として有用な３，６−二置換アザビシクロ［３．１．０］ヘキサン誘導体
CN100364990C (zh) *	2002-10-30	2008-01-30	施万制药	取代的4-氨基-1-(吡啶甲基)哌啶和相关化合物
TWI295669B (en) *	2002-10-30	2008-04-11	Theravance Inc	Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
EP1424079A1 (de) *	2002-11-27	2004-06-02	Boehringer Ingelheim International GmbH	Kombination eines beta-3-Rezeptoragonisten und eines Serotonin und/oder Norepinephrin-Wiederaufnahmeinhibitors
AU2003301184A1 (en) *	2002-12-20	2004-07-22	Dynogen Pharmaceuticals Inc	METHODS OF TREATING NON-PAINFUL BLADDER DISORDERS USING Alpha2Delta SUBUNIT CALCIUM CHANNEL MODULATORS
WO2004084879A1 (en) *	2003-03-21	2004-10-07	Dynogen Pharmaceuticals, Inc.	Methods for treating lower urinary tract disorders using smooth muscle modulators and alpha-2-delta subunit calcium channel modulators
WO2004089898A1 (en)	2003-04-09	2004-10-21	Ranbaxy Laboratories Limited	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2004228452A1 (en)	2003-04-11	2004-10-21	Ranbaxy Laboratories Limited	Azabicyclo derivatives as muscarinic receptor antagonists
JP2007524641A (ja) *	2003-07-11	2007-08-30	セラヴァンス，インコーポレーテッド	置換４−アミノ−１−ベンジルピペリジン化合物
FR2861073B1 (fr) *	2003-10-17	2006-01-06	Sanofi Synthelabo	Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
US7214439B2 (en) *	2003-12-19	2007-05-08	Millennium Cell, Inc.	Triborohydride salts as hydrogen storage materials and preparation thereof
EP2146957B1 (de)	2007-04-24	2013-06-12	Theravance, Inc.	Als antagonisten am muskarinrezeptor geeignete quaternäre ammoniumverbindungen
DE102007020492A1 (de) *	2007-04-30	2008-11-06	Grünenthal GmbH	Substituierte Sulfonamid-Derivate
EP3170807B1 (de) *	2015-11-23	2019-12-11	Frau Pharma S.r.l.	Neues verfahren zur synthese von fenfluramin
SI25272A (sl)	2016-09-23	2018-03-30	Univerza V Ljubljani	Disubstituirani azetidini, pirolidini, piperidini in azepani kot zaviralci monoamin oksidaze B za zdravljenje nevrodegenerativnih bolezni
CN112824378A (zh) *	2019-11-20	2021-05-21	珠海润都制药股份有限公司	一种盐酸坦索罗辛的制备方法

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Publication number	Priority date	Publication date	Assignee	Title
DE68924751T2 (de)	1988-09-26	1996-04-11	Smithkline Beecham Farma	Azacyclische Verbindungen, verwendbar als Arzneimittel.
SU1829346A1 (ru) *	1991-04-01	1996-01-10	Институт Тонкой Органической Химии Им.А.Л.Мнджояна	ДИГИДРОХЛОРИДЫ N-[β-(1,2,5-ТРИМЕТИЛ-4-АРИЛПИПЕРИДИН-4-ИЛ)ЭТИЛ]-N-АЛКИЛ-N-(3,4-ДИМЕТОКСИБЕНЗИЛ)АМИНОВ, ЯВЛЯЮЩИЕСЯ ИНГИБИТОРАМИ КАЛЬЦИЙ-КАЛЬМОДУЛИНЗАВИСИМЫХ ПРОЦЕССОВ
MY110227A (en) *	1991-08-12	1998-03-31	Ciba Geigy Ag	1-acylpiperindine compounds.
FR2681320B1 (fr)	1991-09-12	1994-01-14	Synthelabo	Derives de n-(4,7dimethoxyindan-2-yl)-1-(phenylcarbonyl)-n-propyl-piperidine-4-methanamine, leur preparation et leur application en therapeutique.
FR2681325B1 (fr)	1991-09-16	1993-12-17	Fabre Medicament Pierre	Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
DE69631058T2 (de)	1995-09-15	2004-06-03	Neurosearch A/S	Piperindinverbindungen als calcium-kanal-blocker
DE69615214T2 (de) *	1995-10-13	2002-06-27	Banyu Pharmaceutical Co., Ltd.	Substituierte heteroaromatische derivate

1999
- 1999-02-01 US US09/241,816 patent/US6319920B1/en not_active Expired - Fee Related
- 1999-02-19 DE DE69939053T patent/DE69939053D1/de not_active Expired - Lifetime
- 1999-02-19 YU YU53100A patent/YU53100A/sh unknown
- 1999-02-19 ES ES99908933T patent/ES2310032T3/es not_active Expired - Lifetime
- 1999-02-19 HU HU0100760A patent/HUP0100760A3/hu unknown
- 1999-02-19 HR HR20000544A patent/HRP20000544A2/hr not_active Application Discontinuation
- 1999-02-19 AU AU28353/99A patent/AU753255B2/en not_active Ceased
- 1999-02-19 AT AT99908933T patent/ATE400554T1/de not_active IP Right Cessation
- 1999-02-19 RU RU2000124676/04A patent/RU2220138C2/ru not_active IP Right Cessation
- 1999-02-19 CA CA002321198A patent/CA2321198C/en not_active Expired - Fee Related
- 1999-02-19 PL PL99342692A patent/PL194037B1/pl unknown
- 1999-02-19 TR TR2000/02481T patent/TR200002481T2/xx unknown
- 1999-02-19 IL IL13793699A patent/IL137936A0/xx unknown
- 1999-02-19 EP EP99908933A patent/EP1058680B1/de not_active Expired - Lifetime
- 1999-02-19 BR BR9909253-0A patent/BR9909253A/pt not_active Application Discontinuation
- 1999-02-19 JP JP2000533415A patent/JP3523198B2/ja not_active Expired - Fee Related
- 1999-02-19 WO PCT/EP1999/001102 patent/WO1999043657A1/en active IP Right Grant
- 1999-02-19 NZ NZ506317A patent/NZ506317A/en unknown
- 1999-02-19 CN CNB998045322A patent/CN1143848C/zh not_active Expired - Fee Related
- 1999-02-19 KR KR10-2000-7009431A patent/KR100384906B1/ko not_active Expired - Fee Related
- 1999-02-23 PE PE1999000155A patent/PE20000325A1/es not_active Application Discontinuation
- 1999-02-24 AR ARP990100772A patent/AR015523A1/es not_active Application Discontinuation
- 1999-02-24 CO CO99011501A patent/CO4990939A1/es unknown
- 1999-02-25 MY MYPI99000700A patent/MY133445A/en unknown
- 1999-02-25 MA MA25473A patent/MA26610A1/fr unknown
2000
- 2000-08-25 NO NO20004261A patent/NO317106B1/no unknown

Also Published As

Publication number	Publication date
IL137936A0 (en)	2001-10-31
WO1999043657A1 (en)	1999-09-02
YU53100A (sh)	2003-04-30
AR015523A1 (es)	2001-05-02
PE20000325A1 (es)	2000-05-08
RU2220138C2 (ru)	2003-12-27
EP1058680B1 (de)	2008-07-09
HK1036623A1 (en)	2002-01-11
HUP0100760A3 (en)	2002-12-28
NO20004261L (no)	2000-08-25
BR9909253A (pt)	2000-11-28
ES2310032T3 (es)	2008-12-16
PL342692A1 (en)	2001-07-02
NZ506317A (en)	2003-08-29
CA2321198A1 (en)	1999-09-02
HUP0100760A2 (hu)	2001-08-28
EP1058680A1 (de)	2000-12-13
CO4990939A1 (es)	2000-12-26
CN1295563A (zh)	2001-05-16
NO20004261D0 (no)	2000-08-25
KR20010041321A (ko)	2001-05-15
DE69939053D1 (de)	2008-08-21
JP2002504543A (ja)	2002-02-12
CA2321198C (en)	2009-11-17
NO317106B1 (no)	2004-08-09
CN1143848C (zh)	2004-03-31
AU2835399A (en)	1999-09-15
AU753255B2 (en)	2002-10-10
MA26610A1 (fr)	2004-12-20
TR200002481T2 (tr)	2000-11-21
JP3523198B2 (ja)	2004-04-26
HRP20000544A2 (en)	2001-02-28
PL194037B1 (pl)	2007-04-30
KR100384906B1 (ko)	2003-05-23
US6319920B1 (en)	2001-11-20
MY133445A (en)	2007-11-30

Publication	Publication Date	Title
ATE400554T1 (de)	2008-07-15	2-arylethyl-(piperidin-4-ylmethyl)amine derivatives als muskarin-rezeptor antagonisten
DE60023167D1 (de)	2006-02-23	Pyrazol-derivate als cannabinoidrezeptor-antagonisten
NO20012411D0 (no)	2001-05-16	Pyrrolidin-derivater-CCR-3-reseptorantagonister
ATE288898T1 (de)	2005-02-15	Phenylethenyl- oder phenylethinylderivate als glutamatrezeptorantagonisten
ATE328871T1 (de)	2006-06-15	4-phenyl-pyridin-derivate verwendbar als neurokinin-1 rezeptor antagonisten
ATE280157T1 (de)	2004-11-15	4-aroyl-piperidin-ccr-3 rezeptor antagonisten iii
FI970107L (fi)	1997-03-07	Heterosyklisiä takykiniinireseptoriantagonisteja
ATE299866T1 (de)	2005-08-15	Piperidinderivate verwendbar als ccr5 antagonisten
DE69919171D1 (de)	2004-09-09	Muskarin-rezeptor antagonisten
ATE416173T1 (de)	2008-12-15	1-(3 -heteroarylpropyl- oder -prop -2-enyl) -4- benzylpiperidine als nmda-rezeptor-antagonisten
ATE286022T1 (de)	2005-01-15	Naphthalin-carboxamide als tachykinin rezeptorantagonisten
NO20004503D0 (no)	2000-09-08	Vitronectin-reseptor-antagonister
NO20016053L (no)	2001-12-11	IL-8 reseptor-antagonister
DE50008020D1 (de)	2004-11-04	Substituierte pyrrolidin-2,3,4-trion-derivate wirksam als nmda-rezeptor-antagonisten
ATE244716T1 (de)	2003-07-15	Neue n-triazolylmethyl-piperazinderivate als neurokininrezeptor-antagonisten
NO20016052L (no)	2001-12-11	IL-8-reseptor-antagonister
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