ATE381533T1 - Pharmazeutisch wirksame verbindungen und methoden zu ihrer anwendung - Google Patents

Pharmazeutisch wirksame verbindungen und methoden zu ihrer anwendung

Info

Publication number: ATE381533T1
Authority: AT; Austria
Prior art keywords: methods; compounds; active compounds; pharmaceutically active; treatment
Prior art date: 1997-10-21

Application number

AT98957349T

Other languages

English (en)

Inventor

Graham Durant

Seetharamaiyer Padmanabhan

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-21

Filing date

1998-10-20

Publication date

2008-01-15

1998-10-20 Application filed by Wyeth Corp filed Critical Wyeth Corp

2008-01-15 Application granted granted Critical

2008-01-15 Publication of ATE381533T1 publication Critical patent/ATE381533T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/08—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Otolaryngology (AREA)
Oncology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Quinoline Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)

AT98957349T 1997-10-21 1998-10-20 Pharmazeutisch wirksame verbindungen und methoden zu ihrer anwendung ATE381533T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US6483097P	1997-10-21	1997-10-21

Publications (1)

Publication Number	Publication Date
ATE381533T1 true ATE381533T1 (de)	2008-01-15

Family

ID=22058507

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98957349T ATE381533T1 (de)	1997-10-21	1998-10-20	Pharmazeutisch wirksame verbindungen und methoden zu ihrer anwendung

Country Status (10)

Country	Link
EP (1)	EP1032556B1 (de)
JP (1)	JP2001520215A (de)
KR (1)	KR20010031065A (de)
AT (1)	ATE381533T1 (de)
AU (1)	AU1362699A (de)
CA (1)	CA2307597A1 (de)
DE (1)	DE69838882T2 (de)
DK (1)	DK1032556T3 (de)
ES (1)	ES2297897T3 (de)
WO (1)	WO1999020599A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PE20021046A1 (es) *	2000-09-30	2002-12-14	Gruenenthal Chemie	Sulfonilguanidina que tiene afinidad al punto de fijacion de gabapentina
BR0115079A (pt) *	2000-10-30	2003-08-19	Warner Lambert Co	Ligandos do receptor de serotonina à base de amidino-uréia e composições destes, seus usos farmacêuticos e métodos para a suas sìnteses
GB0219472D0 (en) *	2002-08-21	2002-10-02	Astrazeneca Ab	Chemical compounds
ATE462432T1 (de)	2003-05-05	2010-04-15	Probiodrug Ag	Glutaminylcyclase-hemmer
DE202004021723U1 (de)	2003-05-05	2010-07-15	Probiodrug Ag	Medizinische Verwendung von Hemmern von Glutaminyl- und Glutamatcyclasen
WO2004112687A2 (en)	2003-06-26	2004-12-29	Biotron Limited	Antiviral acylguanidine compounds and methods
ITTO20030668A1 (it)	2003-09-02	2005-03-03	Rotta Res Lab S P A O Ra Rottapharm	Derivati dell'adamantano dotati di attivita' neuroprotettiva, antidepressiva e anti-ischemica e procedimento per la loro preparazione.
BRPI0415409A (pt)	2003-10-15	2006-12-05	Probiodrug Ag	uso de efetuadores de ciclases de glutaminila e glutamato
ATE541835T1 (de) *	2004-02-05	2012-02-15	Probiodrug Ag	Neue inhibitoren von glutaminylcyclase
KR101099206B1 (ko)	2004-02-05	2011-12-27	프로비오드룩 아게	신규한 글루타미닐 시클라제 저해제
DE102004008141A1 (de) *	2004-02-19	2005-09-01	Abbott Gmbh & Co. Kg	Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren
JPWO2005079845A1 (ja) *	2004-02-20	2007-08-02	アステラス製薬株式会社	片頭痛予防薬
BRPI0506139A (pt) *	2004-02-20	2006-10-24	Astellas Pharma Inc	derivados fluoreno
US7417040B2 (en)	2004-03-01	2008-08-26	Bristol-Myers Squibb Company	Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
CN101243046A (zh) *	2005-08-08	2008-08-13	安斯泰来制药有限公司	酰基胍衍生物或其盐
EP1917244A2 (de) *	2005-08-24	2008-05-07	Abbott GmbH & Co. KG	Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
EP1988076A4 (de)	2006-02-20	2013-09-04	Astellas Pharma Inc	Amidderivat oder salz davon
EP2119704A4 (de) *	2007-02-07	2011-06-15	Astellas Pharma Inc	Acylguanidinderivat

Family Cites Families (10)

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Publication number	Priority date	Publication date	Assignee	Title
FR2222375A1 (en) *	1973-03-20	1974-10-18	Ugine Kuhlmann	5-Substd guanidino barbituric acids - intermediates prepd from a cyanamide and a uramil
GB1431589A (en) *	1973-07-13	1976-04-07	Smith Kline French Lab	Ureas, thioureas and guanidines n,n-disubstituted by heterocyclo- alkylene and/or heterocycloalkylenethioalkylene groups
US3972872A (en) *	1974-09-23	1976-08-03	Pfizer Inc.	6-[α-(ω-Guanidinoalkanoylamido)acylamido]penicillanic acids
DE2531343A1 (de) *	1975-07-14	1977-02-10	Henkel & Cie Gmbh	Antimikrobielle mittel
DE2545647C3 (de) *	1975-10-11	1982-03-11	Bayer Ag, 5090 Leverkusen	Stabilisierung synthetischer Polymerer
US4156734A (en) *	1976-02-13	1979-05-29	Merck & Co., Inc.	Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
DE2733440A1 (de) *	1976-08-03	1978-02-09	Sandoz Ag	Benz eckige klammer auf cd eckige klammer zu indolyl-derivate, ihre verwendung und herstellung
DE2802757A1 (de) *	1978-01-23	1979-07-26	Sandoz Ag	Benz eckige klammer auf cd eckige klammer zu indolyl-derivate, ihre verwendung und herstellung
EP0062844B1 (de) *	1981-04-09	1984-11-28	Beiersdorf Aktiengesellschaft	Substituierte Benzo(de)isochinoline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AU1912595A (en) *	1994-02-03	1995-08-21	Cambridge Neuroscience, Inc.	Therapeutic guanidines

1998
- 1998-10-20 WO PCT/US1998/022309 patent/WO1999020599A1/en active IP Right Grant
- 1998-10-20 ES ES98957349T patent/ES2297897T3/es not_active Expired - Lifetime
- 1998-10-20 JP JP2000516941A patent/JP2001520215A/ja active Pending
- 1998-10-20 EP EP98957349A patent/EP1032556B1/de not_active Expired - Lifetime
- 1998-10-20 KR KR1020007003904A patent/KR20010031065A/ko not_active Abandoned
- 1998-10-20 CA CA002307597A patent/CA2307597A1/en not_active Abandoned
- 1998-10-20 AU AU13626/99A patent/AU1362699A/en not_active Abandoned
- 1998-10-20 AT AT98957349T patent/ATE381533T1/de not_active IP Right Cessation
- 1998-10-20 DK DK98957349T patent/DK1032556T3/da active
- 1998-10-20 DE DE69838882T patent/DE69838882T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2307597A1 (en)	1999-04-29
DK1032556T3 (da)	2008-03-25
DE69838882D1 (de)	2008-01-31
JP2001520215A (ja)	2001-10-30
KR20010031065A (ko)	2001-04-16
EP1032556A1 (de)	2000-09-06
DE69838882T2 (de)	2008-12-04
ES2297897T3 (es)	2008-05-01
EP1032556A4 (de)	2005-02-02
EP1032556B1 (de)	2007-12-19
WO1999020599A1 (en)	1999-04-29
AU1362699A (en)	1999-05-10

Publication	Publication Date	Title
ATE381533T1 (de)	2008-01-15	Pharmazeutisch wirksame verbindungen und methoden zu ihrer anwendung
DE69427704D1 (de)	2001-08-16	Neue (r)-5-carbamoyl-8-fluor-3-n,n-disubstituierte-amino-3,4-dihydro-2h-1-benzopyrane
GB0129260D0 (en)	2002-01-23	Pharmaceutical compositions and their uses
NO20045323L (no)	2005-02-10	Antistoffer
DE60126980D1 (de)	2007-04-12	Therapeutische agentien und methoden ihrer verwendung zur behandlung von amyloidogenen erkrankungen
MY129189A (en)	2007-03-30	Prostaglandin agonists and their use to treat bone disorders
TNSN00010A1 (fr)	2002-05-30	DIPHENYLUREE A SUBSTITUTION ω CARBOXYARYLE SERVANT D'INHIBUTEURS DE RAF KINASE.
ATE418986T1 (de)	2009-01-15	Pharmazeutische zusammensetzungen zur vorbeugung und behandlung von störungen des zentralnervensystems welche einen nicotin-analog und einen acetylcholinesterase inhibitor enthalten
MX9101869A (es)	1993-04-01	Ciclosporinas, composicion farmaceutica que las contiene y procedimiento para la produccion de las mismas
BR9708114A (pt)	2000-01-25	Análogos xantona para o tratamento de doenças infecciosas.
GB0111186D0 (en)	2001-06-27	Novel compounds
MY120976A (en)	2005-12-30	2-amino-6-(2-substituted-4-phenoxy)- substituted- pyridines
MY124786A (en)	2006-07-31	Bis-arylsulfones
SE9604348D0 (sv)	1996-11-26	Användning av hydroxyguanidiner
MX9403088A (es)	1997-02-28	Composiciones farmaceuticas que contienen deriva- dos de indol y metodos de uso.
CA2282279A1 (en)	1998-09-03	Atropisomers of 3-heteroaryl-4(3h)-quinazolinones for the treatment of neurodegenerative and cns-trauma related conditions
BG105962A (en)	2002-05-31	Use of saredutant and the pharmaceutically acceptable salts thereof to produce medicaments used to treat or prevent mood disorders, adjustment disorders or mixed anxiety-depression disorders
ATE213233T1 (de)	2002-02-15	Substituierte caprolactame und deren derivate verwendbar zur behandlung der hiv-krankheit
IL144199A0 (en)	2002-05-23	Novel bretylium compositions and kits, and their use in preventing and treating cardiovascular conditions
IL109076A0 (en)	1994-06-24	Imidazolo-quinoxalinones, their preparation and pharmaceutical compositions containing them
HUP0000110A2 (hu)	2000-06-28	Azaciklusos, azabiciklusos vagy tetrahidropiridinszármazékokat tartalmazó, fájdalom kezelésére alkalmas gyógyászati készítmények
ES2190581T3 (es)	2003-08-01	2-aminotetralina opticamente activa, procedimiento para su preparacion y composiciones farmaceuticas que la contienen, activa en la prevencion y tratamiento de shock septico.
EP1406605A4 (de)	2005-10-26	Carbamate von 2-heterozyklischen 1,2-ethandiolen
ATE235249T1 (de)	2003-04-15	Die von morphogenen peptiden hervorgerufene wiederherstellung von gewebe aus sinneszellen
ATE288756T1 (de)	2005-02-15	Verwendung von nk-1 rezeptorantagonisten zur behandlung von schweren depressionen, die von angstzuständen begleitet werden

Legal Events

Date	Code	Title	Description
2008-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties