ATE375332T1 - Imidazol verbindungen und ihre medizinische verwendung - Google Patents
Imidazol verbindungen und ihre medizinische verwendungInfo
- Publication number
- ATE375332T1 ATE375332T1 AT99959929T AT99959929T ATE375332T1 AT E375332 T1 ATE375332 T1 AT E375332T1 AT 99959929 T AT99959929 T AT 99959929T AT 99959929 T AT99959929 T AT 99959929T AT E375332 T1 ATE375332 T1 AT E375332T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazole compounds
- medical uses
- medical
- imidazole
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP36736298 | 1998-12-24 | ||
JP22883899 | 1999-08-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE375332T1 true ATE375332T1 (de) | 2007-10-15 |
Family
ID=26528483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99959929T ATE375332T1 (de) | 1998-12-24 | 1999-12-20 | Imidazol verbindungen und ihre medizinische verwendung |
Country Status (19)
Country | Link |
---|---|
US (1) | US7060721B1 (de) |
EP (1) | EP1142879B1 (de) |
KR (1) | KR20010094731A (de) |
CN (1) | CN1170822C (de) |
AR (1) | AR022019A1 (de) |
AT (1) | ATE375332T1 (de) |
AU (1) | AU758325C (de) |
BR (1) | BR9917112A (de) |
CA (1) | CA2356838A1 (de) |
CZ (1) | CZ20012338A3 (de) |
DE (1) | DE69937307T2 (de) |
ES (1) | ES2292262T3 (de) |
HK (1) | HK1043791A1 (de) |
HU (1) | HUP0104657A3 (de) |
IL (1) | IL143802A0 (de) |
RU (1) | RU2238937C2 (de) |
TR (1) | TR200101865T2 (de) |
TW (1) | TWI239330B (de) |
WO (1) | WO2000039097A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0009037D0 (en) * | 2000-04-13 | 2000-05-31 | Novartis Ag | Organic compounds |
US20030181461A1 (en) * | 2002-01-25 | 2003-09-25 | Lautt Wilfred Wayne | Use of phosphodiesterase antagonists to treat insulin resistance |
AU2012200214B2 (en) * | 2004-05-14 | 2013-10-24 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
ES2249992B1 (es) * | 2004-09-13 | 2007-03-01 | Ferrer Internacional, S.A. | Un procedimiento para fabricar compuestos enantiomericos del imidazol. |
TW200740435A (en) * | 2005-08-10 | 2007-11-01 | Takeda Pharmaceuticals Co | Therapeutic agent for diabetes |
US20090105324A1 (en) * | 2006-04-21 | 2009-04-23 | Astrazeneca Ab | Imidazole derivatives for use as edg-1 antagonists |
TW200838501A (en) * | 2007-02-02 | 2008-10-01 | Theravance Inc | Dual-acting antihypertensive agents |
MX2009008103A (es) * | 2007-02-09 | 2009-08-18 | Takeda Pharmaceutical | Compuestos anulares fusionados como agonistas parciales de prar-gamma. |
TWI448284B (zh) | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
TWI406850B (zh) * | 2007-06-05 | 2013-09-01 | Theravance Inc | 雙效苯并咪唑抗高血壓劑 |
KR100868898B1 (ko) * | 2007-07-30 | 2008-11-14 | 한국기계연구원 | 적층형 pzt를 이용한 압전펌프 |
EP2200975A1 (de) * | 2007-09-07 | 2010-06-30 | Theravance, Inc. | Blutdrucksenkende mittel mit dualer wirkung |
JP2011506459A (ja) | 2007-12-11 | 2011-03-03 | セラヴァンス, インコーポレーテッド | 抗高血圧剤としての二重作用性ベンゾイミダゾール誘導体およびその使用 |
WO2009134741A1 (en) | 2008-04-29 | 2009-11-05 | Theravance, Inc. | Dual-acting antihypertensive agents |
US8124636B2 (en) * | 2008-04-30 | 2012-02-28 | Hoffmann-La Roche Inc. | Imidazolidinone derivatives as 11B-HSD1 inhibitors |
WO2010011821A2 (en) | 2008-07-24 | 2010-01-28 | Theravance, Inc. | Dual-acting antihypertensive agents |
PL2430002T3 (pl) * | 2009-05-15 | 2013-12-31 | Sanofi Sa | Sposób wytwarzania związku przydatnego jako inhibitor TAFI |
EP2451782B1 (de) | 2009-07-07 | 2016-11-09 | Theravance Biopharma R&D IP, LLC | Blutdrucksenkende mittel auf pyrazolbasis mit doppelwirkung |
JP2012533626A (ja) | 2009-07-22 | 2012-12-27 | セラヴァンス, インコーポレーテッド | 二重作用オキサゾール降圧剤 |
US8481549B2 (en) | 2010-01-19 | 2013-07-09 | Theravance, Inc. | Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents |
KR102635225B1 (ko) | 2018-09-04 | 2024-02-07 | 추가이 세이야쿠 가부시키가이샤 | 4환성 화합물의 제조방법 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5215994A (en) | 1990-09-25 | 1993-06-01 | Fujisawa Pharmaceutical Co., Ltd. | Angiotenin II antagonizing heterocyclic derivatives |
TW235963B (de) | 1992-01-16 | 1994-12-11 | Shionogi & Co | |
NZ324834A (en) | 1995-12-28 | 2001-11-30 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives and their use in reducing blood sugar or as inhibitors of PDE5 activity |
RU2199532C2 (ru) | 1997-06-27 | 2003-02-27 | Фудзисава Фармасьютикал Ко., Лтд. | Сульфонамидное соединение |
ES2229510T3 (es) | 1997-06-27 | 2005-04-16 | Fujisawa Pharmaceutical Co., Ltd. | Derivados de anillo aromatico. |
-
1999
- 1999-12-20 KR KR1020017008097A patent/KR20010094731A/ko not_active Application Discontinuation
- 1999-12-20 US US09/869,135 patent/US7060721B1/en not_active Expired - Fee Related
- 1999-12-20 ES ES99959929T patent/ES2292262T3/es not_active Expired - Lifetime
- 1999-12-20 BR BR9917112-0A patent/BR9917112A/pt not_active IP Right Cessation
- 1999-12-20 TR TR2001/01865T patent/TR200101865T2/xx unknown
- 1999-12-20 EP EP99959929A patent/EP1142879B1/de not_active Expired - Lifetime
- 1999-12-20 AT AT99959929T patent/ATE375332T1/de not_active IP Right Cessation
- 1999-12-20 CZ CZ20012338A patent/CZ20012338A3/cs unknown
- 1999-12-20 CN CNB998163600A patent/CN1170822C/zh not_active Expired - Fee Related
- 1999-12-20 HU HU0104657A patent/HUP0104657A3/hu unknown
- 1999-12-20 WO PCT/JP1999/007160 patent/WO2000039097A1/ja not_active Application Discontinuation
- 1999-12-20 DE DE69937307T patent/DE69937307T2/de not_active Expired - Fee Related
- 1999-12-20 RU RU2001120723A patent/RU2238937C2/ru not_active IP Right Cessation
- 1999-12-20 CA CA002356838A patent/CA2356838A1/en not_active Abandoned
- 1999-12-20 AU AU16905/00A patent/AU758325C/en not_active Ceased
- 1999-12-20 IL IL14380299A patent/IL143802A0/xx unknown
- 1999-12-22 TW TW088122630A patent/TWI239330B/zh not_active IP Right Cessation
- 1999-12-23 AR ARP990106750A patent/AR022019A1/es unknown
-
2002
- 2002-07-18 HK HK02105326A patent/HK1043791A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
RU2238937C2 (ru) | 2004-10-27 |
HK1043791A1 (en) | 2002-09-27 |
TWI239330B (en) | 2005-09-11 |
AR022019A1 (es) | 2002-09-04 |
DE69937307D1 (de) | 2007-11-22 |
TR200101865T2 (tr) | 2001-12-21 |
DE69937307T2 (de) | 2008-02-07 |
HUP0104657A3 (en) | 2002-07-29 |
HUP0104657A2 (hu) | 2002-05-29 |
EP1142879B1 (de) | 2007-10-10 |
KR20010094731A (ko) | 2001-11-01 |
EP1142879A1 (de) | 2001-10-10 |
US7060721B1 (en) | 2006-06-13 |
CN1170822C (zh) | 2004-10-13 |
CA2356838A1 (en) | 2000-07-06 |
CZ20012338A3 (cs) | 2001-12-12 |
BR9917112A (pt) | 2002-01-29 |
AU758325C (en) | 2004-10-07 |
WO2000039097A1 (fr) | 2000-07-06 |
AU758325B2 (en) | 2003-03-20 |
IL143802A0 (en) | 2002-04-21 |
AU1690500A (en) | 2000-07-31 |
EP1142879A4 (de) | 2002-02-06 |
ES2292262T3 (es) | 2008-03-01 |
CN1335837A (zh) | 2002-02-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |