[go: up one dir, main page]

ATE375332T1 - Imidazol verbindungen und ihre medizinische verwendung - Google Patents

Imidazol verbindungen und ihre medizinische verwendung

Info

Publication number
ATE375332T1
ATE375332T1 AT99959929T AT99959929T ATE375332T1 AT E375332 T1 ATE375332 T1 AT E375332T1 AT 99959929 T AT99959929 T AT 99959929T AT 99959929 T AT99959929 T AT 99959929T AT E375332 T1 ATE375332 T1 AT E375332T1
Authority
AT
Austria
Prior art keywords
imidazole compounds
medical uses
medical
imidazole
compounds
Prior art date
Application number
AT99959929T
Other languages
English (en)
Inventor
Hiroshi Kayakiri
Yoshito Abe
Hitoshi Hamashima
Hitoshi Sawada
Naoki Ishibashi
Hiroyuki Setoi
Teruo Oku
Noritsugu Yamasaki
Takafumi Imoto
Takahiro Hiramura
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Application granted granted Critical
Publication of ATE375332T1 publication Critical patent/ATE375332T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91Nitro radicals
    • C07D233/92Nitro radicals attached in position 4 or 5
    • C07D233/94Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT99959929T 1998-12-24 1999-12-20 Imidazol verbindungen und ihre medizinische verwendung ATE375332T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP36736298 1998-12-24
JP22883899 1999-08-12

Publications (1)

Publication Number Publication Date
ATE375332T1 true ATE375332T1 (de) 2007-10-15

Family

ID=26528483

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99959929T ATE375332T1 (de) 1998-12-24 1999-12-20 Imidazol verbindungen und ihre medizinische verwendung

Country Status (19)

Country Link
US (1) US7060721B1 (de)
EP (1) EP1142879B1 (de)
KR (1) KR20010094731A (de)
CN (1) CN1170822C (de)
AR (1) AR022019A1 (de)
AT (1) ATE375332T1 (de)
AU (1) AU758325C (de)
BR (1) BR9917112A (de)
CA (1) CA2356838A1 (de)
CZ (1) CZ20012338A3 (de)
DE (1) DE69937307T2 (de)
ES (1) ES2292262T3 (de)
HK (1) HK1043791A1 (de)
HU (1) HUP0104657A3 (de)
IL (1) IL143802A0 (de)
RU (1) RU2238937C2 (de)
TR (1) TR200101865T2 (de)
TW (1) TWI239330B (de)
WO (1) WO2000039097A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0009037D0 (en) * 2000-04-13 2000-05-31 Novartis Ag Organic compounds
US20030181461A1 (en) * 2002-01-25 2003-09-25 Lautt Wilfred Wayne Use of phosphodiesterase antagonists to treat insulin resistance
AU2012200214B2 (en) * 2004-05-14 2013-10-24 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
ES2249992B1 (es) * 2004-09-13 2007-03-01 Ferrer Internacional, S.A. Un procedimiento para fabricar compuestos enantiomericos del imidazol.
TW200740435A (en) * 2005-08-10 2007-11-01 Takeda Pharmaceuticals Co Therapeutic agent for diabetes
US20090105324A1 (en) * 2006-04-21 2009-04-23 Astrazeneca Ab Imidazole derivatives for use as edg-1 antagonists
TW200838501A (en) * 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
MX2009008103A (es) * 2007-02-09 2009-08-18 Takeda Pharmaceutical Compuestos anulares fusionados como agonistas parciales de prar-gamma.
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
TWI406850B (zh) * 2007-06-05 2013-09-01 Theravance Inc 雙效苯并咪唑抗高血壓劑
KR100868898B1 (ko) * 2007-07-30 2008-11-14 한국기계연구원 적층형 pzt를 이용한 압전펌프
EP2200975A1 (de) * 2007-09-07 2010-06-30 Theravance, Inc. Blutdrucksenkende mittel mit dualer wirkung
JP2011506459A (ja) 2007-12-11 2011-03-03 セラヴァンス, インコーポレーテッド 抗高血圧剤としての二重作用性ベンゾイミダゾール誘導体およびその使用
WO2009134741A1 (en) 2008-04-29 2009-11-05 Theravance, Inc. Dual-acting antihypertensive agents
US8124636B2 (en) * 2008-04-30 2012-02-28 Hoffmann-La Roche Inc. Imidazolidinone derivatives as 11B-HSD1 inhibitors
WO2010011821A2 (en) 2008-07-24 2010-01-28 Theravance, Inc. Dual-acting antihypertensive agents
PL2430002T3 (pl) * 2009-05-15 2013-12-31 Sanofi Sa Sposób wytwarzania związku przydatnego jako inhibitor TAFI
EP2451782B1 (de) 2009-07-07 2016-11-09 Theravance Biopharma R&D IP, LLC Blutdrucksenkende mittel auf pyrazolbasis mit doppelwirkung
JP2012533626A (ja) 2009-07-22 2012-12-27 セラヴァンス, インコーポレーテッド 二重作用オキサゾール降圧剤
US8481549B2 (en) 2010-01-19 2013-07-09 Theravance, Inc. Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
KR102635225B1 (ko) 2018-09-04 2024-02-07 추가이 세이야쿠 가부시키가이샤 4환성 화합물의 제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5215994A (en) 1990-09-25 1993-06-01 Fujisawa Pharmaceutical Co., Ltd. Angiotenin II antagonizing heterocyclic derivatives
TW235963B (de) 1992-01-16 1994-12-11 Shionogi & Co
NZ324834A (en) 1995-12-28 2001-11-30 Fujisawa Pharmaceutical Co Benzimidazole derivatives and their use in reducing blood sugar or as inhibitors of PDE5 activity
RU2199532C2 (ru) 1997-06-27 2003-02-27 Фудзисава Фармасьютикал Ко., Лтд. Сульфонамидное соединение
ES2229510T3 (es) 1997-06-27 2005-04-16 Fujisawa Pharmaceutical Co., Ltd. Derivados de anillo aromatico.

Also Published As

Publication number Publication date
RU2238937C2 (ru) 2004-10-27
HK1043791A1 (en) 2002-09-27
TWI239330B (en) 2005-09-11
AR022019A1 (es) 2002-09-04
DE69937307D1 (de) 2007-11-22
TR200101865T2 (tr) 2001-12-21
DE69937307T2 (de) 2008-02-07
HUP0104657A3 (en) 2002-07-29
HUP0104657A2 (hu) 2002-05-29
EP1142879B1 (de) 2007-10-10
KR20010094731A (ko) 2001-11-01
EP1142879A1 (de) 2001-10-10
US7060721B1 (en) 2006-06-13
CN1170822C (zh) 2004-10-13
CA2356838A1 (en) 2000-07-06
CZ20012338A3 (cs) 2001-12-12
BR9917112A (pt) 2002-01-29
AU758325C (en) 2004-10-07
WO2000039097A1 (fr) 2000-07-06
AU758325B2 (en) 2003-03-20
IL143802A0 (en) 2002-04-21
AU1690500A (en) 2000-07-31
EP1142879A4 (de) 2002-02-06
ES2292262T3 (es) 2008-03-01
CN1335837A (zh) 2002-02-13

Similar Documents

Publication Publication Date Title
ATE375332T1 (de) Imidazol verbindungen und ihre medizinische verwendung
ATE279396T1 (de) Imidazolderivate und ihre verwendung als somatostatin rezeptorliganden
DE60123041D1 (de) Entzündungshemmende verbindungen und ihre verwendung
DE60036803D1 (de) Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel
DE59908600D1 (de) Substituierte benzimidazole und ihre verwendung als parp inhibitoren
DE69404382D1 (de) Urea-Derivate und ihre Verwendung als ACAT-hemmenden Verbindungen
DE60044395D1 (de) Arylsubstituierte pyrazole, imidazole, oxazole, thiazole und pyrrole, sowie deren verwendung
NO20003723D0 (no) Triazol- og imidazolderivater
ATE272630T1 (de) Amidin-verbindungen
ATE261449T1 (de) Thienopyrimidin verbindungen, ihre herstellung und verwendung
DE59710422D1 (de) Acylmercapto-triazolyl-derivate und ihre verwendung als mikrobizide
DE59710580D1 (de) Thiocyano-triazolyl-derivate und ihre verwendung als mikrobizide
ATE262903T1 (de) Verwendung substituierter imidazolidin-2,4-dion- verbindungen als schmerzmittel
TR199501561A2 (tr) Imidazol türevleri.
DE59602155D1 (de) Substituierte Imidazolidin-2,4-dion-Verbindungen als Immunodulatoren
DE69826693D1 (de) Amidinoderivate und ihre verwendung als thrombininhibitoren
DE60119963D1 (de) Imidazol derivate, ihre herstellung und ihre verwendung
DE50012542D1 (de) Verwendung von kationischen verbindungen
DE69902387D1 (de) Oxadiazolinderivate und ihre verwendung als insektizide
DE60006970D1 (de) Fluorogene verbindungen und ihre verwendungen
ATE268327T1 (de) Benzazol-verbindungen und ihre verwendung
DE59906907D1 (de) Phosphororganische verbindungen und ihre verwendung
DE69531522D1 (de) Heterozyklische Verbindungen
DE59902692D1 (de) Phosphororganische verbindungen und ihre verwendung
DE69811018D1 (de) Triazol-Derivate und ihre Verwendung als antimykotische Mittel

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties