[go: up one dir, main page]

ATE350044T1 - Thrombopoietinmimetika - Google Patents

Thrombopoietinmimetika

Info

Publication number
ATE350044T1
ATE350044T1 AT00965329T AT00965329T ATE350044T1 AT E350044 T1 ATE350044 T1 AT E350044T1 AT 00965329 T AT00965329 T AT 00965329T AT 00965329 T AT00965329 T AT 00965329T AT E350044 T1 ATE350044 T1 AT E350044T1
Authority
AT
Austria
Prior art keywords
mammal
invented
thrombopoietin mimetics
mimetics
thrombopoietin
Prior art date
Application number
AT00965329T
Other languages
English (en)
Inventor
Kevin J Duffy
Juan I Luengo
Nannan Liu
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE350044T1 publication Critical patent/ATE350044T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
    • C07D231/48—Oxygen atom in position 3 or 5 and nitrogen atom in position 4 with hydrocarbon radicals attached to said nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Television Systems (AREA)
  • Vehicle Body Suspensions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT00965329T 1999-09-24 2000-09-22 Thrombopoietinmimetika ATE350044T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15595899P 1999-09-24 1999-09-24

Publications (1)

Publication Number Publication Date
ATE350044T1 true ATE350044T1 (de) 2007-01-15

Family

ID=22557467

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00965329T ATE350044T1 (de) 1999-09-24 2000-09-22 Thrombopoietinmimetika

Country Status (8)

Country Link
US (1) US6552008B1 (de)
EP (1) EP1223944B1 (de)
JP (1) JP2003509462A (de)
AT (1) ATE350044T1 (de)
AU (1) AU771460B2 (de)
DE (1) DE60032783T2 (de)
ES (1) ES2279769T3 (de)
WO (1) WO2001021180A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
JP3966816B2 (ja) 2000-05-30 2007-08-29 中外製薬株式会社 トロンボポエチン様活性を有する化合物
CA2436288A1 (en) * 2000-12-19 2002-06-27 Smithkline Beecham Corporation Thrombopoietin mimetics
TWI280128B (en) 2002-05-22 2007-05-01 Smithkline Beecham Corp 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)
CA2495184A1 (en) 2002-08-14 2004-02-26 Nissan Chemical Industries, Ltd. Thrombopoietin receptor activators and process for their production
EP2319528B8 (de) 2002-09-18 2020-03-04 Janssen Pharmaceuticals, Inc. Methode zur produktionssteigerung von blutplättchen und hämatopoetischen stammzellen
TWI324593B (en) * 2002-10-09 2010-05-11 Nissan Chemical Ind Ltd Pyrazolone compounds and thrombopoietin receptor activator
EP1622609A4 (de) * 2003-04-29 2008-09-03 Smithkline Beecham Corp Verfahren zur behandlung von degenerativen erkrankungen/verletzungen
US20090298179A1 (en) * 2003-04-29 2009-12-03 Connie Erickson-Miller Methods For Treating Degenerative Diseases/Injuries
US20100004302A1 (en) * 2003-04-29 2010-01-07 Connie Erickson-Miller Methods for Treating Degenerative Diseases/Injuries
US20090048318A1 (en) * 2003-04-29 2009-02-19 Connie Erickson-Miller Methods for treating degenerative diseases/injuries
US20090143453A1 (en) * 2003-04-29 2009-06-04 Connie Erickson-Miller Methods for treating degenerative diseases/injuries
US20050107297A1 (en) * 2003-05-12 2005-05-19 Holmes Christopher P. Novel poly(ethylene glycol) modified compounds and uses thereof
NZ543934A (en) * 2003-05-12 2008-06-30 Affymax Inc Novel spacer moiety for poly (ethylene glycol)-modified peptide-based compounds
AU2004238870B8 (en) 2003-05-12 2010-04-15 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
SI1625156T1 (sl) * 2003-05-12 2013-02-28 Affymax, Inc. Peptidi, ki se veĹľejo k eritropoetinskemu receptorju
JP4848277B2 (ja) 2003-08-28 2011-12-28 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 受容体に結合するペプチドおよび化合物
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
TW200526638A (en) 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
WO2005118551A2 (en) * 2004-05-28 2005-12-15 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
KR100958337B1 (ko) 2004-10-25 2010-05-17 리간드 파마슈티칼스 인코포레이티드 트롬보포이에틴 활성 조절 화합물 및 방법
KR20070108140A (ko) * 2004-11-11 2007-11-08 아피맥스, 인크. 에리트로포이에틴 수용체에 결합하는 신규한 펩타이드
WO2006062685A2 (en) * 2004-11-11 2006-06-15 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
US7125446B2 (en) * 2004-11-19 2006-10-24 Eastman Kodak Company Yellow dyes for ink jet inks
TWI351954B (en) 2004-12-08 2011-11-11 Nissan Chemical Ind Ltd Heterocyclic compounds and thrombopoietin receptor
TWI399368B (zh) 2004-12-14 2013-06-21 Nissan Chemical Ind Ltd Amide compounds and thrombopoietin receptor activators
US7550433B2 (en) 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US8324159B2 (en) * 2005-06-03 2012-12-04 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US7919461B2 (en) 2005-06-03 2011-04-05 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
NZ563202A (en) 2005-07-15 2011-02-25 Nissan Chemical Ind Ltd Thiophene compounds and thrombopoietin receptor activators
JP5104752B2 (ja) 2005-07-20 2012-12-19 日産化学工業株式会社 ピラゾール化合物及びトロンボポエチンレセプター活性化剤
WO2007052808A1 (ja) 2005-11-07 2007-05-10 Nissan Chemical Industries, Ltd. ヒドラジド化合物及びトロンボポエチンレセプター活性化剤
AU2006318527A1 (en) * 2005-11-23 2007-05-31 Ligand Pharmaceuticals Incorporated Thrombopoietin activity modulating compounds and methods
JP5157900B2 (ja) 2006-06-07 2013-03-06 日産化学工業株式会社 含窒素ヘテロ環化合物及びトロンボポエチンレセプター活性化剤
US7737149B2 (en) * 2006-12-21 2010-06-15 Astrazeneca Ab N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
US8106154B2 (en) * 2007-01-31 2012-01-31 Affymax, Inc. Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules
ECSP077628A (es) 2007-05-03 2008-12-30 Smithkline Beechman Corp Nueva composición farmacéutica
KR20110020904A (ko) * 2008-06-19 2011-03-03 아스트라제네카 아베 피라졸 화합물 436
PE20100362A1 (es) 2008-10-30 2010-05-27 Irm Llc Derivados de purina que expanden las celulas madre hematopoyeticas
US8680150B2 (en) * 2009-05-28 2014-03-25 Ligand Pharmaceuticals, Inc. Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors
EA024557B1 (ru) 2009-05-29 2016-09-30 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Способы введения соединений, являющихся агонистами тромбопоэтина
WO2011098095A1 (en) 2010-02-09 2011-08-18 Aplagen Gmbh Peptides binding the tpo receptor
WO2012102937A2 (en) 2011-01-25 2012-08-02 Irm Llc Compounds that expand hematopoietic stem cells
AU2012347534B2 (en) 2011-12-08 2018-01-25 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
SG11201404241SA (en) 2012-01-27 2014-08-28 Univ Montreal Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells
US20140179712A1 (en) 2012-12-21 2014-06-26 Astrazeneca Ab Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide
EP3134409B1 (de) 2014-04-22 2020-02-12 Université de Montréal Verbindungen und verwendung davon in der expansion von hämatopoietischen stammzellen und/oder hämatopoietischen vorläuferzellen
JP6658535B2 (ja) 2014-10-31 2020-03-04 日産化学株式会社 リガンド結合繊維及び当該繊維を用いた細胞培養基材

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2950273A (en) * 1956-11-20 1960-08-23 Agfa Ag Process for the production of symmetrical and unsymmetrical azo compounds
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Also Published As

Publication number Publication date
US6552008B1 (en) 2003-04-22
DE60032783T2 (de) 2007-12-06
JP2003509462A (ja) 2003-03-11
AU771460B2 (en) 2004-03-25
EP1223944A1 (de) 2002-07-24
AU7606400A (en) 2001-04-24
WO2001021180A1 (en) 2001-03-29
ES2279769T3 (es) 2007-09-01
EP1223944B1 (de) 2007-01-03
DE60032783D1 (en) 2007-02-15
EP1223944A4 (de) 2002-10-30

Similar Documents

Publication Publication Date Title
ATE350044T1 (de) Thrombopoietinmimetika
ATE315934T1 (de) Thrombopoietin-mimetika
ATE344031T1 (de) Thrombopoietin-mimetika
MY136707A (en) Thrombopoietin mimetics
WO2002049413A3 (en) Thrombopoietin mimetics
WO2004054515A3 (en) Thrombopoietin mimetics
EP1133291A4 (de) Verfahren zur behandlung der thrombozytopenie
CY1108221T1 (el) Μεθοδος για την αναπαραγωγη πλευρομουτιλινων
DE60124684D1 (de) Sulfonamido-substituierte verbrückte bicycloalkylderivative
DE60101265D1 (de) Behandlung von augenschmerzen
EP1610778A4 (de) Behandlung von benigner prostatahyperplasie
ATE203519T1 (de) Chinolinderivate als antimalariamittel
ATE516027T1 (de) Orazamid orotat zur vorbeugung von leberschäden
EP1117431A4 (de) Behandlung von acidose
DE60101559D1 (de) Benutzung von comt-inhibitoren als analgetika
DK1305037T3 (da) Smertestillende medikament
DE60110748D1 (de) Behandlung von fluorkohlenstoff-beschickungen
DE60112768D1 (de) Behandlung von entzündlichen erkrankungen
CY1106363T1 (el) Χρηση του ενepγοποιημενου παραγοντα πηξης vii για την αγωγη των επαγομενων απο θρομβολυτικη θepαπεια μειζονων αιμορραγιων
BR0010699A (pt) Benzimidazóis substituìdos, sua produção e utilização dos mesmos como agente contra protozoários parasitários
NO20005548D0 (no) Mykobakterieinhibitorer
DE60125035D1 (de) Behandlung von plasmid-haltigen lösungen
LU91009B1 (de) Behandlung von Verbrennungen
DE60019921D1 (de) Verwendung von interleukin-11 zur behandlung von hämoragischem schock
EP1221951A4 (de) Behandlung von pankreas-erkrankungen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties