ATE341309T1 - Pulmonale arzneistoffverabreichung - Google Patents
Pulmonale arzneistoffverabreichungInfo
- Publication number
- ATE341309T1 ATE341309T1 AT99962010T AT99962010T ATE341309T1 AT E341309 T1 ATE341309 T1 AT E341309T1 AT 99962010 T AT99962010 T AT 99962010T AT 99962010 T AT99962010 T AT 99962010T AT E341309 T1 ATE341309 T1 AT E341309T1
- Authority
- AT
- Austria
- Prior art keywords
- formulation
- drug administration
- pulmonary drug
- pulmonary
- dispenser
- Prior art date
Links
- 230000002685 pulmonary effect Effects 0.000 title abstract 2
- 238000001647 drug administration Methods 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 108010039918 Polylysine Proteins 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 239000003086 colorant Substances 0.000 abstract 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229920000656 polylysine Polymers 0.000 abstract 1
- 239000003380 propellant Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11324398P | 1998-12-21 | 1998-12-21 | |
| US09/397,102 US6294153B1 (en) | 1998-12-21 | 1999-09-16 | Aerosol pharmaceutical formulation for pulmonary and nasal delivery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE341309T1 true ATE341309T1 (de) | 2006-10-15 |
Family
ID=26810843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99962010T ATE341309T1 (de) | 1998-12-21 | 1999-12-16 | Pulmonale arzneistoffverabreichung |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6294153B1 (de) |
| EP (1) | EP1143931B1 (de) |
| JP (1) | JP3818852B2 (de) |
| AT (1) | ATE341309T1 (de) |
| AU (1) | AU759051B2 (de) |
| CA (1) | CA2353847C (de) |
| DE (1) | DE69933472T2 (de) |
| DK (1) | DK1143931T3 (de) |
| ES (1) | ES2274651T3 (de) |
| MX (1) | MXPA01006377A (de) |
| NZ (1) | NZ512272A (de) |
| PT (1) | PT1143931E (de) |
| WO (1) | WO2000037052A1 (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US20060171899A1 (en) * | 1998-12-10 | 2006-08-03 | Akwete Adjei | Water-stabilized aerosol formulation system and method of making |
| US7087215B2 (en) * | 1998-12-21 | 2006-08-08 | Generex Pharmaceuticals Incorporated | Methods of administering and enhancing absorption of pharmaceutical agents |
| US6350432B1 (en) * | 1999-03-19 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Pressurized container having an aerosolized pharmaceutical composition |
| ES2529300T3 (es) | 2000-04-12 | 2015-02-18 | Novozymes Biopharma Dk A/S | Proteínas de fusión de albúmina |
| EP1575976A4 (de) | 2001-11-02 | 2006-08-23 | Insert Therapeutics Inc | Verfahren und zusammensetzungen zur therapeutischen verwendung von rna-interferenz |
| MXPA04004730A (es) * | 2001-11-19 | 2004-07-30 | Becton Dickinson Co | Composiciones farmaceuticas en forma particulada. |
| ES2425738T3 (es) | 2001-12-21 | 2013-10-17 | Human Genome Sciences, Inc. | Proteínas de fusión de la albúmina |
| GB2389530B (en) * | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
| KR20050049525A (ko) * | 2002-10-11 | 2005-05-25 | 가부시키가이샤산와카가쿠켄큐쇼 | Glp-1 유도체 및 그의 경점막 흡수형 제제 |
| US7456153B2 (en) * | 2002-11-14 | 2008-11-25 | Adherex Technologies Inc. | Compounds and methods for modulating functions of classical cadherins |
| CA2513213C (en) | 2003-01-22 | 2013-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US8008255B2 (en) | 2003-05-30 | 2011-08-30 | Amylin Pharmaceuticals, Inc. | Methods and compositions for enhanced transmucosal delivery of peptides and proteins |
| CA2550811C (en) * | 2003-12-24 | 2012-05-01 | Jane Hirsh | Temperature-stable formulations, and methods of development thereof |
| US7491263B2 (en) | 2004-04-05 | 2009-02-17 | Technology Innovation, Llc | Storage assembly |
| US20090069226A1 (en) * | 2004-05-28 | 2009-03-12 | Amylin Pharmaceuticals, Inc. | Transmucosal delivery of peptides and proteins |
| ES2704482T3 (es) | 2004-11-24 | 2019-03-18 | Meda Pharmaceuticals Inc | Composiciones que comprenden azelastina y sus métodos de uso |
| US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
| US8758816B2 (en) | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
| TWI335352B (en) | 2005-03-31 | 2011-01-01 | Calando Pharmaceuticals Inc | Inhibitors of ribonucleotide reductase subunit 2 and uses thereof |
| EP2202239A1 (de) | 2005-11-01 | 2010-06-30 | Alnylam Pharmaceuticals Inc. | RNAi-Hemmung von Influenza-Virus-Neubildungen |
| US8229398B2 (en) * | 2006-01-30 | 2012-07-24 | Qualcomm Incorporated | GSM authentication in a CDMA network |
| EP1993611A4 (de) * | 2006-03-16 | 2013-05-22 | Alnylam Pharmaceuticals Inc | Rnai-modulation von tgf-beta und ihre therapeutische verwendung |
| US8153604B2 (en) * | 2006-04-24 | 2012-04-10 | Geron Corporation | CNS-tumor treatment method and composition |
| CN101489566B (zh) * | 2006-05-19 | 2012-04-18 | 阿尔尼拉姆医药品有限公司 | Aha基因的RNAi调控及其治疗性应用 |
| US20140147441A1 (en) * | 2006-09-12 | 2014-05-29 | The General Hospital Corporation | Compositions containing alpha-1-antitrypsin and methods for use |
| ATE544759T1 (de) | 2007-07-21 | 2012-02-15 | Albany Molecular Res Inc | 5-pyridinon-substituierte indazole und pharmazeutische zusammensetzungen davon |
| WO2009023803A2 (en) * | 2007-08-15 | 2009-02-19 | Abbott Respiratory Llc | Modulated release formulation for the delivery of one or more medicaments |
| CN102026970B (zh) | 2007-11-21 | 2013-07-31 | 解码遗传Ehf公司 | 用于治疗肺部和心血管病症的联芳基pde4抑制剂 |
| BRPI0907122B8 (pt) | 2008-01-11 | 2021-05-25 | Albany Molecular Res Inc | compostos de piridoindóis (1-azinona) substituídos, composição farmacêutica compreendendo os referidos compostos, e usos dos mesmos |
| JP2011511674A (ja) | 2008-02-07 | 2011-04-14 | ユニヴァーシティ オブ ワシントン | 周方向エアロゾルデバイス |
| CA2720473A1 (en) | 2008-04-04 | 2009-10-08 | Calando Pharmaceuticals, Inc. | Compositions and use of epas1 inhibitors |
| WO2010059836A1 (en) | 2008-11-20 | 2010-05-27 | Decode Genetics Ehf | Substituted aza-bridged bicyclics for cardiovascular and cns disease |
| KR101675174B1 (ko) | 2009-01-26 | 2016-11-10 | 이스라엘 인스티튜트 포 바이올로지컬 리서치 | 이환형 헤테로사이클릭 스피로 화합물 |
| BR112012012945A2 (pt) | 2009-11-25 | 2020-12-29 | Arisgen Sa | Composição de liberação mucosal, seu método de produção, complexo de peptídeo pré-formado, kit e uso de um agente ativo de peptídeo |
| EP2605816B1 (de) * | 2010-08-20 | 2019-01-23 | University Of Washington | Umlaufende aerosolvorrichtung zur abgabe von arzneimitteln an die riechschleimhaut und das gehirn |
| CA2828884C (en) | 2011-03-03 | 2021-04-27 | Impel Neuropharma, Inc. | Nasal drug delivery device |
| AU2012253569B2 (en) | 2011-05-09 | 2018-02-15 | Impel Pharmaceuticals Inc. | Nozzles for nasal drug delivery |
| RU2657523C2 (ru) * | 2011-11-03 | 2018-06-14 | Олег Петрович Жирнов | Фармацевтический аэрозольный состав ингибиторов протеаз с озон-сберегающим пропеллентом и его получение |
| HK1222358A1 (zh) | 2013-04-28 | 2017-06-30 | Impel Neuropharma Inc. | 医用单位剂量容器 |
| US10004764B2 (en) | 2013-11-07 | 2018-06-26 | University of Pittsburgh—of the Commonwealth System of Higher Education | Red blood cell membrane-derived microparticles and their use for the treatment of lung disease |
| JP6753927B2 (ja) | 2015-09-10 | 2020-09-09 | インペル ニューロファーマ インコーポレイテッド | 直列形経鼻送達デバイス |
| WO2019104192A1 (en) | 2017-11-21 | 2019-05-31 | Impel Neuropharma, Inc. | Intranasal device with inlet interface |
| JP7191099B2 (ja) | 2017-11-21 | 2022-12-16 | インペル ファーマシューティカルズ インコーポレイテッド | 浸漬管を備えた鼻腔内装置 |
| CN111936140A (zh) | 2018-01-05 | 2020-11-13 | 英倍尔药业股份有限公司 | 通过精密鼻装置的双氢麦角胺的鼻内递送 |
| WO2019136308A1 (en) | 2018-01-05 | 2019-07-11 | Impel Neuropharma, Inc. | Intranasal delivery of olanzapine by precision olfactory device |
| CN112135613A (zh) | 2018-03-20 | 2020-12-25 | 西奈山伊坎医学院 | 激酶抑制剂化合物和组合物及使用方法 |
| US11517548B2 (en) | 2018-07-19 | 2022-12-06 | Impel Pharmaceuticals Inc. | Respiratory tract delivery of levodopa and DOPA decarboxylase inhibitor for treatment of Parkinson's Disease |
| CA3111275A1 (en) | 2018-09-06 | 2020-03-12 | Innopharmascreen Inc. | Methods and compositions for treatment of asthma or parkinson's disease |
| CN113508111A (zh) | 2018-12-31 | 2021-10-15 | 西奈山伊坎医学院 | 激酶抑制剂化合物和组合物及使用方法 |
| JP7213991B2 (ja) | 2019-01-03 | 2023-01-27 | インペル ファーマシューティカルズ インコーポレイテッド | 経鼻薬送達器具 |
| WO2020236658A1 (en) | 2019-05-17 | 2020-11-26 | Impel Neuropharma, Inc. | Single-use nasal delivery device |
| CA3210753A1 (en) | 2021-02-09 | 2022-08-18 | University Of Georgia Research Foundation, Inc. | Human monoclonal antibodies against pneumococcal antigens |
| WO2023198757A1 (en) | 2022-04-14 | 2023-10-19 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Alpha-1-antitrypsin for treating paramyxoviridae or orthomyxoviridae infections |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582820A (en) | 1982-12-23 | 1986-04-15 | Research Corporation | Orally administered biologically active peptides and proteins |
| IL68769A (en) | 1983-05-23 | 1986-02-28 | Hadassah Med Org | Pharmaceutical compositions containing insulin for oral administration |
| EP0158441B2 (de) | 1984-03-08 | 2001-04-04 | Phares Pharmaceutical Research N.V. | Liposombildende Zusammensetzung |
| US5288497A (en) | 1985-05-01 | 1994-02-22 | The University Of Utah | Compositions of oral dissolvable medicaments |
| DK179286D0 (da) | 1986-04-18 | 1986-04-18 | Nordisk Gentofte | Insulinpraeparat |
| US4839111A (en) * | 1987-02-02 | 1989-06-13 | The University Of Tennessee Research Corporation | Preparation of solid core liposomes |
| US5690954A (en) | 1987-05-22 | 1997-11-25 | Danbiosyst Uk Limited | Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material |
| US5006343A (en) | 1988-12-29 | 1991-04-09 | Benson Bradley J | Pulmonary administration of pharmaceutically active substances |
| US5174988A (en) * | 1989-07-27 | 1992-12-29 | Scientific Development & Research, Inc. | Phospholipid delivery system |
| US5230884A (en) | 1990-09-11 | 1993-07-27 | University Of Wales College Of Cardiff | Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations |
| US5672581A (en) | 1993-01-29 | 1997-09-30 | Aradigm Corporation | Method of administration of insulin |
| US5747445A (en) | 1993-06-24 | 1998-05-05 | Astra Aktiebolag | Therapeutic preparation for inhalation |
| IS1796B (is) | 1993-06-24 | 2001-12-31 | Ab Astra | Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband |
| TW402506B (en) | 1993-06-24 | 2000-08-21 | Astra Ab | Therapeutic preparation for inhalation |
| DE69432224T2 (de) | 1993-12-02 | 2003-12-04 | Abbott Laboratories, Abbott Park | Aerosole als darreichungsform mit cfc-freiem treibmittel |
| GB9417524D0 (en) | 1994-08-31 | 1994-10-19 | Cortecs Ltd | Pharmaceutical compositions |
| US5653987A (en) | 1995-05-16 | 1997-08-05 | Modi; Pankaj | Liquid formulations for proteinic pharmaceuticals |
| WO1996040057A2 (en) | 1995-06-07 | 1996-12-19 | Alliance Pharmaceutical Corp. | Reverse fluorocarbon emulsion compositions for drug delivery |
| US5891465A (en) | 1996-05-14 | 1999-04-06 | Biozone Laboratories, Inc. | Delivery of biologically active material in a liposomal formulation for administration into the mouth |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5898028A (en) | 1997-03-20 | 1999-04-27 | Novo Nordisk A/S | Method for producing powder formulation comprising an insulin |
| US6090407A (en) * | 1997-09-23 | 2000-07-18 | Research Development Foundation | Small particle liposome aerosols for delivery of anti-cancer drugs |
| US6017545A (en) * | 1998-02-10 | 2000-01-25 | Modi; Pankaj | Mixed micellar delivery system and method of preparation |
-
1999
- 1999-09-16 US US09/397,102 patent/US6294153B1/en not_active Expired - Lifetime
- 1999-12-16 JP JP2000589163A patent/JP3818852B2/ja not_active Expired - Fee Related
- 1999-12-16 NZ NZ512272A patent/NZ512272A/xx not_active IP Right Cessation
- 1999-12-16 PT PT99962010T patent/PT1143931E/pt unknown
- 1999-12-16 EP EP99962010A patent/EP1143931B1/de not_active Expired - Lifetime
- 1999-12-16 DE DE69933472T patent/DE69933472T2/de not_active Expired - Lifetime
- 1999-12-16 AU AU18519/00A patent/AU759051B2/en not_active Ceased
- 1999-12-16 DK DK99962010T patent/DK1143931T3/da active
- 1999-12-16 WO PCT/CA1999/001232 patent/WO2000037052A1/en not_active Ceased
- 1999-12-16 ES ES99962010T patent/ES2274651T3/es not_active Expired - Lifetime
- 1999-12-16 MX MXPA01006377A patent/MXPA01006377A/es not_active IP Right Cessation
- 1999-12-16 AT AT99962010T patent/ATE341309T1/de not_active IP Right Cessation
- 1999-12-16 CA CA002353847A patent/CA2353847C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU1851900A (en) | 2000-07-12 |
| PT1143931E (pt) | 2007-01-31 |
| CA2353847A1 (en) | 2000-06-29 |
| NZ512272A (en) | 2002-12-20 |
| EP1143931B1 (de) | 2006-10-04 |
| DE69933472T2 (de) | 2007-05-31 |
| CA2353847C (en) | 2007-03-06 |
| ES2274651T3 (es) | 2007-05-16 |
| US6294153B1 (en) | 2001-09-25 |
| JP2002532537A (ja) | 2002-10-02 |
| JP3818852B2 (ja) | 2006-09-06 |
| AU759051B2 (en) | 2003-04-03 |
| MXPA01006377A (es) | 2002-05-06 |
| DE69933472D1 (de) | 2006-11-16 |
| WO2000037052A1 (en) | 2000-06-29 |
| EP1143931A1 (de) | 2001-10-17 |
| DK1143931T3 (da) | 2007-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |