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ATE339521T1 - Verfahren zur bestimmung der expression des dihydropyrimidindehydrogenasegens - Google Patents

Verfahren zur bestimmung der expression des dihydropyrimidindehydrogenasegens

Info

Publication number
ATE339521T1
ATE339521T1 AT02704432T AT02704432T ATE339521T1 AT E339521 T1 ATE339521 T1 AT E339521T1 AT 02704432 T AT02704432 T AT 02704432T AT 02704432 T AT02704432 T AT 02704432T AT E339521 T1 ATE339521 T1 AT E339521T1
Authority
AT
Austria
Prior art keywords
expression
determining
dihydropyrimidine dehydrogenase
gen
dehydrogenase gen
Prior art date
Application number
AT02704432T
Other languages
English (en)
Inventor
Kathleen D Danenberg
Original Assignee
Response Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/796,807 external-priority patent/US6956111B2/en
Application filed by Response Genetics Inc filed Critical Response Genetics Inc
Application granted granted Critical
Publication of ATE339521T1 publication Critical patent/ATE339521T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT02704432T 2001-03-02 2002-02-22 Verfahren zur bestimmung der expression des dihydropyrimidindehydrogenasegens ATE339521T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/796,807 US6956111B2 (en) 2001-03-02 2001-03-02 Method of determining dihydropyrimidine dehydrogenase gene expression
US09/842,111 US6905821B2 (en) 2001-03-02 2001-04-26 Method of determining Dihydropyrimidine dehydrogenase gene expression
US09/879,217 US7005278B2 (en) 2001-03-02 2001-06-13 Method of determining dihydropyrimidine dehydrogenase gene expression

Publications (1)

Publication Number Publication Date
ATE339521T1 true ATE339521T1 (de) 2006-10-15

Family

ID=27419931

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02704432T ATE339521T1 (de) 2001-03-02 2002-02-22 Verfahren zur bestimmung der expression des dihydropyrimidindehydrogenasegens

Country Status (15)

Country Link
US (1) US7005278B2 (de)
EP (1) EP1409723B1 (de)
JP (1) JP2005508603A (de)
CN (1) CN1250744C (de)
AR (1) AR032917A1 (de)
AT (1) ATE339521T1 (de)
AU (1) AU2002238115B2 (de)
CA (1) CA2439313C (de)
DE (1) DE60214725T2 (de)
HK (1) HK1068375A1 (de)
IL (1) IL157694A0 (de)
MX (1) MXPA03007884A (de)
NZ (1) NZ528374A (de)
TW (1) TWI274076B (de)
WO (1) WO2002070750A2 (de)

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US20020142328A1 (en) 2000-12-01 2002-10-03 Danenberg Kathleen D. Method of determining a chemotherapeutic regimen by assaying gene expression in primary tumors
ATE353107T1 (de) * 2003-08-28 2007-02-15 Hoffmann La Roche Abhängigkeit des symptomfreien überlebens 5-fu behandelter darmkrebspatienten vom verhältnis der mrna-expressionshöhe aus thymidinphosphorylase und dihydropyrimidindehydrogenase
EP1846030B1 (de) * 2005-01-21 2018-11-21 Genentech, Inc. Fixe dosierung von her-antikörpern
EP1850874B1 (de) 2005-02-23 2013-10-16 Genentech, Inc. Verzögerung des krankheitsverlauf bei eierstockkrebspatienten durch pertuzumab
JP2006316040A (ja) 2005-05-13 2006-11-24 Genentech Inc Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法
US8440398B2 (en) * 2006-01-25 2013-05-14 Taiho Pharmaceutical Co., Ltd. Method for prediction of sensitivity to 5-fluorouracil-type anticancer agent
MX2009008981A (es) 2007-03-02 2009-09-02 Genentech Inc Prediccion de respuesta a un inhibidor her.
WO2008154249A2 (en) 2007-06-08 2008-12-18 Genentech, Inc. Gene expression markers of tumor resistance to her2 inhibitor treatment
US9551033B2 (en) * 2007-06-08 2017-01-24 Genentech, Inc. Gene expression markers of tumor resistance to HER2 inhibitor treatment
CA2691209A1 (en) 2007-06-22 2008-12-31 Kathleen Danenberg Methods for isolating long fragment rna from fixed samples
BRPI0812682A2 (pt) 2008-06-16 2010-06-22 Genentech Inc tratamento de cáncer de mama metastático
KR20130080871A (ko) 2009-03-20 2013-07-15 제넨테크, 인크. 이중특이적 항-ｈｅｒ 항체
EP2435071A1 (de) 2009-05-29 2012-04-04 F. Hoffmann-La Roche AG Modulatoren für den her2-signalweg bei her2-exprimierenden patienten mit magenkrebs
US8079170B2 (en) * 2009-08-28 2011-12-20 Loftin Thomas E Gun barrel cleaning apparatus and method
SI2536748T1 (sl) 2010-02-18 2014-12-31 Genentech, Inc. Nevrogulinski antagonisti in njihova uporaba pri zdravljenju raka
WO2011146568A1 (en) 2010-05-19 2011-11-24 Genentech, Inc. Predicting response to a her inhibitor
EP2643353A1 (de) 2010-11-24 2013-10-02 Novartis AG Multispezifische moleküle
JP5766296B2 (ja) 2010-12-23 2015-08-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
WO2013025853A1 (en) 2011-08-17 2013-02-21 Genentech, Inc. Neuregulin antibodies and uses thereof
WO2013063229A1 (en) 2011-10-25 2013-05-02 The Regents Of The University Of Michigan Her2 targeting agent treatment in non-her2-amplified cancers having her2 expressing cancer stem cells
JP2015500638A (ja) 2011-11-30 2015-01-08 ジェネンテック， インコーポレイテッド 癌におけるｅｒｂｂ３変異
US9376715B2 (en) 2011-12-09 2016-06-28 Roche Molecular Systems, Inc Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene
CA2865082A1 (en) 2012-03-27 2013-10-03 Genentech, Inc. Diagnosis and treatments relating to her3 inhibitors
MX363188B (es) 2012-11-30 2019-03-13 Hoffmann La Roche Identificación de pacientes con necesidad de coterapia del inhibidor de pd-l1.
WO2017194554A1 (en) 2016-05-10 2017-11-16 Inserm (Institut National De La Sante Et De La Recherche Medicale) Combinations therapies for the treatment of cancer

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US4830969A (en) 1981-08-31 1989-05-16 The Research Foundation Of State University Of New York Process for the rapid and simple isolation of nucleic acids
US4843155A (en) 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
US5128247A (en) 1989-08-14 1992-07-07 Board Of Regents, The University Of Texas System Methods for isolation of nucleic acids from eukaryotic and prokaryotic sources
US5620852A (en) 1990-11-14 1997-04-15 Hri Research, Inc. Nucleic acid preparation methods
US5284940A (en) 1990-11-14 1994-02-08 Hri Research, Inc. Preparation for nucleic acid samples
US5654179A (en) 1990-11-14 1997-08-05 Hri Research, Inc. Nucleic acid preparation methods
US5346994A (en) 1992-01-28 1994-09-13 Piotr Chomczynski Shelf-stable product and process for isolating RNA, DNA and proteins
US5502166A (en) 1992-02-26 1996-03-26 Mitsubishi Chemical Corporation NMDH receptor proteins and genes encoding the same
JP3615545B2 (ja) 1993-02-01 2005-02-02 キアゲン・エヌ・ブイ 第四級アンモニウム塩界面活性剤及びそのｒｎａの単離剤
US5637687A (en) 1993-08-31 1997-06-10 Wiggins; James C. Methods and compositions for isolating nucleic acids
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US5643767A (en) 1994-05-02 1997-07-01 The Rockefeller University Process for isolating cellular components
CA2153215A1 (en) 1994-07-06 1996-01-07 Lu Wang Treatment of paraffin embedded tissue for gene analysis
US5856454A (en) * 1994-09-12 1999-01-05 The United States Of America As Represented By The Department Of Health And Human Services CDNA for human and pig dihydropyrimidine dehydrogenase
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DE29601618U1 (de) 1996-01-31 1996-07-04 InViTek GmbH, 13125 Berlin Vorrichtung zur gleichzeitigen multiplen Isolierung
EP0791654A1 (de) 1996-02-21 1997-08-27 Jürgen A. Dr. Richt Polypeptide, die Aminosäuresequenzen der p57 oder p9.5 Proteine aus Borna-Krankheit Virus entsprechen, dafür kodierende Nukleinsäurefragmente und ihre Verwendung zu Diagnose- und Immunisierungzwecke
WO1997035034A1 (en) 1996-03-20 1997-09-25 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations
EP0912726A4 (de) 1996-05-10 2001-07-18 Phylomed Corp Verfahren zur oxidation von disulfid-bindungen durch gebrauch von ozon
AU6764398A (en) 1997-03-20 1998-10-12 Variagenics, Inc. Target genes for allele-specific drugs
IT1302026B1 (it) 1997-08-22 2000-07-20 Hoffmann La Roche Materiali immunologici e metodi per la rivelazione di diidropirimidinadeidrogenasi.
US5952202A (en) * 1998-03-26 1999-09-14 The Perkin Elmer Corporation Methods using exogenous, internal controls and analogue blocks during nucleic acid amplification
AR031457A1 (es) 2000-12-01 2003-09-24 Response Genetics Inc Metodo para determinar un regimen terapeutico mediante el analisis de la expresion genica en tumores primarios
KR101014342B1 (ko) * 2000-12-01 2011-02-15 리스판스 지네틱스, 인크. 표피 성장 인자 수용체 및 ｈｅｒ2-ｎｅｕ 유전자 발현 및 이들 수준과 생존율의 상관성을 측정하는 방법

Also Published As

Publication number Publication date
CA2439313C (en) 2012-08-07
EP1409723B1 (de) 2006-09-13
HK1068375A1 (en) 2005-04-29
EP1409723A2 (de) 2004-04-21
CN1518603A (zh) 2004-08-04
US20030165840A1 (en) 2003-09-04
DE60214725T2 (de) 2007-09-06
US7005278B2 (en) 2006-02-28
CN1250744C (zh) 2006-04-12
NZ528374A (en) 2008-01-31
AR032917A1 (es) 2003-12-03
AU2002238115B2 (en) 2007-06-14
MXPA03007884A (es) 2004-10-15
WO2002070750A3 (en) 2004-02-19
CA2439313A1 (en) 2002-09-12
DE60214725D1 (de) 2006-10-26
IL157694A0 (en) 2004-03-28
JP2005508603A (ja) 2005-04-07
TWI274076B (en) 2007-02-21
WO2002070750A2 (en) 2002-09-12

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