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ATE33635T1 - Substituierte sulfonamidbenzamide, antiarythmische mittel und deren zusammensetzungen. - Google Patents

Substituierte sulfonamidbenzamide, antiarythmische mittel und deren zusammensetzungen.

Info

Publication number
ATE33635T1
ATE33635T1 AT85101112T AT85101112T ATE33635T1 AT E33635 T1 ATE33635 T1 AT E33635T1 AT 85101112 T AT85101112 T AT 85101112T AT 85101112 T AT85101112 T AT 85101112T AT E33635 T1 ATE33635 T1 AT E33635T1
Authority
AT
Austria
Prior art keywords
agents
antiarythmic
benzamides
compositions
substituted sulfonamide
Prior art date
Application number
AT85101112T
Other languages
English (en)
Inventor
David Daniel Davey
William Carl Lumma Jr
Ronald Andre Wohl
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of ATE33635T1 publication Critical patent/ATE33635T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT85101112T 1984-03-20 1985-02-02 Substituierte sulfonamidbenzamide, antiarythmische mittel und deren zusammensetzungen. ATE33635T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/591,649 US4544654A (en) 1984-03-20 1984-03-20 Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof
EP85101112A EP0158775B1 (de) 1984-03-20 1985-02-02 Substituierte Sulfonamidbenzamide, antiarythmische Mittel und deren Zusammensetzungen

Publications (1)

Publication Number Publication Date
ATE33635T1 true ATE33635T1 (de) 1988-05-15

Family

ID=24367304

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85101112T ATE33635T1 (de) 1984-03-20 1985-02-02 Substituierte sulfonamidbenzamide, antiarythmische mittel und deren zusammensetzungen.

Country Status (6)

Country Link
US (2) US4544654A (de)
EP (1) EP0158775B1 (de)
JP (1) JPH075539B2 (de)
AT (1) ATE33635T1 (de)
CA (1) CA1246562A (de)
DE (1) DE3562238D1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4544654A (en) * 1984-03-20 1985-10-01 Schering A.G. Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof
US4751327A (en) * 1985-06-28 1988-06-14 Xerox Corporation Photoconductive imaging members with unsymmetrical squaraine compounds
US4920116A (en) * 1985-06-28 1990-04-24 Schering A.G. N-(aminoalkyl)-substituted(N or C alkyl)-aryl-4(methylsulfonylamino)benzamides
PH23283A (en) * 1986-02-26 1989-06-30 Eisai Co Ltd Piperidine derivative, pharmaceutical composition containing the same and method of use thereof
US5179095A (en) * 1986-02-26 1993-01-12 Eisai Co., Ltd. Piperidine derivative and pharmaceutical composition containing the same
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
IL83767A (en) * 1986-09-18 1992-11-15 American Home Prod Benzenesulfonamide derivatives,their preparation and pharmaceutical compositions containing them
GB8706662D0 (en) * 1987-03-20 1987-04-23 Pfizer Ltd Anti-arrhythmia agents
US4900841A (en) * 1987-04-20 1990-02-13 Schering A.G. 1-[4-[(methyl-sulfonyl)amino]benzoyl]aziridine
PH25458A (en) * 1987-08-24 1991-07-01 Eisai Co Ltd Piperidine derivatives, therapeutic, preventive agents
DE3732094A1 (de) * 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
SE8705150D0 (sv) * 1987-12-23 1987-12-23 Haessle Ab Novel antiarrhythmic agents
GB8804014D0 (en) * 1988-02-23 1988-03-23 Humphreys & Glasgow Ltd Synthesis gas production
US4906634A (en) * 1988-03-08 1990-03-06 Schering A.G. Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
US5144072A (en) * 1988-10-21 1992-09-01 American Home Products Corporation Anti-arrhythmic agents
US5112824A (en) * 1989-12-08 1992-05-12 Merck & Co., Inc. Benzofuran compounds as class III antiarrhythmic agents
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US5032604A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
US5215989A (en) * 1989-12-08 1993-06-01 Merck & Co., Inc. Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
WO1991018904A1 (en) * 1990-05-30 1991-12-12 American Home Products Corporation Substituted arylsulfonamides and benzamides
US5149700A (en) * 1990-05-30 1992-09-22 American Home Products Corporation Substituted arylsulfonamides and benzamides
US5382587A (en) * 1993-06-30 1995-01-17 Merck & Co., Inc. Spirocycles
US5403846A (en) * 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
DE4344648A1 (de) * 1993-12-24 1995-06-29 Dresden Arzneimittel Neue Aminocarbonsäureamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
DE69500377T2 (de) 1994-08-19 1997-10-09 Mitsui Toatsu Chemicals Pyrimidin-Dion-Derivate und diese enthaltende antiarrhythmische Zusammensetzungen
US5612378A (en) * 1995-06-06 1997-03-18 3-Dimensional Pharmaceuticals, Inc. Bis-arylsulfonylaminobenzamide derivatives and the use thereof as factor Xa inhibitors
US5741819A (en) * 1995-06-07 1998-04-21 3-Dimensional Pharmaceuticals, Inc. Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors
US6083991A (en) 1997-06-04 2000-07-04 University Of Florida Research Foundation, Inc. Anti-arrhythmic composition and methods of treatment
MXPA02002578A (es) 1999-09-08 2002-10-23 Guilford Pharm Inc Compuestos de union a ciclofilina no peptidicos, y su uso.
US6656971B2 (en) 2001-01-25 2003-12-02 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
US9556141B2 (en) 2011-11-21 2017-01-31 Basf Se Process for preparing N-substituted 1H-pyrazole-5-carboxylate compounds and derivatives thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH364248A (de) * 1957-12-24 1962-09-15 Geigy Ag J R Verfahren zur Herstellung neuer Aminobenzoesäure-Derivate
GB1509527A (en) * 1974-06-05 1978-05-04 Ici Ltd 1-(aryl-or heteroaryl)oxy-3-(substituted-amino)propan-2-ol derivatives processes for their manufacture and pharmaceutical compositions containing them
DE2428673A1 (de) * 1974-06-14 1976-01-02 Bayer Ag Carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4049821A (en) * 1976-05-12 1977-09-20 A. H. Robins Company, Inc. Method of treating allergy
NZ186175A (en) * 1977-01-27 1980-03-05 Shionogi & Co Meta-sulphonamidobenzamide derivatives
US4301159A (en) * 1980-06-20 1981-11-17 Shionogi & Co., Ltd. N-(Diethylaminoethyl)-2-alkoxy-benzamide derivatives
JPS5955878A (ja) * 1982-09-24 1984-03-31 Chugai Pharmaceut Co Ltd 新規なフエニルピペラジン誘導体
US4544654A (en) * 1984-03-20 1985-10-01 Schering A.G. Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof

Also Published As

Publication number Publication date
EP0158775B1 (de) 1988-04-20
US4629739A (en) 1986-12-16
CA1246562A (en) 1988-12-13
EP0158775A1 (de) 1985-10-23
JPH075539B2 (ja) 1995-01-25
JPS60209559A (ja) 1985-10-22
DE3562238D1 (en) 1988-05-26
US4544654A (en) 1985-10-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee