ATE336262T1 - Monoklonale antikörper die flk-2 rezeptoren erkennen, und die isolierung primitiver hämatopoietischer stammzellpopulationen - Google Patents

Monoklonale antikörper die flk-2 rezeptoren erkennen, und die isolierung primitiver hämatopoietischer stammzellpopulationen

Info

Publication number: ATE336262T1
Authority: AT; Austria
Prior art keywords: flk; hematopoietic stem; receptors; isolation; recognize
Prior art date: 1993-09-08

Application number

AT01122476T

Other languages

English (en)

Inventor

Neil I Goldstein

Ratchaneem Songsakphsan

Caroline Rose

Original Assignee

Imclone Systems Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-08

Filing date

1994-09-07

Publication date

2006-09-15

1994-09-07 Application filed by Imclone Systems Inc filed Critical Imclone Systems Inc

2006-09-15 Application granted granted Critical

2006-09-15 Publication of ATE336262T1 publication Critical patent/ATE336262T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Pharmacology & Pharmacy (AREA)
Cell Biology (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Toxicology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT01122476T 1993-09-08 1994-09-07 Monoklonale antikörper die flk-2 rezeptoren erkennen, und die isolierung primitiver hämatopoietischer stammzellpopulationen ATE336262T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11846893A	1993-09-08	1993-09-08

Publications (1)

Publication Number	Publication Date
ATE336262T1 true ATE336262T1 (de)	2006-09-15

Family

ID=22378791

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT94929168T ATE215598T1 (de)	1993-09-08	1994-09-07	Monoklonale antikörper, die flk-2-rezeptoren erkennen, und die isolierung primitiver hämatopoietischer stammzellpopulationen
AT01122476T ATE336262T1 (de)	1993-09-08	1994-09-07	Monoklonale antikörper die flk-2 rezeptoren erkennen, und die isolierung primitiver hämatopoietischer stammzellpopulationen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT94929168T ATE215598T1 (de)	1993-09-08	1994-09-07	Monoklonale antikörper, die flk-2-rezeptoren erkennen, und die isolierung primitiver hämatopoietischer stammzellpopulationen

Country Status (8)

Country	Link
EP (3)	EP1186301B1 (de)
JP (1)	JPH09502352A (de)
AT (2)	ATE215598T1 (de)
AU (1)	AU7832394A (de)
CA (1)	CA2171112A1 (de)
DE (2)	DE69434828T2 (de)
ES (2)	ES2174879T3 (de)
WO (1)	WO1995007348A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5635388A (en) *	1994-04-04	1997-06-03	Genentech, Inc.	Agonist antibodies against the flk2/flt3 receptor and uses thereof
US5587459A (en) *	1994-08-19	1996-12-24	Regents Of The University Of Minnesota	Immunoconjugates comprising tyrosine kinase inhibitors
US5911995A (en) *	1994-08-19	1999-06-15	Regents Of The University Of Minnesota	EGF-genistein conjugates for the treatment of cancer
DE19608769C1 (de) *	1996-03-07	1997-04-10	Univ Eberhard Karls	Antikörper BV10A4H2
DE19727814C1 (de) *	1997-06-30	1998-10-01	Univ Eberhard Karls	Anitkörper 4G8B4B12
US7361336B1 (en)	1997-09-18	2008-04-22	Ivan Bergstein	Methods of cancer therapy targeted against a cancer stem line
AR071891A1 (es)	2008-05-30	2010-07-21	Imclone Llc	Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano)
IL263744B2 (en)	2016-06-17	2023-11-01	Magenta Therapeutics Inc	Compositions and methods for the depletion of cd117 plus cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5130144B1 (en) *	1984-02-06	1995-08-15	Univ Johns Hopkins	Human stem cells and monoclonal antibodies
US5061620A (en) *	1990-03-30	1991-10-29	Systemix, Inc.	Human hematopoietic stem cell
US5185438A (en) *	1991-04-02	1993-02-09	The Trustees Of Princeton University	Nucleic acids encoding hencatoporetic stem cell receptor flk-2
US6228609B1 (en) *	1992-07-09	2001-05-08	Systemix, Inc.	Soluble Flk-2 sequence

1994
- 1994-09-07 DE DE69434828T patent/DE69434828T2/de not_active Expired - Fee Related
- 1994-09-07 EP EP01122476A patent/EP1186301B1/de not_active Expired - Lifetime
- 1994-09-07 AT AT94929168T patent/ATE215598T1/de not_active IP Right Cessation
- 1994-09-07 EP EP06016925A patent/EP1734053A3/de not_active Withdrawn
- 1994-09-07 JP JP7508812A patent/JPH09502352A/ja not_active Ceased
- 1994-09-07 DE DE69430313T patent/DE69430313T2/de not_active Expired - Fee Related
- 1994-09-07 CA CA002171112A patent/CA2171112A1/en not_active Abandoned
- 1994-09-07 ES ES94929168T patent/ES2174879T3/es not_active Expired - Lifetime
- 1994-09-07 ES ES01122476T patent/ES2269266T3/es not_active Expired - Lifetime
- 1994-09-07 EP EP94929168A patent/EP0722489B1/de not_active Expired - Lifetime
- 1994-09-07 AU AU78323/94A patent/AU7832394A/en not_active Abandoned
- 1994-09-07 AT AT01122476T patent/ATE336262T1/de not_active IP Right Cessation
- 1994-09-07 WO PCT/US1994/010194 patent/WO1995007348A1/en active IP Right Grant

Also Published As

Publication number	Publication date
AU7832394A (en)	1995-03-27
ES2174879T3 (es)	2002-11-16
EP0722489A1 (de)	1996-07-24
CA2171112A1 (en)	1995-03-16
EP1734053A2 (de)	2006-12-20
DE69430313D1 (de)	2002-05-08
JPH09502352A (ja)	1997-03-11
EP1734053A3 (de)	2009-04-22
WO1995007348A1 (en)	1995-03-16
EP1186301B1 (de)	2006-08-16
EP0722489B1 (de)	2002-04-03
EP1186301A3 (de)	2002-05-15
EP0722489A4 (de)	1996-06-11
DE69430313T2 (de)	2002-08-08
ATE215598T1 (de)	2002-04-15
DE69434828D1 (de)	2006-09-28
ES2269266T3 (es)	2007-04-01
DE69434828T2 (de)	2007-03-01
EP1186301A2 (de)	2002-03-13

Publication	Publication Date	Title
DE69029015D1 (de)	1996-12-05	Antikörper gegen menschlichen Interleukin-6-Rezeptor
TW221675B (de)	1994-03-11
DE69232952D1 (de)	2003-04-17	Antikörper der Rezeptoren von pluripotenten hämatopoetischen Stammzellen flk-1
ATE169031T1 (de)	1998-08-15	Zellrezeptor spezifische monoklonale antikörper gegen stammzell-faktor-rezeptor
DE3580654D1 (de)	1991-01-03	Menschlicher hybridomfusionspartner zur herstellung menschlicher monoklonaler antikoerper.
ES2110230T3 (es)	1998-02-01	Ensayo de rapamicina.
ATE94205T1 (de)	1993-09-15	Monoklonale antikoerper gegen melanoma-assoziierte antigene, hybridzellinien, die diese antikoerper produzieren, und ihre verwendung.
NO162179C (no)	1989-11-22	Monoklonale antistoffer for anvendelse in vitro.
ATE215598T1 (de)	2002-04-15	Monoklonale antikörper, die flk-2-rezeptoren erkennen, und die isolierung primitiver hämatopoietischer stammzellpopulationen
NO162797C (no)	1990-02-21	Monoklonalt antistofff for anvendelse in vitro.
DE3480494D1 (en)	1989-12-21	Method and reagent for use in the assay of pivka-ii
AR016681A1 (es)	2001-07-25	Deplecion de celulas th2; composiciones; metodos
DE3850993D1 (de)	1994-09-15	Monoklonaler Antikörper spezifisch gegen humane Pankreas-Phospholipase-A2.
SE0002835D0 (sv)	2000-08-07	Method and kit for production of monoclonal antibodies
DE3851855D1 (de)	1994-11-24	Gegen die Gamma-Kette des T-Zell-Rezeptors gerichteter monoklonaler Antikörper.
ES2061664T3 (es)	1994-12-16	Anticuerpos monoclonales que reconocen a alfa-hanp y correspondientes hibridomas, su preparacion y uso.

Legal Events

Date	Code	Title	Description
2007-06-15	UEP	Publication of translation of european patent specification	Ref document number: 1186301 Country of ref document: EP
2010-06-15	REN	Ceased due to non-payment of the annual fee

Date

Code

Title

Description

2007-06-15

UEP

Publication of translation of european patent specification

Ref document number: 1186301

Country of ref document: EP

2010-06-15

REN

Ceased due to non-payment of the annual fee