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ATE334671T1 - Wortmanninanaloge und verfahren zu deren verwendung - Google Patents

Wortmanninanaloge und verfahren zu deren verwendung

Info

Publication number
ATE334671T1
ATE334671T1 AT02766286T AT02766286T ATE334671T1 AT E334671 T1 ATE334671 T1 AT E334671T1 AT 02766286 T AT02766286 T AT 02766286T AT 02766286 T AT02766286 T AT 02766286T AT E334671 T1 ATE334671 T1 AT E334671T1
Authority
AT
Austria
Prior art keywords
analogs
wordman
inhibiting
mammals
subject
Prior art date
Application number
AT02766286T
Other languages
English (en)
Inventor
Peter Wipf
Garth Powis
Original Assignee
Univ Arizona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arizona filed Critical Univ Arizona
Application granted granted Critical
Publication of ATE334671T1 publication Critical patent/ATE334671T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT02766286T 2001-09-14 2002-09-16 Wortmanninanaloge und verfahren zu deren verwendung ATE334671T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32214301P 2001-09-14 2001-09-14
US32213901P 2001-09-14 2001-09-14

Publications (1)

Publication Number Publication Date
ATE334671T1 true ATE334671T1 (de) 2006-08-15

Family

ID=26983283

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02766286T ATE334671T1 (de) 2001-09-14 2002-09-16 Wortmanninanaloge und verfahren zu deren verwendung

Country Status (8)

Country Link
EP (1) EP1435941B8 (de)
JP (1) JP4540986B2 (de)
AT (1) ATE334671T1 (de)
AU (1) AU2002330029B2 (de)
CA (1) CA2458318C (de)
DE (1) DE60213633T2 (de)
MX (1) MXPA04002445A (de)
WO (1) WO2003024183A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7081475B2 (en) 2001-09-14 2006-07-25 Prolx Pharmaceuticals Corp. Wortmannin analogs and methods of using same
DE10219545A1 (de) * 2002-04-26 2003-11-06 Lang Florian Regulation der Apoptose
US7230139B2 (en) 2002-12-05 2007-06-12 Gemin X Biotechnologies Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents
US20040213757A1 (en) * 2003-04-23 2004-10-28 Wyeth Holdings Corporation Water soluble wortmannin derivatives
DE102004043463A1 (de) * 2004-06-09 2006-02-09 Heinz Voigt Mittel zur Krebsbekämpfung unter Verwendung von Schimmelpilzextrakten
EP1901738A4 (de) * 2004-07-09 2009-11-11 Prolx Pharmaceuticals Inc Wortmannin-analoga und verfahren zu ihrer verwendung in kombination mit chemotherapeutischen mitteln
WO2006044453A1 (en) * 2004-10-13 2006-04-27 Wyeth Analogs of 17-hydroxywortmannin as pi3k inhibitors
WO2006132675A2 (en) * 2004-12-20 2006-12-14 University Of South Florida Xiap-targeted prostate cancer therapy
CA2620855A1 (en) * 2005-09-01 2007-08-02 Beth Israel Deaconess Medical Center Wortmannin conjugates and uses thereof
US20070116736A1 (en) * 2005-11-23 2007-05-24 Argentieri Dennis C Local vascular delivery of PI3 kinase inhibitors alone or in combination with sirolimus to prevent restinosis following vascular injury
CA2636040C (en) * 2005-12-30 2013-12-17 Arizona Board Of Regents, Acting On Behalf Of The University Of Arizona Metabolites of wortmannin analogs and methods of using the same
EP2012794B1 (de) * 2006-04-13 2014-09-17 The Trustees of Columbia University in the City of New York Zusammensetzungen und intraluminale vorrichtung zur verhinderung von gefässverengung
JP2013527248A (ja) * 2010-06-04 2013-06-27 オンコシレオン インク． ウォルトマンニンアナログによる癌の処置
AU2011261243A1 (en) * 2010-06-04 2012-12-20 Oncothyreon Inc. Combination cancer therapies with wortmannin analogs
US11197854B1 (en) 2018-11-14 2021-12-14 National Technology & Engineering Solutions Of Sandia, Llc Inhibitors for targeting flaviviruses
US20220040324A1 (en) 2018-12-21 2022-02-10 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and kinase inhibitor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2302021A (en) * 1996-10-16 1997-01-08 Lilly Co Eli Inhibiting bone loss or resorption

Also Published As

Publication number Publication date
JP4540986B2 (ja) 2010-09-08
CA2458318A1 (en) 2003-03-27
EP1435941B1 (de) 2006-08-02
WO2003024183A3 (en) 2003-06-12
DE60213633D1 (de) 2006-09-14
EP1435941A4 (de) 2004-12-08
EP1435941B8 (de) 2006-10-25
AU2002330029B2 (en) 2006-07-06
CA2458318C (en) 2011-03-15
DE60213633T2 (de) 2007-11-08
JP2005507880A (ja) 2005-03-24
MXPA04002445A (es) 2005-07-25
EP1435941A2 (de) 2004-07-14
WO2003024183A2 (en) 2003-03-27

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Legal Events

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