ATE302772T1 - 2-(1h-indol-3-yl)-2-oxo-acetamide mit antitumoraler wirkung - Google Patents

2-(1h-indol-3-yl)-2-oxo-acetamide mit antitumoraler wirkung

Info

Publication number: ATE302772T1
Authority: AT; Austria
Prior art keywords: indol; oxo; acetamide; tumoral effect; tumoral
Prior art date: 1999-12-23

Application number

AT00985225T

Other languages

English (en)

Inventor

Ernesto Menta

Nicoletta Pescalli

Original Assignee

Cell Therapeutics Europe Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-23

Filing date

2000-12-21

Publication date

2005-09-15

2000-12-21 Application filed by Cell Therapeutics Europe Srl filed Critical Cell Therapeutics Europe Srl

2005-09-15 Application granted granted Critical

2005-09-15 Publication of ATE302772T1 publication Critical patent/ATE302772T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT00985225T 1999-12-23 2000-12-21 2-(1h-indol-3-yl)-2-oxo-acetamide mit antitumoraler wirkung ATE302772T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999MI002693A IT1315267B1 (it)	1999-12-23	1999-12-23	Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale
PCT/EP2000/013068 WO2001047916A1 (en)	1999-12-23	2000-12-21	2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity

Publications (1)

Publication Number	Publication Date
ATE302772T1 true ATE302772T1 (de)	2005-09-15

Family

ID=11384182

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00985225T ATE302772T1 (de)	1999-12-23	2000-12-21	2-(1h-indol-3-yl)-2-oxo-acetamide mit antitumoraler wirkung

Country Status (24)

Country	Link
US (1)	US6753342B2 (de)
EP (1)	EP1244652B1 (de)
JP (1)	JP2003519140A (de)
KR (1)	KR100795533B1 (de)
CN (1)	CN1250542C (de)
AT (1)	ATE302772T1 (de)
AU (1)	AU776332B2 (de)
BR (1)	BR0016553A (de)
CA (1)	CA2395205A1 (de)
CZ (1)	CZ20022170A3 (de)
DE (1)	DE60022227T2 (de)
EA (1)	EA004925B1 (de)
ES (1)	ES2246918T3 (de)
HU (1)	HUP0203524A3 (de)
IL (2)	IL150329A0 (de)
IT (1)	IT1315267B1 (de)
MX (1)	MXPA02006217A (de)
NO (1)	NO323312B1 (de)
NZ (1)	NZ519689A (de)
PL (1)	PL356541A1 (de)
SK (1)	SK285682B6 (de)
TR (1)	TR200201613T2 (de)
WO (1)	WO2001047916A1 (de)
ZA (1)	ZA200204964B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA59443C2 (uk)	1998-04-28	2003-09-15	Арцнайміттельверк Дрезден Гмбх	Гідроксііндол, спосіб його одержання, лікарська форма на його основі та спосіб її одержання
IT1318641B1 (it) *	2000-07-25	2003-08-27	Novuspharma Spa	Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale.
DE10037310A1 (de)	2000-07-28	2002-02-07	Asta Medica Ag	Neue Indolderivate und deren Verwendung als Arzneimittel
US7649012B2 (en) *	2002-07-09	2010-01-19	Fasgen, Inc.	Compounds, pharmaceutical compositions containing same, and methods of use for same
AU2004270733B2 (en)	2003-09-11	2011-05-19	Itherx Pharma, Inc.	Cytokine inhibitors
AU2005229522A1 (en) *	2004-03-11	2005-10-13	Actelion Pharmaceuticals Ltd.	Indol-1-yl-acetic acid derivatives
CA2648719C (en)	2006-04-07	2015-02-24	Vertex Pharmaceuticals Incorporated	Modulators of atp-binding cassette transporters
US7645789B2 (en)	2006-04-07	2010-01-12	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US10022352B2 (en)	2006-04-07	2018-07-17	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
WO2008019357A2 (en) *	2006-08-07	2008-02-14	Ironwood Pharmaceuticals, Inc.	Indole compounds
US8563573B2 (en)	2007-11-02	2013-10-22	Vertex Pharmaceuticals Incorporated	Azaindole derivatives as CFTR modulators
US8802868B2 (en)	2010-03-25	2014-08-12	Vertex Pharmaceuticals Incorporated	Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
NZ734535A (en)	2010-04-22	2019-05-31	Vertex Pharma	Process of producing cycloalkylcarboxamido-indole compounds
AR084433A1 (es)	2010-12-22	2013-05-15	Ironwood Pharmaceuticals Inc	Inhibidores de la faah y composiciones farmaceuticas que los contienen
US9056851B2 (en)	2011-03-25	2015-06-16	The Research Foundation For The State University Of New York	Thiolactone antibiotics
CA2878057A1 (en)	2012-07-16	2014-01-23	Rossitza Gueorguieva Alargova	Pharmaceutical compositions of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
LT3131582T (lt)	2014-04-15	2018-10-25	Vertex Pharmaceuticals Incorporated	Farmacinės kompozicijos, skirtos cistinės fibrozės transmembraninio laidumo reguliatorių sukeltų ligų gydymui
CN115785079B (zh) *	2022-11-28	2024-02-13	沈阳药科大学	4-(1h-吲哚-5-基)氨基呋喃-2(5h)-酮类化合物及其制备和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69624115T2 (de) *	1995-08-02	2003-06-18	Newcastle University Ventures Ltd., Jesmond	Benzimidazol verbindungen
CO4970714A1 (es) *	1997-09-05	2000-11-07	Boehringer Mannheim Gmbh	Derivados ureido y tioureido de 4-amino-2(5h)-furanonas y 4-amino-2(5h) tiofenonas como agentes antitumorales
DE19814838C2 (de) *	1998-04-02	2001-01-18	Asta Medica Ag	Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
UA59443C2 (uk) *	1998-04-28	2003-09-15	Арцнайміттельверк Дрезден Гмбх	Гідроксііндол, спосіб його одержання, лікарська форма на його основі та спосіб її одержання

1999
- 1999-12-23 IT IT1999MI002693A patent/IT1315267B1/it active
2000
- 2000-12-21 HU HU0203524A patent/HUP0203524A3/hu unknown
- 2000-12-21 DE DE60022227T patent/DE60022227T2/de not_active Expired - Fee Related
- 2000-12-21 CZ CZ20022170A patent/CZ20022170A3/cs unknown
- 2000-12-21 KR KR1020027007960A patent/KR100795533B1/ko not_active IP Right Cessation
- 2000-12-21 MX MXPA02006217A patent/MXPA02006217A/es active IP Right Grant
- 2000-12-21 AT AT00985225T patent/ATE302772T1/de not_active IP Right Cessation
- 2000-12-21 ES ES00985225T patent/ES2246918T3/es not_active Expired - Lifetime
- 2000-12-21 EP EP00985225A patent/EP1244652B1/de not_active Expired - Lifetime
- 2000-12-21 JP JP2001549386A patent/JP2003519140A/ja active Pending
- 2000-12-21 AU AU21704/01A patent/AU776332B2/en not_active Ceased
- 2000-12-21 CA CA002395205A patent/CA2395205A1/en not_active Abandoned
- 2000-12-21 EA EA200200558A patent/EA004925B1/ru not_active IP Right Cessation
- 2000-12-21 IL IL15032900A patent/IL150329A0/xx active IP Right Grant
- 2000-12-21 US US10/149,406 patent/US6753342B2/en not_active Expired - Fee Related
- 2000-12-21 SK SK896-2002A patent/SK285682B6/sk not_active IP Right Cessation
- 2000-12-21 PL PL00356541A patent/PL356541A1/xx not_active IP Right Cessation
- 2000-12-21 CN CNB00817492XA patent/CN1250542C/zh not_active Expired - Fee Related
- 2000-12-21 WO PCT/EP2000/013068 patent/WO2001047916A1/en active IP Right Grant
- 2000-12-21 BR BR0016553-0A patent/BR0016553A/pt not_active Application Discontinuation
- 2000-12-21 NZ NZ519689A patent/NZ519689A/en unknown
- 2000-12-21 TR TR2002/01613T patent/TR200201613T2/xx unknown
2002
- 2002-06-19 IL IL150329A patent/IL150329A/en not_active IP Right Cessation
- 2002-06-20 ZA ZA200204964A patent/ZA200204964B/en unknown
- 2002-06-20 NO NO20022976A patent/NO323312B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU2170401A (en)	2001-07-09
ITMI992693A0 (it)	1999-12-23
IL150329A0 (en)	2002-12-01
EA200200558A1 (ru)	2002-12-26
EP1244652A1 (de)	2002-10-02
DE60022227T2 (de)	2006-06-22
EP1244652B1 (de)	2005-08-24
KR20020063247A (ko)	2002-08-01
AU776332B2 (en)	2004-09-02
CN1413205A (zh)	2003-04-23
SK285682B6 (sk)	2007-06-07
DE60022227D1 (de)	2005-09-29
NO20022976L (no)	2002-06-20
CN1250542C (zh)	2006-04-12
HUP0203524A3 (en)	2008-01-28
US20030158153A1 (en)	2003-08-21
JP2003519140A (ja)	2003-06-17
PL356541A1 (en)	2004-06-28
CZ20022170A3 (cs)	2002-09-11
ES2246918T3 (es)	2006-03-01
CA2395205A1 (en)	2001-07-05
KR100795533B1 (ko)	2008-01-16
NO20022976D0 (no)	2002-06-20
ITMI992693A1 (it)	2001-06-23
IT1315267B1 (it)	2003-02-03
SK8962002A3 (en)	2002-11-06
NO323312B1 (no)	2007-03-12
BR0016553A (pt)	2002-09-17
ZA200204964B (en)	2004-01-29
MXPA02006217A (es)	2004-02-26
US6753342B2 (en)	2004-06-22
EA004925B1 (ru)	2004-10-28
TR200201613T2 (tr)	2002-10-21
WO2001047916A1 (en)	2001-07-05
HUP0203524A2 (hu)	2003-03-28
IL150329A (en)	2006-07-05
NZ519689A (en)	2004-02-27

Publication	Publication Date	Title
ATE302772T1 (de)	2005-09-15	2-(1h-indol-3-yl)-2-oxo-acetamide mit antitumoraler wirkung
DE69918422D1 (de)	2004-08-05	Phthalazinone pde iii/iv hemmer
DE60208355D1 (de)	2006-02-02	2-amino-propanol derivate
ATE248175T1 (de)	2003-09-15	Epothilonderivate und ihre verwendung als antitumormittel
EE200000033A (et)	2000-10-16	Uudsed tetrasoolderivaadid
DK1042319T3 (da)	2004-06-01	Dihydrobenzofuraner
PT1086096E (pt)	2003-12-31	Benzamidas com substituintes etra-hidrofuraniloxi como inibidores da fosfodiesterase 4
DE60005689D1 (de)	2003-11-06	Neue aminobenzophenone
ATE259813T1 (de)	2004-03-15	Triazolopyrimidinderivate
MXPA05010651A (es)	2005-12-12	Compuestos de pirazol.
DE60202669D1 (de)	2005-02-24	6-phenylbenzonaphthyidine
ATE330958T1 (de)	2006-07-15	Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate
ATE286887T1 (de)	2005-01-15	Antibakterielle mittel
ES2159489A1 (es)	2001-10-01	Nuevos derivados de imidazol con actividad antiinflamatoria.
ATE213236T1 (de)	2002-02-15	Substituierte benzyloxyimino-verbindungen
ATE218138T1 (de)	2002-06-15	N-substituierte azabicycloheptan-derivate, ihre herstellung und verwendung
ATE243698T1 (de)	2003-07-15	1,2-dihydro-1-oxo-pyrazino(1,2-)indolederivate
ES2166710A1 (es)	2003-12-01	Nuevos compuestos heterociclicos con actividad antiinflamatoria.
CY1110467T1 (el)	2015-04-29	2-(ετερο-)αρυλιο υποκατεστημενα παραγωγα τετραϋδροκινολινης
CY1110529T1 (el)	2015-04-29	Παρασκευη ν-υποκατεστημενων 2,7-διαλκυλο-4-υδροξυ-5-αμινο-8-αρυλοοκτανοϋλαμιδιων
DE602004018276D1 (de)	2009-01-22	Nitratester von phenylaminothiophen-essigsäurederivaten
TR200100476T2 (tr)	2001-07-23	N-İkameli azabisikloheptan türevlerinin üretimleri ve kullanımları.

Legal Events

Date	Code	Title	Description
2006-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties