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ATE294189T1 - Kristallisation von proteinen - Google Patents

Kristallisation von proteinen

Info

Publication number
ATE294189T1
ATE294189T1 AT98901323T AT98901323T ATE294189T1 AT E294189 T1 ATE294189 T1 AT E294189T1 AT 98901323 T AT98901323 T AT 98901323T AT 98901323 T AT98901323 T AT 98901323T AT E294189 T1 ATE294189 T1 AT E294189T1
Authority
AT
Austria
Prior art keywords
solution
value
providing
crystalization
proteins
Prior art date
Application number
AT98901323T
Other languages
English (en)
Inventor
Jean Lesley Whittingham
Per Balschmidt
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE294189T1 publication Critical patent/ATE294189T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT98901323T 1997-02-07 1998-02-03 Kristallisation von proteinen ATE294189T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK14697 1997-02-07
PCT/DK1998/000042 WO1998034953A1 (en) 1997-02-07 1998-02-03 Crystallisation of proteins

Publications (1)

Publication Number Publication Date
ATE294189T1 true ATE294189T1 (de) 2005-05-15

Family

ID=8090294

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98901323T ATE294189T1 (de) 1997-02-07 1998-02-03 Kristallisation von proteinen

Country Status (7)

Country Link
EP (1) EP0966482B1 (de)
JP (1) JP3343129B2 (de)
AT (1) ATE294189T1 (de)
AU (1) AU5749198A (de)
DE (1) DE69829953T2 (de)
ES (1) ES2242270T3 (de)
WO (1) WO1998034953A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU747926B2 (en) 1997-10-24 2002-05-30 Eli Lilly And Company Insoluble insulin compositions
US6531448B1 (en) 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
PT1146896E (pt) * 1999-01-26 2002-10-31 Lilly Co Eli Formulacoes monodispersas de analogo acilado e hexamerico insulina
WO2008102469A1 (ja) * 2007-02-23 2008-08-28 Kwansei Gakuin Educational Foundation 蛋白質結晶化剤および蛋白質結晶化剤を用いた蛋白質結晶化方法
JP6169354B2 (ja) * 2009-08-11 2017-07-26 バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ クロマトグラフィーの方法およびその精製化合物
MX342922B (es) 2011-02-01 2016-10-19 Novo Nordisk As Purificacion de insulina.
EP3185887B1 (de) * 2014-08-26 2021-03-10 Merck Sharp & Dohme Corp. Verfahren zur herstellung von kristallinem insulin oder insulin-analog-zusammensetzungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3856771A (en) * 1973-07-16 1974-12-24 Lilly Co Eli Process for manufacturing alkali metal or ammonium insulin
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5700904A (en) * 1995-06-07 1997-12-23 Eli Lilly And Company Preparation of an acylated protein powder

Also Published As

Publication number Publication date
WO1998034953A1 (en) 1998-08-13
DE69829953T2 (de) 2006-03-02
JP3343129B2 (ja) 2002-11-11
AU5749198A (en) 1998-08-26
DE69829953D1 (de) 2005-06-02
ES2242270T3 (es) 2005-11-01
EP0966482B1 (de) 2005-04-27
JP2000510161A (ja) 2000-08-08
EP0966482A1 (de) 1999-12-29

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Legal Events

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