ATE291585T1 - Traf-inhibitoren - Google Patents
Traf-inhibitorenInfo
- Publication number
- ATE291585T1 ATE291585T1 AT96927409T AT96927409T ATE291585T1 AT E291585 T1 ATE291585 T1 AT E291585T1 AT 96927409 T AT96927409 T AT 96927409T AT 96927409 T AT96927409 T AT 96927409T AT E291585 T1 ATE291585 T1 AT E291585T1
- Authority
- AT
- Austria
- Prior art keywords
- traf
- inhibitors
- trafs
- pharmaceuticals
- nucleic acid
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102100034779 TRAF family member-associated NF-kappa-B activator Human genes 0.000 abstract 1
- 101710140983 TRAF family member-associated NF-kappa-B activator Proteins 0.000 abstract 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 108091006086 inhibitor proteins Proteins 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 238000007423 screening assay Methods 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US238295P | 1995-08-17 | 1995-08-17 | |
| PCT/US1996/013129 WO1997007134A1 (en) | 1995-08-17 | 1996-08-14 | Traf inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE291585T1 true ATE291585T1 (de) | 2005-04-15 |
Family
ID=21700513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96927409T ATE291585T1 (de) | 1995-08-17 | 1996-08-14 | Traf-inhibitoren |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US5789550A (de) |
| EP (2) | EP0845005B1 (de) |
| JP (2) | JP4382878B2 (de) |
| AT (1) | ATE291585T1 (de) |
| AU (1) | AU709535B2 (de) |
| CA (1) | CA2227174A1 (de) |
| DE (1) | DE69634512T2 (de) |
| DK (1) | DK0845005T3 (de) |
| ES (1) | ES2239334T3 (de) |
| IL (1) | IL122980A0 (de) |
| NZ (1) | NZ315514A (de) |
| WO (1) | WO1997007134A1 (de) |
| ZA (1) | ZA966663B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA966663B (en) * | 1995-08-17 | 1998-02-06 | Genentech Inc | Traf Inhibitors. |
| US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
| DE122010000048I1 (de) * | 1996-12-23 | 2011-05-05 | Immunex Corp | Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie |
| US6723517B1 (en) | 1998-06-02 | 2004-04-20 | Minerva Biotechnologies Corporation | Use of self-assembled monolayers to probe the structure of a target molecule |
| WO1999067380A1 (en) * | 1998-06-22 | 1999-12-29 | Temple University - Of The Commonwealth System Of Higher Education | c-Cbl SUPPRESSION OF NEOPLASTIC TRANSFORMATION |
| JP2003510049A (ja) * | 1999-09-23 | 2003-03-18 | ライジェル・ファーマシューティカルズ・インコーポレイテッド | Ｔｒａｆ４関連細胞周期タンパク質、組成物および使用法 |
| WO2002064786A1 (fr) * | 2001-02-15 | 2002-08-22 | Mochida Pharmaceutical Co., Ltd. | Nouveau gene tcif |
| WO2002098458A1 (en) * | 2001-06-07 | 2002-12-12 | Medvet Science Pty Ltd | Sphingosine kinase interacts with traf2 and modulates tumor necrosis factor-induced cellular activity |
| PT2087908T (pt) | 2001-06-26 | 2018-07-16 | Amgen Inc | Anticorpos contra opgl |
| US20030083304A1 (en) * | 2001-10-09 | 2003-05-01 | Smart Robert C. | CCAAT/enhancer binding protein-beta (C/EBPbeta) is a molecular target for cancer treatment |
| IL145918A0 (en) * | 2001-10-14 | 2002-07-25 | Ares Trading Sa | Method and kit for monitoring recruitment of proteins to the intracellular domain of a receptor in intact cells |
| MXPA05001268A (es) * | 2002-08-01 | 2005-10-06 | Wyeth Corp | Metodos y reactivos relacionados con la inflamacion y apoptosis. |
| US20080254029A1 (en) * | 2007-04-11 | 2008-10-16 | Alcon Research, Ltd. | Use of an Inhibitor of TNFa Plus an Antihistamine to Treat Allergic Rhinitis and Allergic Conjunctivitis |
| US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
| US9486498B2 (en) * | 2008-05-19 | 2016-11-08 | Case Western Reserve University | Method of treating CD40-mediated diseases |
| US10669345B2 (en) * | 2008-05-19 | 2020-06-02 | Case Western Reserve University | Method for treating CD40-mediated diseases |
| WO2010090857A2 (en) | 2009-01-21 | 2010-08-12 | Vertex Pharmaceuticals Incorporated | Methods for amplifying hepatitis c virus nucleic acids |
| KR20120091037A (ko) * | 2009-10-01 | 2012-08-17 | 알콘 리서치, 리미티드 | 올로파타딘 조성물 및 그의 용도 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3613167A1 (de) * | 1986-04-18 | 1987-10-29 | Basf Ag | Verwendung von tnf zur herstellung von arzneimitteln |
| US5108901A (en) | 1988-09-02 | 1992-04-28 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
| US5395760A (en) * | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
| EP0417563B1 (de) * | 1989-09-12 | 2000-07-05 | F. Hoffmann-La Roche Ag | TNF-bindende Proteine |
| US5318890A (en) | 1991-05-06 | 1994-06-07 | The Regents Of The University Of California | Assays for inhibitors of leukocyte adhesion |
| WO1996020723A1 (en) * | 1994-12-30 | 1996-07-11 | Brigham & Women's Hospital | Controlling traf-mediated signals |
| ZA966663B (en) * | 1995-08-17 | 1998-02-06 | Genentech Inc | Traf Inhibitors. |
-
1996
- 1996-08-06 ZA ZA9606663A patent/ZA966663B/xx unknown
- 1996-08-14 US US08/700,749 patent/US5789550A/en not_active Expired - Lifetime
- 1996-08-14 DK DK96927409T patent/DK0845005T3/da active
- 1996-08-14 AU AU67237/96A patent/AU709535B2/en not_active Ceased
- 1996-08-14 CA CA002227174A patent/CA2227174A1/en not_active Abandoned
- 1996-08-14 ES ES96927409T patent/ES2239334T3/es not_active Expired - Lifetime
- 1996-08-14 WO PCT/US1996/013129 patent/WO1997007134A1/en active IP Right Grant
- 1996-08-14 AT AT96927409T patent/ATE291585T1/de not_active IP Right Cessation
- 1996-08-14 NZ NZ315514A patent/NZ315514A/xx not_active IP Right Cessation
- 1996-08-14 EP EP96927409A patent/EP0845005B1/de not_active Expired - Lifetime
- 1996-08-14 JP JP50942797A patent/JP4382878B2/ja not_active Expired - Lifetime
- 1996-08-14 IL IL12298096A patent/IL122980A0/xx unknown
- 1996-08-14 EP EP05075669A patent/EP1568708A3/de not_active Withdrawn
- 1996-08-14 DE DE69634512T patent/DE69634512T2/de not_active Expired - Lifetime
-
1998
- 1998-02-09 US US09/020,683 patent/US6294348B1/en not_active Expired - Fee Related
- 1998-02-09 US US09/020,467 patent/US6060303A/en not_active Expired - Fee Related
- 1998-02-09 US US09/020,685 patent/US6063585A/en not_active Expired - Fee Related
- 1998-02-09 US US09/020,684 patent/US6004553A/en not_active Expired - Lifetime
-
2003
- 2003-10-03 US US10/679,014 patent/US20040087774A1/en not_active Abandoned
-
2008
- 2008-12-12 JP JP2008317548A patent/JP2009065981A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009065981A (ja) | 2009-04-02 |
| MX9800995A (es) | 1998-10-31 |
| EP0845005B1 (de) | 2005-03-23 |
| ES2239334T3 (es) | 2005-09-16 |
| US20040087774A1 (en) | 2004-05-06 |
| DE69634512T2 (de) | 2006-02-09 |
| WO1997007134A1 (en) | 1997-02-27 |
| AU709535B2 (en) | 1999-09-02 |
| ZA966663B (en) | 1998-02-06 |
| AU6723796A (en) | 1997-03-12 |
| EP1568708A2 (de) | 2005-08-31 |
| IL122980A0 (en) | 1998-08-16 |
| JPH11511967A (ja) | 1999-10-19 |
| US6004553A (en) | 1999-12-21 |
| NZ315514A (en) | 1998-12-23 |
| EP1568708A3 (de) | 2005-10-12 |
| DK0845005T3 (da) | 2005-08-01 |
| US6063585A (en) | 2000-05-16 |
| JP4382878B2 (ja) | 2009-12-16 |
| US5789550A (en) | 1998-08-04 |
| DE69634512D1 (de) | 2005-04-28 |
| US6294348B1 (en) | 2001-09-25 |
| EP0845005A1 (de) | 1998-06-03 |
| US6060303A (en) | 2000-05-09 |
| CA2227174A1 (en) | 1997-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner | ||
| UEP | Publication of translation of european patent specification |
Ref document number: 0845005 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |