ATE291446T1 - Biomaterialien, modifiziert mit superoxid- dismutase imitatoren - Google Patents
Biomaterialien, modifiziert mit superoxid- dismutase imitatorenInfo
- Publication number
- ATE291446T1 ATE291446T1 AT00932810T AT00932810T ATE291446T1 AT E291446 T1 ATE291446 T1 AT E291446T1 AT 00932810 T AT00932810 T AT 00932810T AT 00932810 T AT00932810 T AT 00932810T AT E291446 T1 ATE291446 T1 AT E291446T1
- Authority
- AT
- Austria
- Prior art keywords
- biomaterials
- mimitators
- modified
- superoxide dismutase
- biomaterials modified
- Prior art date
Links
- 239000012620 biological material Substances 0.000 title abstract 4
- 102000019197 Superoxide Dismutase Human genes 0.000 title 1
- 108010012715 Superoxide dismutase Proteins 0.000 title 1
- 239000003054 catalyst Substances 0.000 abstract 2
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 abstract 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 238000007334 copolymerization reaction Methods 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 238000007323 disproportionation reaction Methods 0.000 abstract 1
- 230000028709 inflammatory response Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
- C08B15/05—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/48—Polyethers
- C08G18/4854—Polyethers containing oxyalkylene groups having four carbon atoms in the alkylene group
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/65—Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen
- C08G18/66—Compounds of groups C08G18/42, C08G18/48, or C08G18/52
- C08G18/6666—Compounds of group C08G18/48 or C08G18/52
- C08G18/667—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38
- C08G18/6681—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/32 or C08G18/3271 and/or polyamines of C08G18/38
- C08G18/6685—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/32 or C08G18/3271 and/or polyamines of C08G18/38 with compounds of group C08G18/3225 or polyamines of C08G18/38
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/71—Monoisocyanates or monoisothiocyanates
- C08G18/718—Monoisocyanates or monoisothiocyanates containing silicon
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/72—Polyisocyanates or polyisothiocyanates
- C08G18/73—Polyisocyanates or polyisothiocyanates acyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
- C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Catalysts (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13629899P | 1999-05-27 | 1999-05-27 | |
| PCT/US2000/014847 WO2000072893A2 (en) | 1999-05-27 | 2000-05-26 | Biomaterials modified with superoxide dismutase mimics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE291446T1 true ATE291446T1 (de) | 2005-04-15 |
Family
ID=22472236
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05006278T ATE383364T1 (de) | 1999-05-27 | 2000-05-26 | Biomaterialien, modifiziert mit superoxid- dismutase imitatoren |
| AT00932810T ATE291446T1 (de) | 1999-05-27 | 2000-05-26 | Biomaterialien, modifiziert mit superoxid- dismutase imitatoren |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05006278T ATE383364T1 (de) | 1999-05-27 | 2000-05-26 | Biomaterialien, modifiziert mit superoxid- dismutase imitatoren |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7445641B1 (de) |
| EP (1) | EP1185312B1 (de) |
| JP (1) | JP2003500174A (de) |
| AT (2) | ATE383364T1 (de) |
| AU (1) | AU5048400A (de) |
| CA (1) | CA2374472A1 (de) |
| DE (2) | DE60018925T2 (de) |
| ES (1) | ES2240101T3 (de) |
| WO (1) | WO2000072893A2 (de) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
| WO1999023097A1 (en) | 1997-11-03 | 1999-05-14 | Duke University | Substituted porphyrins |
| CN1156478C (zh) | 1999-01-25 | 2004-07-07 | 国家犹太医疗及研究中心 | 取代的卟啉 |
| WO2000072893A2 (en) | 1999-05-27 | 2000-12-07 | Monsanto Company | Biomaterials modified with superoxide dismutase mimics |
| US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
| US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
| US7101391B2 (en) | 2000-09-18 | 2006-09-05 | Inflow Dynamics Inc. | Primarily niobium stent |
| US7402173B2 (en) | 2000-09-18 | 2008-07-22 | Boston Scientific Scimed, Inc. | Metal stent with surface layer of noble metal oxide and method of fabrication |
| US20040137638A1 (en) | 2002-03-04 | 2004-07-15 | Slomczynska Urszula J. | Chromatography of metal complexes |
| EP1247537A1 (de) * | 2001-04-04 | 2002-10-09 | Isotis B.V. | Beschichtung für medizinische Vorrichtungen |
| JP2005508864A (ja) | 2001-06-01 | 2005-04-07 | ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター | 糖尿病の治療、または移植術における使用、または免疫寛容の誘導のためのオキシダントスカベンジャー |
| SI1463563T1 (sl) | 2001-12-14 | 2009-06-30 | Alcon Inc | Superoksidni dizmutazni mimetiki za zdravljenje očesnih motenj in bolezni |
| US7919075B1 (en) * | 2002-03-20 | 2011-04-05 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices |
| AU2003237500A1 (en) | 2002-06-07 | 2003-12-22 | Duke University | Substituted porphyrins |
| US6835387B2 (en) | 2002-06-11 | 2004-12-28 | Scimed Life Systems, Inc. | Sustained release of superoxide dismutase mimics from implantable or insertable medical devices |
| US20030232784A1 (en) * | 2002-06-14 | 2003-12-18 | Benedict James J. | Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain |
| MXPA05005937A (es) | 2002-12-06 | 2005-08-18 | Alcon Inc | Imitaciones de superoxido de dismutasa para el tratamiento de trastornos y enfermedades oculares. |
| US20040254629A1 (en) * | 2003-04-25 | 2004-12-16 | Brian Fernandes | Methods and apparatus for treatment of aneurysmal tissue |
| DE602004021022D1 (de) | 2003-10-28 | 2009-06-18 | Medtronic Inc | Verfahren zur herstellung von vernetzten materialien und bioprothetischen vorrichtungen |
| US7299082B2 (en) | 2003-10-31 | 2007-11-20 | Abbott Diabetes Care, Inc. | Method of calibrating an analyte-measurement device, and associated methods, devices and systems |
| MXPA06006187A (es) | 2003-12-11 | 2006-08-25 | Alcon Inc | Imitadores de super oxido dismutasa para el tratamiento de dano retinal y de nervio optico. |
| EP1559728A1 (de) * | 2004-01-28 | 2005-08-03 | Total Petrochemicals Research Feluy | Pfropfung von Übergangsmetallkomplexen auf Trägern |
| US8165651B2 (en) | 2004-02-09 | 2012-04-24 | Abbott Diabetes Care Inc. | Analyte sensor, and associated system and method employing a catalytic agent |
| US7971333B2 (en) * | 2006-05-30 | 2011-07-05 | Advanced Cardiovascular Systems, Inc. | Manufacturing process for polymetric stents |
| US9050393B2 (en) * | 2005-02-08 | 2015-06-09 | Bruce N. Saffran | Medical devices and methods for modulation of physiology using device-based surface chemistry |
| US20070014726A1 (en) * | 2005-07-18 | 2007-01-18 | Sensors For Medicine And Science | Oxidation-resistant indicator macromolecule |
| US7785647B2 (en) * | 2005-07-25 | 2010-08-31 | Advanced Cardiovascular Systems, Inc. | Methods of providing antioxidants to a drug containing product |
| US8394446B2 (en) | 2005-07-25 | 2013-03-12 | Abbott Cardiovascular Systems Inc. | Methods of providing antioxidants to implantable medical devices |
| EP1924299B1 (de) | 2005-08-18 | 2009-11-25 | Zimmer GmbH | Ultrahochmolekulare polyethylen-artikel und verfahren zur herstellung von ultrahochmolekularen polyethylen-artikeln |
| US20070141532A1 (en) * | 2005-12-20 | 2007-06-21 | Ford Christopher W | Force distributing dental implant assembly |
| US7682152B2 (en) | 2005-12-20 | 2010-03-23 | Ford Christopher W | Force distributing dental implant assembly |
| US8647654B2 (en) * | 2005-12-22 | 2014-02-11 | The Penn State Research Foundation | Method and systems for forming and using nanoengineered sculptured thin films |
| US20070160642A1 (en) * | 2006-01-12 | 2007-07-12 | Pacetti Stephen D | Implantable medical devices coated with a polymer-bound superoxide dismutase mimic |
| US7885698B2 (en) | 2006-02-28 | 2011-02-08 | Abbott Diabetes Care Inc. | Method and system for providing continuous calibration of implantable analyte sensors |
| HUE044234T2 (hu) | 2006-10-12 | 2019-10-28 | Galera Labs Llc | Eljárások szájnyálkahártya-gyulladás kezelésére |
| ES2378721T3 (es) | 2007-04-10 | 2012-04-17 | Zimmer, Inc. | Polietileno reticulado de peso molecular ultra alto estabilizado por antioxidantes para aplicaciones en dispositivos médicos |
| US8664290B2 (en) | 2007-04-10 | 2014-03-04 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
| US8425542B2 (en) * | 2007-04-27 | 2013-04-23 | Wisconsin Alumni Research Foundation | Aneurysm occlusion device containing bioactive and biocompatible copolymer shell and biocompatible metallic frame member |
| US8652212B2 (en) | 2008-01-30 | 2014-02-18 | Zimmer, Inc. | Orthopedic component of low stiffness |
| US8011926B2 (en) | 2008-05-15 | 2011-09-06 | Ford Christopher W | Polymeric dental implant assembly |
| US11382895B2 (en) | 2008-05-23 | 2022-07-12 | National Jewish Health | Methods for treating injury associated with exposure to an alkylating species |
| EP2966108B1 (de) * | 2008-08-22 | 2021-03-31 | Saudi Aramco Technologies Company | Katalysatoren und verfahren zur synthese von polymeren |
| WO2010057644A1 (en) | 2008-11-20 | 2010-05-27 | Zimmer Gmbh | Polyethylene materials |
| US8332042B2 (en) * | 2009-01-15 | 2012-12-11 | Medtronic, Inc. | Medical lead with stiffening coil |
| US8399535B2 (en) | 2010-06-10 | 2013-03-19 | Zimmer, Inc. | Polymer [[s]] compositions including an antioxidant |
| WO2013048965A1 (en) | 2011-09-26 | 2013-04-04 | Galera Therapeutics, Llc | Methods for treatment of diseases |
| JP2016523588A (ja) | 2013-05-06 | 2016-08-12 | アボット カーディオヴァスキュラー システムズ インコーポレイテッド | 治療剤配合物が充填されている中空ステント |
| WO2015050851A1 (en) | 2013-10-01 | 2015-04-09 | Zimmer, Inc. | Polymer compositions comprising one or more protected antioxidants |
| AU2014374361B9 (en) | 2013-12-31 | 2019-07-04 | Abbott Diabetes Care Inc. | Self-powered analyte sensor and devices using the same |
| CA2942565A1 (en) | 2014-03-12 | 2015-09-17 | Zimmer, Inc. | Melt-stabilized ultra high molecular weight polyethylene and method of making the same |
| EP3227360B1 (de) | 2014-12-03 | 2024-10-16 | Zimmer, Inc. | Mit antioxidationsmittel infundiertes polyethylen mit ultrahohem molekulargewicht |
| HRP20201092T1 (hr) | 2015-08-11 | 2020-10-30 | Galera Labs, Llc | Pentaaza makrociklički prstenasti kompleksi koji posjeduju oralnu biološku dostupnost |
| JP2019514962A (ja) | 2016-05-03 | 2019-06-06 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーGalera Labs, Llc | 癌治療のための組み合わせ療法 |
| EP3506907B1 (de) | 2016-09-01 | 2023-06-07 | Galera Labs, LLC | Kombinierte krebstherapie mit einem pentaaza-makrocyclischen ring-komplex und einer ascorbatverbindung |
| IL295620B2 (en) | 2017-04-13 | 2024-01-01 | Galera Labs Llc | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| JP2020532643A (ja) * | 2017-09-01 | 2020-11-12 | ピーエムアイディージー・エルエルシーPmidg,Llc | 官能基化および架橋ポリマー |
| US12049026B2 (en) * | 2020-09-17 | 2024-07-30 | Nutech Ventures | Method of reinforcement for keratin materials |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US540383A (en) * | 1895-06-04 | Means for lubricating bearings of steam-engines | ||
| US580458A (en) * | 1897-04-13 | Knotter mechanism fo r grain-binders | ||
| US3506411A (en) * | 1966-11-16 | 1970-04-14 | Amp Inc | Cold crimped sleeve applicator |
| DE3134896C2 (de) | 1981-09-03 | 1985-03-28 | W.C. Heraeus Gmbh, 6450 Hanau | Kabelzuleitung für Herzschrittmacher-Elektroden |
| US4718908A (en) | 1984-06-04 | 1988-01-12 | Richards Medical Company | High-strength, cold-forged type 316L stainless steel for orthopedic implant |
| JPS61135671A (ja) | 1984-12-04 | 1986-06-23 | 三菱鉱業セメント株式会社 | インプラント材 |
| US4863964A (en) * | 1985-07-02 | 1989-09-05 | Biomedical Frontiers, Inc. | Method for the stabilization of deferoxamine to chelate free ions in physiological fluid |
| US4775426A (en) | 1986-04-03 | 1988-10-04 | Richards Medical Company | Method of manufacturing surgical implants from cast stainless steel and product |
| US5227405A (en) * | 1987-03-31 | 1993-07-13 | Duke University | Superoxide dismutase mimic |
| US5334371A (en) * | 1988-07-20 | 1994-08-02 | Schering Aktiengesellschaft | Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI |
| JPH02231078A (ja) | 1989-03-03 | 1990-09-13 | Ube Ind Ltd | ヒアルロン酸修飾スーパーオキシドジスムターゼ |
| US5252720A (en) | 1989-03-06 | 1993-10-12 | Board Of Regents, The University Of Texas System | Metal complexes of water soluble texaphyrins |
| JP2858126B2 (ja) | 1989-06-30 | 1999-02-17 | 京セラ株式会社 | 生体インプラント材とその製法 |
| US5386012A (en) | 1990-02-06 | 1995-01-31 | Strid; Lars | Growth factor in connection with artificial implants |
| US5545208A (en) * | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
| US5626863A (en) | 1992-02-28 | 1997-05-06 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| WO1992014422A1 (fr) | 1991-02-20 | 1992-09-03 | Tdk Corporation | Bio-implant composite et methode de production |
| US5326568A (en) * | 1991-05-03 | 1994-07-05 | Giampapa Vincent C | Method of tissue-specific delivery |
| CA2072934C (en) * | 1991-07-19 | 2007-08-28 | Karl William Aston | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| JP3155552B2 (ja) | 1991-07-19 | 2001-04-09 | モンサント カンパニー | 超酸化物の不均斉変化に有効な触媒としての窒素含有−大環状リガンドのマンガン錯体 |
| EP0579802B1 (de) | 1991-12-10 | 2000-04-26 | The Dow Chemical Company | Bicylclische, polyazamakrocyclocarbonsäure-komplexe, konjugate, herstellung und verwendung als kontraststoffe |
| US5176745A (en) * | 1991-12-11 | 1993-01-05 | Milliken Research Corporation | Aqueous ink composition and colorants useful therein |
| US5507767A (en) | 1992-01-15 | 1996-04-16 | Cook Incorporated | Spiral stent |
| US5876452A (en) | 1992-02-14 | 1999-03-02 | Board Of Regents, University Of Texas System | Biodegradable implant |
| US5879359A (en) | 1992-08-03 | 1999-03-09 | Fidia S.P.A. | Biodegradable guide channels comprised of esters of hyaluronic acid for use in tissue repair as surgical aids |
| US5840319A (en) | 1992-10-08 | 1998-11-24 | Alakhov; Valery Yu | Biological agent compositions |
| US5402834A (en) * | 1992-11-25 | 1995-04-04 | Merck & Co., Inc. | Solution preparation system |
| US5403834A (en) | 1992-12-07 | 1995-04-04 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
| US5834509A (en) | 1992-12-07 | 1998-11-10 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
| US5696109A (en) * | 1992-12-07 | 1997-12-09 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
| CN1088069A (zh) | 1992-12-18 | 1994-06-22 | 胡耀祖 | 香味健美胸罩 |
| US6204259B1 (en) | 1993-01-14 | 2001-03-20 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| US5836313A (en) | 1993-02-08 | 1998-11-17 | Massachusetts Institute Of Technology | Methods for making composite hydrogels for corneal prostheses |
| US6294185B1 (en) | 1993-03-12 | 2001-09-25 | Auburn University | Monomeric and polymeric cyclic amine and N-halamine compounds |
| EP1695698B1 (de) * | 1993-07-19 | 2011-03-23 | Angiotech Pharmaceuticals, Inc. | Anti-Angiogene Mittel und Verfahren zu deren Verwendung |
| US5626861A (en) | 1994-04-01 | 1997-05-06 | Massachusetts Institute Of Technology | Polymeric-hydroxyapatite bone composite |
| GB9407812D0 (en) * | 1994-04-20 | 1994-06-15 | Nycomed Salutar Inc | Compounds |
| CA2188530A1 (en) | 1994-04-22 | 1995-11-02 | John Charles Alexander | Diagnostic image analysis with metal complexes |
| US5525621A (en) * | 1994-05-20 | 1996-06-11 | Cytos Pharmaceuticals Llc | Imidazole derivatives as protective agents in reperfusion injury and severe inflammatory responses |
| GB9412273D0 (en) | 1994-06-18 | 1994-08-10 | Univ Nottingham | Administration means |
| US5749839A (en) | 1994-08-18 | 1998-05-12 | Duke University | Direct mechanical bi-ventricular cardiac assist device |
| US5817303A (en) | 1995-05-05 | 1998-10-06 | Protein Polymer Technologies, Inc. | Bonding together tissue with adhesive containing polyfunctional crosslinking agent and protein polymer |
| AU6031096A (en) * | 1995-06-05 | 1996-12-24 | Duke University | Nitrosylated and nitrated superoxide oxidants and reductants |
| US6525041B1 (en) | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| AU716005B2 (en) * | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
| JPH11507621A (ja) | 1995-06-07 | 1999-07-06 | モンサント カンパニー | 置換ポリアザ大環状化合物の製造法 |
| US6774278B1 (en) * | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
| US5609629A (en) * | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
| WO1997006830A1 (en) | 1995-08-17 | 1997-02-27 | Monsanto Company | Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands |
| US5665428A (en) | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
| JP3008833B2 (ja) * | 1995-10-25 | 2000-02-14 | トヨタ自動車株式会社 | 車体の横滑り速度推定装置 |
| US5830539A (en) | 1995-11-17 | 1998-11-03 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Methods for functionalizing and coating substrates and devices made according to the methods |
| US5861032A (en) | 1996-01-31 | 1999-01-19 | Surface Genesis, Inc. | Medical device having a biocompatible coating and oxidation method of coupling therefor |
| CA2248964A1 (en) * | 1996-03-13 | 1997-09-18 | Monsanto Company | Iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| AU1962497A (en) * | 1996-03-13 | 1997-10-01 | Monsanto Company | Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| US5891862A (en) | 1996-03-15 | 1999-04-06 | Geltex Pharmaceuticals, Inc. | Polyvalent polymers for the treatment of rotavirus infection |
| US5876433A (en) | 1996-05-29 | 1999-03-02 | Ethicon, Inc. | Stent and method of varying amounts of heparin coated thereon to control treatment |
| US5824047A (en) | 1996-10-11 | 1998-10-20 | C. R. Bard, Inc. | Vascular graft fabric |
| US5877263A (en) | 1996-11-25 | 1999-03-02 | Meadox Medicals, Inc. | Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents |
| JPH10279605A (ja) * | 1997-04-04 | 1998-10-20 | Touin Gakuen | 錯体組成物 |
| JPH10298531A (ja) * | 1997-04-23 | 1998-11-10 | Touin Gakuen | 金属錯体導入不溶性支持体 |
| US5879697A (en) | 1997-04-30 | 1999-03-09 | Schneider Usa Inc | Drug-releasing coatings for medical devices |
| US5885609A (en) | 1997-05-23 | 1999-03-23 | Northeastern University | Biocompatible articles and method for making same |
| US6180620B1 (en) | 1997-06-20 | 2001-01-30 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
| US5837752A (en) * | 1997-07-17 | 1998-11-17 | Massachusetts Institute Of Technology | Semi-interpenetrating polymer networks |
| US5851227A (en) | 1997-07-30 | 1998-12-22 | Sulzer Intermedics Inc. | Cardiac pacemaker cable lead |
| EP1045676A1 (de) * | 1997-08-26 | 2000-10-25 | Technion Research & Development Foundation Ltd. | Intravaskuläre vorrichtung sowie anwendungsverfahren |
| US6323218B1 (en) * | 1998-03-11 | 2001-11-27 | The General Hospital Corporation | Agents for use in the treatment of Alzheimer's disease |
| AU4699799A (en) * | 1998-06-19 | 2000-01-05 | Oxibio, Inc. | Medical device having anti-infective and contraceptive properties |
| US20040110722A1 (en) | 1999-05-27 | 2004-06-10 | Ornberg Richard L. | Modified hyaluronic acid polymers |
| WO2000072893A2 (en) | 1999-05-27 | 2000-12-07 | Monsanto Company | Biomaterials modified with superoxide dismutase mimics |
| US20030232784A1 (en) | 2002-06-14 | 2003-12-18 | Benedict James J. | Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain |
-
2000
- 2000-05-26 WO PCT/US2000/014847 patent/WO2000072893A2/en not_active Ceased
- 2000-05-26 JP JP2000620999A patent/JP2003500174A/ja active Pending
- 2000-05-26 EP EP00932810A patent/EP1185312B1/de not_active Expired - Lifetime
- 2000-05-26 DE DE60018925T patent/DE60018925T2/de not_active Expired - Lifetime
- 2000-05-26 AU AU50484/00A patent/AU5048400A/en not_active Abandoned
- 2000-05-26 DE DE60037768T patent/DE60037768T2/de not_active Expired - Lifetime
- 2000-05-26 AT AT05006278T patent/ATE383364T1/de not_active IP Right Cessation
- 2000-05-26 ES ES00932810T patent/ES2240101T3/es not_active Expired - Lifetime
- 2000-05-26 CA CA002374472A patent/CA2374472A1/en not_active Abandoned
- 2000-05-26 AT AT00932810T patent/ATE291446T1/de not_active IP Right Cessation
- 2000-05-26 US US09/580,007 patent/US7445641B1/en not_active Expired - Fee Related
-
2003
- 2003-11-05 US US10/702,407 patent/US7004976B2/en not_active Expired - Fee Related
-
2005
- 2005-09-15 US US11/227,318 patent/US20060089710A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000072893A3 (en) | 2001-08-30 |
| WO2000072893A2 (en) | 2000-12-07 |
| EP1185312A2 (de) | 2002-03-13 |
| JP2003500174A (ja) | 2003-01-07 |
| US7445641B1 (en) | 2008-11-04 |
| CA2374472A1 (en) | 2000-12-07 |
| US7004976B2 (en) | 2006-02-28 |
| ES2240101T3 (es) | 2005-10-16 |
| DE60018925D1 (de) | 2005-04-28 |
| ATE383364T1 (de) | 2008-01-15 |
| US20060089710A1 (en) | 2006-04-27 |
| DE60018925T2 (de) | 2006-04-13 |
| DE60037768D1 (de) | 2008-02-21 |
| US20040116332A1 (en) | 2004-06-17 |
| DE60037768T2 (de) | 2009-01-15 |
| EP1185312B1 (de) | 2005-03-23 |
| AU5048400A (en) | 2000-12-18 |
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