[go: up one dir, main page]

ATE283719T1 - Vorrichtung zur elektroporation durch gewebemikroporen - Google Patents

Vorrichtung zur elektroporation durch gewebemikroporen

Info

Publication number
ATE283719T1
ATE283719T1 AT99911185T AT99911185T ATE283719T1 AT E283719 T1 ATE283719 T1 AT E283719T1 AT 99911185 T AT99911185 T AT 99911185T AT 99911185 T AT99911185 T AT 99911185T AT E283719 T1 ATE283719 T1 AT E283719T1
Authority
AT
Austria
Prior art keywords
tissue
electroporation
micropore
micropores
microporating
Prior art date
Application number
AT99911185T
Other languages
English (en)
Inventor
Jonathan A Eppstein
Michael R Hatch
Original Assignee
Spectrx Inc
Altea Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrx Inc, Altea Therapeutics Corp filed Critical Spectrx Inc
Application granted granted Critical
Publication of ATE283719T1 publication Critical patent/ATE283719T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0412Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416Anode and cathode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0472Structure-related aspects
    • A61N1/0476Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
AT99911185T 1998-03-06 1999-03-05 Vorrichtung zur elektroporation durch gewebemikroporen ATE283719T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/036,169 US6022316A (en) 1998-03-06 1998-03-06 Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
PCT/US1999/004984 WO1999044678A1 (en) 1998-03-06 1999-03-05 Apparatus for electroporation through microporated tissue

Publications (1)

Publication Number Publication Date
ATE283719T1 true ATE283719T1 (de) 2004-12-15

Family

ID=21887040

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99911185T ATE283719T1 (de) 1998-03-06 1999-03-05 Vorrichtung zur elektroporation durch gewebemikroporen

Country Status (9)

Country Link
US (1) US6022316A (de)
EP (1) EP1059960B1 (de)
JP (1) JP3619453B2 (de)
AT (1) ATE283719T1 (de)
AU (1) AU748376B2 (de)
CA (1) CA2329169C (de)
DE (1) DE69922353T2 (de)
ES (1) ES2237091T3 (de)
WO (1) WO1999044678A1 (de)

Families Citing this family (196)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060240381A1 (en) 1995-08-31 2006-10-26 Biolase Technology, Inc. Fluid conditioning system
US20090143775A1 (en) * 1995-08-31 2009-06-04 Rizoiu Ioana M Medical laser having controlled-temperature and sterilized fluid output
AU3399197A (en) * 1996-06-18 1998-01-07 Alza Corporation Device for enhancing transdermal agent delivery or sampling
CA2259437C (en) * 1996-07-03 2006-12-05 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US20060002959A1 (en) * 1996-11-14 2006-01-05 Government Of The United States Skin-sctive adjuvants for transcutaneous immuization
US5980898A (en) * 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US6517532B1 (en) 1997-05-15 2003-02-11 Palomar Medical Technologies, Inc. Light energy delivery head
US7204832B2 (en) 1996-12-02 2007-04-17 Pálomar Medical Technologies, Inc. Cooling system for a photo cosmetic device
US20060149343A1 (en) * 1996-12-02 2006-07-06 Palomar Medical Technologies, Inc. Cooling system for a photocosmetic device
US8182473B2 (en) * 1999-01-08 2012-05-22 Palomar Medical Technologies Cooling system for a photocosmetic device
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
JP4056091B2 (ja) 1997-05-15 2008-03-05 パロマー・メディカル・テクノロジーズ・インコーポレーテッド 皮膚科的治療方法及び装置
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US20050003008A1 (en) * 1997-09-23 2005-01-06 Natalya Rapoport Method of in vivo drug targeting to solid tumors via acoustically triggered drug delivery in polymeric micelles
US20040258703A1 (en) * 1997-11-14 2004-12-23 The Government Of The Us, As Represented By The Secretary Of The Army Skin-active adjuvants for transcutaneous immunization
US6173202B1 (en) 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
WO1999046005A1 (en) 1998-03-12 1999-09-16 Palomar Medical Technologies, Inc. System for electromagnetic radiation of the skin
AU761522B2 (en) 1998-07-13 2003-06-05 Genetronics, Inc. Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications
US6697669B2 (en) 1998-07-13 2004-02-24 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US6678556B1 (en) 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
ES2317699T3 (es) 1998-07-14 2009-04-16 Altea Therapeutics Corporation Eliminacion controlada de una membrana biologica mediante una carga pirotecnica para un transporte transmembranico.
US6602678B2 (en) 1998-09-04 2003-08-05 Powderject Research Limited Non- or minimally invasive monitoring methods
KR20010088797A (ko) 1998-09-04 2001-09-28 파우더젝트 리서치 리미티드 입자송출 방법을 이용한 모니터링 방법
US6059820A (en) 1998-10-16 2000-05-09 Paradigm Medical Corporation Tissue cooling rod for laser surgery
US6708060B1 (en) * 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
US6148232A (en) * 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6597946B2 (en) * 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
MXPA01009830A (es) 1999-04-01 2002-11-04 Spectrx Inc Dispositivo de ensaye de doble funcion.
CA2376368C (en) 1999-06-08 2009-08-11 Altea Technologies, Inc. Apparatus for microporation of biological membranes using thin film tissue interface devices, and method therefor
US6951411B1 (en) 1999-06-18 2005-10-04 Spectrx, Inc. Light beam generation, and focusing and redirecting device
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US20020091377A1 (en) * 2000-01-25 2002-07-11 Anderson R. Rox Method and apparatus for medical treatment utilizing long duration electromagnetic radiation
IT1320520B1 (it) * 2000-04-21 2003-12-10 Igea Srl Dispositivo e metodo di elettro-porazione in cui la misura delleproprieta' elettriche dei campioni svolta dopo l'emissione degli
US6629949B1 (en) 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6659982B2 (en) 2000-05-08 2003-12-09 Sterling Medivations, Inc. Micro infusion drug delivery device
US20050277887A1 (en) * 2000-05-08 2005-12-15 Joel Douglas Micro infusion drug delivery device
US7597692B2 (en) * 2000-06-08 2009-10-06 Massachusetts Institute Of Technology Microscission processes and procedures
US6706032B2 (en) 2000-06-08 2004-03-16 Massachusetts Institute Of Technology Localized molecular and ionic transport to and from tissues
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
TW495353B (en) 2000-09-01 2002-07-21 Bayer Ag Adjustable endcap for lancing device
PT1335711E (pt) 2000-09-08 2007-09-05 Alza Corp Dispositivo transdérmico.
IT1315449B1 (it) * 2000-09-22 2003-02-11 Elisabetta Rossi Dispositivo e metodo per il trasporto molecolare transdermico
WO2002026191A2 (en) * 2000-09-28 2002-04-04 Nanocyte Inc. Methods, compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue
US20070281037A9 (en) * 2000-09-28 2007-12-06 Nanocyte Inc. Sterile preparations and compositions including stinging capsules and methods of producing and using same
US7632522B2 (en) 2000-09-28 2009-12-15 Nanocyte Inc. Use of stinging cells/capsules for the delivery of active agents to keratinous substances
US20060020309A1 (en) * 2004-04-09 2006-01-26 Palomar Medical Technologies, Inc. Methods and products for producing lattices of EMR-treated islets in tissues, and uses therefor
EP2311399A3 (de) * 2000-12-28 2011-08-10 Palomar Medical Technologies, Inc. Verfahren und Vorrichtung zur therapeutischen Behandlung der Haut mit elektromagnetischen Strahlen (EMR)
US20080214988A1 (en) * 2000-12-28 2008-09-04 Palomar Medical Technologies, Inc. Methods And Devices For Fractional Ablation Of Tissue
DE10102817B4 (de) * 2001-01-23 2006-01-12 Lts Lohmann Therapie-Systeme Ag Vorrichtung und Verfahren zur Hitzepulsgestützten transdermalen Applikation von Wirkstoffen
CA2437899C (en) 2001-02-13 2012-05-15 Gregory M. Glenn Vaccine for transcutaneous immunization against etec-caused traveler's diarrhea
US6888319B2 (en) * 2001-03-01 2005-05-03 Palomar Medical Technologies, Inc. Flashlamp drive circuit
EP1365699A2 (de) * 2001-03-02 2003-12-03 Palomar Medical Technologies, Inc. Vorrichtung und verfahren zur fotokosmetischen und fotodermatologischen behandlung
WO2002070040A1 (en) * 2001-03-05 2002-09-12 Klaus Hoyer Skin cleaning apparatus for the removal of puss or tallow by suction
US6687537B2 (en) 2001-04-06 2004-02-03 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and cellulite reduction
US7083580B2 (en) 2001-04-06 2006-08-01 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
US7496401B2 (en) 2001-04-06 2009-02-24 Mattioli Engineering Ltd Method and apparatus for skin absorption enhancement and transdermal drug delivery
US7520875B2 (en) 2001-04-06 2009-04-21 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
US7010343B2 (en) 2001-04-06 2006-03-07 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
US6980854B2 (en) 2001-04-06 2005-12-27 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery of lidocaine and/or other drugs
US8541021B2 (en) 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
AU2002308612B2 (en) 2001-05-01 2008-04-10 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
US6790179B2 (en) 2001-08-01 2004-09-14 Johnson & Johnson Consumer Companies, Inc. Method of examining and diagnosing skin health
US6840910B2 (en) 2001-08-01 2005-01-11 Johnson & Johnson Consumer Companies, Inc. Method of distributing skin care products
US6855117B2 (en) 2001-08-01 2005-02-15 Johnson & Johnson Consumer Companies, Inc. Method of treating the skin of a subject
US6733485B1 (en) 2001-05-25 2004-05-11 Advanced Bionics Corporation Microstimulator-based electrochemotherapy methods and systems
AU2002353444A1 (en) 2001-11-07 2003-05-19 Transpharma Medical Ltd. Integrated transdermal drug delivery system
US20040147984A1 (en) * 2001-11-29 2004-07-29 Palomar Medical Technologies, Inc. Methods and apparatus for delivering low power optical treatments
US20030109860A1 (en) * 2001-12-12 2003-06-12 Michael Black Multiple laser treatment
US20030216719A1 (en) * 2001-12-12 2003-11-20 Len Debenedictis Method and apparatus for treating skin using patterns of optical energy
US20030109787A1 (en) * 2001-12-12 2003-06-12 Michael Black Multiple laser diagnostics
US20040082940A1 (en) * 2002-10-22 2004-04-29 Michael Black Dermatological apparatus and method
US20050049582A1 (en) * 2001-12-12 2005-03-03 Debenedictis Leonard C. Method and apparatus for fractional photo therapy of skin
US6952604B2 (en) 2001-12-21 2005-10-04 Becton, Dickinson And Company Minimally-invasive system and method for monitoring analyte levels
AU2002367397A1 (en) * 2001-12-27 2003-07-24 Palomar Medical Technologies, Inc. Method and apparatus for improved vascular related treatment
US20040073175A1 (en) * 2002-01-07 2004-04-15 Jacobson James D. Infusion system
US8116860B2 (en) * 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
US9918665B2 (en) * 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
AU2003225735A1 (en) * 2002-03-11 2003-09-29 Altea Therapeutics Corporation Transdermal drug delivery patch system, method of making same and method of using same
DE60320793D1 (de) * 2002-03-26 2008-06-19 Nanocyte Inc Nesselzellen mit expression eines exogenen polynucleotids, das ein therapeutisches, diagnostisches oder kosmetisches mittel kodiert, und diese nesselzellen verwendende verfahren, zusammensetzungen und vorrichtungen oder daraus gewonnene kapseln zur ametischen mittels in ein gewebe
WO2003089043A2 (en) 2002-04-19 2003-10-30 Transpharma Medical Ltd. Handheld transdermal drug delivery and analyte extraction
US20070213698A1 (en) * 2006-03-10 2007-09-13 Palomar Medical Technologies, Inc. Photocosmetic device
BR0311901A (pt) * 2002-06-19 2005-04-05 Gen Hospital Corp Processo e aparelho para tratamento fototérmico de tecido a fundo
US7276058B2 (en) 2002-06-19 2007-10-02 Palomar Medical Technologies, Inc. Method and apparatus for treatment of cutaneous and subcutaneous conditions
US20070219604A1 (en) * 2006-03-20 2007-09-20 Palomar Medical Technologies, Inc. Treatment of tissue with radiant energy
CA2501098C (en) 2002-10-23 2014-04-08 Palomar Medical Technologies, Inc. Phototreatment device for use with coolants and topical substances
US8133505B2 (en) * 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152575A (en) * 2002-10-31 2008-12-29 Transpharma Medical Ltd A skin-to-skin transmission system of water-insoluble drugs
US7383084B2 (en) * 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
US7662404B2 (en) * 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
IL152573A (en) 2002-10-31 2009-11-18 Transpharma Medical Ltd A system for the transmission through the skin of a medical preparation against vomiting and nausea
JP2006511275A (ja) * 2002-12-20 2006-04-06 パロマー・メディカル・テクノロジーズ・インコーポレイテッド アクネ及び他の毛胞障害の光線治療装置
US20060217695A1 (en) * 2003-12-31 2006-09-28 Debenedictis Leonard C Optically-induced treatment of internal tissue
US20070179481A1 (en) * 2003-02-14 2007-08-02 Reliant Technologies, Inc. Laser System for Treatment of Skin Laxity
US20070265606A1 (en) * 2003-02-14 2007-11-15 Reliant Technologies, Inc. Method and Apparatus for Fractional Light-based Treatment of Obstructive Sleep Apnea
KR20050100404A (ko) * 2003-02-19 2005-10-18 팔로마 메디칼 테크놀로지스, 인코포레이티드 수발 가성모낭염을 치료하기 위한 방법 및 장치
DE602004031327D1 (de) * 2003-03-27 2011-03-24 Gen Hospital Corp Gerät für die dermatologische behandlung und fraktionale oberflächenerneuerung der haut
ES2737835T3 (es) 2003-04-23 2020-01-16 Valeritas Inc Bomba accionada hidráulicamente para la administración de medicamentos de larga duración
US7258673B2 (en) * 2003-06-06 2007-08-21 Lifescan, Inc Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
US20040253736A1 (en) * 2003-06-06 2004-12-16 Phil Stout Analytical device with prediction module and related methods
US20040249254A1 (en) * 2003-06-06 2004-12-09 Joel Racchini Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
CA2529953A1 (en) * 2003-06-23 2004-12-29 Transpharma Medical Ltd. Transdermal delivery system for cosmetic agents
US7189341B2 (en) * 2003-08-15 2007-03-13 Animas Technologies, Llc Electrochemical sensor ink compositions, electrodes, and uses thereof
JP2007533346A (ja) 2003-08-15 2007-11-22 アニマス・テクノロジーズ・リミテッド・ライアビリティ・カンパニー 生理学的分析対象のモニタリングに使用するマイクロプロセッサ、デバイス、および方法
US8016811B2 (en) * 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
IL159273A0 (en) * 2003-12-09 2004-06-01 Transpharma Medical Ltd Transdermal delivery system for sustained release of polypeptides
US7220254B2 (en) * 2003-12-31 2007-05-22 Palomar Medical Technologies, Inc. Dermatological treatment with visualization
US20100151406A1 (en) 2004-01-08 2010-06-17 Dmitri Boutoussov Fluid conditioning system
JP5594925B2 (ja) 2004-01-30 2014-09-24 コリウム インターナショナル, インコーポレイテッド 活性物質の送達のための急速に溶解するフィルム
ES2629960T3 (es) * 2004-03-25 2017-08-16 University College Cork-National University Of Ireland, Cork Aparato para profilaxis o tratamiento de tejido
AU2005231443B2 (en) 2004-04-01 2012-02-23 The General Hospital Corporation Method and apparatus for dermatological treatment and tissue reshaping
US20050234440A1 (en) * 2004-04-19 2005-10-20 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System with a sensor for perfusion management
US7857767B2 (en) * 2004-04-19 2010-12-28 Invention Science Fund I, Llc Lumen-traveling device
US7850676B2 (en) * 2004-04-19 2010-12-14 The Invention Science Fund I, Llc System with a reservoir for perfusion management
US20070010868A1 (en) * 2004-04-19 2007-01-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Lumenally-active device
US8019413B2 (en) * 2007-03-19 2011-09-13 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US7998060B2 (en) * 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling delivery device
US9011329B2 (en) * 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
US8512219B2 (en) 2004-04-19 2013-08-20 The Invention Science Fund I, Llc Bioelectromagnetic interface system
US20070244520A1 (en) * 2004-04-19 2007-10-18 Searete Llc Lumen-traveling biological interface device and method of use
US8092549B2 (en) 2004-09-24 2012-01-10 The Invention Science Fund I, Llc Ciliated stent-like-system
US8337482B2 (en) * 2004-04-19 2012-12-25 The Invention Science Fund I, Llc System for perfusion management
US8353896B2 (en) 2004-04-19 2013-01-15 The Invention Science Fund I, Llc Controllable release nasal system
US8361013B2 (en) * 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
US7413572B2 (en) * 2004-06-14 2008-08-19 Reliant Technologies, Inc. Adaptive control of optical pulses for laser medicine
WO2006014425A1 (en) * 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
JP5270158B2 (ja) 2004-08-05 2013-08-21 コリウム インターナショナル, インコーポレイテッド 粘着性組成物
BRPI0516978A (pt) * 2004-10-21 2008-09-30 Bayer Healthcare Llc método para determinação da concentração de um análito em um fluido corpóreo e sistema para o mesmo
US20060122584A1 (en) * 2004-10-27 2006-06-08 Bommannan D B Apparatus and method to treat heart disease using lasers to form microchannels
US7776373B2 (en) * 2004-11-19 2010-08-17 Eteka Llc Apparatus and method for the enhancement of food properties and food prepared therefrom
CN101137323A (zh) * 2004-12-09 2008-03-05 弹性医疗系统有限责任公司 用于连续实时痕量生物分子采样、分析和递送的装置和方法
CA2597719A1 (en) * 2005-02-18 2006-08-24 Palomar Medical Technologies, Inc. Dermatological treatment device
US20060253176A1 (en) * 2005-02-18 2006-11-09 Palomar Medical Technologies, Inc. Dermatological treatment device with deflector optic
US8834862B2 (en) * 2005-04-19 2014-09-16 Nanocyte Inc. Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent
US7856985B2 (en) 2005-04-22 2010-12-28 Cynosure, Inc. Method of treatment body tissue using a non-uniform laser beam
CA2612866A1 (en) * 2005-05-11 2006-11-23 Corium International, Inc. Permeabilization of biological membranes
EP1896122B1 (de) * 2005-06-03 2020-10-14 Biolase, Inc. Vorrichtung für die behandlung von gewebe
JP2008543359A (ja) * 2005-06-10 2008-12-04 トランスファーマ メディカル,リミティド 経皮投薬用のパッチ
TWI419717B (zh) * 2005-06-17 2013-12-21 Altea Therapeutics Corp 滲透傳送系統及其使用方法
JP2009512463A (ja) * 2005-06-24 2009-03-26 バイオレーズ テクノロジー インコーポレイテッド 電磁エネルギー出力装置用の視覚フィードバック器
CA2622560A1 (en) 2005-09-15 2007-03-29 Palomar Medical Technologies, Inc. Skin optical characterization device
US8333874B2 (en) * 2005-12-09 2012-12-18 Flexible Medical Systems, Llc Flexible apparatus and method for monitoring and delivery
US20070194717A1 (en) * 2006-02-17 2007-08-23 Palomar Medical Technologies, Inc. Lamp for use in a tissue treatment device
US20070212335A1 (en) * 2006-03-07 2007-09-13 Hantash Basil M Treatment of alopecia by micropore delivery of stem cells
KR101361376B1 (ko) 2006-03-30 2014-02-10 발레리타스 인코포레이티드 복합-카트리지 유체 전달 장치
WO2007117580A2 (en) * 2006-04-06 2007-10-18 Palomar Medical Technologies, Inc. Apparatus and method for skin treatment with compression and decompression
US20120035438A1 (en) 2006-04-12 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Path selection by a lumen traveling device in a body tub tree based on previous path
US8936629B2 (en) 2006-04-12 2015-01-20 Invention Science Fund I Llc Autofluorescent imaging and target ablation
WO2007127339A2 (en) * 2006-04-26 2007-11-08 Tyco Healthcare Group Lp Multi-stage microporation device
US7586957B2 (en) 2006-08-02 2009-09-08 Cynosure, Inc Picosecond laser apparatus and methods for its operation and use
WO2008052198A2 (en) * 2006-10-26 2008-05-02 Reliant Technologies, Inc. Methods of increasing skin permeability by treatment with electromagnetic radiation
US20080161782A1 (en) * 2006-10-26 2008-07-03 Reliant Technologies, Inc. Micropore delivery of active substances
CN101541374B (zh) * 2006-11-24 2012-12-05 皇家飞利浦电子股份有限公司 离子电渗设备
CA2925191C (en) 2007-01-22 2018-07-24 Nitto Denko Corporation Transdermal porator and patch system and method for using same
US9101377B2 (en) * 2007-01-25 2015-08-11 Biolase, Inc. Electromagnetic energy output system
US7815630B2 (en) * 2007-01-25 2010-10-19 Biolase Technology, Inc. Target-close electromagnetic energy emitting device
US7695469B2 (en) * 2007-01-25 2010-04-13 Biolase Technology, Inc. Electromagnetic energy output system
US20080186591A1 (en) * 2007-02-01 2008-08-07 Palomar Medical Technologies, Inc. Dermatological device having a zoom lens system
WO2008101968A2 (en) 2007-02-20 2008-08-28 Galderma Research & Development A method for delivery of a therapeutic substance into the skin
US20090225060A1 (en) * 2007-05-03 2009-09-10 Rizoiu Ioana M Wrist-mounted laser with animated, page-based graphical user-interface
JP5466161B2 (ja) * 2007-10-09 2014-04-09 トランスファーマ メディカル リミテッド 磁気的なパッチ連結物
CA2696227A1 (en) * 2007-10-17 2009-04-23 Transpharma Medical Ltd. Dissolution rate verification
CA2704164A1 (en) * 2007-10-29 2009-05-07 Transpharma Medical Ltd. Vertical patch drying
CN102688089A (zh) 2007-12-05 2012-09-26 赛诺龙医疗公司 一次性电磁能施用器以及使用它的方法
US20100004536A1 (en) * 2008-07-03 2010-01-07 Avner Rosenberg Method and apparatus for ultrasound tissue treatment
US20100017750A1 (en) * 2008-07-16 2010-01-21 Avner Rosenberg User interface
JP2012500663A (ja) * 2008-08-22 2012-01-12 エル. フォーペル、マーク 極低周波電磁場を用いる疾病の診断およびスクリーニングのための方法および装置
CA2751884C (en) 2009-01-14 2018-09-25 Corium International, Inc. Transdermal administration of tamsulosin
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
EP2424602B1 (de) * 2009-05-01 2015-07-22 Botanical Essentials PTY LTD System zur freisetzung eines therapeutikums in die haut eines patienten
US9919168B2 (en) 2009-07-23 2018-03-20 Palomar Medical Technologies, Inc. Method for improvement of cellulite appearance
US20110245756A1 (en) 2009-12-03 2011-10-06 Rishi Arora Devices for material delivery, electroporation, sonoporation, and/or monitoring electrophysiological activity
US9877673B2 (en) 2010-12-10 2018-01-30 Clinitech, Llc Transdermal sampling and analysis device
US9451913B2 (en) 2010-12-10 2016-09-27 Touchtek Labs, Llc Transdermal sampling and analysis device
US9968284B2 (en) 2011-12-02 2018-05-15 Clinitech, Llc Anti-interferent barrier layers for non-invasive transdermal sampling and analysis device
KR102136901B1 (ko) 2012-04-18 2020-07-22 싸이노슈어, 엘엘씨 피코초 레이저 장치 및 그를 사용한 표적 조직의 치료 방법
US20180099140A1 (en) * 2012-06-18 2018-04-12 Michael Tavger Method and system for triggering wound recovery by delivering solution into the pores of recipient
WO2013190537A1 (en) * 2012-06-18 2013-12-27 Michael Tavger Method and system for delivering solution into the pores of recipient human skin
US10898116B2 (en) * 2013-03-15 2021-01-26 Cambridge Medical Technologies LLC Methods of manufacture to optimize performance of transdermal sampling and analysis device
WO2014145707A2 (en) 2013-03-15 2014-09-18 Cynosure, Inc. Picosecond optical radiation systems and methods of use
CA3092248A1 (en) 2018-02-26 2019-08-29 Mirko Mirkov Q-switched cavity dumped sub-nanosecond laser
WO2019237107A1 (en) * 2018-06-08 2019-12-12 Mayo Foundation For Medical Education And Research Dermatological electroporation devices and methods
US11633129B2 (en) 2019-04-05 2023-04-25 Cambridge Medical Technologies LLC Non-invasive transdermal sampling and analysis device incorporating redox cofactors
US11375931B2 (en) 2019-08-08 2022-07-05 Cambridge Medical Technologies LLC Non-invasive transdermal sampling and analysis device incorporating an electrochemical bioassay
AU2020370871A1 (en) * 2019-10-24 2022-06-02 Kiffik Inc. Artificial kidney system and devices
CN111107679B (zh) * 2019-12-02 2021-06-04 天津大学 一种用于反离子电渗抽取的柔性温控系统
CN115361993A (zh) * 2020-03-20 2022-11-18 艾诺奥医药品有限公司 真空辅助电穿孔装置以及相关系统和方法
JP2023523857A (ja) * 2020-05-04 2023-06-07 ラトガーズ、ザ ステイト ユニバーシティ オブ ニュージャージー 細胞の透過化およびトランスフェクションを強化するために吸引を使用するシステムおよび方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4715388U (de) * 1971-03-20 1972-10-23
DE68925030T2 (de) * 1988-01-21 1996-07-25 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US5749847A (en) * 1988-01-21 1998-05-12 Massachusetts Institute Of Technology Delivery of nucleotides into organisms by electroporation
US5547467A (en) * 1988-01-21 1996-08-20 Massachusettes Institute Of Technology Method for rapid temporal control of molecular transport across tissue
WO1989006989A1 (en) * 1988-01-29 1989-08-10 The Regents Of The University Of California Iontophoretic non-invasive sampling or delivery device
US5362307A (en) * 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
JP2804968B2 (ja) * 1988-03-02 1998-09-30 新日本無線株式会社 試料採取用具
US5137817A (en) * 1990-10-05 1992-08-11 Amoco Corporation Apparatus and method for electroporation
US5215520A (en) * 1991-09-17 1993-06-01 Centre Internationale De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Method for delivering an active substance topically or percutaneously
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5464386A (en) * 1992-08-17 1995-11-07 Genetronics, Inc. Transdermal drug delivery by electroincorporation of vesicles
US5318514A (en) * 1992-08-17 1994-06-07 Btx, Inc. Applicator for the electroporation of drugs and genes into surface cells
US5462520A (en) * 1992-08-17 1995-10-31 Genetronics, Inc. Transsurface drug delivery by electrofusion of microbubbles to the tissue surface
US5439440A (en) * 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5445611A (en) * 1993-12-08 1995-08-29 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal delivery with ultrasound and chemical enhancers
US5458140A (en) * 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
ES2150001T3 (es) * 1994-06-24 2000-11-16 Cygnus Therapeutic Systems Dispositivo de muestreo iontoforetico.
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy

Also Published As

Publication number Publication date
CA2329169A1 (en) 1999-09-10
EP1059960B1 (de) 2004-12-01
EP1059960A1 (de) 2000-12-20
AU748376B2 (en) 2002-06-06
CA2329169C (en) 2014-11-25
AU2988999A (en) 1999-09-20
DE69922353T2 (de) 2005-12-22
JP2002505171A (ja) 2002-02-19
JP3619453B2 (ja) 2005-02-09
ES2237091T3 (es) 2005-07-16
DE69922353D1 (de) 2005-01-05
WO1999044678A1 (en) 1999-09-10
US6022316A (en) 2000-02-08

Similar Documents

Publication Publication Date Title
ATE283719T1 (de) Vorrichtung zur elektroporation durch gewebemikroporen
ATE350514T1 (de) Vorrichtung und verfahren zur elektrolytischen behandlung von elektrisch isolierten strukturen
DE60215130D1 (de) Verfahren und vorrichtung zum dauerhaften verändern einer neuralen funktion eines patienten
DE60331351D1 (de) Verfahren zur feststellung von stimulationsparametern
DE60322523D1 (de) Ien mit übersetzenden elektrischen feldern und elektroden-polaritäts-umkehr
DE502006000803D1 (de) Vorrichtung zur transkutanen stimulation eines nervs des menschlichen körpers
IL158582A0 (en) Handheld apparatus and method for transdermal drug delivery and analyte extraction
ATE256484T1 (de) Einbringen von makromolekülen in zellen
EP1785160A3 (de) Vorrichtung zur Nervenstimulation
TW368420B (en) Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum
ATE376454T1 (de) Behältnis und vorrichtung zur erzeugung von elektrischen feldern in einzelnen reaktionsräumen
WO2007010441A3 (en) Apparatus and method for coupling implanted electrodes to nervous tissue
ATE333843T1 (de) Vorrichtung zum mapping
JP2011506078A5 (de)
DE60333457D1 (de) Elektrode für die behandlung von oberflächen mit elektrischen entladungen, verfahren zur behandlung von oberflächen mit elektrischen entladungen und vorrichtung zur behandlung von oberflächen mit elektrischen entladungen
ATE435279T1 (de) Kombiniertes elektroporations- und mikroinjektionsverfahren zur durchdringung von membranen mit lipid-doppelschichten
WO2009027596A3 (fr) Source micronique d'émission ionique
DE50214747D1 (de) Verfahren und Vorrichtung zur Bildung von Erdalkalicarbonat
DE502006007713D1 (de) Vorrichtung zur Elektrostimulation
WO2007046484A8 (ja) 誘電泳動チップおよび誘電泳動装置並びに誘電泳動システム
ATE360471T1 (de) Vorrichtung und verfahren zur trennung von molekülen und bewegung von fluiden mittels elektrophorese
DE10344489A1 (de) Vorrichtung und Verfahren zur plasmagestützten Abgasreinigung
SU1764569A1 (ru) Способ стимулировани каллюсообразовани прививок
WO2005123182A3 (en) Nervous tissue electrode device
KR20120124959A (ko) 의료용 전극의 작동 방법

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties