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ATE282089T1 - Inhibitorresistente serinproteasen - Google Patents

Inhibitorresistente serinproteasen

Info

Publication number
ATE282089T1
ATE282089T1 AT93917972T AT93917972T ATE282089T1 AT E282089 T1 ATE282089 T1 AT E282089T1 AT 93917972 T AT93917972 T AT 93917972T AT 93917972 T AT93917972 T AT 93917972T AT E282089 T1 ATE282089 T1 AT E282089T1
Authority
AT
Austria
Prior art keywords
pct
serine proteases
inhibitor
date feb
sec
Prior art date
Application number
AT93917972T
Other languages
English (en)
Inventor
Keith Martyn Dawson
Richard James Gilbert
Original Assignee
Vernalis Oxford Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis Oxford Ltd filed Critical Vernalis Oxford Ltd
Application granted granted Critical
Publication of ATE282089T1 publication Critical patent/ATE282089T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT93917972T 1992-08-04 1993-08-03 Inhibitorresistente serinproteasen ATE282089T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929216558A GB9216558D0 (en) 1992-08-04 1992-08-04 Modified proteases
PCT/GB1993/001632 WO1994003614A1 (en) 1992-08-04 1993-08-03 Inhibitor resistant serine proteases

Publications (1)

Publication Number Publication Date
ATE282089T1 true ATE282089T1 (de) 2004-11-15

Family

ID=10719807

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93917972T ATE282089T1 (de) 1992-08-04 1993-08-03 Inhibitorresistente serinproteasen

Country Status (10)

Country Link
US (2) US5645833A (de)
EP (1) EP0658206B1 (de)
JP (1) JP3449717B2 (de)
AT (1) ATE282089T1 (de)
AU (1) AU4720093A (de)
DE (1) DE69333689T2 (de)
ES (1) ES2232812T3 (de)
GB (1) GB9216558D0 (de)
WO (1) WO1994003614A1 (de)
ZA (1) ZA935660B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7278094A (en) * 1994-06-07 1996-01-04 M D Serv Europe S.A. Intravasal thrombolysis
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
US6942978B1 (en) * 1999-03-03 2005-09-13 The Board Of Trustees Of The University Of Arkansas Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
US7700341B2 (en) * 2000-02-03 2010-04-20 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
JP2001275677A (ja) * 2000-03-30 2001-10-09 Canon Inc 核酸断片プライマーまたはプローブ、およびこれを用いたポリヒドロキシアルカノエート合成微生物の検出方法
AU2001286171B2 (en) 2001-05-25 2008-01-10 Serono Genetics Institute S.A. Human CDNAs and proteins and uses thereof
DE102006053404A1 (de) * 2006-11-10 2008-05-15 Hydro Aluminium Alucast Gmbh Gießform zum Gießen eines Gussteils und Verwendung einer solchen Gießform
EA201891012A1 (ru) * 2015-11-25 2019-01-31 Академиш Зикенхёйс Лейден Рекомбинантные сериновые протеазы
CN113661239A (zh) 2018-12-28 2021-11-16 催化剂生物科学公司 经修饰的尿激酶型纤溶酶原激活物多肽和使用方法
US11613744B2 (en) 2018-12-28 2023-03-28 Vertex Pharmaceuticals Incorporated Modified urokinase-type plasminogen activator polypeptides and methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2007364A1 (en) * 1989-01-17 1990-07-17 David J. Livingston Gene sequences encoding modified residues situated in the protease domain of tpa
US5304482A (en) * 1989-03-06 1994-04-19 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
ATE226636T1 (de) * 1989-03-06 2002-11-15 Univ Texas Serpin-resistenter t-pa; mutanten; gene
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids

Also Published As

Publication number Publication date
ES2232812T3 (es) 2005-06-01
EP0658206A1 (de) 1995-06-21
US5645833A (en) 1997-07-08
ZA935660B (en) 1994-03-17
JPH07509610A (ja) 1995-10-26
WO1994003614A1 (en) 1994-02-17
JP3449717B2 (ja) 2003-09-22
US5932213A (en) 1999-08-03
AU4720093A (en) 1994-03-03
DE69333689D1 (de) 2004-12-16
EP0658206B1 (de) 2004-11-10
DE69333689T2 (de) 2005-11-03
GB9216558D0 (en) 1992-09-16

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Legal Events

Date Code Title Description
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