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ATE279113T1 - HYPOXANTHINE AND THIOHYPXANTHINE COMPOUNDS - Google Patents

HYPOXANTHINE AND THIOHYPXANTHINE COMPOUNDS

Info

Publication number
ATE279113T1
ATE279113T1 AT00953925T AT00953925T ATE279113T1 AT E279113 T1 ATE279113 T1 AT E279113T1 AT 00953925 T AT00953925 T AT 00953925T AT 00953925 T AT00953925 T AT 00953925T AT E279113 T1 ATE279113 T1 AT E279113T1
Authority
AT
Austria
Prior art keywords
compounds
thiohypxanthine
hypoxanthine
inhibitors
formula
Prior art date
Application number
AT00953925T
Other languages
German (de)
Inventor
Mark Chasin
Peter Hofer
David Cavalla
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of ATE279113T1 publication Critical patent/ATE279113T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Disclosed are compounds of formula (I) wherein R3, R6, R8 are as described herein. The compounds are effective selective PDE IV inhibitors.
AT00953925T 1999-08-12 2000-08-09 HYPOXANTHINE AND THIOHYPXANTHINE COMPOUNDS ATE279113T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14862399P 1999-08-12 1999-08-12
PCT/US2000/021836 WO2001011967A1 (en) 1999-08-12 2000-08-09 Novel hypoxanthine and thiohypoxanthine compounds

Publications (1)

Publication Number Publication Date
ATE279113T1 true ATE279113T1 (en) 2004-10-15

Family

ID=22526585

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00953925T ATE279113T1 (en) 1999-08-12 2000-08-09 HYPOXANTHINE AND THIOHYPXANTHINE COMPOUNDS

Country Status (7)

Country Link
EP (1) EP1202628B1 (en)
JP (1) JP2003506467A (en)
AT (1) ATE279113T1 (en)
AU (1) AU6629000A (en)
CA (1) CA2379356A1 (en)
DE (1) DE60014915T2 (en)
WO (1) WO2001011967A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003037345A1 (en) * 2001-10-26 2003-05-08 Sciclone Pharmaceuticals, Inc. Pharmaceutical formulations comprising substituted xanthine compounds
AR039385A1 (en) 2002-04-19 2005-02-16 Astrazeneca Ab THIOXANTINE DERIVATIVES AS INHIBITORS OF MIELOPEROXIDASA
CN114588161A (en) * 2020-12-07 2022-06-07 四川大学华西医院 Hypoxlavine derivatives with prevention and treatment of pneumonia

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL24642A (en) * 1965-11-18 1971-06-23 Rashi M Method for preparation of 6-thioxo purines from 6-methylthio purines
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
DE69531506T2 (en) * 1994-12-13 2004-06-24 Euroceltique S.A. ARYLTHIOXANTHINE
US5864037A (en) * 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
JP2002508378A (en) * 1997-12-12 2002-03-19 ユーロ−セルティーク，エス．エイ． Method for producing 3-substituted adenine and imidazopyridine

Also Published As

Publication number Publication date
EP1202628A4 (en) 2002-10-30
CA2379356A1 (en) 2001-02-22
DE60014915T2 (en) 2005-10-13
JP2003506467A (en) 2003-02-18
EP1202628A1 (en) 2002-05-08
EP1202628B1 (en) 2004-10-13
DE60014915D1 (en) 2004-11-18
WO2001011967A1 (en) 2001-02-22
AU6629000A (en) 2001-03-13

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties