ATE276274T1 - Konjugate von alpha-msh mit einer fettsäure, verfahren zu ihrer herstellung und ihre verwendung als medikament - Google Patents

Konjugate von alpha-msh mit einer fettsäure, verfahren zu ihrer herstellung und ihre verwendung als medikament

Info

Publication number: ATE276274T1
Authority: AT; Austria
Prior art keywords: alpha; msh; sequence; amino; acids
Prior art date: 1995-06-12

Application number

AT96922103T

Other languages

English (en)

Inventor

D Hinterland Lucien Dussourd

Anne-Marie Pinel

Original Assignee

Inst Europeen Biolog Cellulair

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-12

Filing date

1996-06-12

Publication date

2004-10-15

1996-06-12 Application filed by Inst Europeen Biolog Cellulair filed Critical Inst Europeen Biolog Cellulair

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE276274T1 publication Critical patent/ATE276274T1/de

Links

235000014113 dietary fatty acids Nutrition 0.000 title abstract 2
229930195729 fatty acid Natural products 0.000 title abstract 2
239000000194 fatty acid Substances 0.000 title abstract 2
150000004665 fatty acids Chemical class 0.000 title abstract 2
WHNFPRLDDSXQCL-UAZQEYIDSA-N α-msh Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(N)=O)NC(=O)[C@H](CO)NC(C)=O)C1=CC=C(O)C=C1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 0.000 title abstract 2
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
101800001751 Melanocyte-stimulating hormone alpha Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
-1 amino, hydroxy Chemical group 0.000 abstract 1
150000001991 dicarboxylic acids Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
239000000863 peptide conjugate Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/68—Melanocyte-stimulating hormone [MSH]
- C07K14/685—Alpha-melanotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Fats And Perfumes (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT96922103T 1995-06-12 1996-06-12 Konjugate von alpha-msh mit einer fettsäure, verfahren zu ihrer herstellung und ihre verwendung als medikament ATE276274T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9506909A FR2735131B1 (fr)	1995-06-12	1995-06-12	Conjugues d'msh avec un acide gras, leur procede de preparation et leur utilisation a titre de medicament
PCT/FR1996/000890 WO1996041815A2 (fr)	1995-06-12	1996-06-12	CONJUGUES D'αMSH AVEC UN ACIDE GRAS, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT

Publications (1)

Publication Number	Publication Date
ATE276274T1 true ATE276274T1 (de)	2004-10-15

Family

ID=9479857

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96922103T ATE276274T1 (de)	1995-06-12	1996-06-12	Konjugate von alpha-msh mit einer fettsäure, verfahren zu ihrer herstellung und ihre verwendung als medikament

Country Status (8)

Country	Link
EP (1)	EP0837881B1 (de)
JP (1)	JPH11507661A (de)
AT (1)	ATE276274T1 (de)
AU (1)	AU6309496A (de)
DE (1)	DE69633391T2 (de)
ES (1)	ES2227597T3 (de)
FR (1)	FR2735131B1 (de)
WO (1)	WO1996041815A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7176279B2 (en)	2000-06-28	2007-02-13	Palatin Technologies, Inc.	Cyclic peptide compositions and methods for treatment of sexual dysfunction
US6579968B1 (en) *	1999-06-29	2003-06-17	Palatin Technologies, Inc.	Compositions and methods for treatment of sexual dysfunction
EP1593384A3 (de) *	1999-06-29	2006-04-26	Palatin Technologies, Inc.	Verbindungen zur Behandlung von sexuellen Funktionsstörungen
GB9930026D0 (en) *	1999-12-21	2000-02-09	Univ Sheffield	Novel compounds of unsaturated fatty acids
US7144862B2 (en)	2000-08-24	2006-12-05	The Regents Of The University Of California	Orally administered peptides to ameliorate atherosclerosis
US7199102B2 (en)	2000-08-24	2007-04-03	The Regents Of The University Of California	Orally administered peptides synergize statin activity
US7166578B2 (en)	2000-08-24	2007-01-23	The Regents Of The University Of California	Orally administered peptides synergize statin activity
US7148197B2 (en) *	2000-08-24	2006-12-12	The Regents Of The University Of California	Orally administered small peptides synergize statin activity
US20040161443A1 (en) *	2001-04-17	2004-08-19	Macneil Sheila	Vehicle
EP1827472A4 (de)	2004-12-06	2012-09-05	Univ California	Verfahren zur verbesserung der struktur und funktion von arteriolen
JPWO2009014105A1 (ja) *	2007-07-20	2010-10-07	株式会社山田養蜂場本社	新規カルボン酸およびそれを有効成分とする抗うつ用組成物
JP5715104B2 (ja) *	2012-09-27	2015-05-07	アブビーインコーポレイティド	治療的に活性なα−ＭＳＨアナログ
US10588980B2 (en)	2014-06-23	2020-03-17	Novartis Ag	Fatty acids and their use in conjugation to biomolecules
US11590209B2 (en)	2020-01-21	2023-02-28	Palatin Technologies, Inc.	Use of bremelanotide in patients with controlled hypertension

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0389950A1 (de) *	1989-03-23	1990-10-03	Lion Corporation	Inhibitor des melanocytenstimulierenden Hormons und dieses enthaltendes, äusserlich anwendbares Präparat
CA2070061C (en) *	1991-06-07	2004-02-10	Shigeyuki Takama	Physiologically active polypeptide-containing pharmaceutical composition
FR2691465B1 (fr) *	1992-05-25	1995-08-11	Pf Medicament	Complexes comprenant au moins un peptide derive de l'alpha msh, peptide, microsphere, medicament et composition galenique les comprenant.
FR2710340B1 (fr) *	1993-09-22	1995-12-15	D Hinterland Lucien Dussourd	Dérivés peptidiques de l'alpha-MSH et leur application .

1995
- 1995-06-12 FR FR9506909A patent/FR2735131B1/fr not_active Expired - Fee Related
1996
- 1996-06-12 JP JP9502708A patent/JPH11507661A/ja active Pending
- 1996-06-12 EP EP96922103A patent/EP0837881B1/de not_active Expired - Lifetime
- 1996-06-12 DE DE69633391T patent/DE69633391T2/de not_active Expired - Fee Related
- 1996-06-12 WO PCT/FR1996/000890 patent/WO1996041815A2/fr active IP Right Grant
- 1996-06-12 ES ES96922103T patent/ES2227597T3/es not_active Expired - Lifetime
- 1996-06-12 AU AU63094/96A patent/AU6309496A/en not_active Abandoned
- 1996-06-12 AT AT96922103T patent/ATE276274T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
FR2735131A1 (fr)	1996-12-13
WO1996041815A2 (fr)	1996-12-27
EP0837881A2 (de)	1998-04-29
JPH11507661A (ja)	1999-07-06
WO1996041815A3 (fr)	1997-01-30
ES2227597T3 (es)	2005-04-01
EP0837881B1 (de)	2004-09-15
FR2735131B1 (fr)	1997-08-22
AU6309496A (en)	1997-01-09
DE69633391T2 (de)	2005-02-24
DE69633391D1 (de)	2004-10-21

Publication	Publication Date	Title
ATE276274T1 (de)	2004-10-15	Konjugate von alpha-msh mit einer fettsäure, verfahren zu ihrer herstellung und ihre verwendung als medikament
CO4520232A1 (es)	1997-10-15	Conjugados de interferon-polimero y proceso para preparar el mismo
IE791292L (en)	1980-01-19	Poly-(carbonate-urethanes).
DE69423911D1 (de)	2000-05-11	Neue retinoidkonjugate zur behandlung von alterserscheinungen der haut
ATE174604T1 (de)	1999-01-15	Lipopeptide aus actinoplanes sp. mit pharmakologischer wirkung, verfahren zu ihrer herstellung und verwendung derselben
ATE145649T1 (de)	1996-12-15	Kardioaktive 17-aryl und 17-heterozyklyl-14 beta- 5alpha-androstane, androstene und androstadiene, ein verfahren zu ihrer herstellung und pharmazeutische präperate davon
RU94045952A (ru)	1996-10-10	Домен ингибитора протеазы, днк, вектор, клетка, способ получения ингибитора протеазы, фармацевтическая композиция, применение домена
NZ290757A (en)	2000-09-29	Delivery of nucleic acid into a cell
IT1277596B1 (it)	1997-11-11	Composti macromolecolari di tipo dendrimerico
DE3885928D1 (de)	1994-01-13	Verfahren zur Herstellung von parenteral verabreichbaren Chinoloncarbonsäuren.
DE69613272D1 (de)	2001-07-19	An polyungesättigten Fettsäuren reiche Triglyceride
IT1249732B (it)	1995-03-09	Oligonucleotidi antisenso.
YU108691A (sh)	1994-01-20	Nove 3,3'-ditiobis (propionske kiseline) i njihovi estri
IT1254996B (it)	1995-10-11	Esteri amminoalchilcarbammici dell'eserolina atti all'impiego come anticolinesterasici e relativo procedimento di preparazione
ATE271078T1 (de)	2004-07-15	Copolymere mit amphiphilen untereinheiten, verfahren zu deren herstellung und deren verwendung
ES8704754A1 (es)	1987-04-16	Un procedimiento para la preparacion de composiciones de un acido amino hidrocarbil sulfonico n-acilado o una sal del mismo.
EP0366041A3 (de)	1991-10-23	Imido-percarbonsäuren
FR2491922B1 (de)	1983-12-16
ATE32229T1 (de)	1988-02-15	Carboxylmodifizierte vinylesterurethan-harze, ihre anwendung und verwertung.
ES2058047T3 (es)	1998-01-16	Resolucion de acido arilalcanoico.
ATE27464T1 (de)	1987-06-15	Herstellung von ursodeoxycholsaeurekonjugaten.
ATE25708T1 (de)	1987-03-15	Biologisch aktive konjugate, ihre herstellung und ihre anwendung.
KR850000468A (ko)	1985-02-27	사이클릭 펩타이드의 제조방법
KR840002346A (ko)	1984-06-25	펩타이드의 제조방법
ATE224373T1 (de)	2002-10-15	Verfahren zur herstellung von alkylimidazolidinon(meth)acrylaten

Legal Events

Date	Code	Title	Description
2005-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties