ATE254460T1 - Anhydrovinblastin zur behandlung von krebs - Google Patents
Anhydrovinblastin zur behandlung von krebsInfo
- Publication number
- ATE254460T1 ATE254460T1 AT98909249T AT98909249T ATE254460T1 AT E254460 T1 ATE254460 T1 AT E254460T1 AT 98909249 T AT98909249 T AT 98909249T AT 98909249 T AT98909249 T AT 98909249T AT E254460 T1 ATE254460 T1 AT E254460T1
- Authority
- AT
- Austria
- Prior art keywords
- cancer
- treatment
- anhydrovinblastin
- vinblastine
- present
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- FFRFGVHNKJYNOV-UHFFFAOYSA-N ac1l8myg Chemical compound C1C(CC)=CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 FFRFGVHNKJYNOV-UHFFFAOYSA-N 0.000 title 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical class C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 2
- FFRFGVHNKJYNOV-DOVUUNBWSA-N 3',4'-Anhydrovinblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C=C(C2)CC)N2CCC2=C1NC1=CC=CC=C21 FFRFGVHNKJYNOV-DOVUUNBWSA-N 0.000 abstract 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 abstract 1
- 229940034982 antineoplastic agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229960003048 vinblastine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2199065 CA2199065A1 (en) | 1997-03-04 | 1997-03-04 | Anhydrovinblastine for the treatment of cancer |
| CA 2205314 CA2205314A1 (en) | 1997-03-04 | 1997-05-14 | Anhydrovinblastine for the treatment of cervical and lung cancer |
| CA002219095A CA2219095A1 (en) | 1997-03-04 | 1997-10-24 | Anhydrovinblastine for the treatment of cervical and lung cancer |
| PCT/CA1998/000195 WO1998039004A1 (en) | 1997-03-04 | 1998-03-04 | Anhydrovinblastine for the treatment of cervical and lung cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE254460T1 true ATE254460T1 (de) | 2003-12-15 |
Family
ID=27170289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98909249T ATE254460T1 (de) | 1997-03-04 | 1998-03-04 | Anhydrovinblastin zur behandlung von krebs |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6326376B1 (de) |
| EP (1) | EP0969839B1 (de) |
| AT (1) | ATE254460T1 (de) |
| AU (1) | AU6388598A (de) |
| CA (1) | CA2219095A1 (de) |
| DE (1) | DE69819875T2 (de) |
| DK (1) | DK0969839T3 (de) |
| ES (1) | ES2212272T3 (de) |
| NZ (1) | NZ337752A (de) |
| WO (1) | WO1998039004A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04010233A (es) * | 2002-04-16 | 2005-07-26 | Univ British Columbia | Anhidrovinblastina para el tratamiento de cancer. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4279817A (en) | 1975-05-30 | 1981-07-21 | The United States Of America As Represented By The Department Of Health & Human Services | Method for producing dimer alkaloids |
| US4029663A (en) | 1975-07-10 | 1977-06-14 | Eli Lilly And Company | Dimeric anhydro-vinca derivatives |
| US4307100A (en) * | 1978-08-24 | 1981-12-22 | Agence Nationale De Valorisation De La Recherche (Anvar) | Nor bis-indole compounds usable as medicaments |
| US4778885A (en) * | 1986-09-18 | 1988-10-18 | Allelix Inc. | Production of alkaloid dimers using ferric ion |
| US5037977A (en) | 1988-08-11 | 1991-08-06 | Mitsui Petrochemical Industries Ltd. | Method for production of dimeric alkaloids |
| US6011041A (en) | 1995-07-28 | 2000-01-04 | University Of British Columbia | Use of anhydrovinblastine |
-
1997
- 1997-10-24 CA CA002219095A patent/CA2219095A1/en not_active Abandoned
-
1998
- 1998-03-04 ES ES98909249T patent/ES2212272T3/es not_active Expired - Lifetime
- 1998-03-04 AT AT98909249T patent/ATE254460T1/de not_active IP Right Cessation
- 1998-03-04 US US09/380,540 patent/US6326376B1/en not_active Expired - Fee Related
- 1998-03-04 AU AU63885/98A patent/AU6388598A/en not_active Abandoned
- 1998-03-04 NZ NZ337752A patent/NZ337752A/xx unknown
- 1998-03-04 DK DK98909249T patent/DK0969839T3/da active
- 1998-03-04 WO PCT/CA1998/000195 patent/WO1998039004A1/en not_active Ceased
- 1998-03-04 EP EP98909249A patent/EP0969839B1/de not_active Expired - Lifetime
- 1998-03-04 DE DE69819875T patent/DE69819875T2/de not_active Expired - Fee Related
-
2001
- 2001-09-04 US US09/946,149 patent/US20020103218A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69819875D1 (de) | 2003-12-24 |
| DE69819875T2 (de) | 2004-11-11 |
| US6326376B1 (en) | 2001-12-04 |
| NZ337752A (en) | 2001-08-31 |
| WO1998039004A1 (en) | 1998-09-11 |
| ES2212272T3 (es) | 2004-07-16 |
| EP0969839A1 (de) | 2000-01-12 |
| DK0969839T3 (da) | 2004-03-29 |
| EP0969839B1 (de) | 2003-11-19 |
| AU6388598A (en) | 1998-09-22 |
| HK1026610A1 (en) | 2000-12-22 |
| CA2219095A1 (en) | 1998-09-04 |
| US20020103218A1 (en) | 2002-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0969839 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |