ATE252096T1 - Prolylendopeptidase-inhibitoren, ihre herstellung und ihre pharmazeutische verwendung - Google Patents

Prolylendopeptidase-inhibitoren, ihre herstellung und ihre pharmazeutische verwendung

Info

Publication number: ATE252096T1
Authority: AT; Austria
Prior art keywords: preparation; pharmaceutical use; prolylendopeptidase; inhibitors; prolylendopeptidase inhibitors
Prior art date: 1995-08-17

Application number

AT96925926T

Other languages

English (en)

Inventor

Karoly Kanai

Sandor Erdo

Andrea Szappanos

Judit Bence

Istvan Hermecz

Gyoergyne Szvoboda

Sandor Batori

Gergely Heja

Maria Balogh

Agnes Horvath

Judit Sipos

Bodor Veronika Bartane

Zsolt Parkany

Viktor Lakics

Peter Molnar

Original Assignee

Sandor Erdoe Dr

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-17

Filing date

1996-07-26

Publication date

2003-11-15

1996-07-26 Application filed by Sandor Erdoe Dr filed Critical Sandor Erdoe Dr

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE252096T1 publication Critical patent/ATE252096T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT96925926T 1995-08-17 1996-07-26 Prolylendopeptidase-inhibitoren, ihre herstellung und ihre pharmazeutische verwendung ATE252096T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU9502426A HUT76640A (en)	1995-08-17	1995-08-17	Compounds of pharmaceutical activity cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use
PCT/HU1996/000041 WO1997007116A1 (en)	1995-08-17	1996-07-26	Prolylendopeptidase inhibitors

Publications (1)

Publication Number	Publication Date
ATE252096T1 true ATE252096T1 (de)	2003-11-15

Family

ID=10987143

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96925926T ATE252096T1 (de)	1995-08-17	1996-07-26	Prolylendopeptidase-inhibitoren, ihre herstellung und ihre pharmazeutische verwendung

Country Status (29)

Country	Link
US (1)	US6191161B1 (de)
EP (1)	EP0861246B1 (de)
JP (1)	JPH11514970A (de)
KR (1)	KR19990037669A (de)
CN (1)	CN1092193C (de)
AR (1)	AR009225A1 (de)
AT (1)	ATE252096T1 (de)
AU (1)	AU725429B2 (de)
BG (1)	BG102323A (de)
BR (1)	BR9610075A (de)
CA (1)	CA2235677A1 (de)
CZ (1)	CZ45798A3 (de)
DE (1)	DE69630391T2 (de)
EA (1)	EA001399B1 (de)
EE (1)	EE9800044A (de)
HR (1)	HRP960375B1 (de)
HU (1)	HUT76640A (de)
IL (1)	IL123268A0 (de)
IS (1)	IS4668A (de)
MX (1)	MX9801190A (de)
NO (1)	NO980643L (de)
NZ (1)	NZ313751A (de)
PL (1)	PL325013A1 (de)
SK (1)	SK18998A3 (de)
TR (1)	TR199800243T1 (de)
TW (1)	TW486476B (de)
WO (1)	WO1997007116A1 (de)
YU (1)	YU47096A (de)
ZA (1)	ZA966554B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP9700442A1 (hu) *	1997-02-14	1999-09-28	Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt.	Gyűrűs amidszármazékok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk
WO1999050254A1 (en)	1998-03-31	1999-10-07	Warner-Lambert Company	Quinoxalinones as serine protease inhibitors such as factor xa and thrombin
HUP0101484A3 (en)	1998-03-31	2003-02-28	Warner Lambert Co	Quinolones as serine protease inhibitors and medicaments containing them
US8642051B2 (en)	2000-03-21	2014-02-04	Suzanne Jaffe Stillman	Method of hydration; infusion packet system(s), support member(s), delivery system(s), and method(s); with business model(s) and Method(s)
WO2005019188A1 (ja) *	2003-08-22	2005-03-03	Takeda Pharmaceutical Company Limited	縮合ピリミジン誘導体およびその用途
US7320992B2 (en) *	2003-08-25	2008-01-22	Amgen Inc.	Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
AU2004275718B2 (en) *	2003-09-23	2008-02-07	Merck Sharp & Dohme Corp.	Quinazoline potassium channel inhibitors
WO2006058720A2 (en)	2003-11-03	2006-06-08	Probiodrug Ag	Novel compounds for the treatment of neurological disorders
EP1888562B1 (de) *	2005-04-22	2014-06-18	Alantos Pharmaceuticals Holding, Inc.	Dipeptidylpeptidase-iv-hemmer
EP2730571A1 (de) *	2012-11-12	2014-05-14	Universitat De Barcelona	1-[1-(Benzoyl)-pyrrolidin-2-carbonyl]-pyrrolidin-2-carbonitril-Derivate
US9392814B2 (en)	2014-06-06	2016-07-19	Nicholas J. Singer	Delivery system for drinks
USD773313S1 (en)	2015-06-23	2016-12-06	Nicholas J. Singer	Package
JOP20170113B1 (ar) *	2016-05-09	2023-03-28	Bayer Pharma AG	مركبات 5، 6، 7، 8-رباعي هيدرو [1، 2، 4] تريازولو [4، 3-أ] بيريدين 3(2h)-ون مستبدلة ومركبات 2، 5، 6، 7-رباعي هيدرو-3h-بيرولو [2، 1-ج] [1، 2، 4] تريازول-3-ون واستخداماتها

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1320734C (en)	1986-02-04	1993-07-27	Suntory Limited	Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
CA2004028C (en) *	1988-12-08	1998-09-22	Motoki Torizuka	Condensed benzene derivative
EP0419683A4 (en) *	1989-04-13	1992-03-11	Japan Tobacco Inc.	New amino acid derivatives having prolylendopeptidase inhibitor activity
EP0468469A2 (de) *	1990-07-27	1992-01-29	Japan Tobacco Inc.	Prolinderivate

1995
- 1995-08-17 HU HU9502426A patent/HUT76640A/hu unknown
1996
- 1996-07-26 MX MX9801190A patent/MX9801190A/es unknown
- 1996-07-26 NZ NZ313751A patent/NZ313751A/xx unknown
- 1996-07-26 IL IL12326896A patent/IL123268A0/xx unknown
- 1996-07-26 SK SK189-98A patent/SK18998A3/sk unknown
- 1996-07-26 JP JP9509080A patent/JPH11514970A/ja not_active Ceased
- 1996-07-26 BR BR9610075A patent/BR9610075A/pt unknown
- 1996-07-26 EE EE9800044A patent/EE9800044A/xx unknown
- 1996-07-26 WO PCT/HU1996/000041 patent/WO1997007116A1/en not_active Application Discontinuation
- 1996-07-26 PL PL96325013A patent/PL325013A1/xx unknown
- 1996-07-26 TR TR1998/00243T patent/TR199800243T1/xx unknown
- 1996-07-26 CA CA002235677A patent/CA2235677A1/en not_active Abandoned
- 1996-07-26 KR KR1019980701148A patent/KR19990037669A/ko not_active Application Discontinuation
- 1996-07-26 DE DE69630391T patent/DE69630391T2/de not_active Expired - Fee Related
- 1996-07-26 EA EA199800200A patent/EA001399B1/ru not_active IP Right Cessation
- 1996-07-26 EP EP96925926A patent/EP0861246B1/de not_active Expired - Lifetime
- 1996-07-26 AU AU66279/96A patent/AU725429B2/en not_active Ceased
- 1996-07-26 US US09/011,703 patent/US6191161B1/en not_active Expired - Fee Related
- 1996-07-26 CZ CZ98457A patent/CZ45798A3/cs unknown
- 1996-07-26 AT AT96925926T patent/ATE252096T1/de not_active IP Right Cessation
- 1996-07-26 CN CN96197030A patent/CN1092193C/zh not_active Expired - Fee Related
- 1996-08-01 ZA ZA9606554A patent/ZA966554B/xx unknown
- 1996-08-13 HR HR960375A patent/HRP960375B1/xx not_active IP Right Cessation
- 1996-08-15 YU YU47096A patent/YU47096A/sh unknown
- 1996-08-15 TW TW085109928A patent/TW486476B/zh active
- 1996-08-16 AR ARP960104018A patent/AR009225A1/es unknown
1998
- 1998-02-16 IS IS4668A patent/IS4668A/is unknown
- 1998-02-16 NO NO980643A patent/NO980643L/no not_active Application Discontinuation
- 1998-03-12 BG BG102323A patent/BG102323A/bg unknown

Also Published As

Publication number	Publication date
TW486476B (en)	2002-05-11
HRP960375A2 (en)	1998-02-28
DE69630391T2 (de)	2004-06-24
EA199800200A1 (ru)	1998-10-29
US6191161B1 (en)	2001-02-20
NZ313751A (en)	2000-01-28
PL325013A1 (en)	1998-07-06
HU9502426D0 (en)	1995-10-30
CA2235677A1 (en)	1997-02-27
KR19990037669A (ko)	1999-05-25
EA001399B1 (ru)	2001-02-26
EP0861246B1 (de)	2003-10-15
AR009225A1 (es)	2000-04-12
JPH11514970A (ja)	1999-12-21
AU6627996A (en)	1997-03-12
WO1997007116A1 (en)	1997-02-27
HRP960375B1 (en)	2003-06-30
HUT76640A (en)	1997-10-28
SK18998A3 (en)	1998-07-08
NO980643L (no)	1998-04-07
MX9801190A (es)	1998-04-30
IL123268A0 (en)	1998-09-24
BR9610075A (pt)	1999-03-02
CN1196728A (zh)	1998-10-21
CN1092193C (zh)	2002-10-09
EP0861246A1 (de)	1998-09-02
DE69630391D1 (de)	2003-11-20
BG102323A (bg)	1998-12-30
YU47096A (sh)	1998-12-23
CZ45798A3 (cs)	1998-07-15
EE9800044A (et)	1998-08-17
IS4668A (is)	1998-02-16
TR199800243T1 (xx)	1998-06-22
ZA966554B (en)	1997-02-24
AU725429B2 (en)	2000-10-12
NO980643D0 (no)	1998-02-16

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ATE187063T1 (de)	1999-12-15	Arzneimittel
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