ATE240299T1 - Diester prodrugs von decahydroischinoline-3- carbonsäure - Google Patents
Diester prodrugs von decahydroischinoline-3- carbonsäureInfo
- Publication number
- ATE240299T1 ATE240299T1 AT00941172T AT00941172T ATE240299T1 AT E240299 T1 ATE240299 T1 AT E240299T1 AT 00941172 T AT00941172 T AT 00941172T AT 00941172 T AT00941172 T AT 00941172T AT E240299 T1 ATE240299 T1 AT E240299T1
- Authority
- AT
- Austria
- Prior art keywords
- carboxylic acid
- decahydroischinoline
- prodrugs
- prodrug forms
- decahydroisoquinoline
- Prior art date
Links
- 239000000651 prodrug Substances 0.000 title abstract 4
- 229940002612 prodrug Drugs 0.000 title abstract 4
- -1 (4-carboxy)phenyl Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14248499P | 1999-07-06 | 1999-07-06 | |
| PCT/US2000/015030 WO2001002367A2 (en) | 1999-07-06 | 2000-06-13 | Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE240299T1 true ATE240299T1 (de) | 2003-05-15 |
Family
ID=22500022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00941172T ATE240299T1 (de) | 1999-07-06 | 2000-06-13 | Diester prodrugs von decahydroischinoline-3- carbonsäure |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6486175B1 (de) |
| EP (1) | EP1208087B1 (de) |
| AT (1) | ATE240299T1 (de) |
| AU (1) | AU5591900A (de) |
| DE (1) | DE60002733T2 (de) |
| ES (1) | ES2198323T3 (de) |
| WO (1) | WO2001002367A2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20014488A3 (cs) | 1999-07-06 | 2003-01-15 | Eli Lilly And Company | Selektivní antagonisté iGluR5 receptoru pro léčení migrény |
| EP1257545A1 (de) | 1999-12-22 | 2002-11-20 | Eli Lilly And Company | Selektive iglur5 rezeptor antagonisten |
| US6924294B2 (en) | 2001-01-05 | 2005-08-02 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US7205313B2 (en) | 2001-01-05 | 2007-04-17 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| EP1351951A2 (de) | 2001-01-05 | 2003-10-15 | Eli Lilly And Company | Pyrrolidinylmethyl- und piperidinyl-substituierte decahydroisochinoline als antagonisten von exzitatorischen aminosäurerezeptoren |
| US6855725B2 (en) | 2001-01-05 | 2005-02-15 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| EP1355640A1 (de) * | 2001-01-23 | 2003-10-29 | Neurosearch A/S | Verwendung von nicht kompetitiven und selektiven glur5-antagonisten als modulierende verbindungen des glutamatrezeptors |
| AU2003226277B2 (en) | 2002-04-26 | 2009-03-26 | Eli Lilly And Company | Ester derivatives of a decahydroisoquinoline-3-carboxylic acid as analgesics |
| RS55585B1 (sr) | 2006-11-22 | 2017-06-30 | Clinical Research Associates LLC | Postupci za lečenje daunovog sindroma, krhkog x sindroma i autizma |
| EP2544688B1 (de) | 2010-03-02 | 2016-09-07 | President and Fellows of Harvard College | Verfahren und zusammensetzungen zur behandlung des angelman-syndroms |
| WO2011150380A1 (en) | 2010-05-28 | 2011-12-01 | Xenoport, Inc. | Methods of treatment of fragile x syndrome, down's syndrome, autism and related disorders |
| US20120016021A1 (en) | 2010-07-15 | 2012-01-19 | Xenoport, Inc. | Methods of treating fragile x syndrome, down's syndrome, autism and related disorders |
| WO2012054724A1 (en) | 2010-10-21 | 2012-04-26 | Massachusetts Institute Of Technology | Methods of treating seizure disorders |
| IL299471A (en) | 2020-07-02 | 2023-02-01 | Sea Pharmaceuticals Llc | Pharmaceutical compositions of 6-(2-(2h-tetrazol-5-yl)ethyl)-6-fluorodecahydroisoquinoline-3-carboxylic acid and ester derivatives thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2252381B (en) | 1990-12-14 | 1995-08-09 | Charles Bickford | Improved fixing |
| US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5446051A (en) * | 1994-05-31 | 1995-08-29 | Eli Lilly And Company | Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists |
| WO1998045270A1 (en) * | 1997-04-07 | 1998-10-15 | Eli Lilly And Company | Pharmacological agents |
-
2000
- 2000-06-13 EP EP00941172A patent/EP1208087B1/de not_active Expired - Lifetime
- 2000-06-13 DE DE60002733T patent/DE60002733T2/de not_active Expired - Fee Related
- 2000-06-13 WO PCT/US2000/015030 patent/WO2001002367A2/en active IP Right Grant
- 2000-06-13 ES ES00941172T patent/ES2198323T3/es not_active Expired - Lifetime
- 2000-06-13 AU AU55919/00A patent/AU5591900A/en not_active Abandoned
- 2000-06-13 AT AT00941172T patent/ATE240299T1/de not_active IP Right Cessation
- 2000-06-13 US US10/018,038 patent/US6486175B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001002367A2 (en) | 2001-01-11 |
| DE60002733T2 (de) | 2004-03-18 |
| WO2001002367A3 (en) | 2001-03-08 |
| EP1208087A2 (de) | 2002-05-29 |
| AU5591900A (en) | 2001-01-22 |
| DE60002733D1 (de) | 2003-06-18 |
| ES2198323T3 (es) | 2004-02-01 |
| US6486175B1 (en) | 2002-11-26 |
| EP1208087B1 (de) | 2003-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |