[go: up one dir, main page]

ATE239709T1 - Racemisches huperzin a - Google Patents

Racemisches huperzin a

Info

Publication number
ATE239709T1
ATE239709T1 AT01203687T AT01203687T ATE239709T1 AT E239709 T1 ATE239709 T1 AT E239709T1 AT 01203687 T AT01203687 T AT 01203687T AT 01203687 T AT01203687 T AT 01203687T AT E239709 T1 ATE239709 T1 AT E239709T1
Authority
AT
Austria
Prior art keywords
huperzine
racemic
racemic huperzine
medicament
cholesterase
Prior art date
Application number
AT01203687T
Other languages
English (en)
Inventor
Alain P Kozikowski
Yan Xia
Original Assignee
Mayo Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation filed Critical Mayo Foundation
Application granted granted Critical
Publication of ATE239709T1 publication Critical patent/ATE239709T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT01203687T 1989-02-21 1990-02-21 Racemisches huperzin a ATE239709T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/313,118 US4929731A (en) 1989-02-21 1989-02-21 Method for the synthesis of huperzine A and analogs thereof and compounds useful therein

Publications (1)

Publication Number Publication Date
ATE239709T1 true ATE239709T1 (de) 2003-05-15

Family

ID=23214460

Family Applications (3)

Application Number Title Priority Date Filing Date
AT90904089T ATE219061T1 (de) 1989-02-21 1990-02-21 Huperzin a analoge verbindungen
AT00201492T ATE330943T1 (de) 1989-02-21 1990-02-21 Herstellungsverfahren von huperzine a und deren analogen und verbindungen nützlich dazu
AT01203687T ATE239709T1 (de) 1989-02-21 1990-02-21 Racemisches huperzin a

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT90904089T ATE219061T1 (de) 1989-02-21 1990-02-21 Huperzin a analoge verbindungen
AT00201492T ATE330943T1 (de) 1989-02-21 1990-02-21 Herstellungsverfahren von huperzine a und deren analogen und verbindungen nützlich dazu

Country Status (10)

Country Link
US (1) US4929731A (de)
EP (3) EP1026157B1 (de)
JP (1) JP2933386B2 (de)
AT (3) ATE219061T1 (de)
CA (2) CA2047744C (de)
DE (3) DE69033970T2 (de)
DK (2) DK0460062T3 (de)
ES (2) ES2194003T3 (de)
HK (1) HK1030604A1 (de)
WO (1) WO1990009993A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177082A (en) * 1985-11-05 1993-01-05 Yu Chao Mei Huperzines and analogs
US5104880A (en) * 1991-05-01 1992-04-14 Mayo Foundation For Medical Education And Research Huperzine a analogs as acetylcholinesterase inhibitors
US5145973A (en) * 1991-09-30 1992-09-08 Union Carbide Chemicals & Plastics Technology Corporation Oxa-Bicyclic polyfunctional compounds and preparation thereof
US5206393A (en) * 1991-09-30 1993-04-27 Union Carbide Chemicals & Plastics Technology Corporation Oxa-bicyclic polyfunctional compounds and preparation thereof
US5547960A (en) * 1994-09-07 1996-08-20 Mayo Foundation For Medical Education And Research C-10 analogs of huperzine a
CN1125725A (zh) * 1994-12-28 1996-07-03 中国科学院上海药物研究所 一类海克林碱衍生物及它的用途
USRE38460E1 (en) 1994-12-28 2004-03-09 Shanghai Institute Of Materia Medica Chinese Academy Of Sciences Huperzine A derivatives, their preparation and their use
AU6053900A (en) * 1999-06-25 2001-01-31 Morris Notelovitz Compositions for treating or preventing neurodegeneration and cognitive decline
US6271379B1 (en) 2000-03-08 2001-08-07 Georgetown University Intermediates useful for the synthesis of huperzine A
US6436972B1 (en) 2000-04-10 2002-08-20 Dalhousie University Pyridones and their use as modulators of serine hydrolase enzymes
US6369052B1 (en) 2000-08-07 2002-04-09 Georgetown University Combination of huperzine and nicotinic compounds as a neuroprotective agent
KR100390777B1 (ko) * 2000-12-19 2003-07-10 한국화학연구원 피리돈 유도체의 제조방법
US6967206B2 (en) 2002-12-05 2005-11-22 Access Business Group International Llc Compositions and methods for increasing growth hormone levels
CA2609612C (en) 2005-05-23 2014-09-23 President & Fellows Of Harvard College Use of huperzine to treat epilepsy
US8097726B2 (en) * 2006-05-17 2012-01-17 Industrial Technology Research Institute Huperzine a compound for treatment of alzheimer's disease
US20090247754A1 (en) * 2008-03-25 2009-10-01 Debiopharm S.A. Method of preparing huperzine a and derivatives thereof
WO2010028134A2 (en) * 2008-09-04 2010-03-11 President And Fellows Of Harvard College Treatment of neurological disorders using huperzine
CN104496900A (zh) * 2014-12-15 2015-04-08 陕西嘉禾植物化工有限责任公司 一种2-甲氧基-6-酮-5,7,8-三氢-喹啉的制备方法
CN104496998B (zh) * 2014-12-15 2017-07-11 陕西嘉禾生物科技股份有限公司 一种1′‑苄基‑2′‑酮‑5′，7′，8′‑三氢‑螺‑[1，3‑二氧五环‑2]‑喹啉的制备方法
CN109705038B (zh) * 2017-10-25 2020-11-03 广州市朗启医药科技有限责任公司 石杉碱甲的合成方法
CN114716449B (zh) * 2022-04-12 2023-09-29 浙江工业大学 一种2-甲氧基-6-乙二醇缩酮-5,7,8-三氢喹啉的制备方法

Also Published As

Publication number Publication date
EP0460062A1 (de) 1991-12-11
DK0460062T3 (da) 2002-08-26
WO1990009993A3 (en) 1990-11-01
CA2296915A1 (en) 1990-08-22
EP1167354A3 (de) 2002-01-09
DE69034226T2 (de) 2007-06-21
DK1167354T3 (da) 2003-09-01
ATE330943T1 (de) 2006-07-15
ES2173858T3 (es) 2002-11-01
DE69034070T2 (de) 2003-12-18
WO1990009993A2 (en) 1990-09-07
DE69033970T2 (de) 2002-10-02
CA2047744A1 (en) 1990-08-22
EP1167354A2 (de) 2002-01-02
EP0460062B1 (de) 2002-06-12
CA2047744C (en) 2000-05-02
JP2933386B2 (ja) 1999-08-09
HK1030604A1 (en) 2001-05-11
DE69033970D1 (de) 2002-07-18
US4929731A (en) 1990-05-29
EP1167354B1 (de) 2003-05-07
ES2194003T3 (es) 2003-11-16
EP1026157A3 (de) 2004-08-11
EP1026157B1 (de) 2006-06-21
DE69034070D1 (de) 2003-06-12
ATE219061T1 (de) 2002-06-15
EP0460062A4 (en) 1992-07-01
EP1026157A2 (de) 2000-08-09
DE69034226D1 (de) 2006-08-03

Similar Documents

Publication Publication Date Title
DE69034070D1 (de) Racemisches Huperzin A
NZ240230A (en) Mercaptoacetylamide derivatives; preparation, use and pharmaceutical compositions thereof
SE9504661D0 (sv) New compounds
KR880005932A (ko) 신경중독손상을 감소시키기 위한 약제 조성물
UA26303A1 (uk) Фармацевтичhа композиція, яка має імуhосупресорhу та аhтимікробhу активhість
NO971889L (no) Forbindelser og sammensetninger for levering av aktive midler
DE69011353D1 (de) Oral anzuwendende antifungale Arzneizubereitungen.
MX9700885A (es) Nuevas heteroariloxazolidinonas.
BR9811099A (pt) Inibidores de urocinase
IT8323205A0 (it) Composizioni farmaceutiche adattivita' antiinfiammatoria e/o analgesica, non ulcerogene.
ATE252885T1 (de) Plan zur verabreichung von h+, k+-atpase inhibitoren
HUP9602498A2 (hu) Antimikrobiális hatású gyógyászati készítmények
HUP0004282A2 (hu) 2-Halogén-6-0-szubsztituált ketolidszármazékok
AU563831B2 (en) N-(2-amino-3,5-dibromobenzyl)- trans-4-amino-cyclohexanol derivatives
CA2163118A1 (en) Aurintricaboxylic Acid Fractions and Analogues with Anti-Angiogenic Activity and Methods of Use
MA19882A1 (fr) Derives d'acides w-amines, leur preparation et utilisation ainsi que les compositions contenant ces acides.
NO983177L (no) Anvendelse av 1-enantiomeren av centkroman til fremstilling av et farmasaytisk preparat for behandling eller profylakse av brystkreft
NO911459D0 (no) Anvendelse av metallion-komplekser som belegginhibitorer.
ES2089286T3 (es) Nuevas 2-amino-5-ciano-1,4-dihidropiridinas, procedimiento para su preparacion y su uso en medicamentos.
SE9504662D0 (sv) New compounds
EA200000531A1 (ru) Применение кетолидов для профилактики тромботических артериальных осложнений, связанных с атеросклерозом
LV10917A (lv) Bambuterina pielietojums lipidu saturu pazeminosu farmaceitisku kompoziciju pagatavosanai
AU7028798A (en) Use of 2-methylthiazolidine-2,4-dicarboxylic acid as mucolytic agent
DE60039122D1 (de) 6-o-alkyl-2-nor-2-substituierte ketolidderivate
ATE102934T1 (de) Fluorierte flavon-essigsaeure.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1167354

Country of ref document: EP

REN Ceased due to non-payment of the annual fee