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ATE238317T1 - Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-biphosphonsäure und ihres trihydratisierten mononatriumsalzes - Google Patents

Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-biphosphonsäure und ihres trihydratisierten mononatriumsalzes

Info

Publication number
ATE238317T1
ATE238317T1 AT00945957T AT00945957T ATE238317T1 AT E238317 T1 ATE238317 T1 AT E238317T1 AT 00945957 T AT00945957 T AT 00945957T AT 00945957 T AT00945957 T AT 00945957T AT E238317 T1 ATE238317 T1 AT E238317T1
Authority
AT
Austria
Prior art keywords
hydroxybutylidene
amino
trihydrated
producing
acid
Prior art date
Application number
AT00945957T
Other languages
English (en)
Inventor
I Llado Jordi Bosch
Lista Eugenia Pagans
Miguel M Del Carmen Onrubia
Original Assignee
Medichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa filed Critical Medichem Sa
Application granted granted Critical
Publication of ATE238317T1 publication Critical patent/ATE238317T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT00945957T 1999-08-06 2000-07-17 Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-biphosphonsäure und ihres trihydratisierten mononatriumsalzes ATE238317T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009901806A ES2153794B1 (es) 1999-08-06 1999-08-06 Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
PCT/ES2000/000254 WO2001010874A1 (es) 1999-08-06 2000-07-17 Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada

Publications (1)

Publication Number Publication Date
ATE238317T1 true ATE238317T1 (de) 2003-05-15

Family

ID=8309563

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00945957T ATE238317T1 (de) 1999-08-06 2000-07-17 Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-biphosphonsäure und ihres trihydratisierten mononatriumsalzes

Country Status (18)

Country Link
US (1) US6573401B1 (de)
EP (1) EP1205484B1 (de)
KR (1) KR100688287B1 (de)
AT (1) ATE238317T1 (de)
AU (1) AU5987300A (de)
BR (1) BR0013031A (de)
CA (1) CA2380841C (de)
CR (1) CR6575A (de)
DE (1) DE60002347T2 (de)
DK (1) DK1205484T3 (de)
ES (2) ES2153794B1 (de)
HU (1) HUP0202196A3 (de)
IL (1) IL148000A (de)
MX (1) MXPA02001293A (de)
PL (1) PL191733B1 (de)
PT (1) PT1205484E (de)
SI (1) SI1205484T1 (de)
WO (1) WO2001010874A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ552514A (en) * 2001-12-24 2008-08-29 Teva Pharma Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
ITMI20020908A1 (it) 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
WO2003097655A1 (en) * 2002-05-17 2003-11-27 Teva Pharmaceutical Industries Ltd. Use of certain diluents for making bisphosphonic acids
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
WO2005035542A1 (en) * 2003-10-14 2005-04-21 Pliva-Istrazivanje I Razvoj D.O.O. Solid-state form of alendronate sodium and preparation thereof
ES2324015T1 (es) * 2005-05-06 2009-07-29 Medichem, S.A. Proceso de sintesis de acidos bisfosfonicos geminales o de sus sales farmaceuticamente aceptables o de sus hidratos.
US7872144B2 (en) * 2005-06-13 2011-01-18 Jubilant Organosys Limited Process for producing biphosphonic acids and forms thereof
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
MX2008014248A (es) * 2006-05-11 2009-02-23 Ind Swift Lab Ltd Proceso para la preparacion de sales y acido risedronico puros.
CN102639545B (zh) 2009-10-02 2016-08-03 施里特马克控股公司 制备氨基羟基二膦酸的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016289A1 (de) 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) * 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
GB2248061A (en) * 1990-09-18 1992-03-25 Merck & Co Inc Amino-hydroxy-alkylidene bis phosphonic acids
US5039819A (en) 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
US5510517A (en) 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
TW257765B (de) 1993-08-25 1995-09-21 Merck & Co Inc
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
PT1169326E (pt) * 1999-02-17 2004-10-29 Teva Pharma Novo processo para a preparacao de acido alendronico

Also Published As

Publication number Publication date
IL148000A (en) 2005-12-18
DE60002347D1 (de) 2003-05-28
HUP0202196A2 (en) 2002-10-28
BR0013031A (pt) 2002-04-16
EP1205484A1 (de) 2002-05-15
EP1205484B1 (de) 2003-04-23
US6573401B1 (en) 2003-06-03
MXPA02001293A (es) 2002-07-22
AU5987300A (en) 2001-03-05
CA2380841A1 (en) 2001-02-15
SI1205484T1 (en) 2003-12-31
DK1205484T3 (da) 2003-08-11
ES2153794B1 (es) 2001-10-16
ES2194753T3 (es) 2003-12-01
PL191733B1 (pl) 2006-06-30
IL148000A0 (en) 2002-09-12
KR20020024320A (ko) 2002-03-29
CA2380841C (en) 2009-09-15
DE60002347T2 (de) 2004-02-12
PT1205484E (pt) 2003-08-29
CR6575A (es) 2002-08-16
ES2153794A1 (es) 2001-03-01
HUP0202196A3 (en) 2002-12-28
PL354033A1 (en) 2003-12-15
KR100688287B1 (ko) 2007-02-28
WO2001010874A1 (es) 2001-02-15

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