ATE236878T1 - Neue produktionsmethode - Google Patents
Neue produktionsmethodeInfo
- Publication number
- ATE236878T1 ATE236878T1 AT99963732T AT99963732T ATE236878T1 AT E236878 T1 ATE236878 T1 AT E236878T1 AT 99963732 T AT99963732 T AT 99963732T AT 99963732 T AT99963732 T AT 99963732T AT E236878 T1 ATE236878 T1 AT E236878T1
- Authority
- AT
- Austria
- Prior art keywords
- production method
- new production
- new
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9804002A SE9804002D0 (sv) | 1998-11-23 | 1998-11-23 | New manufacturing process |
PCT/SE1999/002155 WO2000031035A1 (en) | 1998-11-23 | 1999-11-22 | New manufacturing process |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE236878T1 true ATE236878T1 (de) | 2003-04-15 |
Family
ID=20413379
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99963732T ATE236878T1 (de) | 1998-11-23 | 1999-11-22 | Neue produktionsmethode |
Country Status (12)
Country | Link |
---|---|
US (1) | US6350877B1 (de) |
EP (1) | EP1133473B1 (de) |
JP (1) | JP4553490B2 (de) |
AR (1) | AR021369A1 (de) |
AT (1) | ATE236878T1 (de) |
AU (1) | AU759211B2 (de) |
CA (1) | CA2349195C (de) |
DE (1) | DE69906787T2 (de) |
NZ (1) | NZ511503A (de) |
SE (1) | SE9804002D0 (de) |
WO (1) | WO2000031035A1 (de) |
ZA (1) | ZA200103434B (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100105743A1 (en) * | 2008-08-01 | 2010-04-29 | Gopal Krishna | Pharmaceutical compositions and methods for stabilizing the same |
NZ591205A (en) * | 2008-08-01 | 2012-11-30 | Medicines Co | Pharmaceutical compositions comprising clevidipine and methods for producing low impurity concentrations of the same |
CA2701087A1 (en) * | 2010-04-12 | 2011-10-12 | Alphora Research Inc. | Preparation of clevidipine butyrate ring the same |
CA2701272A1 (en) * | 2010-04-21 | 2011-10-21 | Alphora Research Inc. | Preparation of intermediates for the synthesis of dihydropyridine calcium channel blockers |
US8455655B2 (en) | 2010-05-07 | 2013-06-04 | Laboratorios Lesvi, S.L. | Preparation of dihydropyridines |
EP2386544B1 (de) | 2010-05-07 | 2016-02-10 | Laboratorios Lesvi, S.L. | Herstellung von Dihydropyridinen |
PT2627173E (pt) | 2010-10-12 | 2015-07-24 | Medicines Co | Formulações de clevidipina em emulsão contendo agentes antimicrobianos |
US8658676B2 (en) | 2010-10-12 | 2014-02-25 | The Medicines Company | Clevidipine emulsion formulations containing antimicrobial agents |
CN102001992B (zh) * | 2010-10-14 | 2012-05-23 | 清远嘉博制药有限公司 | 一种丁酸氯维地平的制备方法 |
CN102531998A (zh) * | 2010-12-09 | 2012-07-04 | 天津药物研究院 | α型多晶型丁酸氯维地平结晶、其制备方法、用途和药物组合物 |
WO2012135617A1 (en) | 2011-04-01 | 2012-10-04 | The Medicines Company | Short -acting dihydropyridines (clevidipine) for use in reducing stroke damage |
CN102827068A (zh) * | 2011-06-17 | 2012-12-19 | 张锐豪 | 一种4-(2, 3-二氯苯基)-2, 6-二甲基-1, 4-二氢-5-甲氧基羰基-3-吡啶羧酸的制备方法 |
CN103420899B (zh) * | 2012-05-25 | 2016-01-27 | 四川科伦药物研究有限公司 | 一种丁酸氯维地平的纯化方法 |
CA2889584C (en) | 2012-10-26 | 2018-08-14 | The Medicines Company | Methods for controlling blood pressure and reducing dyspnea in heart failure |
CN103086956B (zh) * | 2013-01-17 | 2015-11-04 | 北京嘉林药业股份有限公司 | 一种丁酸氯维地平中间体的纯化方法 |
WO2015179334A1 (en) | 2014-05-19 | 2015-11-26 | The Medicines Company | Clevidipine nanoparticles and pharmaceutical compositions thereof |
CN105198797B (zh) * | 2015-11-12 | 2017-12-08 | 华仁药业股份有限公司 | 丁酸氯维地平的纯化方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1093549A (en) | 1976-02-16 | 1981-01-13 | Michael Gregson | Cephalosporin antibiotics |
SE9303657D0 (sv) * | 1993-11-05 | 1993-11-05 | Astra Ab | Short-acting dihydropyridines |
SE9303744D0 (sv) * | 1993-11-12 | 1993-11-12 | Astra Ab | Pharmaceutical emulsion |
-
1998
- 1998-11-23 SE SE9804002A patent/SE9804002D0/xx unknown
-
1999
- 1999-11-22 JP JP2000583863A patent/JP4553490B2/ja not_active Expired - Lifetime
- 1999-11-22 AT AT99963732T patent/ATE236878T1/de not_active IP Right Cessation
- 1999-11-22 WO PCT/SE1999/002155 patent/WO2000031035A1/en active IP Right Grant
- 1999-11-22 NZ NZ511503A patent/NZ511503A/xx not_active IP Right Cessation
- 1999-11-22 AU AU20105/00A patent/AU759211B2/en not_active Expired
- 1999-11-22 US US09/508,260 patent/US6350877B1/en not_active Expired - Lifetime
- 1999-11-22 CA CA002349195A patent/CA2349195C/en not_active Expired - Lifetime
- 1999-11-22 DE DE69906787T patent/DE69906787T2/de not_active Expired - Lifetime
- 1999-11-22 EP EP99963732A patent/EP1133473B1/de not_active Expired - Lifetime
- 1999-11-23 AR ARP990105951A patent/AR021369A1/es unknown
-
2001
- 2001-04-26 ZA ZA200103434A patent/ZA200103434B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2010500A (en) | 2000-06-13 |
EP1133473B1 (de) | 2003-04-09 |
NZ511503A (en) | 2002-11-26 |
CA2349195A1 (en) | 2000-06-02 |
ZA200103434B (en) | 2002-07-26 |
AU759211B2 (en) | 2003-04-10 |
DE69906787D1 (de) | 2003-05-15 |
EP1133473A1 (de) | 2001-09-19 |
JP4553490B2 (ja) | 2010-09-29 |
AR021369A1 (es) | 2002-07-17 |
SE9804002D0 (sv) | 1998-11-23 |
CA2349195C (en) | 2008-12-30 |
JP2002530376A (ja) | 2002-09-17 |
US6350877B1 (en) | 2002-02-26 |
WO2000031035A1 (en) | 2000-06-02 |
DE69906787T2 (de) | 2004-02-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |