ATE236148T1 - Synthese der terfenadin und deren derivate - Google Patents
Synthese der terfenadin und deren derivateInfo
- Publication number
- ATE236148T1 ATE236148T1 AT98901831T AT98901831T ATE236148T1 AT E236148 T1 ATE236148 T1 AT E236148T1 AT 98901831 T AT98901831 T AT 98901831T AT 98901831 T AT98901831 T AT 98901831T AT E236148 T1 ATE236148 T1 AT E236148T1
- Authority
- AT
- Austria
- Prior art keywords
- terfenadine
- synthesis
- derivatives
- processes
- general formula
- Prior art date
Links
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 229960000351 terfenadine Drugs 0.000 title 1
- -1 carboxy, carboxy, hydroxymethyl Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/803,895 US5925761A (en) | 1997-02-04 | 1997-02-04 | Synthesis of terfenadine and derivatives |
| PCT/US1998/000898 WO1998033789A1 (en) | 1997-02-04 | 1998-01-20 | Synthesis of terfenadine and derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE236148T1 true ATE236148T1 (de) | 2003-04-15 |
Family
ID=25187720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98901831T ATE236148T1 (de) | 1997-02-04 | 1998-01-20 | Synthese der terfenadin und deren derivate |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5925761A (de) |
| EP (1) | EP0956286B1 (de) |
| JP (1) | JP4330179B2 (de) |
| AT (1) | ATE236148T1 (de) |
| AU (1) | AU724665B2 (de) |
| CA (1) | CA2279960C (de) |
| DE (1) | DE69812895T2 (de) |
| DK (1) | DK0956286T3 (de) |
| ES (1) | ES2196531T3 (de) |
| PT (1) | PT956286E (de) |
| WO (1) | WO1998033789A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6153754A (en) * | 1995-12-21 | 2000-11-28 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| US6201124B1 (en) * | 1995-12-21 | 2001-03-13 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| IN191492B (de) * | 1999-05-25 | 2003-12-06 | Ranbaxy Lab Ltd | |
| HUP0400299A2 (en) * | 2001-04-09 | 2007-08-28 | Teva Pharma | Polymorphs of fexofenadine hydrochloride |
| US20030021849A1 (en) * | 2001-04-09 | 2003-01-30 | Ben-Zion Dolitzky | Polymorphs of fexofenadine hydrochloride |
| JP2005532356A (ja) * | 2002-06-10 | 2005-10-27 | テバ ファーマシューティカル インダストリーズ リミティド | 塩酸フェキソフェナジンの多型体ｘｖｉ |
| SK285548B6 (sk) * | 2002-11-13 | 2007-03-01 | Zentiva, A. S. | Spôsob prípravy terfenadinu a jeho derivátov |
| KR20070007196A (ko) * | 2004-04-26 | 2007-01-12 | 테바 파마슈티컬 인더스트리즈 리미티드 | 펙소페나딘 히드로클로라이드의 결정형 및 이의 제조 방법 |
| JP2008514641A (ja) * | 2004-09-28 | 2008-05-08 | テバ ファーマシューティカル インダストリーズ リミティド | 結晶形フェキソフェナジン、およびその調製方法 |
| WO2007135693A2 (en) * | 2006-05-18 | 2007-11-29 | Ind-Swift Laboratories Limited | Intermediates useful for the preparation of antihistaminic piperidine derivative |
| GEP20115306B (de) | 2006-09-15 | 2011-10-10 | Pfizer Prod Inc | |
| US7868200B2 (en) * | 2008-12-30 | 2011-01-11 | Lyondellbasell Flavors & Fragrances, Llc | Process for preparing alicyclic carboxylic acid compounds |
| JP6447517B2 (ja) * | 2013-12-26 | 2019-01-09 | 住友化学株式会社 | ハロゲン置換フタリドの製造方法 |
| CN104876853B (zh) * | 2015-06-17 | 2017-06-16 | 苏州卫生职业技术学院 | 盐酸非索非那定的合成方法 |
| US10092087B2 (en) | 2016-06-03 | 2018-10-09 | Israel Harry Zimmerman | Self-righting toothbrush |
| US10485330B2 (en) | 2017-02-20 | 2019-11-26 | Israel Harry Zimmerman | Self-righting toothbrush |
| US10517386B2 (en) | 2017-03-30 | 2019-12-31 | Israel Harry Zimmerman | Self-righting toothbrush |
| USD876097S1 (en) | 2018-03-23 | 2020-02-25 | Israel Harry Zimmerman | Toothbrush handle |
| USD874832S1 (en) | 2018-03-23 | 2020-02-11 | Israel Harry Zimmerman | Toothbrush handle |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3141024A (en) * | 1964-07-14 | S-trimethoxy benzoyl amino | ||
| US3965257A (en) * | 1972-01-28 | 1976-06-22 | Richardson-Merrell Inc. | Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions |
| US3806526A (en) * | 1972-01-28 | 1974-04-23 | Richardson Merrell Inc | 1-aroylalkyl-4-diphenylmethyl piperidines |
| US4254129A (en) * | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| DE69131842T2 (de) * | 1990-10-05 | 2000-07-27 | Ajinomoto Co., Inc. | Piperidinderivate und ihre Verwendung als antiarrhythmische Wirkstoffe |
| PT1214937E (pt) * | 1992-08-03 | 2007-07-25 | Sepracor Inc | Carboxilato de terfenadina e o tratamento de irritação dérmica. |
| PT1026147E (pt) * | 1993-06-24 | 2004-04-30 | Albany Molecular Res Inc | Compostos uteis como intermediarios na producao de derivados de piperidina |
| CN1159277C (zh) * | 1993-06-25 | 2004-07-28 | 默里尔药物公司 | 用于制备抗组胺哌啶衍生物的新中间体 |
| ATE194328T1 (de) * | 1994-05-16 | 2000-07-15 | Merrell Pharma Inc | Verfahren und diastereomere salze nützlich bei der racemattrennung von racemischer 4-(4-(4- (hydroxydiphenylmethyl)-1-piperidinyl)-1- hydroxybutyl)-alpha,alpha-dimethylphenyl essigsäure sowie entsprechende diastereomere salze |
-
1997
- 1997-02-04 US US08/803,895 patent/US5925761A/en not_active Expired - Lifetime
-
1998
- 1998-01-20 WO PCT/US1998/000898 patent/WO1998033789A1/en active IP Right Grant
- 1998-01-20 CA CA002279960A patent/CA2279960C/en not_active Expired - Fee Related
- 1998-01-20 AU AU58262/98A patent/AU724665B2/en not_active Ceased
- 1998-01-20 AT AT98901831T patent/ATE236148T1/de active
- 1998-01-20 DK DK98901831T patent/DK0956286T3/da active
- 1998-01-20 DE DE69812895T patent/DE69812895T2/de not_active Expired - Lifetime
- 1998-01-20 ES ES98901831T patent/ES2196531T3/es not_active Expired - Lifetime
- 1998-01-20 PT PT98901831T patent/PT956286E/pt unknown
- 1998-01-20 EP EP98901831A patent/EP0956286B1/de not_active Expired - Lifetime
- 1998-01-20 JP JP53292198A patent/JP4330179B2/ja not_active Expired - Fee Related
-
1999
- 1999-05-24 US US09/316,104 patent/US6147217A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4330179B2 (ja) | 2009-09-16 |
| US5925761A (en) | 1999-07-20 |
| US6147217A (en) | 2000-11-14 |
| EP0956286B1 (de) | 2003-04-02 |
| EP0956286A1 (de) | 1999-11-17 |
| CA2279960A1 (en) | 1998-08-06 |
| AU5826298A (en) | 1998-08-25 |
| ES2196531T3 (es) | 2003-12-16 |
| AU724665B2 (en) | 2000-09-28 |
| WO1998033789A1 (en) | 1998-08-06 |
| CA2279960C (en) | 2007-07-17 |
| DE69812895D1 (de) | 2003-05-08 |
| DK0956286T3 (da) | 2003-07-14 |
| PT956286E (pt) | 2003-08-29 |
| JP2001511144A (ja) | 2001-08-07 |
| DE69812895T2 (de) | 2004-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner | ||
| UEP | Publication of translation of european patent specification |
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