ATE234918T1 - Monoklonale antikörper gegen lösliche tnf-alpha rezeptoren p55 und p75 als auch gegen tnf-alpha und dessen analogen - Google Patents

Monoklonale antikörper gegen lösliche tnf-alpha rezeptoren p55 und p75 als auch gegen tnf-alpha und dessen analogen

Info

Publication number: ATE234918T1
Authority: AT; Austria
Prior art keywords: alpha; tnf; monoclonal antibodies; receptors; analogues
Prior art date: 1995-08-04

Application number

AT96926042T

Other languages

English (en)

Inventor

Serbec Vladka Curin

Annette Schuurbiers

Viktor Menart

Porekar Vladimira Gaderc

Anton Stalc

Petra Zunec

Janja Ocvirk

Borut Stabuc

Original Assignee

Lek Tovarna Farmacevtskih

Zd Republike Slovenije Za Tran

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-04

Filing date

1996-07-31

Publication date

2003-04-15

1995-08-04 Priority claimed from SI9500249A external-priority patent/SI9500249B/sl

1996-06-28 Priority claimed from SI9600206A external-priority patent/SI9600206B/sl

1996-07-31 Application filed by Lek Tovarna Farmacevtskih, Zd Republike Slovenije Za Tran filed Critical Lek Tovarna Farmacevtskih

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE234918T1 publication Critical patent/ATE234918T1/de

Links

GOZMBJCYMQQACI-UHFFFAOYSA-N 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;dihydrochloride Chemical compound Cl.Cl.C=1OC2=CC(C)=C(C)C=C2C(=O)C=1CN(C)CCN(C)CC(C1=CC=CC=C11)=CN1C1=CC=CC(C(F)(F)F)=C1 GOZMBJCYMQQACI-UHFFFAOYSA-N 0.000 abstract 7
238000000034 method Methods 0.000 abstract 2
101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 abstract 1
241000699670 Mus sp. Species 0.000 abstract 1
239000000427 antigen Substances 0.000 abstract 1
102000036639 antigens Human genes 0.000 abstract 1
108091007433 antigens Proteins 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
102000057041 human TNF Human genes 0.000 abstract 1
210000004408 hybridoma Anatomy 0.000 abstract 1
230000003053 immunization Effects 0.000 abstract 1
238000002649 immunization Methods 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Zoology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Cell Biology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)

AT96926042T 1995-08-04 1996-07-31 Monoklonale antikörper gegen lösliche tnf-alpha rezeptoren p55 und p75 als auch gegen tnf-alpha und dessen analogen ATE234918T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
SI9500249A SI9500249B (sl)	1995-08-04	1995-08-04	Monoklonska protitelesa proti topnima TNF-alfa receptorjema p55 in p75 ter TNF-alfa in njegovim analogom
SI9600206A SI9600206B (sl)	1996-06-28	1996-06-28	Monoklonska protitelesa proti topnima TNF-alfa receptorjema p55 in p75 ter TNF-alfa in njegovim analogom
PCT/SI1996/000018 WO1997006251A1 (en)	1995-08-04	1996-07-31	MONOCLONAL ANTIBODIES AGAINST SOLUBLE TNF-α RECEPTORS p55 and p75 AS WELL AS AGAINST TNF-α AND ITS ANALOGUES

Publications (1)

Publication Number	Publication Date
ATE234918T1 true ATE234918T1 (de)	2003-04-15

Family

ID=26665256

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96926042T ATE234918T1 (de)	1995-08-04	1996-07-31	Monoklonale antikörper gegen lösliche tnf-alpha rezeptoren p55 und p75 als auch gegen tnf-alpha und dessen analogen

Country Status (5)

Country	Link
EP (1)	EP0846169B1 (de)
AT (1)	ATE234918T1 (de)
AU (1)	AU703091B2 (de)
DE (1)	DE69626829T2 (de)
WO (1)	WO1997006251A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7427492B1 (en)	1995-06-05	2008-09-23	Human Genome Sciences, Inc.	Polynucleotides encoding human tumor necrosis factor receptor-like2
US7429646B1 (en)	1995-06-05	2008-09-30	Human Genome Sciences, Inc.	Antibodies to human tumor necrosis factor receptor-like 2
ATE408688T1 (de)	1998-10-06	2008-10-15	Univ Queensland	Polypeptide zur modulierung des überlebens von zellen
US7112409B2 (en)	1999-01-29	2006-09-26	Center For Molecular Medicine And Immunology	Method of determining cytokine dosage for myelosuppressive state
US6649352B1 (en) *	1999-01-29	2003-11-18	Center For Molecular Medicine And Immunology	Method of evaluating myelosuppressive state
CA2365405A1 (en) *	1999-03-22	2000-09-28	Human Genome Sciences, Inc.	Human tumor necrosis factor receptor-like 2
US9028822B2 (en)	2002-06-28	2015-05-12	Domantis Limited	Antagonists against TNFR1 and methods of use therefor
US20040033228A1 (en)	2002-08-16	2004-02-19	Hans-Juergen Krause	Formulation of human antibodies for treating TNF-alpha associated disorders
SI21373A (sl) *	2002-11-22	2004-06-30	LEK farmacevtska družba d.d.	Metoda za moduliranje biološke aktivnosti proteinov
RU2401842C2 (ru) *	2004-10-08	2010-10-20	Домантис Лимитед	Антагонисты и способы их применения
WO2007060411A1 (en) *	2005-11-24	2007-05-31	Ucb Pharma S.A.	Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r
US10023628B2 (en) †	2012-07-06	2018-07-17	Bioverativ Therapeutics Inc.	Cell line expressing single chain factor VIII polypeptides and uses thereof
CA3004830A1 (en)	2015-11-11	2017-05-18	Opi Vi- Ip Holdco Llc	Composition and methods for anti-tnfr2 antibodies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4870163A (en) *	1985-08-29	1989-09-26	New York Blood Center, Inc.	Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor
US5075236A (en) *	1987-04-24	1991-12-24	Teijin Limited	Method of detecting kawasaki disease using anti-tumor necrosis antibody
DE3823804A1 (de) *	1988-07-14	1990-01-18	Basf Ag	Neutralisation der in vitro und in vivo toxischen eigenschaften von tnf-(alpha) durch monoklonale antikoerper und den davon abgeleiteten fragmenten
GB9028123D0 (en) *	1990-12-28	1991-02-13	Erba Carlo Spa	Monoclonal antibodies against human tumor necrosis factor alpha
WO1992022666A1 (de) *	1991-06-19	1992-12-23	Boehringer Ingelheim International Gmbh	Monoklonale antikörper gegen das humane tnf-bindende protein i (tnf-bp i)

1996
- 1996-07-31 AT AT96926042T patent/ATE234918T1/de not_active IP Right Cessation
- 1996-07-31 DE DE69626829T patent/DE69626829T2/de not_active Expired - Lifetime
- 1996-07-31 AU AU66345/96A patent/AU703091B2/en not_active Ceased
- 1996-07-31 WO PCT/SI1996/000018 patent/WO1997006251A1/en active IP Right Grant
- 1996-07-31 EP EP96926042A patent/EP0846169B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69626829T2 (de)	2004-03-18
EP0846169A1 (de)	1998-06-10
DE69626829D1 (de)	2003-04-24
AU703091B2 (en)	1999-03-18
AU6634596A (en)	1997-03-05
EP0846169B1 (de)	2003-03-19
WO1997006251A1 (en)	1997-02-20

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Legal Events

Date	Code	Title	Description
2003-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties