ATE228122T1 - Umgekehrt hydroxamat inhibitoren von matrix metalloproteinasen - Google Patents

Umgekehrt hydroxamat inhibitoren von matrix metalloproteinasen

Info

Publication number: ATE228122T1
Authority: AT; Austria
Prior art keywords: hydroxamat; inhibitors; reverse; matrix metalloproteinases; metalloproteinases
Prior art date: 1999-01-27

Application number

AT00905758T

Other languages

English (en)

Inventor

Michael L Curtin

Yujia Dai

Steven K Davidsen

Howard R Heyman

James H Holmes

Michael R Michaelides

Douglas H Steinman

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-27

Filing date

2000-01-27

Publication date

2002-12-15

2000-01-27 Application filed by Abbott Lab filed Critical Abbott Lab

2002-12-15 Application granted granted Critical

2002-12-15 Publication of ATE228122T1 publication Critical patent/ATE228122T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Furan Compounds (AREA)
Pyrrole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT00905758T 1999-01-27 2000-01-27 Umgekehrt hydroxamat inhibitoren von matrix metalloproteinasen ATE228122T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US23908799A	1999-01-27	1999-01-27
PCT/US2000/002038 WO2000044739A1 (en)	1999-01-27	2000-01-27	Reverse hydroxamate inhibitors of matrix metalloproteinases

Publications (1)

Publication Number	Publication Date
ATE228122T1 true ATE228122T1 (de)	2002-12-15

Family

ID=22900549

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00905758T ATE228122T1 (de)	1999-01-27	2000-01-27	Umgekehrt hydroxamat inhibitoren von matrix metalloproteinasen

Country Status (28)

Country	Link
US (1)	US20020007060A1 (de)
EP (1)	EP1147101B1 (de)
JP (1)	JP4718686B2 (de)
KR (1)	KR100748010B1 (de)
CN (1)	CN1222519C (de)
AR (1)	AR029329A1 (de)
AT (1)	ATE228122T1 (de)
AU (1)	AU764383B2 (de)
BG (1)	BG105782A (de)
BR (1)	BR0007278A (de)
CA (1)	CA2358951C (de)
CO (1)	CO5150194A1 (de)
CZ (1)	CZ20012591A3 (de)
DE (1)	DE60000819T2 (de)
DK (1)	DK1147101T3 (de)
ES (1)	ES2187443T3 (de)
HK (1)	HK1043115A1 (de)
HU (1)	HUP0105477A2 (de)
IL (1)	IL143713A0 (de)
NO (1)	NO20013669L (de)
NZ (1)	NZ512372A (de)
PL (1)	PL349771A1 (de)
PT (1)	PT1147101E (de)
SK (1)	SK10582001A3 (de)
TR (1)	TR200102159T2 (de)
TW (1)	TWI225486B (de)
WO (1)	WO2000044739A1 (de)
ZA (1)	ZA200104979B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9923078D0 (en) *	1999-09-29	1999-12-01	Phytopharm Plc	Sapogenin derivatives and their use
WO2003063762A2 (en) *	2001-01-12	2003-08-07	Abbott Laboratories	Process for the preparation of matrix metalloproteinase inhibitors
EP1431285B1 (de)	2001-09-07	2009-01-07	Kaken Pharmaceutical Co., Ltd.	Reverse hydroxamsäurederivate
US7790767B2 (en) *	2005-06-27	2010-09-07	Nabriva Therapeutics Forschungs Gmbh	Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group
EP2543368A1 (de)	2007-12-11	2013-01-09	Viamet Pharmaceuticals, Inc.	Metalloenzymhemmer mit metallbindenden Teilen in Kombination mit Targeting-Teilen
WO2015107139A1 (en)	2014-01-17	2015-07-23	Proyecto De Biomedicina Cima, S.L.	Compounds for use as antifibrinolytic agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE225343T1 (de) *	1995-12-20	2002-10-15	Hoffmann La Roche	Matrix-metalloprotease inhibitoren

2000
- 2000-01-25 CO CO00003867A patent/CO5150194A1/es unknown
- 2000-01-26 AR ARP000100349A patent/AR029329A1/es not_active Application Discontinuation
- 2000-01-27 JP JP2000595995A patent/JP4718686B2/ja not_active Expired - Fee Related
- 2000-01-27 AU AU27391/00A patent/AU764383B2/en not_active Ceased
- 2000-01-27 HU HU0105477A patent/HUP0105477A2/hu unknown
- 2000-01-27 DK DK00905758T patent/DK1147101T3/da active
- 2000-01-27 EP EP00905758A patent/EP1147101B1/de not_active Expired - Lifetime
- 2000-01-27 PT PT00905758T patent/PT1147101E/pt unknown
- 2000-01-27 DE DE60000819T patent/DE60000819T2/de not_active Expired - Lifetime
- 2000-01-27 CN CNB008032378A patent/CN1222519C/zh not_active Expired - Fee Related
- 2000-01-27 KR KR1020017009393A patent/KR100748010B1/ko not_active Expired - Fee Related
- 2000-01-27 NZ NZ512372A patent/NZ512372A/xx unknown
- 2000-01-27 CA CA002358951A patent/CA2358951C/en not_active Expired - Fee Related
- 2000-01-27 IL IL14371300A patent/IL143713A0/xx unknown
- 2000-01-27 AT AT00905758T patent/ATE228122T1/de not_active IP Right Cessation
- 2000-01-27 WO PCT/US2000/002038 patent/WO2000044739A1/en not_active Application Discontinuation
- 2000-01-27 BR BR0007278-8A patent/BR0007278A/pt not_active Application Discontinuation
- 2000-01-27 ES ES00905758T patent/ES2187443T3/es not_active Expired - Lifetime
- 2000-01-27 TR TR2001/02159T patent/TR200102159T2/xx unknown
- 2000-01-27 SK SK1058-2001A patent/SK10582001A3/sk unknown
- 2000-01-27 PL PL00349771A patent/PL349771A1/xx not_active Application Discontinuation
- 2000-01-27 CZ CZ20012591A patent/CZ20012591A3/cs unknown
- 2000-02-25 TW TW089101383A patent/TWI225486B/zh not_active IP Right Cessation
2001
- 2001-06-18 ZA ZA200104979A patent/ZA200104979B/en unknown
- 2001-07-16 US US09/905,242 patent/US20020007060A1/en not_active Abandoned
- 2001-07-26 NO NO20013669A patent/NO20013669L/no not_active Application Discontinuation
- 2001-08-03 BG BG105782A patent/BG105782A/xx unknown
2002
- 2002-04-18 HK HK02102947.8A patent/HK1043115A1/zh unknown

Also Published As

Publication number	Publication date
AU764383B2 (en)	2003-08-14
ES2187443T3 (es)	2003-06-16
NO20013669D0 (no)	2001-07-26
IL143713A0 (en)	2002-04-21
CA2358951C (en)	2009-10-20
HUP0105477A2 (hu)	2002-05-29
NZ512372A (en)	2003-01-31
DK1147101T3 (da)	2003-03-10
CA2358951A1 (en)	2000-08-03
BR0007278A (pt)	2001-11-27
CN1222519C (zh)	2005-10-12
PL349771A1 (en)	2002-09-09
NO20013669L (no)	2001-09-27
ZA200104979B (en)	2002-09-18
EP1147101B1 (de)	2002-11-20
EP1147101A1 (de)	2001-10-24
TR200102159T2 (tr)	2001-12-21
TWI225486B (en)	2004-12-21
DE60000819D1 (de)	2003-01-02
HK1043115A1 (zh)	2002-09-06
JP4718686B2 (ja)	2011-07-06
KR20010101709A (ko)	2001-11-14
CZ20012591A3 (cs)	2001-12-12
AR029329A1 (es)	2003-06-25
DE60000819T2 (de)	2003-09-04
CN1339032A (zh)	2002-03-06
SK10582001A3 (sk)	2001-12-03
JP2002535398A (ja)	2002-10-22
WO2000044739A1 (en)	2000-08-03
US20020007060A1 (en)	2002-01-17
CO5150194A1 (es)	2002-04-29
KR100748010B1 (ko)	2007-08-09
PT1147101E (pt)	2003-04-30
BG105782A (en)	2002-04-30
AU2739100A (en)	2000-08-18

Publication	Publication Date	Title
DK0923585T3 (da)	2002-07-01	Phosphinatbaserede inhibitorer af matrixmetalloproteinaser
DE60002193D1 (de)	2003-05-22	Metalloprotease inhibitoren
NO995433D0 (no)	1999-11-05	Protease-inhibitorer
NO20034044L (no)	2003-11-10	Metallproteinase-inhibitorer
NO20012980D0 (no)	2001-06-15	Proteaseinhibitorer
DE69928195D1 (de)	2005-12-15	Komplettierung von Untrerdruck-Bohrlöchern
NO991922D0 (no)	1999-04-22	Heteroarylsuccinamider og deres anvendelse som metalloproteinaseinhibitorer
ATE524441T1 (de)	2011-09-15	Vla-4-inhibitoren
MA26812A1 (fr)	2004-12-20	Pyrimidine-2,4,6-triones inhibitrices de metalloproteinases
ATE512949T1 (de)	2011-07-15	Reninhemmer
NO20034032D0 (no)	2003-09-11	Metallproteinase-inhibitorer
NO996313L (no)	2000-02-21	Nye amidinoderivater og deres anvendelse som trombininhibitorer
DE60035039D1 (de)	2007-07-12	Renin inhibitoren
NO995435D0 (no)	1999-11-05	Protease-inhibitorer
NO995434L (no)	1999-11-05	Proteaseinhibitorer
NO995268D0 (no)	1999-10-28	Proteaseinhibitorer
NO20014243D0 (no)	2001-08-31	Dihetero-substituerte metalloprotease inhibitorer
DK1047665T3 (da)	2004-02-02	Matrix metalloprotease inhibitorer
DE50115086D1 (de)	2009-10-15	Lösungen von UV-vernetzbaren Polyacrylaten
DE60024101D1 (de)	2005-12-22	Enzyminhibitoren
ATE228122T1 (de)	2002-12-15	Umgekehrt hydroxamat inhibitoren von matrix metalloproteinasen
DE60009260D1 (de)	2004-04-29	Thiopyranderivate as mmp-inhibitoren
DE60031450D1 (de)	2006-11-30	Polymorph v von torasemid
EE200100084A (xx)	2002-08-15	NOS inhibiitorite uued farmatseutilised kasutusv�imalused
ATE227288T1 (de)	2002-11-15	Acetylenische ortho-sulfonamido- und phosphinsäure-amido-bicyclische heteroarylhydroxamsäure als tace-inhibitoren

Legal Events

Date	Code	Title	Description
2003-06-15	UEP	Publication of translation of european patent specification	Ref document number: 1147101 Country of ref document: EP
2008-10-15	REN	Ceased due to non-payment of the annual fee

Date

Code

Title

Description

2003-06-15

UEP

Publication of translation of european patent specification

Ref document number: 1147101

Country of ref document: EP

2008-10-15

REN

Ceased due to non-payment of the annual fee