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ATE218854T1 - Behandlung von herzrythmusstörungen durch hemmung einer multifunktionalen calcium/calmodulin- abhängigen protein kinase - Google Patents

Behandlung von herzrythmusstörungen durch hemmung einer multifunktionalen calcium/calmodulin- abhängigen protein kinase

Info

Publication number
ATE218854T1
ATE218854T1 AT98904783T AT98904783T ATE218854T1 AT E218854 T1 ATE218854 T1 AT E218854T1 AT 98904783 T AT98904783 T AT 98904783T AT 98904783 T AT98904783 T AT 98904783T AT E218854 T1 ATE218854 T1 AT E218854T1
Authority
AT
Austria
Prior art keywords
calmodulin
protein kinase
dependent protein
treatment
arthry
Prior art date
Application number
AT98904783T
Other languages
English (en)
Inventor
Mark E Anderson
Andrew P Braun
Howard Schulman
Ruey J Sung
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of ATE218854T1 publication Critical patent/ATE218854T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
AT98904783T 1997-01-31 1998-01-30 Behandlung von herzrythmusstörungen durch hemmung einer multifunktionalen calcium/calmodulin- abhängigen protein kinase ATE218854T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3683397P 1997-01-31 1997-01-31
PCT/US1998/001829 WO1998033491A2 (en) 1997-01-31 1998-01-30 Treatment of arrhythmias via inhibition of a multifunctional calcium/calmodulin-dependent protein kinase

Publications (1)

Publication Number Publication Date
ATE218854T1 true ATE218854T1 (de) 2002-06-15

Family

ID=21890905

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98904783T ATE218854T1 (de) 1997-01-31 1998-01-30 Behandlung von herzrythmusstörungen durch hemmung einer multifunktionalen calcium/calmodulin- abhängigen protein kinase

Country Status (8)

Country Link
US (2) US6518245B1 (de)
EP (1) EP0966274B1 (de)
JP (1) JP2001509808A (de)
AT (1) ATE218854T1 (de)
AU (1) AU6257798A (de)
DE (1) DE69805973T2 (de)
ES (1) ES2178157T3 (de)
WO (1) WO1998033491A2 (de)

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WO2002016415A2 (en) * 2000-08-25 2002-02-28 Merck Patent Gmbh Identification of a cam-kinase ii inhibitor
US7369890B2 (en) * 2000-11-02 2008-05-06 Cardiac Pacemakers, Inc. Technique for discriminating between coordinated and uncoordinated cardiac rhythms
US6689117B2 (en) * 2000-12-18 2004-02-10 Cardiac Pacemakers, Inc. Drug delivery system for implantable medical device
DE10126405A1 (de) * 2001-05-22 2003-02-27 Trommsdorff Gmbh & Co Physiologisch verträgliche Kalium- und Magnesiumsalze enthaltendes pharmazeutisches Präparat sowie dessen Verwendung zur Prophylaxe und/oder Therapie von QT-Zeitverlängerungen
US7493162B2 (en) * 2001-06-15 2009-02-17 Cardiac Pacemakers, Inc. Pulmonary vein stent for treating atrial fibrillation
US7209783B2 (en) * 2001-06-15 2007-04-24 Cardiac Pacemakers, Inc. Ablation stent for treating atrial fibrillation
US7340303B2 (en) * 2001-09-25 2008-03-04 Cardiac Pacemakers, Inc. Evoked response sensing for ischemia detection
MXPA04003040A (es) 2001-10-01 2004-07-15 Vanderbil University Uso de inhibidores de calmodulin quinasa ii para tratar la disfuncion miocardica en la enfermedad de corazon estructural.
US20030153951A1 (en) * 2002-02-08 2003-08-14 Ideker Raymond E. Methods and devices for treating arrhythmias using defibrillation shocks
US7005425B2 (en) * 2002-04-18 2006-02-28 Cv Therapeutics, Inc. Method for treating arrhythmias
US7089055B2 (en) 2002-06-28 2006-08-08 Cardiac Pacemakers, Inc. Method and apparatus for delivering pre-shock defibrillation therapy
US7072711B2 (en) 2002-11-12 2006-07-04 Cardiac Pacemakers, Inc. Implantable device for delivering cardiac drug therapy
US7627373B2 (en) * 2002-11-30 2009-12-01 Cardiac Pacemakers, Inc. Method and apparatus for cell and electrical therapy of living tissue
US20040158289A1 (en) * 2002-11-30 2004-08-12 Girouard Steven D. Method and apparatus for cell and electrical therapy of living tissue
US20100113563A1 (en) * 2004-01-30 2010-05-06 Zaijie Wang Method for Treating Pain with a Calmodulin Inhibitor
US7256200B2 (en) * 2003-02-10 2007-08-14 The Board Of Trustees Of The University Of Illinois, A Body Corporate And Politic Of The State Of Illinois Method and composition for potentiating an oplate analgesic
US7320675B2 (en) 2003-08-21 2008-01-22 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
US20050137626A1 (en) * 2003-12-19 2005-06-23 Pastore Joseph M. Drug delivery system and method employing external drug delivery device in conjunction with computer network
US7840263B2 (en) * 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US20050245972A1 (en) * 2004-04-29 2005-11-03 Medtronic, Inc. Apparatus and methods for treating arrhythmia and lowering defibrillation threshold
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US20060079445A1 (en) * 2004-06-16 2006-04-13 Pitt Geoffrey S CaMKII/calcium channel binding-related compositions and methods
US20060057639A1 (en) * 2004-06-16 2006-03-16 Pitt Geoffrey S CaMKII/calcium channel phosphorylation-related compositions and methods
US7828711B2 (en) * 2004-08-16 2010-11-09 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular growth and regeneration using ventricular assist device
US7567841B2 (en) * 2004-08-20 2009-07-28 Cardiac Pacemakers, Inc. Method and apparatus for delivering combined electrical and drug therapies
US8060219B2 (en) * 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US7499748B2 (en) * 2005-04-11 2009-03-03 Cardiac Pacemakers, Inc. Transvascular neural stimulation device
US7617003B2 (en) * 2005-05-16 2009-11-10 Cardiac Pacemakers, Inc. System for selective activation of a nerve trunk using a transvascular reshaping lead
US7616990B2 (en) 2005-10-24 2009-11-10 Cardiac Pacemakers, Inc. Implantable and rechargeable neural stimulator
US8841423B2 (en) * 2008-04-28 2014-09-23 University Of Iowa Research Foundation Monoclonal antibodies specific for oxidized calcium/calmodulin dependent protein kinase II
WO2012145077A1 (en) 2011-04-22 2012-10-26 Topera, Inc. Method for detection of cardiac rhythm disorders using basket style cardiac mapping catheter
CN105517549B (zh) 2013-03-06 2018-11-23 阿略斯泰罗斯医疗公司 CaMKII抑制剂和其用途
US10759792B2 (en) 2014-09-05 2020-09-01 The Johns Hopkins University CaMKII inhibitors and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089526A (en) * 1983-05-23 1992-02-18 Bristol-Myers Company Antiarrhythmic class III process
CA1290813C (en) * 1985-08-12 1991-10-15 Michael B. Sweeney Pacemaker for detecting and terminating a tachycardia
US4860749A (en) * 1988-01-06 1989-08-29 Wayne State University Tachycardia detection for automatic implantable cardioverter/defibrillator with atrial and ventricular sensing capability
IT1225572B (it) * 1988-11-07 1990-11-22 Giocondo Baggio Procedimento di palissonatura per pelli e macchina atta a realizzare tale procedimento.
JPH0753505A (ja) * 1992-10-01 1995-02-28 Hokuriku Seiyaku Co Ltd ベンゼンスルホンアミド誘導体及びその用途

Also Published As

Publication number Publication date
AU6257798A (en) 1998-08-25
DE69805973D1 (de) 2002-07-18
ES2178157T3 (es) 2002-12-16
US6518245B1 (en) 2003-02-11
US7251525B2 (en) 2007-07-31
EP0966274A2 (de) 1999-12-29
EP0966274B1 (de) 2002-06-12
WO1998033491A3 (en) 1999-02-18
JP2001509808A (ja) 2001-07-24
WO1998033491A2 (en) 1998-08-06
DE69805973T2 (de) 2002-12-19
US20030134777A1 (en) 2003-07-17

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