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ATE209905T1 - Pharmazeutische zusammensetzungen in form von polymeren mikropartikeln erhalten durch extrusion und bildung von kügelchen - Google Patents

Pharmazeutische zusammensetzungen in form von polymeren mikropartikeln erhalten durch extrusion und bildung von kügelchen

Info

Publication number
ATE209905T1
ATE209905T1 AT99910199T AT99910199T ATE209905T1 AT E209905 T1 ATE209905 T1 AT E209905T1 AT 99910199 T AT99910199 T AT 99910199T AT 99910199 T AT99910199 T AT 99910199T AT E209905 T1 ATE209905 T1 AT E209905T1
Authority
AT
Austria
Prior art keywords
extrusion
pharmaceutical compositions
beads
formation
polymeric microparticles
Prior art date
Application number
AT99910199T
Other languages
English (en)
Inventor
Fabio Carli
Massimo Bresciani
Tiziana Canal
Paolo Gambini
Original Assignee
Eurand Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand Int filed Critical Eurand Int
Application granted granted Critical
Publication of ATE209905T1 publication Critical patent/ATE209905T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT99910199T 1998-02-06 1999-02-05 Pharmazeutische zusammensetzungen in form von polymeren mikropartikeln erhalten durch extrusion und bildung von kügelchen ATE209905T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT98MI000233A IT1298574B1 (it) 1998-02-06 1998-02-06 Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione
PCT/EP1999/000781 WO1999039692A2 (en) 1998-02-06 1999-02-05 Pharmaceutical compositions in form of polymeric microparticles obtained by extrusion and spheronization

Publications (1)

Publication Number Publication Date
ATE209905T1 true ATE209905T1 (de) 2001-12-15

Family

ID=11378855

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99910199T ATE209905T1 (de) 1998-02-06 1999-02-05 Pharmazeutische zusammensetzungen in form von polymeren mikropartikeln erhalten durch extrusion und bildung von kügelchen

Country Status (15)

Country Link
US (1) US6355273B1 (de)
EP (1) EP1051158B1 (de)
JP (1) JP2002502809A (de)
KR (1) KR20010040727A (de)
AT (1) ATE209905T1 (de)
AU (1) AU738029B2 (de)
BR (1) BR9907682A (de)
CA (1) CA2319463A1 (de)
DE (1) DE69900544T2 (de)
DK (1) DK1051158T3 (de)
ES (1) ES2168855T3 (de)
IT (1) IT1298574B1 (de)
NZ (1) NZ506639A (de)
PT (1) PT1051158E (de)
WO (1) WO1999039692A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1323400A (en) * 1998-10-27 2000-05-15 Fuisz Technologies Ltd. Microparticles containing peg and/or peg glyceryl esters
ITRN20000051A1 (it) 2000-12-22 2002-06-22 Ascor Chimici Srl Metodo e apparecchiatura per formare sferule composite contenenti principi attivi del tipo farmaceutico e/o integratori alimentari o cosmeti
NZ530826A (en) * 2001-06-29 2004-09-24 Eurand Pharmaceuticals Ltd Water-insoluble drugs co-ground with a cross-linked polymeric carrier in dry conditions so they are more soluble and bioavailable
EP1446100B1 (de) * 2001-11-14 2011-05-04 Durect Corporation Injizierbare depotzusammensetzungen und deren verwendung
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
US7829109B2 (en) * 2001-11-14 2010-11-09 Durect Corporation Catheter injectable depot compositions and uses thereof
US6572889B1 (en) * 2002-03-07 2003-06-03 Noveon Ip Holdings Corp. Controlled release solid dosage carbamazepine formulations
WO2003077886A1 (fr) * 2002-03-20 2003-09-25 Hosokawa Micron Corporation Procede de fabrication de particules composites contenant un produit chimique
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
CN1684663A (zh) * 2002-07-31 2005-10-19 阿尔萨公司 可注射的多模式聚合物储库组合物以及其用途
CN1668276A (zh) * 2002-07-31 2005-09-14 阿尔萨公司 可注射的储库组合物及其用途
WO2005060938A1 (en) * 2003-12-23 2005-07-07 Temrel Limited Process for producing pellets for pharmaceutical compositions
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
US8318230B2 (en) * 2005-05-02 2012-11-27 Henkel Ag & Co. Kgaa Use of debranched starch in extrusion-spheronization pharmaceutical pellets
NZ593217A (en) * 2008-12-05 2013-05-31 Bayer Ip Gmbh Extrudate having spicular active substances
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
ES2882639T3 (es) * 2017-12-28 2021-12-02 Imerys Usa Inc Copolímeros anfifílicos como modificadores de superficie para la producción de polvos de carbonato de calcio mejorados
JP2023515918A (ja) 2020-01-13 2023-04-17 デュレクト コーポレーション 不純物が低減された徐放性薬物送達システム及び関連の方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086346A (en) * 1974-04-06 1978-04-25 Bayer Aktiengesellschaft Preparation of melt-sprayed spherical phenacetin granules
IT1241417B (it) * 1990-03-06 1994-01-14 Vectorpharma Int Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
US5350584A (en) * 1992-06-26 1994-09-27 Merck & Co., Inc. Spheronization process using charged resins
EP0744941B1 (de) * 1994-02-16 2003-06-04 Abbott Laboratories Verfahren zur herstellung feinteiliger pharmazeutischer formulierungen
DE19504831A1 (de) * 1995-02-14 1996-09-05 Basf Ag Feste Wirkstoffzubereitungen enthaltend Hydroxypropylcellulose

Also Published As

Publication number Publication date
AU738029B2 (en) 2001-09-06
ITMI980233A1 (it) 1999-08-06
JP2002502809A (ja) 2002-01-29
AU2925199A (en) 1999-08-23
DK1051158T3 (da) 2002-04-02
KR20010040727A (ko) 2001-05-15
DE69900544T2 (de) 2002-08-22
DE69900544D1 (de) 2002-01-17
EP1051158A2 (de) 2000-11-15
US6355273B1 (en) 2002-03-12
ES2168855T3 (es) 2002-06-16
IT1298574B1 (it) 2000-01-12
PT1051158E (pt) 2002-05-31
WO1999039692A3 (en) 1999-09-23
BR9907682A (pt) 2000-11-14
NZ506639A (en) 2003-05-30
CA2319463A1 (en) 1999-08-12
WO1999039692A2 (en) 1999-08-12
EP1051158B1 (de) 2001-12-05

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