ATE207922T1 - Carbapenem-derivate - Google Patents
Carbapenem-derivateInfo
- Publication number
- ATE207922T1 ATE207922T1 AT95909978T AT95909978T ATE207922T1 AT E207922 T1 ATE207922 T1 AT E207922T1 AT 95909978 T AT95909978 T AT 95909978T AT 95909978 T AT95909978 T AT 95909978T AT E207922 T1 ATE207922 T1 AT E207922T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- substituted
- lower alkyl
- alkyl group
- single bond
- Prior art date
Links
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical class C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000005153 alkyl sulfamoyl group Chemical group 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- -1 pyridinio group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000001422 pyrrolinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5268694 | 1994-02-25 | ||
| JP6460694 | 1994-03-08 | ||
| JP10756894 | 1994-04-22 | ||
| JP11028994 | 1994-04-26 | ||
| JP11428894 | 1994-04-28 | ||
| PCT/JP1995/000280 WO1995023150A1 (fr) | 1994-02-25 | 1995-02-24 | Derive de carbapendem |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE207922T1 true ATE207922T1 (de) | 2001-11-15 |
Family
ID=27523026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95909978T ATE207922T1 (de) | 1994-02-25 | 1995-02-24 | Carbapenem-derivate |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5707987A (de) |
| EP (1) | EP0747381B1 (de) |
| JP (1) | JP4182545B2 (de) |
| AT (1) | ATE207922T1 (de) |
| AU (1) | AU680736B2 (de) |
| CA (1) | CA2184101C (de) |
| DE (1) | DE69523574T2 (de) |
| WO (1) | WO1995023150A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2315056A1 (en) * | 1997-12-16 | 1999-06-24 | Terutaka Hashizume | Carbapenem derivatives |
| CA2415740A1 (en) | 2000-07-19 | 2002-01-31 | F. Hoffmann-La Roche Ag | Pyrrolidine derivatives as metalloprotease inhibitors |
| JP3813152B2 (ja) * | 2002-03-12 | 2006-08-23 | メルク エンド カムパニー インコーポレーテッド | 置換アミド類 |
| TWI281914B (en) | 2002-05-29 | 2007-06-01 | Glaxo Group Ltd | Compounds |
| ATE479683T1 (de) | 2002-11-05 | 2010-09-15 | Glaxo Group Ltd | Antibakterielle mittel |
| DK2666481T3 (en) | 2003-12-26 | 2019-02-25 | Masatoshi Hagiwara | A method for regulating the phosphorylation of SR protein and antiviral agents comprising an SR protein activity regulator as the active ingredient |
| US20070149607A1 (en) * | 2003-12-26 | 2007-06-28 | Daichi Paharmaceutical Co., Ltd. | Method for producing pyrrolidine derivative |
| KR100599876B1 (ko) * | 2004-08-31 | 2006-07-13 | 한국화학연구원 | 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법 |
| WO2006045096A2 (en) * | 2004-10-20 | 2006-04-27 | Resverlogix Corp. | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases |
| AU2006275514B2 (en) * | 2005-07-29 | 2012-04-05 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| TW200831084A (en) * | 2006-11-21 | 2008-08-01 | Genelabs Tech Inc | Anti-viral compounds |
| ES2454966T3 (es) * | 2007-02-01 | 2014-04-14 | Resverlogix Corp. | Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares |
| CN101343272B (zh) * | 2007-07-13 | 2011-02-09 | 山东轩竹医药科技有限公司 | 含有环己烷的碳青霉烯化合物 |
| CN101412720B (zh) * | 2007-08-27 | 2011-05-18 | 山东轩竹医药科技有限公司 | 含有巯基氮杂环乙烯基的碳青霉烯化合物 |
| SI2346837T1 (sl) | 2008-06-26 | 2015-05-29 | Resverlogix Corporation | Postopki pripravljanja kinazolinonskih derivatov |
| JP5635535B2 (ja) | 2009-01-08 | 2014-12-03 | レスバーロジックス コーポレイション | 心血管疾患の予防および治療のための化合物 |
| NZ755378A (en) | 2009-03-18 | 2022-07-29 | Resverlogix Corp | Novel quinazolinones and related compounds for use as anti-inflammatory agents |
| ES2821018T3 (es) | 2009-04-22 | 2021-04-23 | Resverlogix Corp | Nuevos agentes antiinflamatorios |
| US9610251B2 (en) | 2011-11-01 | 2017-04-04 | Resverlogix Corp. | Pharmaceutical compositions for substituted quinazolinones |
| US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
| WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
| KR20150096794A (ko) | 2012-12-21 | 2015-08-25 | 제니쓰 에피제네틱스 코포레이션 | 브로모도메인 저해제로서의 신규한 헤테로사이클릭 화합물 |
| JO3789B1 (ar) | 2015-03-13 | 2021-01-31 | Resverlogix Corp | التراكيب والوسائل العلاجية المعتمدة لمعالجة الامراض المتعلقة بالمتممة |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62155279A (ja) * | 1984-11-08 | 1987-07-10 | Sumitomo Pharmaceut Co Ltd | 新規なβ−ラクタム化合物 |
| JPH0780883B2 (ja) * | 1986-03-27 | 1995-08-30 | 住友製薬株式会社 | 新規なβ−ラクタム化合物 |
| DE3784147T2 (de) * | 1986-11-24 | 1993-06-03 | Fujisawa Pharmaceutical Co | 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-en-2-carbonsaeure-derivate. |
| US4925838A (en) * | 1988-03-18 | 1990-05-15 | Fujisawa Pharmaceutical Company, Ltd. | 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds |
| US4963544A (en) * | 1988-05-23 | 1990-10-16 | Fujisawa Pharmaceutical Company, Ltd. | 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds |
| DE68916908T2 (de) * | 1988-11-08 | 1994-12-01 | Daiichi Seiyaku Co | Carbapenemderivate. |
| CA2091309A1 (en) * | 1992-03-26 | 1993-09-27 | Frederic H. Jung | Antibiotic compounds |
-
1995
- 1995-02-24 AU AU18240/95A patent/AU680736B2/en not_active Ceased
- 1995-02-24 WO PCT/JP1995/000280 patent/WO1995023150A1/ja active IP Right Grant
- 1995-02-24 AT AT95909978T patent/ATE207922T1/de not_active IP Right Cessation
- 1995-02-24 DE DE69523574T patent/DE69523574T2/de not_active Expired - Lifetime
- 1995-02-24 JP JP52226095A patent/JP4182545B2/ja not_active Expired - Fee Related
- 1995-02-24 US US08/696,910 patent/US5707987A/en not_active Expired - Lifetime
- 1995-02-24 CA CA002184101A patent/CA2184101C/en not_active Expired - Fee Related
- 1995-02-24 EP EP95909978A patent/EP0747381B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU1824095A (en) | 1995-09-11 |
| DE69523574D1 (de) | 2001-12-06 |
| AU680736B2 (en) | 1997-08-07 |
| DE69523574T2 (de) | 2002-05-29 |
| JP4182545B2 (ja) | 2008-11-19 |
| CA2184101C (en) | 2005-11-22 |
| EP0747381A4 (de) | 1997-04-02 |
| CA2184101A1 (en) | 1995-08-31 |
| US5707987A (en) | 1998-01-13 |
| WO1995023150A1 (fr) | 1995-08-31 |
| EP0747381B1 (de) | 2001-10-31 |
| EP0747381A1 (de) | 1996-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |