ATE206136T1 - Lhrh antagonisten mit modifizierten aminoacylresten an den positionen 5 und 6 - Google Patents
Lhrh antagonisten mit modifizierten aminoacylresten an den positionen 5 und 6Info
- Publication number
- ATE206136T1 ATE206136T1 AT94905391T AT94905391T ATE206136T1 AT E206136 T1 ATE206136 T1 AT E206136T1 AT 94905391 T AT94905391 T AT 94905391T AT 94905391 T AT94905391 T AT 94905391T AT E206136 T1 ATE206136 T1 AT E206136T1
- Authority
- AT
- Austria
- Prior art keywords
- residuals
- positions
- lhrh antagonists
- modified aminoacyl
- alkylated
- Prior art date
Links
- 229940124041 Luteinizing hormone releasing hormone (LHRH) antagonist Drugs 0.000 title 1
- 125000000266 alpha-aminoacyl group Chemical group 0.000 abstract 2
- -1 4-(substituted-amino)cyclohexylalanyl Chemical group 0.000 abstract 1
- 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 abstract 1
- 102100024028 Progonadoliberin-1 Human genes 0.000 abstract 1
- 101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000000405 phenylalanyl group Chemical group 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99320292A | 1992-12-18 | 1992-12-18 | |
| PCT/US1993/012196 WO1994014841A1 (en) | 1992-12-18 | 1993-12-14 | Lhrh antagonists having modified aminoacyl residues at postions 5 and 6 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE206136T1 true ATE206136T1 (de) | 2001-10-15 |
Family
ID=25539225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94905391T ATE206136T1 (de) | 1992-12-18 | 1993-12-14 | Lhrh antagonisten mit modifizierten aminoacylresten an den positionen 5 und 6 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5491217A (de) |
| EP (1) | EP0683792B1 (de) |
| JP (1) | JP3568952B2 (de) |
| AT (1) | ATE206136T1 (de) |
| CA (1) | CA2136079A1 (de) |
| DE (1) | DE69330838T2 (de) |
| DK (1) | DK0683792T3 (de) |
| ES (1) | ES2164096T3 (de) |
| MX (1) | MX9308014A (de) |
| PT (1) | PT683792E (de) |
| WO (1) | WO1994014841A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4801577A (en) * | 1987-02-05 | 1989-01-31 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists |
| US5516759A (en) * | 1994-12-08 | 1996-05-14 | Tap Holdings Inc. | LHRH antagonists having lactam groups at the N-terminus |
| US5681928A (en) * | 1994-12-16 | 1997-10-28 | The Salk Institute For Biological Studies | Betides and methods for screening peptides using same |
| US5843901A (en) * | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
| DE19544212A1 (de) * | 1995-11-28 | 1997-06-05 | Asta Medica Ag | Neue LH-RH-Antagonisten mit verbesserter Wirkung |
| US5925730A (en) * | 1997-04-11 | 1999-07-20 | Ferring Bv | GnRH antagonists |
| WO2001068676A2 (de) | 2000-03-14 | 2001-09-20 | Zentaris Ag | Lh-rh-antagonisten, deren herstellung und verwendung als arzeimittel |
| US7125828B2 (en) | 2000-11-27 | 2006-10-24 | The Procter & Gamble Company | Detergent products, methods and manufacture |
| US7098305B2 (en) | 2001-09-06 | 2006-08-29 | Ardana Bioscience Limited | Sustained release of microcrystalline peptide suspensions |
| CA2523197C (en) | 2003-04-22 | 2016-05-24 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Peptide vectors |
| CN101987865B (zh) * | 2009-07-29 | 2014-07-30 | 中国人民解放军军事医学科学院毒物药物研究所 | 含有乙内酰脲结构的促黄体生成素释放激素拮抗剂 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4317815A (en) * | 1979-06-13 | 1982-03-02 | Coy David Howard | LH-RH Antagonists |
| DE3165535D1 (en) * | 1980-06-02 | 1984-09-20 | Andrew Victor Schally | Lh-rh antagonists |
| US4481190A (en) * | 1982-12-21 | 1984-11-06 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists |
| US4667014A (en) * | 1983-03-07 | 1987-05-19 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
| US4530920A (en) * | 1983-11-07 | 1985-07-23 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist |
| US4866160A (en) * | 1985-04-09 | 1989-09-12 | The Administrators Of The Tulane Educational Fund | Therapeutic decapeptides |
| US5073624A (en) * | 1985-04-09 | 1991-12-17 | Administrators Of The Tulane Educational Fund | Therapeutic decapeptides |
| US5171835A (en) * | 1988-10-21 | 1992-12-15 | The Administrators Of The Tulane Educational Fund | LHRH antagonists |
| US5169932A (en) * | 1989-10-30 | 1992-12-08 | The Salk Institute For Biological Studies | Gnrh analogs |
| CN1036343C (zh) * | 1990-11-10 | 1997-11-05 | 天津市计划生育研究所 | 新促黄体生成素释放激素拮抗类似物的制备方法 |
| IL108509A0 (en) * | 1993-02-22 | 1994-05-30 | Salk Inst For Biological Studi | GnRH antagonist peptides |
-
1993
- 1993-12-14 PT PT94905391T patent/PT683792E/pt unknown
- 1993-12-14 ES ES94905391T patent/ES2164096T3/es not_active Expired - Lifetime
- 1993-12-14 AT AT94905391T patent/ATE206136T1/de not_active IP Right Cessation
- 1993-12-14 JP JP51527494A patent/JP3568952B2/ja not_active Expired - Fee Related
- 1993-12-14 DK DK94905391T patent/DK0683792T3/da active
- 1993-12-14 EP EP94905391A patent/EP0683792B1/de not_active Expired - Lifetime
- 1993-12-14 WO PCT/US1993/012196 patent/WO1994014841A1/en active IP Right Grant
- 1993-12-14 CA CA002136079A patent/CA2136079A1/en not_active Abandoned
- 1993-12-14 DE DE69330838T patent/DE69330838T2/de not_active Expired - Fee Related
- 1993-12-15 MX MX9308014A patent/MX9308014A/es not_active IP Right Cessation
-
1994
- 1994-07-28 US US08/282,411 patent/US5491217A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5491217A (en) | 1996-02-13 |
| ES2164096T3 (es) | 2002-02-16 |
| PT683792E (pt) | 2002-03-28 |
| DK0683792T3 (da) | 2002-01-14 |
| WO1994014841A1 (en) | 1994-07-07 |
| JPH08505611A (ja) | 1996-06-18 |
| MX9308014A (es) | 1994-08-31 |
| DE69330838D1 (de) | 2001-10-31 |
| EP0683792A4 (de) | 1998-11-18 |
| EP0683792A1 (de) | 1995-11-29 |
| JP3568952B2 (ja) | 2004-09-22 |
| EP0683792B1 (de) | 2001-09-26 |
| DE69330838T2 (de) | 2002-04-25 |
| CA2136079A1 (en) | 1994-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |