ATE200485T1 - Verfahren zur herstellung und isolierung von atracurium besylate - Google Patents
Verfahren zur herstellung und isolierung von atracurium besylateInfo
- Publication number
- ATE200485T1 ATE200485T1 AT97905920T AT97905920T ATE200485T1 AT E200485 T1 ATE200485 T1 AT E200485T1 AT 97905920 T AT97905920 T AT 97905920T AT 97905920 T AT97905920 T AT 97905920T AT E200485 T1 ATE200485 T1 AT E200485T1
- Authority
- AT
- Austria
- Prior art keywords
- atracurium besylate
- besylate
- isolation
- production
- reaction mixture
- Prior art date
Links
- 229960002945 atracurium besylate Drugs 0.000 title abstract 3
- XXZSQOVSEBAPGS-UHFFFAOYSA-L atracurium besylate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1.[O-]S(=O)(=O)C1=CC=CC=C1.C1=C(OC)C(OC)=CC=C1CC1[N+](CCC(=O)OCCCCCOC(=O)CC[N+]2(C)C(C3=CC(OC)=C(OC)C=C3CC2)CC=2C=C(OC)C(OC)=CC=2)(C)CCC2=CC(OC)=C(OC)C=C21 XXZSQOVSEBAPGS-UHFFFAOYSA-L 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000002955 isolation Methods 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 229940125904 compound 1 Drugs 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- CZXGXYBOQYQXQD-UHFFFAOYSA-N methyl benzenesulfonate Chemical compound COS(=O)(=O)C1=CC=CC=C1 CZXGXYBOQYQXQD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Element Separation (AREA)
- Organic Insulating Materials (AREA)
- Photoreceptors In Electrophotography (AREA)
- Paints Or Removers (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/602,945 US5684154A (en) | 1996-02-16 | 1996-02-16 | Process for the preparation and isolation of atracurium besylate |
| PCT/US1997/002196 WO1997030033A1 (en) | 1996-02-16 | 1997-02-12 | Process for the preparation and isolation of atracurium besylate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE200485T1 true ATE200485T1 (de) | 2001-04-15 |
Family
ID=24413409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97905920T ATE200485T1 (de) | 1996-02-16 | 1997-02-12 | Verfahren zur herstellung und isolierung von atracurium besylate |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5684154A (de) |
| EP (1) | EP0882020B1 (de) |
| JP (1) | JP2000513328A (de) |
| AT (1) | ATE200485T1 (de) |
| DE (1) | DE69704553T2 (de) |
| DK (1) | DK0882020T3 (de) |
| ES (1) | ES2158499T3 (de) |
| GR (1) | GR3036083T3 (de) |
| PT (1) | PT882020E (de) |
| WO (1) | WO1997030033A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5213137B2 (ja) * | 2006-12-06 | 2013-06-19 | コーネル リサーチ ファウンデーション， インコーポレイテッド | 中程度の持続時間の神経筋遮断剤およびそのアンタゴニスト |
| BRPI0808272A2 (pt) * | 2007-03-08 | 2014-07-08 | Chemagis Ltd | "método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio" |
| US20100087650A1 (en) * | 2007-03-26 | 2010-04-08 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
| AU2008243747B2 (en) * | 2007-05-01 | 2013-03-07 | Chemagis Ltd. | Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates |
| CA2685491A1 (en) * | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Process for producing cisatracurium compounds and associated intermediates |
| WO2009007946A1 (en) * | 2007-07-09 | 2009-01-15 | Chemagis Ltd. | Process for producing cisatracurium and associated intermediates |
| BRPI0811687A2 (pt) * | 2007-06-18 | 2015-02-18 | Chemagis Ltd | MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO |
| AU2008320380A1 (en) * | 2007-10-29 | 2009-05-07 | Chemagis Ltd. | Novel R,R'-atracurium salts |
| AU2009241211A1 (en) * | 2008-05-01 | 2009-11-05 | Chemagis Ltd. | Cisatracurium derivatives, preparation and uses thereof |
| US8592451B2 (en) | 2009-03-17 | 2013-11-26 | Cornell University | Reversible nondepolarizing neuromuscular blockade agents and methods for their use |
| CN102573794B (zh) | 2009-08-19 | 2017-03-15 | 康奈尔大学 | 供生理注射用的半胱氨酸 |
| CN114014806B (zh) * | 2021-12-03 | 2024-11-12 | 江苏诚信药业有限公司 | 一种新晶型顺苯磺酸阿曲库铵及其结晶方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1579822A (en) * | 1976-10-29 | 1980-11-26 | Wellcome Found | Tetrahydroisoquinolinium muscle relaxants |
| AU506657B2 (en) * | 1975-12-10 | 1980-01-17 | Wellcome Foundation Limited, The | Isoquinoline derivatives |
| GB9015473D0 (en) * | 1990-07-13 | 1990-08-29 | Wellcome Found | Neuromuscular blocking agents |
| US5453510A (en) * | 1990-07-13 | 1995-09-26 | Burroughs Wellcome Co. | Neuromuscular blocking agents |
-
1996
- 1996-02-16 US US08/602,945 patent/US5684154A/en not_active Expired - Lifetime
-
1997
- 1997-02-12 DE DE69704553T patent/DE69704553T2/de not_active Expired - Fee Related
- 1997-02-12 AT AT97905920T patent/ATE200485T1/de not_active IP Right Cessation
- 1997-02-12 PT PT97905920T patent/PT882020E/pt unknown
- 1997-02-12 EP EP97905920A patent/EP0882020B1/de not_active Expired - Lifetime
- 1997-02-12 WO PCT/US1997/002196 patent/WO1997030033A1/en active IP Right Grant
- 1997-02-12 ES ES97905920T patent/ES2158499T3/es not_active Expired - Lifetime
- 1997-02-12 DK DK97905920T patent/DK0882020T3/da active
- 1997-02-12 JP JP09529450A patent/JP2000513328A/ja not_active Ceased
-
2001
- 2001-06-19 GR GR20010400928T patent/GR3036083T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2158499T3 (es) | 2001-09-01 |
| GR3036083T3 (en) | 2001-09-28 |
| EP0882020A1 (de) | 1998-12-09 |
| JP2000513328A (ja) | 2000-10-10 |
| DE69704553T2 (de) | 2001-11-08 |
| DK0882020T3 (da) | 2001-08-20 |
| US5684154A (en) | 1997-11-04 |
| DE69704553D1 (de) | 2001-05-17 |
| PT882020E (pt) | 2001-09-28 |
| WO1997030033A1 (en) | 1997-08-21 |
| EP0882020B1 (de) | 2001-04-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |