ATE199709T1 - Verfahren zur herstellung von (+)compactin und (+)mevinolin derivaten mit beta-hydroxy-delta- lactonresten - Google Patents
Verfahren zur herstellung von (+)compactin und (+)mevinolin derivaten mit beta-hydroxy-delta- lactonrestenInfo
- Publication number
- ATE199709T1 ATE199709T1 AT96938297T AT96938297T ATE199709T1 AT E199709 T1 ATE199709 T1 AT E199709T1 AT 96938297 T AT96938297 T AT 96938297T AT 96938297 T AT96938297 T AT 96938297T AT E199709 T1 ATE199709 T1 AT E199709T1
- Authority
- AT
- Austria
- Prior art keywords
- compactin
- delta
- beta
- hydroxy
- lactone
- Prior art date
Links
- AJLFOPYRIVGYMJ-UHFFFAOYSA-N SJ000287055 Natural products C12C(OC(=O)C(C)CC)CCC=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 AJLFOPYRIVGYMJ-UHFFFAOYSA-N 0.000 title abstract 2
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical class C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 239000007806 chemical reaction intermediate Substances 0.000 abstract 2
- -1 (+)mevinolin analog compounds Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9514093A FR2741620B1 (fr) | 1995-11-28 | 1995-11-28 | Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline |
| PCT/FR1996/001782 WO1997019917A1 (fr) | 1995-11-28 | 1996-11-12 | PROCEDE DE PREPARATION DE COMPOSES A GROUPEMENT β-HYDROXY-δ-LACTONE ANALOGUES DE LA (+) COMPACTINE ET DE LA (+) MEVINOLINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE199709T1 true ATE199709T1 (de) | 2001-03-15 |
Family
ID=9484968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96938297T ATE199709T1 (de) | 1995-11-28 | 1996-11-12 | Verfahren zur herstellung von (+)compactin und (+)mevinolin derivaten mit beta-hydroxy-delta- lactonresten |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0805800B1 (de) |
| JP (1) | JP3119663B2 (de) |
| AT (1) | ATE199709T1 (de) |
| DE (1) | DE69612086T2 (de) |
| ES (1) | ES2157466T3 (de) |
| FR (1) | FR2741620B1 (de) |
| WO (1) | WO1997019917A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0623580B2 (ja) * | 1986-11-19 | 1994-03-30 | 株式会社三ッ葉電機製作所 | スタータのクラッチのアウタとインナ間の開放端を閉塞するカバ−の固定構造及び固定方法 |
| EP1323715B1 (de) * | 1997-04-16 | 2004-06-30 | The University of New Mexico | Cholesterin Esterase Inhibitoren |
| DE69824901D1 (de) * | 1997-04-16 | 2004-08-05 | Univ New Mexico Albuquerque | Cholesterin Esterase Inhibitoren |
| GB9903472D0 (en) * | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Chemical process |
| GB0011120D0 (en) | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
| NL1015744C2 (nl) | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
| CN1301977C (zh) | 2001-07-13 | 2007-02-28 | 阿斯特拉曾尼卡英国有限公司 | 氨基嘧啶化合物的制备方法 |
| EP1323717A1 (de) | 2001-12-27 | 2003-07-02 | Dsm N.V. | Prozess für die Herstellung von 2-(6-Substituierten-1,3-Dioxan-4-yl) Essigsäure Derivaten |
| US20060234337A1 (en) * | 2002-04-12 | 2006-10-19 | Akira Arisawa | Expression system for actinomycete-origin cytochrome p-450 in escherichia coli |
| EP1375493A1 (de) | 2002-06-17 | 2004-01-02 | Dsm N.V. | Verfahren zur Herstellung von Dioxanessigsäureester |
| GB0218781D0 (en) * | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| KR101060215B1 (ko) | 2002-12-16 | 2011-08-29 | 아스트라제네카 유케이 리미티드 | 피리미딘 화합물의 제조 방법 |
| GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
| UY28501A1 (es) | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
| GB0322552D0 (en) | 2003-09-26 | 2003-10-29 | Astrazeneca Uk Ltd | Therapeutic treatment |
| GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
| GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
| ES2564250T3 (es) | 2006-05-03 | 2016-03-21 | Msn Laboratories Private Limited | Nuevo proceso para estatinas y sus sales farmacéuticamente aceptables de las mismas |
| ES2567171T3 (es) | 2006-10-09 | 2016-04-20 | Msn Laboratories Private Limited | Nuevo procedimiento para la preparación de estatinas y sus sales farmacéuticamente aceptables |
| WO2010089770A2 (en) | 2009-01-19 | 2010-08-12 | Msn Laboratories Limited | Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof |
| US8987444B2 (en) | 2010-01-18 | 2015-03-24 | Msn Laboratories Private Limited | Process for the preparation of amide intermediates and their use thereof |
-
1995
- 1995-11-28 FR FR9514093A patent/FR2741620B1/fr not_active Expired - Fee Related
-
1996
- 1996-11-12 JP JP09520222A patent/JP3119663B2/ja not_active Expired - Fee Related
- 1996-11-12 EP EP96938297A patent/EP0805800B1/de not_active Expired - Lifetime
- 1996-11-12 ES ES96938297T patent/ES2157466T3/es not_active Expired - Lifetime
- 1996-11-12 AT AT96938297T patent/ATE199709T1/de not_active IP Right Cessation
- 1996-11-12 WO PCT/FR1996/001782 patent/WO1997019917A1/fr active IP Right Grant
- 1996-11-12 DE DE69612086T patent/DE69612086T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0805800B1 (de) | 2001-03-14 |
| FR2741620A1 (fr) | 1997-05-30 |
| JPH10504845A (ja) | 1998-05-12 |
| DE69612086D1 (de) | 2001-04-19 |
| FR2741620B1 (fr) | 1997-12-26 |
| ES2157466T3 (es) | 2001-08-16 |
| DE69612086T2 (de) | 2001-06-21 |
| JP3119663B2 (ja) | 2000-12-25 |
| WO1997019917A1 (fr) | 1997-06-05 |
| EP0805800A1 (de) | 1997-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |