ATE199088T1 - Substituierte tetracyclische oxazepine- und thiazepinederivate mit 5-ht2 rezeptoraffinität - Google Patents

Substituierte tetracyclische oxazepine- und thiazepinederivate mit 5-ht2 rezeptoraffinität

Info

Publication number: ATE199088T1
Authority: AT; Austria
Prior art keywords: 6alkyl; hydrogen; pct; trifluoromethyl; oxazepine
Prior art date: 1994-11-02

Application number

AT95937007T

Other languages

English (en)

Inventor

Francisco Javi Fernandez-Gadea

Victor Karel Sipido

Jose Ignacio Andres-Gil

Theo Frans Meert

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-02

Filing date

1995-10-25

Publication date

2001-02-15

1995-10-25 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2001-02-15 Application granted granted Critical

2001-02-15 Publication of ATE199088T1 publication Critical patent/ATE199088T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT95937007T 1994-11-02 1995-10-25 Substituierte tetracyclische oxazepine- und thiazepinederivate mit 5-ht2 rezeptoraffinität ATE199088T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP94203177		1994-11-02
PCT/EP1995/004197 WO1996014321A1 (en)	1994-11-02	1995-10-25	Substituted tetracyclic oxazepine and thiazepine derivatives with 5-ht2 receptor affinity

Publications (1)

Publication Number	Publication Date
ATE199088T1 true ATE199088T1 (de)	2001-02-15

Family

ID=8217336

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95937007T ATE199088T1 (de)	1994-11-02	1995-10-25	Substituierte tetracyclische oxazepine- und thiazepinederivate mit 5-ht2 rezeptoraffinität

Country Status (17)

Country	Link
US (1)	US5773433A (de)
EP (1)	EP0789702B1 (de)
JP (1)	JP3887785B2 (de)
AT (1)	ATE199088T1 (de)
AU (1)	AU699545B2 (de)
CA (1)	CA2203664A1 (de)
DE (1)	DE69520071T2 (de)
DK (1)	DK0789702T3 (de)
ES (1)	ES2155899T3 (de)
GR (1)	GR3035666T3 (de)
MY (1)	MY114106A (de)
NZ (1)	NZ295657A (de)
PL (1)	PL183618B1 (de)
PT (1)	PT789702E (de)
RU (1)	RU2161159C2 (de)
WO (1)	WO1996014321A1 (de)
ZA (1)	ZA959216B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU716470B2 (en) *	1996-04-12	2000-02-24	Janssen Pharmaceutica N.V.	Isoxazolidine derivatives
UA52778C2 (uk) *	1997-10-10	2003-01-15	Янссен Фармацевтика Н.В.	Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі
HRP20020305A8 (en)	2002-04-10	2009-03-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7414038A (nl) *	1974-10-28	1976-05-03	Akzo Nv	Nieuwe tetracyclische pyrrolidino derivaten.
TW206227B (de) *	1989-10-05	1993-05-21	Sankyo Co

1995
- 1995-10-25 WO PCT/EP1995/004197 patent/WO1996014321A1/en active IP Right Grant
- 1995-10-25 AU AU39250/95A patent/AU699545B2/en not_active Ceased
- 1995-10-25 ES ES95937007T patent/ES2155899T3/es not_active Expired - Lifetime
- 1995-10-25 DK DK95937007T patent/DK0789702T3/da active
- 1995-10-25 NZ NZ295657A patent/NZ295657A/en unknown
- 1995-10-25 RU RU97108688/04A patent/RU2161159C2/ru not_active IP Right Cessation
- 1995-10-25 US US08/817,989 patent/US5773433A/en not_active Expired - Fee Related
- 1995-10-25 EP EP95937007A patent/EP0789702B1/de not_active Expired - Lifetime
- 1995-10-25 PT PT95937007T patent/PT789702E/pt unknown
- 1995-10-25 PL PL95319870A patent/PL183618B1/pl not_active IP Right Cessation
- 1995-10-25 JP JP51501096A patent/JP3887785B2/ja not_active Expired - Fee Related
- 1995-10-25 DE DE69520071T patent/DE69520071T2/de not_active Expired - Fee Related
- 1995-10-25 CA CA002203664A patent/CA2203664A1/en not_active Abandoned
- 1995-10-25 AT AT95937007T patent/ATE199088T1/de not_active IP Right Cessation
- 1995-10-31 ZA ZA959216A patent/ZA959216B/xx unknown
- 1995-11-02 MY MYPI95003314A patent/MY114106A/en unknown
2001
- 2001-03-29 GR GR20010400516T patent/GR3035666T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA959216B (en)	1997-04-30
PL183618B1 (pl)	2002-06-28
DE69520071D1 (de)	2001-03-15
MY114106A (en)	2002-08-30
NZ295657A (en)	1998-08-26
JPH10508309A (ja)	1998-08-18
CA2203664A1 (en)	1996-05-17
GR3035666T3 (en)	2001-06-29
PL319870A1 (en)	1997-09-01
JP3887785B2 (ja)	2007-02-28
ES2155899T3 (es)	2001-06-01
EP0789702B1 (de)	2001-02-07
EP0789702A1 (de)	1997-08-20
AU3925095A (en)	1996-05-31
US5773433A (en)	1998-06-30
DE69520071T2 (de)	2001-09-13
PT789702E (pt)	2001-07-31
RU2161159C2 (ru)	2000-12-27
WO1996014321A1 (en)	1996-05-17
DK0789702T3 (da)	2001-06-11
AU699545B2 (en)	1998-12-03

Publication	Publication Date	Title
BR9706639A (pt)	1999-01-12	Derivados de tetrahidrofurano tetracíclicos substituídos
MY129224A (en)	2007-03-30	4-phenyl-pyridine derivatives
CA2305612A1 (en)	1999-04-22	Halogen substituted tetracyclic tetrahydrofuran derivatives
ATE199088T1 (de)	2001-02-15	Substituierte tetracyclische oxazepine- und thiazepinederivate mit 5-ht2 rezeptoraffinität
MY125562A (en)	2006-08-30	Hexahydro-pyrido (4,3-b) indole derivatives as antipsychotic drugs
EE9600142A (et)	1997-04-15	Helicobacter spp. vastased asoloonide derivaadid, nende valmistamise meetod ja kasutamine, vaheühendid, farmatseutiline kompositsioon ja selle valmistamise meetod ning terapeutiline kombinatsioon.
MXPA03002914A (es)	2003-09-10	Compuestos quimicos.
MY126781A (en)	2006-10-31	2,4-disubstituted triazine derivatives
MX9703250A (es)	1997-07-31	Derivados tetraciclicos de oxazepina y tiazepina sustituidos con afinidad al receptor de 5-ht2.
ATE222911T1 (de)	2002-09-15	Isoxazolidine derivate
MX9703255A (es)	1997-07-31	Derivados de azepina tetraciclica substituida que tienen afinidad para los receptores de 5-ht2.
CA2232195A1 (en)	1997-10-23	Isoxazolidine derivatives

Legal Events

Date	Code	Title	Description
2008-07-15	REN	Ceased due to non-payment of the annual fee