ATE195949T1 - Verfahren und zusammensetzungen zur behandlung der thrombose - Google Patents
Verfahren und zusammensetzungen zur behandlung der thromboseInfo
- Publication number
- ATE195949T1 ATE195949T1 AT94920270T AT94920270T ATE195949T1 AT E195949 T1 ATE195949 T1 AT E195949T1 AT 94920270 T AT94920270 T AT 94920270T AT 94920270 T AT94920270 T AT 94920270T AT E195949 T1 ATE195949 T1 AT E195949T1
- Authority
- AT
- Austria
- Prior art keywords
- peptides
- amino acid
- contain
- hydrophobic amino
- compositions
- Prior art date
Links
- 208000007536 Thrombosis Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 230000002209 hydrophobic effect Effects 0.000 abstract 2
- 102000001189 Cyclic Peptides Human genes 0.000 abstract 1
- 108010069514 Cyclic Peptides Proteins 0.000 abstract 1
- 102100037362 Fibronectin Human genes 0.000 abstract 1
- 108010017707 Fibronectin Receptors Proteins 0.000 abstract 1
- 102100022337 Integrin alpha-V Human genes 0.000 abstract 1
- 108010048673 Vitronectin Receptors Proteins 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
- C07K14/70557—Integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7944193A | 1993-06-18 | 1993-06-18 | |
| US17106893A | 1993-12-20 | 1993-12-20 | |
| PCT/US1994/006913 WO1995000544A1 (en) | 1993-06-18 | 1994-06-17 | Method and composition for treating thrombosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE195949T1 true ATE195949T1 (de) | 2000-09-15 |
Family
ID=26762011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94920270T ATE195949T1 (de) | 1993-06-18 | 1994-06-17 | Verfahren und zusammensetzungen zur behandlung der thrombose |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0705274B1 (de) |
| JP (1) | JPH09501910A (de) |
| AT (1) | ATE195949T1 (de) |
| AU (1) | AU7112794A (de) |
| CA (1) | CA2165332A1 (de) |
| DE (1) | DE69425745T2 (de) |
| WO (1) | WO1995000544A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| US5770565A (en) * | 1994-04-13 | 1998-06-23 | La Jolla Cancer Research Center | Peptides for reducing or inhibiting bone resorption |
| EP0727225A3 (de) * | 1995-02-14 | 1997-01-15 | Sonus Pharma Inc | Zusammensetzungen und Verfahren zur Herstellung von gerichteter Ultraschallabbildung |
| US5858972A (en) * | 1996-01-11 | 1999-01-12 | La Jolla Cancer Research Foundation | Antithrombotic agents and methods of use |
| US6235877B1 (en) | 1999-08-04 | 2001-05-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors |
| ES2378544T3 (es) | 2003-07-08 | 2012-04-13 | Accumetrics, Inc. | Activación selectiva de plaquetas para el seguimiento de terapia con antagonistas de ADP |
| US20070243632A1 (en) | 2003-07-08 | 2007-10-18 | Coller Barry S | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
| US7595169B2 (en) * | 2005-04-27 | 2009-09-29 | Accumetrics, Inc. | Method for determining percent platelet aggregation |
| WO2007038749A2 (en) | 2005-09-28 | 2007-04-05 | Biovascular, Inc. | Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation |
| US20070231258A1 (en) * | 2006-03-31 | 2007-10-04 | Karyon Ctt Ltd. | Peptide conjugates |
| GB2453589A (en) * | 2007-10-12 | 2009-04-15 | King S College London | Protease inhibition |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZW6189A1 (en) * | 1988-05-09 | 1990-05-09 | Smithkline Beckman Corp | Anti-aggregatory peptides |
| US5318899A (en) * | 1989-06-16 | 1994-06-07 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
| EP0749979A3 (de) * | 1990-04-06 | 1998-03-11 | La Jolla Cancer Research Foundation | Methode und Zusammensetzung zur Behandlung von Thrombose |
| US5192746A (en) * | 1990-07-09 | 1993-03-09 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
-
1994
- 1994-06-17 CA CA002165332A patent/CA2165332A1/en not_active Abandoned
- 1994-06-17 AU AU71127/94A patent/AU7112794A/en not_active Abandoned
- 1994-06-17 WO PCT/US1994/006913 patent/WO1995000544A1/en active IP Right Grant
- 1994-06-17 DE DE69425745T patent/DE69425745T2/de not_active Expired - Lifetime
- 1994-06-17 JP JP7503001A patent/JPH09501910A/ja not_active Ceased
- 1994-06-17 EP EP94920270A patent/EP0705274B1/de not_active Expired - Lifetime
- 1994-06-17 AT AT94920270T patent/ATE195949T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU7112794A (en) | 1995-01-17 |
| DE69425745T2 (de) | 2001-04-19 |
| DE69425745D1 (de) | 2000-10-05 |
| EP0705274A1 (de) | 1996-04-10 |
| WO1995000544A1 (en) | 1995-01-05 |
| JPH09501910A (ja) | 1997-02-25 |
| CA2165332A1 (en) | 1995-01-05 |
| EP0705274B1 (de) | 2000-08-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69126871D1 (de) | Verfahren und verbindung zur behandlung von thrombose | |
| DE69011102T2 (de) | Hydrophobe bindungsstelle für adhäsionspeptide. | |
| Lee et al. | Osteoblastic differentiation of human bone marrow stromal cells in self-assembled BMP-2 receptor-binding peptide-amphiphiles | |
| ATE195949T1 (de) | Verfahren und zusammensetzungen zur behandlung der thrombose | |
| DK0661989T3 (da) | Proteinsammensætninger med vedvarende frigivelse | |
| DE69739035D1 (de) | Zusammensetzungen und Methoden zur Behandlung von Infektionen unter Verwendung von Indolicidinanalogen | |
| DE69835279D1 (de) | Zusammensetzungen und verfahren zur behandlung von infektionen unter verwendung von kationischen peptiden allein oder in kombination mit antibiotika | |
| HUP0300465A2 (hu) | A paratiroid hormon és a paratiroid hormonnal rokon fehérje receptorainak modulátorai | |
| IL109403A0 (en) | Oral drug delivery compositions and methods | |
| ES8203385A1 (es) | Procedimiento de obtencion de nuevos derivados de la vin- blastina | |
| IL128829A0 (en) | Improved solid-phase peptide and agent for use in such synthesis | |
| Peng et al. | Isolation, characterization and amino acid sequence of echicetin β subunit, a specific inhibitor of von Willebrand factor and thrombin interaction with glycoprotein Ib | |
| Krstenansky et al. | Development of MDL 28,050, a small stable antithrombin agent based on a functional domain of the leech protein, hirudin | |
| TW364850B (en) | Nematocidal compositions | |
| EA200300678A1 (ru) | Пептиды и/или белки, а также их применение для получения терапевтической и/или профилактической фармацевтической композиции | |
| Otto et al. | Dipeptide uptake by adenohypophysial folliculostellate cells | |
| AU3850997A (en) | Immunologically active proteins of borrelia burgdorferi, coded nuclein acids of such and their use in test kits and vaccines | |
| US20040220110A1 (en) | Synthetic peptide analogs of Arg-Pro-Pro-Gly-Phe as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4 | |
| HU0102043D0 (en) | Pharmaceutical compounds which interact with an ca2+ channel alpha2delta subunit | |
| CA2453202A1 (en) | Peptides which modulate blood coagulation and methods of use thereof | |
| Gerdin et al. | Structural requirements for microvascular permeability-increasing ability of peptides: Studies on analogues of a fibrinogen pentapeptide fragment | |
| ATE427955T1 (de) | Zusammensetzungen und verfahren zur erfassung von stress induzierten proteinen | |
| Iwabuchi et al. | Sialogogic effects on rat submandibular gland of analogs of the C-terminal hexapeptide of substance P | |
| DE69331193D1 (de) | Verfahren und zusammensetzungen zur verhinderung von entzündungen, die durch endothelzellen und fibrinogen ausgelöst werden | |
| Glusa | Desulfated hirugen (hirudin 54-65) induces endothelium-dependent relaxation of porcine pulmonary arteries |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |