ATE194613T1 - 1-phenyl-imidazol-2-on bipehenylmethyl verbindungen zur behandlung von kreislaufstörungen - Google Patents
1-phenyl-imidazol-2-on bipehenylmethyl verbindungen zur behandlung von kreislaufstörungenInfo
- Publication number
- ATE194613T1 ATE194613T1 AT94912751T AT94912751T ATE194613T1 AT E194613 T1 ATE194613 T1 AT E194613T1 AT 94912751 T AT94912751 T AT 94912751T AT 94912751 T AT94912751 T AT 94912751T AT E194613 T1 ATE194613 T1 AT E194613T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- hydrogen
- treatment
- phenyl
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- ZZNMRBGELWVJND-UHFFFAOYSA-N 3-phenyl-1h-imidazol-2-one Chemical compound O=C1NC=CN1C1=CC=CC=C1 ZZNMRBGELWVJND-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229940123413 Angiotensin II antagonist Drugs 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000004692 haloalkylcarbonyl group Chemical group 0.000 abstract 1
- -1 hydroxy, nitro, amino Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3631693A | 1993-03-24 | 1993-03-24 | |
| PCT/US1994/002156 WO1994021629A1 (en) | 1993-03-24 | 1994-03-08 | 1-phenyl-imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE194613T1 true ATE194613T1 (de) | 2000-07-15 |
Family
ID=21887905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94912751T ATE194613T1 (de) | 1993-03-24 | 1994-03-08 | 1-phenyl-imidazol-2-on bipehenylmethyl verbindungen zur behandlung von kreislaufstörungen |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6630497B2 (de) |
| EP (2) | EP0978515A3 (de) |
| JP (1) | JPH08508249A (de) |
| KR (1) | KR960701041A (de) |
| CN (1) | CN1119861A (de) |
| AT (1) | ATE194613T1 (de) |
| AU (1) | AU6516994A (de) |
| CA (1) | CA2156741A1 (de) |
| DE (1) | DE69425250D1 (de) |
| WO (1) | WO1994021629A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0978515A3 (de) * | 1993-03-24 | 2000-05-17 | G.D. Searle & Co. | 1-(substituiertes Phenyl)-4-Biphenylmethyl-imidazol-2-on Derivate, deren Herstellung und deren Verwendung als Angiotensin II Antagonisten |
| US20060258691A1 (en) * | 2005-05-13 | 2006-11-16 | Joseph Barbosa | Methods and compositions for improving cognition |
| JP2008540575A (ja) * | 2005-05-13 | 2008-11-20 | レキシコン・ファーマシューティカルズ・インコーポレーテッド | 多環系化合物とその使用の方法 |
| TW200827345A (en) * | 2006-11-07 | 2008-07-01 | Lexicon Pharmaceuticals Inc | (R)-phenyl(heterocycle)methanol-based compounds, compositions comprising them and methods of their use |
| TW200823193A (en) * | 2006-11-07 | 2008-06-01 | Lexicon Pharmaceuticals Inc | (S)-phenyl(heterocycle)methanol-based compounds, compositions comprising them and methods of their use |
| US7803940B2 (en) | 2006-11-24 | 2010-09-28 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases |
| TWI448284B (zh) | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
| WO2009134741A1 (en) | 2008-04-29 | 2009-11-05 | Theravance, Inc. | Dual-acting antihypertensive agents |
| WO2010011821A2 (en) | 2008-07-24 | 2010-01-28 | Theravance, Inc. | Dual-acting antihypertensive agents |
| TW201014830A (en) | 2008-09-30 | 2010-04-16 | Theravance Inc | Crystalline form of an alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid |
| EP2451782B1 (de) | 2009-07-07 | 2016-11-09 | Theravance Biopharma R&D IP, LLC | Blutdrucksenkende mittel auf pyrazolbasis mit doppelwirkung |
| JP2012533626A (ja) | 2009-07-22 | 2012-12-27 | セラヴァンス， インコーポレーテッド | 二重作用オキサゾール降圧剤 |
| US8481549B2 (en) | 2010-01-19 | 2013-07-09 | Theravance, Inc. | Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5087634A (en) * | 1990-10-31 | 1992-02-11 | G. D. Searle & Co. | N-substituted imidazol-2-one compounds for treatment of circulatory disorders |
| US5238952A (en) * | 1990-10-31 | 1993-08-24 | G. D. Searle & Co. | N-substituted imidazol-2-one compounds for treatment of circulatory disorders |
| US5164403A (en) * | 1991-04-05 | 1992-11-17 | G. D. Searle & Co. | N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders |
| EP0978515A3 (de) * | 1993-03-24 | 2000-05-17 | G.D. Searle & Co. | 1-(substituiertes Phenyl)-4-Biphenylmethyl-imidazol-2-on Derivate, deren Herstellung und deren Verwendung als Angiotensin II Antagonisten |
-
1994
- 1994-03-08 EP EP99115158A patent/EP0978515A3/de not_active Withdrawn
- 1994-03-08 EP EP94912751A patent/EP0690854B1/de not_active Expired - Lifetime
- 1994-03-08 CN CN94191581A patent/CN1119861A/zh active Pending
- 1994-03-08 JP JP6521052A patent/JPH08508249A/ja active Pending
- 1994-03-08 AU AU65169/94A patent/AU6516994A/en not_active Abandoned
- 1994-03-08 WO PCT/US1994/002156 patent/WO1994021629A1/en active IP Right Grant
- 1994-03-08 DE DE69425250T patent/DE69425250D1/de not_active Expired - Lifetime
- 1994-03-08 CA CA002156741A patent/CA2156741A1/en not_active Abandoned
- 1994-03-08 AT AT94912751T patent/ATE194613T1/de not_active IP Right Cessation
-
1995
- 1995-09-23 KR KR1019950704072A patent/KR960701041A/ko not_active Application Discontinuation
-
2001
- 2001-04-03 US US09/825,029 patent/US6630497B2/en not_active Expired - Fee Related
-
2003
- 2003-08-27 US US10/649,210 patent/US6858636B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6630497B2 (en) | 2003-10-07 |
| JPH08508249A (ja) | 1996-09-03 |
| EP0978515A2 (de) | 2000-02-09 |
| EP0690854B1 (de) | 2000-07-12 |
| AU6516994A (en) | 1994-10-11 |
| US20040048911A1 (en) | 2004-03-11 |
| EP0690854A1 (de) | 1996-01-10 |
| US6858636B2 (en) | 2005-02-22 |
| US20020038035A1 (en) | 2002-03-28 |
| DE69425250D1 (de) | 2000-08-17 |
| CA2156741A1 (en) | 1994-09-29 |
| CN1119861A (zh) | 1996-04-03 |
| KR960701041A (ko) | 1996-02-24 |
| WO1994021629A1 (en) | 1994-09-29 |
| EP0978515A3 (de) | 2000-05-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |