ATE188692T1 - Fibrinogenrezeptorantagonisten - Google Patents
FibrinogenrezeptorantagonistenInfo
- Publication number
- ATE188692T1 ATE188692T1 AT94913969T AT94913969T ATE188692T1 AT E188692 T1 ATE188692 T1 AT E188692T1 AT 94913969 T AT94913969 T AT 94913969T AT 94913969 T AT94913969 T AT 94913969T AT E188692 T1 ATE188692 T1 AT E188692T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- fibrinogen receptor
- fibrinogen
- image
- blood platelets
- Prior art date
Links
- 239000002319 fibrinogen receptor antagonist Substances 0.000 title abstract 2
- 210000001772 blood platelet Anatomy 0.000 abstract 2
- 102000008946 Fibrinogen Human genes 0.000 abstract 1
- 108010049003 Fibrinogen Proteins 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 229940012952 fibrinogen Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/042,963 US5441952A (en) | 1993-04-05 | 1993-04-05 | Fibrinogen receptor antagonists |
| PCT/US1994/003400 WO1994022825A1 (en) | 1993-04-05 | 1994-03-29 | Fibrinogen receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE188692T1 true ATE188692T1 (de) | 2000-01-15 |
Family
ID=21924701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94913969T ATE188692T1 (de) | 1993-04-05 | 1994-03-29 | Fibrinogenrezeptorantagonisten |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5441952A (de) |
| EP (1) | EP0693067B1 (de) |
| JP (1) | JPH08508501A (de) |
| AT (1) | ATE188692T1 (de) |
| AU (1) | AU683882B2 (de) |
| CA (1) | CA2159482A1 (de) |
| DE (1) | DE69422615T2 (de) |
| WO (1) | WO1994022825A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996017833A1 (en) * | 1994-12-09 | 1996-06-13 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| ATE274499T1 (de) | 1995-09-29 | 2004-09-15 | Lilly Co Eli | Spiro verbindungen als inhibitoren der fibrinogen-abhängigen blutplättchen aggregation |
| US6011029A (en) * | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| ES2271971T3 (es) * | 1996-07-25 | 2007-04-16 | Biogen Idec Ma Inc. | Inhibidores de la adhesion celular. |
| US6686350B1 (en) | 1996-07-25 | 2004-02-03 | Biogen, Inc. | Cell adhesion inhibitors |
| US6265418B1 (en) * | 1997-07-31 | 2001-07-24 | Ube Industries, Ltd. | N-acylamino acid amide compounds and intermediates for preparation thereof |
| US6623981B2 (en) * | 1998-01-27 | 2003-09-23 | Bristol-Myers Squibb Company | Detection of patients at risk for developing integrin antagonist/agonist mediated disease states |
| DE60227185D1 (de) | 2001-11-13 | 2008-07-31 | Ortho Mcneil Pharm Inc | Substituierte 1,4-benzodiazepine und ihre anwendung in der krebsbehandlung |
| EP1591120A4 (de) * | 2003-01-28 | 2009-06-10 | Takeda Chemical Industries Ltd | Rezeptor-agonisten |
| US9416132B2 (en) | 2011-07-21 | 2016-08-16 | Tolero Pharmaceuticals, Inc. | Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors |
| EP3924351B1 (de) | 2019-02-12 | 2025-05-21 | Sumitomo Pharma America, Inc. | Kristalline form des hydrochlorid salzes von 2-((1r,4r)-4-((3-(3-(trifluoromethyl)phenyl) imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4313947A (en) * | 1974-06-24 | 1982-02-02 | Otsuka Pharmaceutical Co., Ltd. | Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use |
| DE2549999A1 (de) * | 1975-11-07 | 1977-05-12 | Boehringer Mannheim Gmbh | Piperidin-derivate und verfahren zu ihrer herstellung |
| US4064125A (en) * | 1976-10-29 | 1977-12-20 | E. R. Squibb And Sons, Inc. | Substituted amides having antiinflammatory activity |
| EP0021592B1 (de) * | 1979-05-23 | 1983-09-28 | BEECHAM - WUELFING GmbH & Co. KG | Benzolsulfonamid-Derivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Medikamente |
| DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
| KR880007441A (ko) * | 1986-12-11 | 1988-08-27 | 알렌 제이.스피겔 | 스피로-치환된 글루타르아미드 이뇨제 |
| US4879313A (en) * | 1988-07-20 | 1989-11-07 | Mosanto Company | Novel platelet-aggregation inhibitors |
| US5039805A (en) * | 1988-12-08 | 1991-08-13 | Hoffmann-La Roche Inc. | Novel benzoic and phenylacetic acid derivatives |
| US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
| CA2008116C (en) * | 1989-02-23 | 2001-11-20 | Thomas Weller | Glycine derivatives |
| NZ234264A (en) * | 1989-06-29 | 1993-05-26 | Warner Lambert Co | N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions |
| NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
| CA2112360A1 (en) * | 1991-06-28 | 1993-12-23 | William Edward Bondinell | Bicyclic fibrinogen antagonists |
-
1993
- 1993-04-05 US US08/042,963 patent/US5441952A/en not_active Expired - Fee Related
-
1994
- 1994-03-29 AT AT94913969T patent/ATE188692T1/de not_active IP Right Cessation
- 1994-03-29 WO PCT/US1994/003400 patent/WO1994022825A1/en not_active Ceased
- 1994-03-29 EP EP94913969A patent/EP0693067B1/de not_active Expired - Lifetime
- 1994-03-29 AU AU66218/94A patent/AU683882B2/en not_active Ceased
- 1994-03-29 CA CA002159482A patent/CA2159482A1/en not_active Abandoned
- 1994-03-29 DE DE69422615T patent/DE69422615T2/de not_active Expired - Fee Related
- 1994-03-29 JP JP6522292A patent/JPH08508501A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0693067B1 (de) | 2000-01-12 |
| AU683882B2 (en) | 1997-11-27 |
| DE69422615D1 (de) | 2000-02-17 |
| EP0693067A4 (de) | 1995-12-12 |
| EP0693067A1 (de) | 1996-01-24 |
| DE69422615T2 (de) | 2000-08-03 |
| JPH08508501A (ja) | 1996-09-10 |
| US5441952A (en) | 1995-08-15 |
| CA2159482A1 (en) | 1994-10-13 |
| WO1994022825A1 (en) | 1994-10-13 |
| AU6621894A (en) | 1994-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |